EP4096659A4 - SREBP INHIBITORS COMPRISING A THIOPHENIC RING - Google Patents

SREBP INHIBITORS COMPRISING A THIOPHENIC RING Download PDF

Info

Publication number: EP4096659A4
Authority: EP; European Patent Office
Prior art keywords: srebp; inhibitors; thiophenic ring; thiophenic; ring
Prior art date: 2020-01-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP21748420.3A

Other languages

German (de)

French (fr)

Other versions

EP4096659A1 (en

Inventor

Michael John Green

Barry Patrick Hart

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Capulus Therapeutics LLC

Original Assignee

Capulus Therapeutics LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-01-27

Filing date

2021-01-26

Publication date

2023-10-18

2021-01-26 Application filed by Capulus Therapeutics LLC filed Critical Capulus Therapeutics LLC

2022-12-07 Publication of EP4096659A1 publication Critical patent/EP4096659A1/en

2023-10-18 Publication of EP4096659A4 publication Critical patent/EP4096659A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP21748420.3A 2020-01-27 2021-01-26 SREBP INHIBITORS COMPRISING A THIOPHENIC RING Withdrawn EP4096659A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US202062966358P	2020-01-27	2020-01-27
US202063056410P	2020-07-24	2020-07-24
PCT/US2021/015101 WO2021154735A1 (en)	2020-01-27	2021-01-26	Srebp inhibitors comprising a thiophene central ring

Publications (2)

Publication Number	Publication Date
EP4096659A1 EP4096659A1 (en)	2022-12-07
EP4096659A4 true EP4096659A4 (en)	2023-10-18

Family

ID=77079187

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP21748420.3A Withdrawn EP4096659A4 (en)	2020-01-27	2021-01-26	SREBP INHIBITORS COMPRISING A THIOPHENIC RING

Country Status (2)

Country	Link
EP (1)	EP4096659A4 (en)
WO (1)	WO2021154735A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2024089216A1 (en)	2022-10-27	2024-05-02	Syngenta Crop Protection Ag	Novel sulfur-containing heteroaryl carboxamide compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2015031710A1 (en) *	2013-08-29	2015-03-05	Baylor College Of Medicine	Compositions and methods for the treatment of metabolic and body weight related disorders
WO2017190086A1 (en) *	2016-04-29	2017-11-02	Fgh Biotech, Inc.	Di-substituted pyrazole compounds for the treatment of diseases
WO2018049080A1 (en) *	2016-09-07	2018-03-15	Fgh Biotech, Inc.	Di-substituted pyrazole compounds for the treatment of diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2008214095B2 (en) *	2007-02-02	2014-07-10	Baylor College Of Medicine	Compositions and methods for the treatment of metabolic disorders
KR20160067841A (en) *	2013-08-28	2016-06-14	메디베이션 테크놀로지즈, 인크.	Heterocyclic compounds and methods of use
CA2978627A1 (en) *	2015-03-04	2016-09-09	Medivation Technologies, Inc.	Srebp blockers for use in treating liver fibrosis, elevated cholesterol and insulin resistance
CA2977539A1 (en) *	2015-03-04	2016-09-09	Medivation Technologies, Inc.	Sterol regulatory element-binding proteins (srebps) inhibitors

2021
- 2021-01-26 EP EP21748420.3A patent/EP4096659A4/en not_active Withdrawn
- 2021-01-26 WO PCT/US2021/015101 patent/WO2021154735A1/en not_active Ceased

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2015031710A1 (en) *	2013-08-29	2015-03-05	Baylor College Of Medicine	Compositions and methods for the treatment of metabolic and body weight related disorders
WO2017190086A1 (en) *	2016-04-29	2017-11-02	Fgh Biotech, Inc.	Di-substituted pyrazole compounds for the treatment of diseases
WO2018049080A1 (en) *	2016-09-07	2018-03-15	Fgh Biotech, Inc.	Di-substituted pyrazole compounds for the treatment of diseases

Also Published As

Publication number	Publication date
EP4096659A1 (en)	2022-12-07
WO2021154735A1 (en)	2021-08-05

Publication	Publication Date	Title
JP1707203S (en)	2022-02-09	ring
JP1706911S (en)	2022-02-04	ring
JP1706905S (en)	2022-02-04	ring
JP1707066S (en)	2022-02-08	ring
JP1706899S (en)	2022-02-04	ring
JP1707206S (en)	2022-02-09	ring
JP1707200S (en)	2022-02-09	ring
JP1707075S (en)	2022-02-08	ring
EP4458777A4 (en)	2025-10-29	PRODUCTION DEVICE
CL2021001491S1 (en)	2022-01-21	Talking.
LT3990414T (en)	2023-09-11	METHOD OF MANUFACTURING A CARBONATE-BONDED, COMPACTED PRODUCT
IL286750A (en)	2021-10-31	becomes a semiconductor
EP4413158A4 (en)	2025-07-09	B(EAD-BASED) A(TACSEQ) P(ROCESSING)
EP4096659A4 (en)	2023-10-18	SREBP INHIBITORS COMPRISING A THIOPHENIC RING
EP4251372C0 (en)	2025-09-24	Radial Press Tool
EP4087724C0 (en)	2024-07-10	TABLETTING MACHINE
EP4093601C0 (en)	2024-02-07	RADIAL PRESS
EP4058014A4 (en)	2023-12-13	SREBP INHIBITOR HAVING A THIOPHENIC RING
JP1709267S (en)	2022-03-08	ring
EP4074954A4 (en)	2023-12-27	PRESSURE RING
ES1210863Y (en)	2018-07-17	A MOBILE ELBOW.
EP4135973C0 (en)	2024-01-10	RADIAL PRESS
ES1278739Y (en)	2021-12-29	A PURSE
EP4474359A4 (en)	2025-10-29	PRODUCTION DEVICE
JP1737691S (en)	2023-02-27	die grinder

Legal Events

Date	Code	Title	Description
2021-08-06	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2022-11-04	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2022-11-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2022-12-07	17P	Request for examination filed	Effective date: 20220802
2022-12-07	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2023-05-03	DAV	Request for validation of the european patent (deleted)
2023-05-03	DAX	Request for extension of the european patent (deleted)
2023-09-08	REG	Reference to a national code	Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: A61K0031442700 Ipc: C07D0409040000
2023-10-18	A4	Supplementary search report drawn up and despatched	Effective date: 20230914
2023-10-18	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/4436 20060101ALI20230908BHEP Ipc: A61K 31/436 20060101ALI20230908BHEP Ipc: A61P 3/06 20060101ALI20230908BHEP Ipc: A61P 1/16 20060101ALI20230908BHEP Ipc: C07D 491/056 20060101ALI20230908BHEP Ipc: C07D 409/04 20060101AFI20230908BHEP
2024-08-08	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2024-09-11	18D	Application deemed to be withdrawn	Effective date: 20240416