[go: up one dir, main page]

EP1888618A4 - GLYCYL-PROLYL-GLUTAMATE ANALOGS - Google Patents

GLYCYL-PROLYL-GLUTAMATE ANALOGS

Info

Publication number
EP1888618A4
EP1888618A4 EP06770950A EP06770950A EP1888618A4 EP 1888618 A4 EP1888618 A4 EP 1888618A4 EP 06770950 A EP06770950 A EP 06770950A EP 06770950 A EP06770950 A EP 06770950A EP 1888618 A4 EP1888618 A4 EP 1888618A4
Authority
EP
European Patent Office
Prior art keywords
glycyl
prolyl
glutamate analogs
glutamate
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06770950A
Other languages
German (de)
French (fr)
Other versions
EP1888618A2 (en
Inventor
Margaret Anne Brimble
Paul William Richard Harris
Frank Sieg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuren Pharmaceuticals Ltd
Original Assignee
Neuren Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuren Pharmaceuticals Ltd filed Critical Neuren Pharmaceuticals Ltd
Publication of EP1888618A2 publication Critical patent/EP1888618A2/en
Publication of EP1888618A4 publication Critical patent/EP1888618A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
EP06770950A 2005-05-23 2006-05-23 GLYCYL-PROLYL-GLUTAMATE ANALOGS Withdrawn EP1888618A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68381305P 2005-05-23 2005-05-23
PCT/US2006/019909 WO2006127702A2 (en) 2005-05-23 2006-05-23 Analogs of glycyl-prolyl-glutamate

Publications (2)

Publication Number Publication Date
EP1888618A2 EP1888618A2 (en) 2008-02-20
EP1888618A4 true EP1888618A4 (en) 2009-07-15

Family

ID=37452742

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06770950A Withdrawn EP1888618A4 (en) 2005-05-23 2006-05-23 GLYCYL-PROLYL-GLUTAMATE ANALOGS

Country Status (3)

Country Link
EP (1) EP1888618A4 (en)
JP (1) JP2008545697A (en)
WO (1) WO2006127702A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5220724B2 (en) * 2006-03-14 2013-06-26 ニューレン ファーマシューティカルズ リミテッド Oral formulation of glycyl-2-methylprolyl glutamate
WO2009007080A1 (en) * 2007-07-06 2009-01-15 University Of Zurich Method of preventing and treating acute brain pathologies
AU2008297935A1 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a RGD-peptide and/or parathyroid hormone (1-34 ) as anti-HIV agent
AU2008303945A1 (en) 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
SG191291A1 (en) * 2011-01-19 2013-07-31 Galapagos Nv Azetidine derivatives useful for the treatment of metabolic and inflammatory diseases
US9708366B2 (en) * 2011-01-27 2017-07-18 Neuren Pharmaceuticals Ltd. Treatment of fragile X syndrome using glycyl-L-2-methylprolyl-L-glutamate
SG187271A1 (en) * 2011-07-07 2013-02-28 Agency Science Tech & Res Anti-amyloidogenic, alpha-helix breaking ultra-small peptide therapeutic
BR112015012506A2 (en) * 2012-11-28 2017-07-11 Neuren Pharmaceuticals Ltd treatment of autism spectrum disorders using glycyl-1-2-methylprolyl-1-glutamic acid
CN103275106B (en) * 2013-04-19 2015-09-30 暨南大学 A kind of indole alkaloid adduct and preparation method thereof and preparing the application in antitumor drug
CN114667136A (en) * 2019-08-05 2022-06-24 诺仁制药有限公司 Composition of TROFINETIDE
GB202102709D0 (en) * 2021-02-25 2021-04-14 Univ Southampton Compounds
CN113135983B (en) * 2021-04-12 2022-06-24 四川大学华西医院 Antitumor compound and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094856A2 (en) * 2001-05-24 2002-11-28 Neuronz Limited Gpe analogs and peptidomimetics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187906B1 (en) * 1997-08-11 2001-02-13 Aukland Uniservices Limited Methods to improve neural outcome

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094856A2 (en) * 2001-05-24 2002-11-28 Neuronz Limited Gpe analogs and peptidomimetics

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ALONSO DE DIEGO S A ET AL: "Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 9, 2 May 2005 (2005-05-02), pages 2279 - 2283, XP025313633, ISSN: 0960-894X, [retrieved on 20050502] *
ALONSO DE DIEGO S A ET AL: "The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 16, no. 13, 1 July 2006 (2006-07-01), pages 3396 - 3400, XP025107379, ISSN: 0960-894X, [retrieved on 20060701] *
BRIMBLE MARGARET A ET AL: "Synthesis and pharmacological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE).", BIOORGANIC & MEDICINAL CHEMISTRY 17 JAN 2005, vol. 13, no. 2, 17 January 2005 (2005-01-17), pages 519 - 532, XP002528279, ISSN: 0968-0896 *
GILLESSEN D ET AL: "[Syntheses of thyrotropin-releasing hormones (TRH) (Schaf) and related peptides]", HELVETICA CHIMICA ACTA 1970, vol. 53, no. 1, 1970, pages 63 - 72, XP002528278, ISSN: 0018-019X *
LAI MICHELLE Y H ET AL: "Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE).", BIOORGANIC & MEDICINAL CHEMISTRY 17 JAN 2005, vol. 13, no. 2, 17 January 2005 (2005-01-17), pages 533 - 548, XP002528274, ISSN: 0968-0896 *
MAEHASHI K ET AL: "Isolation of peptides from an enzymatic hydrolysate of food proteins and characterization of their taste properties.", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY MAR 1999, vol. 63, no. 3, March 1999 (1999-03-01), pages 555 - 559, XP002528276, ISSN: 0916-8451 *
PARK JUNG-NIM ET AL: "Taste effects of oligopeptides in a Vietnamese fish sauce", FISHERIES SCIENCE (TOKYO), vol. 68, no. 4, August 2002 (2002-08-01), pages 921 - 928, XP002528277, ISSN: 0919-9268 *
SLOOTSTRA J W ET AL: "STRUCTURAL ASPECTS OF ANTIBODY-ANTIGEN INTERACTION REVEALED THROUGH SMALL RANDOM PEPTIDE LIBRARIES", MOLECULAR DIVERSITY, ESCOM SCIENCE PUBLISHERS, LEIDEN, NL, vol. 1, no. 2, 1 January 1995 (1995-01-01), pages 87 - 96, XP008065429, ISSN: 1381-1991 *
TROTTER NICHOLAS S ET AL: "Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L-glutamic acid (GPE) modified at the alpha-carboxylic acid.", BIOORGANIC & MEDICINAL CHEMISTRY 17 JAN 2005, vol. 13, no. 2, 17 January 2005 (2005-01-17), pages 501 - 517, XP002528275, ISSN: 0968-0896 *

Also Published As

Publication number Publication date
WO2006127702A2 (en) 2006-11-30
EP1888618A2 (en) 2008-02-20
WO2006127702A3 (en) 2007-06-14
JP2008545697A (en) 2008-12-18

Similar Documents

Publication Publication Date Title
MA28841B1 (en) TETRAPEPTITIIC ANALOGS
EP1994182A4 (en) DEGENATED NUCLEOBASE ANALOGS
EP2096917A4 (en) CYCLOPAMINE ANALOGS
MA28857B1 (en) PIPERAZINYL-PYRIDINE BIARYLIC SUBSTITUTED ANALOGUES
DK1819670T3 (en) 12-aryl-prostaglandin analogues
EP2029597A4 (en) ANALOGUES OF THE PURINE
DK1960422T3 (en) VERY EFFECTIVE COMPSTATIN ANALOGS
DK1928882T3 (en) (S) -N-methylnaltrexone
DE502005002342D1 (en) Light-emitting component
EP1968937A4 (en) DIAZAPURIN ANALOGUES OF 1'-AZA-L-NUCLEOSIDES
CY2013047I1 (en) DIARYLYDANTOIN COMPOUNDS
BRPI0911269A2 (en) halicondrin analogues b
BRPI0608999A2 (en) fastening set
EP1870803A4 (en) PROCESSOR
DE502005010582D1 (en) Grommet
FI20055649L (en) Location techniques
CR10675A (en) 2-PHENOXYPIRIMIDINONE ANALOGS
EP1908697A4 (en) refill
NO20054669D0 (en) Substituted quinobenzoxazine analogues
BRPI0607440A2 (en) fastening set
EP1841430A4 (en) Substituted pyridazinyl-and pyrimidinyl-quinolin-4-ylamine analogues
EP1888618A4 (en) GLYCYL-PROLYL-GLUTAMATE ANALOGS
BRPI0619124A2 (en) fastening set
EP1916896A4 (en) NON-STEROIDIAN ANTIANDROGENES
DE602006010523D1 (en) DANCE

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20071206

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 25/00 20060101ALI20090602BHEP

Ipc: A61P 27/00 20060101ALI20090602BHEP

Ipc: A61P 29/00 20060101ALI20090602BHEP

Ipc: C07K 5/08 20060101AFI20071220BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20090615

17Q First examination report despatched

Effective date: 20091117

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20100528