EP0950060A4 - Antisense inhibition of human adhesion molecules - Google Patents

Antisense inhibition of human adhesion molecules

Info

Publication number: EP0950060A4
Authority: EP; European Patent Office
Prior art keywords: adhesion molecules; antisense inhibition; human adhesion; human; antisense
Prior art date: 1996-12-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP96945380A

Other languages

German (de)

French (fr)

Other versions

EP0950060A1 (en

Inventor

Glenn D Hoke

Matthews O Bradley

Taffy J Williams

Che-Hung Lee

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Dyad Pharmaceutical Corp

Original Assignee

Dyad Pharmaceutical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-02

Filing date

1996-12-02

Publication date

2000-07-05

1996-12-02 Application filed by Dyad Pharmaceutical Corp filed Critical Dyad Pharmaceutical Corp

1999-10-20 Publication of EP0950060A1 publication Critical patent/EP0950060A1/en

2000-07-05 Publication of EP0950060A4 publication Critical patent/EP0950060A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Biotechnology (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
General Engineering & Computer Science (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP96945380A 1996-12-02 1996-12-02 Antisense inhibition of human adhesion molecules Withdrawn EP0950060A4 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1996/019194 WO1998024797A1 (en)	1996-12-02	1996-12-02	Antisense inhibition of human adhesion molecules

Publications (2)

Publication Number	Publication Date
EP0950060A1 EP0950060A1 (en)	1999-10-20
EP0950060A4 true EP0950060A4 (en)	2000-07-05

Family

ID=22256225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP96945380A Withdrawn EP0950060A4 (en)	1996-12-02	1996-12-02	Antisense inhibition of human adhesion molecules

Country Status (5)

Country	Link
EP (1)	EP0950060A4 (en)
JP (1)	JP2001505432A (en)
AU (1)	AU1564897A (en)
CA (1)	CA2273203A1 (en)
WO (1)	WO1998024797A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6193699A (en) *	1998-09-25	2000-04-17	Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts	Antisense-sequences for inhibiting the expression of the adhesion molecule icam-1
DE19844111A1 (en) *	1998-09-25	2000-04-20	Deutsches Krebsforsch	Novel antisense nucleic acids targeted to specific sequences within the ICAM-1 gene, useful for treating inflammation and metastasis
US6114517A (en) *	1998-12-10	2000-09-05	Isis Pharmaceuticals Inc.	Methods of modulating tumor necrosis factor α-induced expression of cell adhesion molecules
US6670321B1 (en)	1998-12-30	2003-12-30	The Children's Medical Center Corporation	Prevention and treatment for retinal ischemia and edema
DK1621212T3 (en)	1999-01-27	2012-03-05	Coda Therapeutics Inc	Formulations comprising antisense nucleotides for connexins
DE10019252A1 (en) *	2000-04-18	2001-10-31	Klaus Karl Degitz	Polydeoxyribonucleotides to inhibit ICAM-1 gene expression
DE10141443B4 (en) *	2001-08-23	2007-02-01	Christos C. Prof. Dr. Zouboulis	Use of molecular biologically produced, non-viral agents for the treatment of acne
KR20130008653A (en)	2003-12-03	2013-01-22	코다 테라퓨틱스 (엔지) 리미티드	Antisense compounds targeted to connexins and methods of use thereof
US9248141B2 (en)	2005-02-03	2016-02-02	Coda Therapeutics, Inc.	Methods of treatment by administering anti-connexin proteins and mimetics
KR20150072458A (en)	2006-11-15	2015-06-29	코다 테라퓨틱스, 인크.	Improved methods and compositions for wound healing
AU2007333535B2 (en)	2006-12-11	2014-04-17	Coda Therapeutics, Inc.	Anticonnexin polynucleotides as impaired wound healing compositions
WO2009085270A2 (en)	2007-12-21	2009-07-09	Coda Therapeutics, Inc.	Use of inhibitors of c0nnexin43 for treatment of fibrotic conditions
CN114010788A (en)	2014-08-22	2022-02-08	奥克兰联合服务有限公司	channel modulator
JP7495230B2 (en)	2017-04-28	2024-06-04	オークランドユニサービシズリミテッド	Treatment methods and novel constructs

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993001286A2 (en) *	1991-06-28	1993-01-21	Massachusetts Institute Of Technology	Localized oligonucleotide therapy
WO1994022488A1 (en) *	1993-04-01	1994-10-13	Isis Pharmaceuticals, Inc.	ANTISENSE OLIGOS WHICH INTERFERE WITH mRNA CAP ACTIVITY AND INHIBIT TRANSLATION
WO1996015780A1 (en) *	1994-11-23	1996-05-30	Isis Pharmaceuticals, Inc.	Compositions and methods for preventing and treating allograft rejection
US5580969A (en) *	1992-07-24	1996-12-03	The United States Of America As Represented By The Secretary Of The Navy	Antisense oligonucleotides directed against human ICAM-I RNA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5284931A (en) *	1987-05-04	1994-02-08	Dana Farber Cancer Institute	Intercellular adhesion molecules, and their binding ligands
US5591623A (en) *	1990-08-14	1997-01-07	Isis Pharmaceuticals, Inc.	Oligonucleotide modulation of cell adhesion
EP0558697A1 (en) *	1991-06-28	1993-09-08	Massachusetts Institute Of Technology	Localized oligonucleotide therapy

1996
- 1996-12-02 EP EP96945380A patent/EP0950060A4/en not_active Withdrawn
- 1996-12-02 CA CA002273203A patent/CA2273203A1/en not_active Abandoned
- 1996-12-02 AU AU15648/97A patent/AU1564897A/en not_active Abandoned
- 1996-12-02 WO PCT/US1996/019194 patent/WO1998024797A1/en not_active Ceased
- 1996-12-02 JP JP52553398A patent/JP2001505432A/en not_active Ceased

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993001286A2 (en) *	1991-06-28	1993-01-21	Massachusetts Institute Of Technology	Localized oligonucleotide therapy
US5580969A (en) *	1992-07-24	1996-12-03	The United States Of America As Represented By The Secretary Of The Navy	Antisense oligonucleotides directed against human ICAM-I RNA
WO1994022488A1 (en) *	1993-04-01	1994-10-13	Isis Pharmaceuticals, Inc.	ANTISENSE OLIGOS WHICH INTERFERE WITH mRNA CAP ACTIVITY AND INHIBIT TRANSLATION
WO1996015780A1 (en) *	1994-11-23	1996-05-30	Isis Pharmaceuticals, Inc.	Compositions and methods for preventing and treating allograft rejection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BENNETT C F ET AL: "INHIBITION OF ICAM-1, VCAM-1 AND E-SELECTIN EXPRESSION WITH ANTISENSE OLIGONUCLEOTIDES", JOURNAL OF CELLULAR BIOCHEMISTRY. SUPPLEMENT, 9 January 1993 (1993-01-09), pages 354, XP000647853 *
LEE CH. ET AL.: "Antisense gene suppression against human ICAM-1, ELAM-1, and VCAM-1 in cultured human umbilical vein endothelial cells.", SHOCK 1995 JUL;4(1):1-10, XP000892942 *
See also references of WO9824797A1 *

Also Published As

Publication number	Publication date
CA2273203A1 (en)	1998-06-11
EP0950060A1 (en)	1999-10-20
WO1998024797A1 (en)	1998-06-11
AU1564897A (en)	1998-06-29
JP2001505432A (en)	2001-04-24

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EG21382A (en)	2001-09-30	Treatment of water
PL329875A1 (en)	1999-04-12	Derivatives of carbolin
PL329195A1 (en)	1999-03-15	Derivatives of 6-phenylpyridol-2-amine
PL327569A1 (en)	1998-12-21	Promedications of thrombosin inhibitors
GB9526560D0 (en)	1996-02-28	Use of 2-Amino-Heterocycles
EP0950060A4 (en)	2000-07-05	Antisense inhibition of human adhesion molecules
SG42329A1 (en)	1997-08-15	Use of phenylcyclohexylcarboxamides
IL113992A0 (en)	1995-10-31	Use of copolymer-1
HU9702480D0 (en)	1998-03-02	New polymorphe modification of doxazosin-mesylate
GB9615159D0 (en)	1996-09-04	Treatment of liquid
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GB2328397B (en)	1999-08-11	Manufacture of elongate members
HU9702479D0 (en)	1998-03-02	New polymorphe modification of doxazosin-mesylate
ZA971958B (en)	1998-09-07	Treatment of cocoa
IL134210A0 (en)	2001-04-30	Use of transcription factor brn-3a
AU6920898A (en)	1998-09-29	Antisense inhibition of human stat-6
AU6578298A (en)	1998-10-20	Antisense inhibition of angiogenin expression
ZA976333B (en)	1998-07-23	Treatment of obesity
GB9611315D0 (en)	1996-08-07	Treatment of painted surfaces
PL313849A1 (en)	1997-10-27	Beta-aminoesters of o-hydrobenzylamides
SG64924A1 (en)	1999-05-25	Inhibiting photodecompostion of 3-substituted-2- oxindoles
GB9724088D0 (en)	1998-01-14	Treatment of dyskinesia
GB9612603D0 (en)	1996-08-21	Treatment of biosolids
PL105402U1 (en)	1998-04-14	Hardware of line stand-isolator
ZA9811524B (en)	1999-06-21	Treatment of effluent

Legal Events

Date	Code	Title	Description
1999-09-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1999-10-20	17P	Request for examination filed	Effective date: 19990616
1999-10-20	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2000-07-05	A4	Supplementary search report drawn up and despatched	Effective date: 20000518
2000-07-05	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-09-11	17Q	First examination report despatched	Effective date: 20020724
2004-12-03	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2005-01-19	18D	Application deemed to be withdrawn	Effective date: 20040716