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EP0868179A4 - Nouvelle utilisation du losartan - Google Patents

Nouvelle utilisation du losartan

Info

Publication number
EP0868179A4
EP0868179A4 EP96944328A EP96944328A EP0868179A4 EP 0868179 A4 EP0868179 A4 EP 0868179A4 EP 96944328 A EP96944328 A EP 96944328A EP 96944328 A EP96944328 A EP 96944328A EP 0868179 A4 EP0868179 A4 EP 0868179A4
Authority
EP
European Patent Office
Prior art keywords
losartan
new use
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96944328A
Other languages
German (de)
English (en)
Other versions
EP0868179A1 (fr
Inventor
Sheila M Cohen
Jeffrey G Werrmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603376.6A external-priority patent/GB9603376D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0868179A1 publication Critical patent/EP0868179A1/fr
Publication of EP0868179A4 publication Critical patent/EP0868179A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP96944328A 1995-12-12 1996-12-09 Nouvelle utilisation du losartan Withdrawn EP0868179A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US875795P 1995-12-12 1995-12-12
US8757 1995-12-12
GBGB9603376.6A GB9603376D0 (en) 1996-02-16 1996-02-16 New use for Iosartan
GB9603376 1996-02-16
PCT/US1996/019781 WO1997021436A1 (fr) 1995-12-12 1996-12-09 Nouvelle utilisation du losartan

Publications (2)

Publication Number Publication Date
EP0868179A1 EP0868179A1 (fr) 1998-10-07
EP0868179A4 true EP0868179A4 (fr) 2002-01-30

Family

ID=26308746

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96944328A Withdrawn EP0868179A4 (fr) 1995-12-12 1996-12-09 Nouvelle utilisation du losartan

Country Status (4)

Country Link
EP (1) EP0868179A4 (fr)
JP (1) JP2000501736A (fr)
CA (1) CA2238975A1 (fr)
WO (1) WO1997021436A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225254A1 (en) 1989-08-07 2003-12-04 Rathjen Deborah Ann Tumour necrosis factor binding ligands
EP0855392A3 (fr) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Hétérocycles à cinq chaínons contenant des substituants biphénylylsulphoniques, leur procédé de préparation, leur utilisation comme médicament ou agent diagnostique ainsi que médicament les contenant
IT1295405B1 (it) * 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
AU742506B2 (en) 1997-10-17 2002-01-03 Eurogene Limited The use of inhibitors of the renin-angiotensin system
GB2337701A (en) * 1998-05-26 1999-12-01 United Medical And Dental Schools Of Guys St Thomas Hospitals Treatment of ischemia with an angiotensin II antagonist
CN101011390A (zh) 1999-01-26 2007-08-08 诺瓦提斯公司 血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用
CA2464561A1 (fr) * 2001-10-25 2003-05-01 Depomed, Inc. Traitement utilisant une dose posologique de losartan a retention gastrique
DE60325709D1 (de) 2002-04-09 2009-02-26 Flamel Tech Sa Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
AU2003290699B2 (en) * 2002-11-13 2009-08-27 Novartis Vaccines And Diagnostics, Inc. Methods of treating cancer and related methods
CA2556872C (fr) 2004-02-20 2015-05-12 Chiron Corporation Modulation de processus inflammatoires et metastiques
FR2884145A1 (fr) * 2005-04-06 2006-10-13 Flamel Technologies Sa Forme pharmaceutique orale de losartan
FR2882260A1 (fr) * 2005-02-21 2006-08-25 Flamel Technologies Sa Forme pharmaceutique orale multimicroparticulaire a liberation modifiee d'antagonistes des recepteurs de l'angiotensine ii
JP2008530185A (ja) * 2005-02-21 2008-08-07 フラメル・テクノロジー ロサルタンの経口医薬剤形態
DK1885187T3 (da) 2005-05-13 2013-12-09 Novartis Ag Fremgangsmåde til behandling af lægemiddelresistent cancer
WO2010151080A2 (fr) * 2009-06-25 2010-12-29 진양제약 주식회사 Composition pharmaceutique contenant du carboxy-losartan et son procede de production

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565485A (en) * 1993-03-19 1996-10-15 Merck & Co., Inc. Biphenyl compounds useful or endothelin antagonists
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CAPASSO ET AL.: "Efficacy of ACE inhibition and AT1 receptor blockade on cardiac pump performance after myocardial infarction in rats", J. CARDIOVASC. PHARMACOL., vol. 23, 1994, pages 584 - 593, XP001033935 *
FLEETWOOD G ET AL: "INVOLVEMENT OF THE RENIN ANGIOTENSIN SYSTEM IN ISCHEMIC DAMAGE AND REPERFUSION ARRHYTHMIAS IN THE ISOLATED PERFUSED RAT HEART", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol. 17, no. 3, 1991, pages 351 - 356, XP001029360, ISSN: 0160-2446 *
IZUMI HISAKO ET AL: "Effects of BIBR-277, an angiotensin II type 1 receptor antagonist, on stunned myocardium in dogs.", CORONARY ARTERY DISEASE, vol. 7, no. 10, 1996, pages 775 - 779, XP001033778, ISSN: 0954-6928 *
SCHIEFFER ET AL.: "Comparative effects of chronic ACE inhibition and AII type1 receptor blockade on cardiac remodeling after myocardial infarction in the rat", CIRCULATION, vol. 89, 1994, pages 2273 - 2282, XP001033870 *
See also references of WO9721436A1 *
WERRMANN JEFFREY G ET AL: "Comparison of effects of angiotensin-converting enzyme inhibition with those of angiotensin II receptor antagonism on functional and metabolic recovery in postischemic working rat heart as studied by (31P) nuclear magnetic resonance.", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, vol. 24, no. 4, 1994, pages 573 - 586, XP001029379, ISSN: 0160-2446 *
YOSHIYAMA ET AL.: "cardioprotective effect of the AII type 1 receptor antagonisr TCV-116 on ischemia-reperfusion injury", AMERICAN HEART JOURNAL, vol. 128, 1994, pages 1-6, XP001029664 *
YOSHIYAMA MINORU ET AL: "Protective effect of pretreatment with angiotensin II type I receptor antagonist on the ischemia-reperfused myocardium.", CIRCULATION, vol. 88, no. 4 PART 2, 1993, 66th Scientific Sessions of the American Heart Association;Atlanta, Georgia, USA; November 8-11, 1993, pages I474, XP001029391, ISSN: 0009-7322 *
ZWEIER JAY L ET AL: "Angiotensin II receptor blockade decreases neutrophil-mediated injury in the postischemic heart.", FASEB JOURNAL, vol. 9, no. 4, 1995, Experimental Biology 95, Part II;Atlanta, Georgia, USA; April 9-13, 1995, pages A844, XP001029375, ISSN: 0892-6638 *

Also Published As

Publication number Publication date
CA2238975A1 (fr) 1997-06-19
AU704841B2 (en) 1999-05-06
AU1416497A (en) 1997-07-03
JP2000501736A (ja) 2000-02-15
WO1997021436A1 (fr) 1997-06-19
EP0868179A1 (fr) 1998-10-07

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Effective date: 20040422