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EP0240464A1 - Reinigungszusammensetzungen für weiche und harte Kontaktlinsen - Google Patents

Reinigungszusammensetzungen für weiche und harte Kontaktlinsen Download PDF

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Publication number
EP0240464A1
EP0240464A1 EP87810185A EP87810185A EP0240464A1 EP 0240464 A1 EP0240464 A1 EP 0240464A1 EP 87810185 A EP87810185 A EP 87810185A EP 87810185 A EP87810185 A EP 87810185A EP 0240464 A1 EP0240464 A1 EP 0240464A1
Authority
EP
European Patent Office
Prior art keywords
composition according
heterogeneous composition
compound
particulate
polyethoxylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87810185A
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German (de)
English (en)
French (fr)
Inventor
Lynn Winterton
Kai Chiang Su
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of EP0240464A1 publication Critical patent/EP0240464A1/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
    • C11D17/0013—Liquid compositions with insoluble particles in suspension
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/261—Alcohols; Phenols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/263—Ethers
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/265—Carboxylic acids or salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/268—Carbohydrates or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/32—Organic compounds containing nitrogen
    • C11D7/3227—Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/50—Solvents
    • C11D7/5004—Organic solvents
    • C11D7/5022—Organic solvents containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/38—Cationic compounds
    • C11D1/42—Amino alcohols or amino ethers
    • C11D1/44—Ethers of polyoxyalkylenes with amino alcohols; Condensation products of epoxyalkanes with amines
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/38—Cationic compounds
    • C11D1/52—Carboxylic amides, alkylolamides or imides or their condensation products with alkylene oxides
    • C11D1/526—Carboxylic amides (R1-CO-NR2R3), where R1, R2 or R3 are polyalkoxylated
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/72—Ethers of polyoxyalkylene glycols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/74—Carboxylates or sulfonates esters of polyoxyalkylene glycols

Definitions

  • compositions contain a particulate water-insoluble material, such as a silica abrasive or polymeric microbeads, in a suitable carrier liquid, such as water, which is thickened with a viscosity-increasing agent; see, for example, U.S. Patents 4,493,783 and 4,394,179.
  • compositions are generally suitable for removing such deposits, the presence of residual water-insoluble particulate material on the surface of the contact lens can and may even impair the patient lead to corneal injuries. Therefore, when using such heterogeneous suspensions known from the prior art, vigorous washing of such lenses is necessary.
  • An object of this invention relates to a heterogeneous composition for cleaning contact lenses, which contains an effective amount of a particulate water-soluble compound, for removing proteinaceous and non-proteinaceous deposits that normally accumulate on the surface of such contact lenses when worn. wherein the particulate compound is dispersed in a predominantly non-aqueous but water-miscible organic liquid suspension medium which is essentially a non-solvent for the particulate compound.
  • the type of water-soluble particulate compound can be varied widely. However, it should be chemically inert to the contact lens material in the environment in which it is used. The particulate compound should therefore not react chemically with the surface, so that it is irreversibly changed. In addition, the particles of the compound should be physically inert to the contact lens material, that is, the particles should not substantially scratch or grind the surface of the lens material, making the lens material unsuitable for further use.
  • the water-soluble particulate material is therefore preferably chosen so that it is substantially free of irregularities damaging the lens in the environment in which it is used.
  • the water-soluble particulate material typically has an average particle size of less than about 750 microns, preferably between about 1 and about 500 microns, and most preferably between about 1 and about 200 microns.
  • the particulate component should be sufficiently water-soluble that its particles dissolve in the heterogeneous composition when such a composition is introduced into water or an aqueous solution under normal conditions.
  • the hardness of the selected particulate material is not critical. However, the resistance of the selected particulate material to sustained deformation under the load associated with the cleaning process caused by rubbing should at least be sufficient to ensure effective removal of proteinaceous and non-proteinaceous deposits.
  • Suitable particulate water-soluble materials include water-soluble crystalline or glassy inorganic and organic compounds and mixtures thereof. These are preferably compounds which, in aqueous solutions in concentrations of between about 3 and about 20% by weight, give solutions which are isoosmotic with isotonic saline, preferably in concentrations of between about 4 and about 15% by weight, particularly preferably in concentrations between about 8 and about 12 percent by weight.
  • Isotonic saline is understood to mean an aqueous sodium chloride solution which contains about 0.9% by weight sodium chloride.
  • the particulate compound is pharmaceutically acceptable in the vicinity of the eye tissue.
  • Particularly advantageous are those particulate compounds which, when dissolved in water, are essentially non-irritating to the eye.
  • particulate compounds for the compositions according to the invention are sugars, such as monosaccharides, including pentoses, hexoses and heptoses, such as disaccharides, for example sucrose, maltose and lactose, and how trisaccharides, e.g. B. raffinose, and the water-soluble pharmaceutically acceptable derivatives thereof. Saccharin is also preferred.
  • suspension medium can also be varied within a wide range.
  • Preferred water-soluble liquid dispersants comprise conventional inert organic water-soluble media which do not substantially dissolve the suspended particulate material.
  • Pharmaceutically acceptable suspension media are particularly preferred.
  • Suitable suspension media include liquid, essentially non-ionic organic dispersing agents, for example glycerol, polypropylene glycol, polyethylene glycol, lower alkanols, for example ethanol or isopropanol, lower alkyl ethers, for example diethyl ether, lower alkyl esters of lower alkane carboxylic acids, for example isoamyl acetate, and mixtures thereof, and also essentially non-aqueous pharmaceutically acceptable surfactants, such as, but not limited to, polyethoxylated ones Alkanols having 6 to 20 carbon atoms, polyethoxylated Alkylphenylharmen, polyethoxylated polypropylene glycols, for example, poloxamers, polyethoxylated fatty acids, polyethoxylated fatty amides, polyethoxylated amines, polysorbates, tyloxapol, higher alkyl sulfates, higher alkyl sulfonates,
  • the suspension medium is preferably essentially nonionic in character.
  • “lower” means groups or compounds with up to 7 carbon atoms.
  • “higher” denotes groups or compounds with 7 and more carbon atoms, preferably up to 30 carbon atoms.
  • Suitable dispersing agents and dispersing components are widely available and include, but are not limited to, poloxamers, such as, for example, Pluronic® surfactants (BASF Wyandotte), for example Poloxamer 401, 402, 331, 333, 282, 231, 235, 182, 124 and 105; Polysorbates, for example Tween® tenside (ICI America), for example polysorbate 20, 40, 60, 65, 80 and 85; Tyloxapol, for example Superinon® detergent (Winthrop), polypropylene glycols, for example those with an average molecular weight between about 500 and about 5000, for example PPG 2025 with an average molecular weight of about 2000, or PPG 3025 with an average molecular weight of about 3000; Polyethylene glycols, for example those with an average molecular weight between about 300 and about 6000, for example polyethylene glycols 300, 400, 600, 1500, 1540, 4000 and 6000; Amine oxides of N-higher alkyl-N, N-
  • N, N-dimethyl-N-laurylamine oxide ethoxylated monoglycerides of fatty acids, e.g. polyethoxylated (on average 30 units) monoglycerides of coconut oil fatty acids, the polyethoxylated (on average 67 units ) Monoglyceride of coconut oil fatty acids or the polyethoxylated (on average 82 units) monoglyceride of tallow fatty acids; and polyethoxylated fatty acids and alcohols, for example Myrj® or Brij® surfactants (ICI America), such as for example polyoxyl 8 stearate, polyoxyl 40 stearate, polyoxyl 50 stearate, polyoxyl 10 oleyl ether and the like.
  • ICI America ICI America
  • the liquid medium which can be prepared from one or more suspending agents, is either a pourable liquid or a non-pourable viscous liquid, such as a gel, under normal conditions. If the liquid medium is produced from different components, one or more of them can be solid under normal conditions, as long as only the mixture which is the suspension medium is liquid, preferably additionally homogeneous.
  • the liquid medium may also contain minor amounts of a thickening agent such as polyvinyl alcohol, gelatin, agargar and the like. If a thickener is present, it is usually from about 0.1 to about 5 percent by weight based on the weight of the composition.
  • a thickening agent such as polyvinyl alcohol, gelatin, agargar and the like. If a thickener is present, it is usually from about 0.1 to about 5 percent by weight based on the weight of the composition.
  • the liquid medium may also contain minor amounts of one or more conventional ophthalmologically acceptable additives, such as preservatives, which include bactericides or fungistatics, as well as fragrances and the like.
  • additives such as preservatives, which include bactericides or fungistatics, as well as fragrances and the like.
  • preservatives include bactericides or fungistatics, as well as fragrances and the like.
  • fragrances and the like usually have a proportion of about 0.1 to about 2 percent by weight based on the weight of the composition.
  • the organic liquid medium can also contain smaller amounts of water. Understandably, the upper limit for the permissible water content in compositions according to the invention depends on the type of particulate water-soluble material and on the organic constituents of the liquid suspension medium.
  • the liquid suspension medium binds water massively, as is the case when polyethylene glycol or various polyethoxylated derivatives of organic compounds are used, up to about 50 volume percent water can be tolerated, based on the total volume of the liquid medium, without the water-soluble particulate material is essentially solvati is settled.
  • a small amount of water in the liquid organic suspension medium is advantageous for removing sharp irregularities, possibly damaging the lens, from the water-soluble particulate material.
  • the water-soluble particulate material which is preferably crystalline or glass-like and has an average particle size below about 750 micrometers, is dispersed in an organic liquid medium, such as by stirring or gently swirling at a temperature between about 10 ° C and about 30 ° C, which medium for the particulate material is essentially a non-solvent in that it has the property of solvating only small amounts of the particulate material, for example generally less than 20 percent by weight, preferably less than 10 percent by weight of that Amount of particulate material added to the liquid medium. Nevertheless, this slight solvating effect of the medium is usually sufficient to remove sharp-edged irregularities, which could possibly damage the lens, from the surface of the particles. In this way particles are obtained which are usually free of sharp edges and dispersed in the liquid medium.
  • the water-soluble particulate materials in the form in which they are used can already be free from sharp irregularities which may damage the lens.
  • the water-soluble particulate material which is preferably crystalline or glass-like, can be pretreated with a liquid medium in which it is soluble, for example by briefly mixing and swirling to remove sharp edges from the particulate material by solvation.
  • the particulate material can be suitably dried, for example using conventional fluid bed drying techniques, or by tumbling under drying conditions such as under reduced pressure.
  • the treated like this Particulate material is now free of sharp edges damaging a lens and is now dispersed in the non-solvent medium, for example by stirring or swirling the heterogeneous mixture.
  • the proportion of the particulate water-soluble compound in the heterogeneous composition can be varied within wide limits, but is in principle between about 1 and about 60 percent by weight, preferably between about 1 and about 40 percent by weight, and particularly preferably between about 1.5 and about 20 percent by weight, based on the weight of the total composition.
  • the contact lens can be cleaned using the ophthalmic cleaning composition according to the present invention by techniques that are already known as such.
  • the lens to be cleaned is removed from the eye or a storage container and placed on the palm of one hand.
  • an amount suitable for cleaning e.g. a few drops or their volume equivalent of the ophthalmic cleaning composition according to this invention are applied to the surface of the contact lens to be cleaned.
  • the cleaning composition is then rubbed onto the surface of the contact lens to remove proteinaceous and non-proteinaceous deposits. This happens for a period of e.g. 15 to 30 seconds using the index finger or thumb of the other hand.
  • the lens can be rinsed briefly, for example with water or other aqueous conventional ophthalmologically acceptable rinsing solutions, such as an isotonic saline solution, and placed in the eye. During the short rinsing phase, the particulate material of the cleaning composition dissolves.
  • aqueous conventional ophthalmologically acceptable rinsing solutions such as an isotonic saline solution
  • the lens can also be placed directly in either an aqueous chemical disinfection system, such as one that uses aqueous hydrogen peroxide without having to rinse the lens in between, or in an aqueous heat sterilizer, saline solution, or other aqueous heat disinfectant solution disinfection schedules recommended by manufacturers should be followed before inserting the lens into the wearer's eye.
  • an aqueous chemical disinfection system such as one that uses aqueous hydrogen peroxide without having to rinse the lens in between, or in an aqueous heat sterilizer, saline solution, or other aqueous heat disinfectant solution disinfection schedules recommended by manufacturers should be followed before inserting the lens into the wearer's eye.
  • Rinsing by contact with an aqueous rinsing solution or an aqueous disinfection system also serves to disperse the deposits that have been removed or detached from the lens surface during the rubbing.
  • Example 1 50 ml of water, 50 ml of Polysorbate 80 (Tween® 80, trademark of ICI America) and 50 ml of Polysorbate 20 (Tween® 20, trademark of ICI America) are placed in a 500 ml beaker. The mixture is stirred until a clear homogeneous solution has formed under normal room conditions. 20 g of crystalline sucrose, which has an average particle size of about 100 micrometers, are added to this solution with stirring. The thick heterogeneous suspension obtained does not settle within 24 hours. The addition of a few drops (3 to 4) to a contact lens and rubbing the composition onto its surface leads to the lens being cleaned of deposits. After rinsing the lens with water, the lens drips well without leaving any visible residues on the surface.
  • Example 2 Using the procedure of Example 1, 50 ml of polyethylene glycol with an average molecular weight of 2000 and 50 ml of polysorbate 20 are mixed together. 20 g of sucrose, which has an average particle size of 100 micrometers, are added to this liquid medium. The composition does not settle within 24 hours. It is a little thinner than that according to Example 1, and contact lenses that are cleaned with it turn out to be easy to rinse off, without any visible residues remaining on the surface.
  • Example 3 Using the procedure of Example 1, 50 ml of glycerin and 10 g of sucrose, which has an average particle size of approximately 100 micrometers, are mixed together. The composition obtained does not settle within 24 hours and can be easily rinsed off contact lenses.
  • Example 4 Using the procedure of Example 1, 50 ml of polyethylene glycol with an average molecular weight of about 2000 and 10 g of sucrose are mixed together. The composition is stable and does not settle within 24 hours. It is satisfactory as a cleaning composition for contact lenses, but cannot be rinsed off from contact lenses as well as the composition according to Example 3.
  • Example 5 Using the procedure of Example 1, 50 ml of polypropylene glycol with an average molecular weight of about 400 and 10 g of sucrose are mixed together. The composition is stable after 24 hours and can be easily rinsed off contact lenses.
  • Example 6 Using the procedure of Example 1, 50 ml of polyethylene glycol with an average molecular weight of about 400 and 10 g of sucrose are mixed together. The composition is stable and does not settle within 24 hours. It can be easily rinsed off contact lens surfaces. It has a thinner consistency than the composition of Example 5.
  • Example 7 Using the procedure of Example 1, 50 ml of polyethylene glycol with an average molecular weight of about 400 and 50 ml of dimethyl lauryl amine oxide are combined. 10 g of sucrose are added to this mixture. This composition can be rinsed off well from contact lens surfaces, but is not as stable as that according to Example 6. A partial separation can be observed after about 22 hours.
  • Example 8 Using the procedure of Example 1, 50 ml of polysorbate 20, 50 ml of polyethylene glycol and 10 ml of water are mixed and 20 g of sucrose are added. The composition cleans contact lenses effectively and is easy to rinse off. However, it tends to separate quickly and therefore needs to be shaken before use. will.
  • Example 9 Using the procedure of Example 1, 50 ml of ethoxylated monoglyceride of coconut fatty acid (on average 30 ethoxy units), 5 ml of polyethylene glycol with an average molecular weight of about 400 and 20 g of sucrose are mixed together. The composition is stable and viscous and is suitable for cleaning contact lenses, although it is not as easy to rinse as that of Example 1.
  • Example 10 Using the procedure of Example 1, 50 ml of dimethyl laurylamine oxide, 50 ml of glycerol, 25 ml of polyethylene glycol with an average molecular weight of about 2000 and 20 g of sucrose are mixed together. Unfortunately, this particular combination of dispersants acts as a solvent for the sugar and is obviously not suitable.
  • Example 11 Using the procedure of Example 1, 90 ml of polypropylene glycol with an average molecular weight of about 2000, 5 ml of 80 polysorbate and 5 ml of 282 polyoxamer are mixed together and 2.5 g of sucrose are added. The composition obtained has excellent properties with regard to stability, cleanability and rinsability of contact lens surfaces.
  • Example 12 Using the procedure of Example 1, 90 ml of polypropylene glycol with an average molecular weight of about 3000, 5 ml of Polysorbate 80 and 5 ml of Poloxamer 282 are mixed together and 2.5 g of sucrose are added. The composition obtained has excellent properties with regard to stability, cleanability and rinsability of contact lens surfaces.
  • Example 13 Using the procedure of Example 1, 80 ml of polypropylene glycol with an average molecular weight of about 700, 10 ml of Poloxamer 231 and 10 ml of Polysorbate 80 are mixed with 3 g of sucrose. The composition obtained is suitable for cleaning contact lenses, in particular for cleaning hard contact lenses, such as hard gas-permeable contact lenses.
  • Example 14 Using the procedure of Example 1, 80 ml of polyethylene glycol with an average molecular weight of approximately 400, 10 ml of Poloxamer 231 and 10 ml of Polysorbate 80 are mixed with 1.5 g of sucrose. The composition obtained is well suited for cleaning contact lenses, especially hard gas-permeable contact lenses.
  • Example 15 Using the procedure of Example 1, 90 ml of polyethylene glycol with an average molecular weight of about 400 and Polysorbate 80 are mixed with 1.5 g of sucrose. The composition is particularly suitable for cleaning hard gas-permeable contact lenses.
  • Example 16 Following the procedure of Example 1, 70 ml of polyethylene glycol with an average molecular weight of about 400, 10 ml of polypropylene glycol with an average molecular weight of about 700, 10 ml of polysorbate 80 and 10 ml of Poloxamer 231 are mixed with 1.5 g of sucrose. This gives a composition which is suitable for cleaning contact lenses, particularly for hard gas-permeable lenses.
  • Example 17 Following the procedure of Example 1, 40 ml of polypropylene glycol with an average molecular weight of about 1000, 40 ml of polypropylene glycol with an average molecular weight of about 2000, 10 ml of polysorbate 80 and 10 ml of Poloxamer 231 are mixed with 3 g of sucrose.
  • the composition obtained is well suited for cleaning contact lenses and is particularly preferred for cleaning soft hydrophilic hydrogel contact lenses.
  • Example 18 The procedure of Example 17 is repeated, but 2 g of mannose are now used instead of 3 g of sucrose. The composition obtained is well suited for cleaning hard and soft contact lenses.
  • Example 19 The procedure of Example 17 is repeated, but 5 g of lactose are now used instead of 3 g of sucrose. Once again, the composition obtained proves to be well suited for cleaning hard and soft contact lenses.
  • Example 20 Using the procedure of Example 1, 80 ml of Poloxamer 105 and 20 ml of Polysorbate 80 are mixed with 3 g of sucrose. The composition obtained is well suited for cleaning both hard and soft lenses.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Detergent Compositions (AREA)
  • Eyeglasses (AREA)
EP87810185A 1986-04-03 1987-03-30 Reinigungszusammensetzungen für weiche und harte Kontaktlinsen Withdrawn EP0240464A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/847,986 US4734222A (en) 1986-04-03 1986-04-03 Composition and method for cleaning soft and hard contact lenses
US847986 1986-04-03

Publications (1)

Publication Number Publication Date
EP0240464A1 true EP0240464A1 (de) 1987-10-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP87810185A Withdrawn EP0240464A1 (de) 1986-04-03 1987-03-30 Reinigungszusammensetzungen für weiche und harte Kontaktlinsen

Country Status (8)

Country Link
US (1) US4734222A (da)
EP (1) EP0240464A1 (da)
JP (1) JPS62242916A (da)
AU (1) AU7093387A (da)
BR (1) BR8701504A (da)
DK (1) DK167987A (da)
FI (1) FI871433L (da)
PT (1) PT84600A (da)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2624520A1 (da) * 1987-12-14 1989-06-16 Colgate Palmolive Co
JPH01177013A (ja) * 1987-12-28 1989-07-13 Tome Sangyo Kk ソフトコンタクトレンズの洗浄方法
EP0394456A4 (en) * 1988-06-18 1991-03-20 Tomei Sangyo Kabushiki Kaisha Detergent for contact lens and method for washing contact lens
EP0441003A3 (en) * 1989-12-20 1992-01-29 Lawrence Goldman Ophthalmic medication
EP0357724B1 (en) * 1988-02-18 1992-12-02 Baxter International Inc. Stabilized heparin solution
EP0550921A1 (en) * 1991-11-27 1993-07-14 ZAMBON GROUP S.p.A. Pharmaceutical composition for ophthalmic use comprising a nonsteroidal anti-inflammatory and a decongestant drug
WO1993013750A1 (en) * 1992-01-10 1993-07-22 Allergan, Inc. Nonirritating nonionic surfactant compositions
US10064927B2 (en) 2011-05-17 2018-09-04 Hadasit Medical Research Services And Development Ltd. Allogeneic tumor cell vaccination

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4784788A (en) * 1985-12-14 1988-11-15 Colgate-Palmolive Co. Cleaning paste with soluble abrasive
JPS63159821A (ja) * 1986-12-23 1988-07-02 Tome Sangyo Kk コンタクトレンズ用洗浄剤
CA1337320C (en) * 1987-02-13 1995-10-17 Murray J. Sibley Contact lens cleaning with dissolving abradant
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NL8802358A (nl) * 1987-12-14 1989-07-03 Colgate Palmolive Co Reinigingspasta met oplosbaar schuurmiddel.
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PT84600A (en) 1987-05-01
AU7093387A (en) 1987-10-08
FI871433A0 (fi) 1987-04-01
DK167987D0 (da) 1987-04-02
JPS62242916A (ja) 1987-10-23
US4734222A (en) 1988-03-29
FI871433A7 (fi) 1987-10-04
BR8701504A (pt) 1988-01-19
DK167987A (da) 1987-10-04
FI871433L (fi) 1987-10-04

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