EG25683A - Benzoxazine derivatives and uses thereof - Google Patents

Benzoxazine derivatives and uses thereof

Info

Publication number: EG25683A
Authority: EG; Egypt
Prior art keywords: benzoxazine derivatives; benzoxazine; derivatives
Prior art date: 2002-05-13

Application number

EG2003050432A

Other languages

English (en)

Inventor

Jacob Berger

Robin D Clark

Shu-Hai Zhao

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-13

Filing date

2003-05-10

Publication date

2012-05-16

2003-05-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2012-05-16 Application granted granted Critical

2012-05-16 Publication of EG25683A publication Critical patent/EG25683A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

EG2003050432A 2002-05-13 2003-05-10 Benzoxazine derivatives and uses thereof EG25683A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37800302P	2002-05-13	2002-05-13

Publications (1)

Publication Number	Publication Date
EG25683A true EG25683A (en)	2012-05-16

Family

ID=29420358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG2003050432A EG25683A (en)	2002-05-13	2003-05-10	Benzoxazine derivatives and uses thereof

Country Status (36)

Country	Link
US (4)	US6867204B2 (xx)
EP (1)	EP1506179B1 (xx)
JP (1)	JP4307377B2 (xx)
KR (1)	KR100636475B1 (xx)
CN (1)	CN100429206C (xx)
AR (1)	AR039988A1 (xx)
AT (1)	ATE316523T1 (xx)
AU (1)	AU2003233231B2 (xx)
BR (1)	BRPI0310032B8 (xx)
CA (1)	CA2485136C (xx)
DE (1)	DE60303376T2 (xx)
DK (1)	DK1506179T3 (xx)
EA (1)	EA009982B1 (xx)
EC (1)	ECSP045420A (xx)
EG (1)	EG25683A (xx)
ES (1)	ES2256744T3 (xx)
GT (1)	GT200300108A (xx)
HR (1)	HRP20041030B1 (xx)
IL (1)	IL164928A0 (xx)
JO (1)	JO2413B1 (xx)
MA (1)	MA27118A1 (xx)
MX (1)	MXPA04011254A (xx)
MY (1)	MY139612A (xx)
NO (1)	NO329380B1 (xx)
NZ (1)	NZ536230A (xx)
PA (1)	PA8573501A1 (xx)
PE (1)	PE20040757A1 (xx)
PL (1)	PL211057B1 (xx)
PT (1)	PT1506179E (xx)
RS (1)	RS51042B (xx)
TN (1)	TNSN04225A1 (xx)
TW (1)	TWI258479B (xx)
UA (1)	UA76877C2 (xx)
UY (1)	UY27803A1 (xx)
WO (1)	WO2003095434A1 (xx)
ZA (1)	ZA200408783B (xx)

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EP1408976B3 (en) *	2001-07-20	2010-08-25	Psychogenics Inc.	Treatment for attention-deficit hyperactivity disorder
US7452888B2 (en)	2002-03-27	2008-11-18	Glaxo Group Limited	Quinoline derivatives and their use as 5-ht6 ligands
JP4307377B2 (ja) *	2002-05-13	2009-08-05	エフ．ホフマン−ラロシュアーゲー	５−ｈｔ６モジュレーターとしてのベンゾオキサジン誘導体及びそれらの使用
PL377770A1 (pl) *	2002-11-08	2006-02-20	F. Hoffmann-La Roche Ag	Podstawione benzoksazynony i ich zastosowanie
MXPA06000795A (es)	2003-07-22	2006-08-23	Arena Pharm Inc	Derivados de diaril y arilheteroaril urea como moduladores del receptor 5-ht2a de serotonina utiles para la profilaxis y tratamiento de desordenes relacionados con el mismo.
KR100827915B1 (ko)	2003-12-09	2008-05-07	에프. 호프만-라 로슈 아게	벤즈옥사진 유도체 및 그의 용도
BRPI0506909A (pt) *	2004-01-16	2007-05-29	Hoffmann La Roche	derivados de 1-benzil-5piperazin-1-il-3,4 diidro-1h-quinazolin-2-ona e os respectivos derivados de 1h-benzo (1,2,6) tiadiazina-2,2-dióxido e 1,4-diidro-benzo (d) (1,3)oxazin-2-ona como moduladores do receptor de 5-hidroxitriptamina (5-ht) para o tratamento de doenças do sistema nervoso central
CN100540546C (zh) *	2004-05-05	2009-09-16	弗·哈夫曼-拉罗切有限公司	用于调节5-ht6受体、5-ht2a受体或两者的芳基磺酰基苯并二烷
AU2005291542B2 (en) *	2004-09-30	2010-11-04	F. Hoffmann-La Roche Ag	Compositions and methods for treating cognitive disorders
CA2581921A1 (en) *	2004-09-30	2006-04-13	F. Hoffmann-La Roche Ag	Benzoxazine and quinoxaline derivatives and uses
US7378415B2 (en) *	2004-09-30	2008-05-27	Roche Palo Alto Llc	Benzoxazine and quinoxaline derivatives and uses thereof
US7713954B2 (en) *	2004-09-30	2010-05-11	Roche Palo Alto Llc	Compositions and methods for treating cognitive disorders
EP2508177A1 (en)	2007-12-12	2012-10-10	Glaxo Group Limited	Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
US20110021538A1 (en)	2008-04-02	2011-01-27	Arena Pharmaceuticals, Inc.	Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en)	2008-10-28	2010-06-03	Arena Pharmaceuticals, Inc.	Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
AR078770A1 (es) *	2009-10-27	2011-11-30	Elara Pharmaceuticals Gmbh	Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas.
KR101293384B1 (ko) *	2010-10-13	2013-08-05	주식회사 대웅제약	신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US9403800B2 (en) *	2012-01-24	2016-08-02	Chemregen, Inc.	Compounds for inhibition of cancer cell proliferation
EP3091984B1 (en)	2014-01-09	2020-04-22	The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone	Substituted benzoxazine and related compounds
RU2017145976A (ru)	2015-06-12	2019-07-15	Аксовант Сайенсиз Гмбх	Производные диарил- и арилгетероарилмочевины, применимые для профилактики и лечения нарушения поведения во время REM-фазы сна
EP3322415A4 (en)	2015-07-15	2019-03-13	Axovant Sciences GmbH	DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR FOR PROPHYLAXIS AND TREATMENT OF HALLUCINATIONS RELATED TO A NEUROGENERATIVE DISEASE

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2003
- 2003-05-05 JP JP2004503451A patent/JP4307377B2/ja not_active Expired - Lifetime
- 2003-05-05 DE DE60303376T patent/DE60303376T2/de not_active Expired - Lifetime
- 2003-05-05 CA CA2485136A patent/CA2485136C/en not_active Expired - Lifetime
- 2003-05-05 HR HRP20041030AA patent/HRP20041030B1/hr not_active IP Right Cessation
- 2003-05-05 PL PL374019A patent/PL211057B1/pl unknown
- 2003-05-05 DK DK03727430T patent/DK1506179T3/da active
- 2003-05-05 UA UA20041210144A patent/UA76877C2/uk unknown
- 2003-05-05 PT PT03727430T patent/PT1506179E/pt unknown
- 2003-05-05 KR KR1020047018299A patent/KR100636475B1/ko not_active Expired - Fee Related
- 2003-05-05 CN CNB038109972A patent/CN100429206C/zh not_active Expired - Lifetime
- 2003-05-05 BR BRPI0310032A patent/BRPI0310032B8/pt not_active IP Right Cessation
- 2003-05-05 EP EP03727430A patent/EP1506179B1/en not_active Expired - Lifetime
- 2003-05-05 RS YUP-970/04A patent/RS51042B/sr unknown
- 2003-05-05 ES ES03727430T patent/ES2256744T3/es not_active Expired - Lifetime
- 2003-05-05 AU AU2003233231A patent/AU2003233231B2/en not_active Expired
- 2003-05-05 MX MXPA04011254A patent/MXPA04011254A/es active IP Right Grant
- 2003-05-05 AT AT03727430T patent/ATE316523T1/de active
- 2003-05-05 WO PCT/EP2003/004671 patent/WO2003095434A1/en not_active Ceased
- 2003-05-05 EA EA200401455A patent/EA009982B1/ru not_active IP Right Cessation
- 2003-05-05 NZ NZ536230A patent/NZ536230A/en not_active IP Right Cessation
- 2003-05-08 TW TW092112575A patent/TWI258479B/zh not_active IP Right Cessation
- 2003-05-08 JO JO200352A patent/JO2413B1/en active
- 2003-05-09 US US10/435,732 patent/US6867204B2/en not_active Expired - Lifetime
- 2003-05-09 PE PE2003000452A patent/PE20040757A1/es active IP Right Grant
- 2003-05-09 GT GT200300108A patent/GT200300108A/es unknown
- 2003-05-09 PA PA20038573501A patent/PA8573501A1/es unknown
- 2003-05-09 AR ARP030101624A patent/AR039988A1/es active IP Right Grant
- 2003-05-10 EG EG2003050432A patent/EG25683A/xx active
- 2003-05-12 UY UY27803A patent/UY27803A1/es not_active IP Right Cessation
- 2003-05-12 MY MYPI20031765A patent/MY139612A/en unknown
2004
- 2004-10-28 IL IL16492804A patent/IL164928A0/xx unknown
- 2004-10-28 NO NO20044665A patent/NO329380B1/no not_active IP Right Cessation
- 2004-10-29 ZA ZA2004/08783A patent/ZA200408783B/en unknown
- 2004-11-10 EC EC2004005420A patent/ECSP045420A/es unknown
- 2004-11-11 TN TNP2004000225A patent/TNSN04225A1/fr unknown
- 2004-11-12 MA MA27944A patent/MA27118A1/fr unknown
2005
- 2005-01-31 US US11/047,284 patent/US20050130962A1/en not_active Abandoned
2009
- 2009-09-04 US US12/584,373 patent/US8377931B2/en not_active Expired - Fee Related
2012
- 2012-12-13 US US13/713,484 patent/US20130123251A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2485136C (en)	2011-12-20
EP1506179A1 (en)	2005-02-16
US6867204B2 (en)	2005-03-15
HK1080846A1 (zh)	2006-05-04
HRP20041030A2 (en)	2005-06-30
IL164928A0 (en)	2005-12-18
ATE316523T1 (de)	2006-02-15
TNSN04225A1 (fr)	2007-03-12
EA009982B1 (ru)	2008-04-28
WO2003095434A1 (en)	2003-11-20
ECSP045420A (es)	2005-01-03
PA8573501A1 (es)	2003-12-10
KR100636475B1 (ko)	2006-10-18
BR0310032A (pt)	2005-02-15
TW200400188A (en)	2004-01-01
JO2413B1 (en)	2007-11-11
ES2256744T3 (es)	2006-07-16
US20090325950A1 (en)	2009-12-31
CN1653054A (zh)	2005-08-10
CN100429206C (zh)	2008-10-29
ZA200408783B (en)	2005-12-28
HRP20041030B1 (hr)	2013-03-31
PL374019A1 (en)	2005-09-19
PE20040757A1 (es)	2004-11-06
MA27118A1 (fr)	2004-12-20
KR20040106538A (ko)	2004-12-17
AU2003233231A1 (en)	2003-11-11
PT1506179E (pt)	2006-06-30
MY139612A (en)	2009-10-30
NO20044665L (no)	2004-12-03
PL211057B1 (pl)	2012-04-30
US20130123251A1 (en)	2013-05-16
US20050130962A1 (en)	2005-06-16
EP1506179B1 (en)	2006-01-25
AR039988A1 (es)	2005-03-09
UA76877C2 (uk)	2006-09-15
RS97004A (sr)	2006-10-27
CA2485136A1 (en)	2003-11-20
AU2003233231B2 (en)	2009-02-26
NZ536230A (en)	2007-05-31
NO329380B1 (no)	2010-10-04
US20030232825A1 (en)	2003-12-18
BRPI0310032B8 (pt)	2021-05-25
UY27803A1 (es)	2003-11-28
JP4307377B2 (ja)	2009-08-05
JP2005530774A (ja)	2005-10-13
DE60303376D1 (de)	2006-04-13
US8377931B2 (en)	2013-02-19
GT200300108A (es)	2004-03-15
MXPA04011254A (es)	2005-01-25
EA200401455A1 (ru)	2005-06-30
TWI258479B (en)	2006-07-21
DK1506179T3 (da)	2006-06-06
DE60303376T2 (de)	2006-11-16
BRPI0310032B1 (pt)	2019-01-08
RS51042B (sr)	2010-10-31

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