EE9900248A - 7-(2-oksa-5,8-diasabitsüklo[4.3.0]non-8-üül) kinoloonkarboksüülhappe- ja -naftüridoonkarboksüülhappederivaatide kasutamine Helicobacter pylori infektsioonide ja sellega assotsieeruvate gastroduodenaalhaiguste teraapiaks - Google Patents

7-(2-oksa-5,8-diasabitsüklo[4.3.0]non-8-üül) kinoloonkarboksüülhappe- ja -naftüridoonkarboksüülhappederivaatide kasutamine Helicobacter pylori infektsioonide ja sellega assotsieeruvate gastroduodenaalhaiguste teraapiaks

Info

Publication number: EE9900248A
Authority: EE; Estonia
Prior art keywords: carboxylic acid; oxa; diazabicyclo; helicobacter pylori; treatment
Prior art date: 1996-12-16

Application number

EEP199900248A

Other languages

English (en)

Other versions

EE04090B1 (et

Inventor

Matzke Michael

Petersen Uwe

Jaetsch Thomas

Bartel Stephan

Schenke Thomas

Himmler Thomas

Baasner Bernd

Werling Hans-Otto

Schaller Klaus

Labischinski Harald

Original Assignee

Bayer Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-16

Filing date

1997-12-04

Publication date

1999-12-15

1997-12-04 Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft

1999-12-15 Publication of EE9900248A publication Critical patent/EE9900248A/et

2003-08-15 Publication of EE04090B1 publication Critical patent/EE04090B1/et

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

EEP199900248A 1996-12-16 1997-12-04 7-(2-oksa-5,8-diasabitsüklo[4.3.0]non-8-üül) kinoloonkarboksüülhappe ja -naftüridoonkarboksüülhappederivaadid kasutamiseks Helicobacter pylori infektsioonide ja nendega kaasnevate gastroduodenaalsetehaiguste raviks EE04090B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19652239A DE19652239A1 (de)	1996-12-16	1996-12-16	Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
PCT/EP1997/006781 WO1998026779A1 (de)	1996-12-16	1997-12-04	Verwendung von 7-(2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinoloncarbonsäure- und -naphthyridoncarbonsäure-derivaten zur therapie von helicobacter-pylori-infektionen und den damit assoziierten gastroduodenalen erkrankungen

Publications (2)

Publication Number	Publication Date
EE9900248A true EE9900248A (et)	1999-12-15
EE04090B1 EE04090B1 (et)	2003-08-15

Family

ID=7814837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900248A EE04090B1 (et)	1996-12-16	1997-12-04	7-(2-oksa-5,8-diasabitsüklo[4.3.0]non-8-üül) kinoloonkarboksüülhappe ja -naftüridoonkarboksüülhappederivaadid kasutamiseks Helicobacter pylori infektsioonide ja nendega kaasnevate gastroduodenaalsetehaiguste raviks

Country Status (27)

Country	Link
US (2)	US6133260A (et)
EP (1)	EP0946176B1 (et)
JP (3)	JP3463939B2 (et)
KR (1)	KR100536153B1 (et)
CN (1)	CN100335054C (et)
AT (1)	ATE214929T1 (et)
AU (1)	AU717751B2 (et)
BG (1)	BG64615B1 (et)
BR (1)	BR9714032A (et)
CA (1)	CA2274894C (et)
CZ (2)	CZ297363B6 (et)
DE (2)	DE19652239A1 (et)
DK (1)	DK0946176T3 (et)
EA (1)	EA002477B1 (et)
EE (1)	EE04090B1 (et)
ES (1)	ES2175519T3 (et)
HU (1)	HU226523B1 (et)
IL (1)	IL130311A (et)
NO (1)	NO325617B1 (et)
NZ (2)	NZ336228A (et)
PL (1)	PL191193B1 (et)
PT (1)	PT946176E (et)
RS (1)	RS49684B (et)
SK (2)	SK283224B6 (et)
TR (1)	TR199901754T2 (et)
UA (1)	UA57055C2 (et)
WO (1)	WO1998026779A1 (et)

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IL147043A0 (en) *	1999-07-01	2002-08-14	Wakunaga Pharma Co Ltd	Quinolinecarboxylic acid derivative or salts thereof
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DK1575951T3 (da) *	2002-12-06	2014-09-15	Debiopharm Int Sa	Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi
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ES2402420T3 (es)	2003-09-29	2013-05-03	Daiichi Sankyo Company, Limited	Derivado del ácido 8-cianoquinolonacarboxílico
US7759362B2 (en)	2004-04-21	2010-07-20	Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences	Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
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BR122021020778B1 (pt)	2012-06-19	2022-07-12	Debiopharm International Sa	Derivados de pró-fármaco de (e)-n-metil-n-((3-metilbenzofuran-2-il) metil)-3-(7-oxo-5,6,7,8-tetraidro- 1, 8- naftirindin-3-il) acrilamida
US9504691B2 (en) *	2012-12-06	2016-11-29	Alcon Research, Ltd.	Finafloxacin suspension compositions
MX2016001912A (es)	2013-08-12	2016-06-02	Novartis Ag	Metodos para tratar infecciones oticas luego de la colocacion de un tubo de timpanostomia.
DE102014115951A1 (de)	2014-11-03	2016-05-04	Merlion Pharmaceuticals Pte Ltd.	Zusammensetzungen, die Finafloxacin und Tris enthalten
DE102015100068A1 (de)	2015-01-06	2016-07-07	Merlion Pharmaceuticals Pte Ltd.	Finafloxacin zur verwendung bei der behandlung von harnwegsinfektionen
SI3419628T1 (sl)	2016-02-26	2021-03-31	Debiopharm International Sa	Zdravilo za zdravljenje infekcij diabetičnega stopala
CN107987074B (zh) *	2017-10-27	2020-12-29	浙江美诺华药物化学有限公司	一种普拉沙星的合成方法
AU2019260015C1 (en) *	2018-04-25	2024-11-21	Elanco Animal Health Gmbh	Process for the hydrolysis of quinolone carboxylic esters
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UA129222C2 (uk)	2019-06-14	2025-02-12	Дебіофарм Інтернешнл С.А.	Лікарський засіб і його застосування для лікування бактеріальних інфекцій, пов'язаних з біоплівкою

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1996
- 1996-12-16 DE DE19652239A patent/DE19652239A1/de not_active Withdrawn
1997
- 1997-04-12 UA UA99074093A patent/UA57055C2/uk unknown
- 1997-12-04 TR TR1999/01754T patent/TR199901754T2/xx unknown
- 1997-12-04 DE DE59706808T patent/DE59706808D1/de not_active Expired - Lifetime
- 1997-12-04 RS YUP-274/99A patent/RS49684B/sr unknown
- 1997-12-04 CZ CZ0216899A patent/CZ297363B6/cs not_active IP Right Cessation
- 1997-12-04 CN CNB971817200A patent/CN100335054C/zh not_active Expired - Lifetime
- 1997-12-04 SK SK1496-2000A patent/SK283224B6/sk not_active IP Right Cessation
- 1997-12-04 EE EEP199900248A patent/EE04090B1/et unknown
- 1997-12-04 CA CA002274894A patent/CA2274894C/en not_active Expired - Lifetime
- 1997-12-04 EA EA199900526A patent/EA002477B1/ru not_active IP Right Cessation
- 1997-12-04 PT PT97954354T patent/PT946176E/pt unknown
- 1997-12-04 WO PCT/EP1997/006781 patent/WO1998026779A1/de not_active Ceased
- 1997-12-04 PL PL333928A patent/PL191193B1/pl unknown
- 1997-12-04 KR KR10-1999-7005330A patent/KR100536153B1/ko not_active Expired - Lifetime
- 1997-12-04 AT AT97954354T patent/ATE214929T1/de active
- 1997-12-04 HU HU0000450A patent/HU226523B1/hu unknown
- 1997-12-04 BR BR9714032-5A patent/BR9714032A/pt not_active IP Right Cessation
- 1997-12-04 EP EP97954354A patent/EP0946176B1/de not_active Expired - Lifetime
- 1997-12-04 US US09/319,888 patent/US6133260A/en not_active Expired - Lifetime
- 1997-12-04 IL IL13031197A patent/IL130311A/en not_active IP Right Cessation
- 1997-12-04 AU AU58541/98A patent/AU717751B2/en not_active Expired
- 1997-12-04 NZ NZ336228A patent/NZ336228A/xx not_active IP Right Cessation
- 1997-12-04 DK DK97954354T patent/DK0946176T3/da active
- 1997-12-04 JP JP52725098A patent/JP3463939B2/ja not_active Expired - Lifetime
- 1997-12-04 SK SK795-99A patent/SK283223B6/sk not_active IP Right Cessation
- 1997-12-04 ES ES97954354T patent/ES2175519T3/es not_active Expired - Lifetime
- 1997-12-04 CZ CZ20003148A patent/CZ297364B6/cs not_active IP Right Cessation
1999
- 1999-06-08 BG BG103474A patent/BG64615B1/bg unknown
- 1999-06-14 NO NO19992903A patent/NO325617B1/no not_active IP Right Cessation
- 1999-11-08 US US09/436,316 patent/US6432948B1/en not_active Expired - Lifetime
2000
- 2000-05-25 JP JP2000154543A patent/JP4463380B2/ja not_active Expired - Lifetime
- 2000-08-04 NZ NZ506162A patent/NZ506162A/en not_active IP Right Cessation
2009
- 2009-07-22 JP JP2009171127A patent/JP5112395B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CZ297364B6 (cs)	2006-11-15
EA199900526A1 (ru)	2000-08-28
UA57055C2 (uk)	2003-06-16
DK0946176T3 (da)	2002-06-10
PT946176E (pt)	2002-08-30
SK283223B6 (sk)	2003-03-04
NZ506162A (en)	2001-06-29
DE59706808D1 (de)	2002-05-02
PL191193B1 (pl)	2006-03-31
WO1998026779A1 (de)	1998-06-25
RS49684B (sr)	2007-11-15
EE04090B1 (et)	2003-08-15
IL130311A0 (en)	2000-06-01
JP3463939B2 (ja)	2003-11-05
JP2000514825A (ja)	2000-11-07
EA002477B1 (ru)	2002-06-27
SK283224B6 (sk)	2003-03-04
CN1245428A (zh)	2000-02-23
JP2000351781A (ja)	2000-12-19
BG103474A (en)	2000-01-31
YU27499A (sh)	2002-10-18
NZ336228A (en)	2000-12-22
KR100536153B1 (ko)	2005-12-14
AU717751B2 (en)	2000-03-30
US6133260A (en)	2000-10-17
HK1025517A1 (zh)	2000-11-17
PL333928A1 (en)	2000-01-31
SK79599A3 (en)	2001-01-18
CZ297363B6 (cs)	2006-11-15
EP0946176B1 (de)	2002-03-27
SK14962000A3 (sk)	2003-01-09
ATE214929T1 (de)	2002-04-15
AU5854198A (en)	1998-07-15
HUP0000450A2 (hu)	2000-10-28
DE19652239A1 (de)	1998-06-18
CA2274894C (en)	2009-04-07
CA2274894A1 (en)	1998-06-25
CZ216899A3 (cs)	2000-02-16
KR20000069483A (ko)	2000-11-25
JP4463380B2 (ja)	2010-05-19
HUP0000450A3 (en)	2001-02-28
US6432948B1 (en)	2002-08-13
BG64615B1 (bg)	2005-09-30
IL130311A (en)	2004-01-04
ES2175519T3 (es)	2002-11-16
CN100335054C (zh)	2007-09-05
NO992903D0 (no)	1999-06-14
NO325617B1 (no)	2008-06-30
BR9714032A (pt)	2000-05-09
EP0946176A1 (de)	1999-10-06
NO992903L (no)	1999-06-14
JP2009235106A (ja)	2009-10-15
TR199901754T2 (xx)	1999-09-21
HU226523B1 (en)	2009-03-30
JP5112395B2 (ja)	2013-01-09

Publication	Publication Date	Title
EE9900248A (et)	1999-12-15	7-(2-oksa-5,8-diasabitsüklo[4.3.0]non-8-üül) kinoloonkarboksüülhappe- ja -naftüridoonkarboksüülhappederivaatide kasutamine Helicobacter pylori infektsioonide ja sellega assotsieeruvate gastroduodenaalhaiguste teraapiaks
TNSN03144A1 (en)	2005-12-23	Pyrrolopyrimidines as protein kinase inhibitors
UY25792A1 (es)	2001-08-27	Preparado farmacéutico de moxifloxacina.
AP2003002929A0 (en)	2003-12-31	Pyrrolopyrimidines as protein kinase inhibitors
MA27566A1 (fr)	2005-10-03	Inhibiteurs de 4-oxo-1-(3-phenyle substitue -1, 4-dihydro-1, 8-naphthyridine-3-carboxamide phosphodiesterase-4
FI873248A0 (fi)	1987-07-24	7-((3-(aminometyl)-3-alkyl)-1 -pyrrolidinyl)-kinolin-karboxylsyror.
NO983444D0 (no)	1998-07-24	Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer
DE60111553D1 (de)	2005-07-21	Hexahydropyrazino[1'2':1,6]-pyrido[3,4-b]indole-1,4-dion-derivate zur behandlung von cardiovaskulären erkrankungen und erektionsstörungen
WO1998026768A3 (de)	1998-08-06	Verwendung von 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-chinoloncarbonsäure- und -naphthyridoncarbonsäure-derivaten zur therapie von helicobacter-pylori-infektionen und den damit assoziierten gastroduodenalen erkrankungen
DK0704443T3 (da)	2001-01-29	Quinolon- og naphthyridoncarboxylsyrederivater
BR0014052A (pt)	2002-05-21	Derivados de aminas
MX8232A (es)	1993-12-01	Derivados de triazolopirimidina.

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