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EE9700348A - Neurotroopse ja neuroprotektiivse toimega 4-arüül-1-fenüülalküül-1,2,3,6-tetrahüdropüridiinid - Google Patents

Neurotroopse ja neuroprotektiivse toimega 4-arüül-1-fenüülalküül-1,2,3,6-tetrahüdropüridiinid

Info

Publication number
EE9700348A
EE9700348A EE9700348A EE9700348A EE9700348A EE 9700348 A EE9700348 A EE 9700348A EE 9700348 A EE9700348 A EE 9700348A EE 9700348 A EE9700348 A EE 9700348A EE 9700348 A EE9700348 A EE 9700348A
Authority
EE
Estonia
Prior art keywords
alkyl
aryl
alkoxy
tetrahydropyridines
neurotropic
Prior art date
Application number
EE9700348A
Other languages
English (en)
Other versions
EE03870B1 (et
Inventor
Badone Domenico
Baroni Marco
Cardamone Rosanna
Fournier Jacqueline
Guzzi Umberto
Ielmini Alessandra
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of EE9700348A publication Critical patent/EE9700348A/et
Publication of EE03870B1 publication Critical patent/EE03870B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
EE9700348A 1995-06-28 1996-06-26 Neurotroopse ja neuroprotektiivse toimega 4-arüül-1-fenüülalküül-1,2,3,6-tetrahüdropüridiinid EE03870B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9507760A FR2736053B1 (fr) 1995-06-28 1995-06-28 Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
PCT/FR1996/000995 WO1997001536A1 (fr) 1995-06-28 1996-06-26 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines ayant une activite neurotrophique et neuroprotectrice

Publications (2)

Publication Number Publication Date
EE9700348A true EE9700348A (et) 1998-06-15
EE03870B1 EE03870B1 (et) 2002-10-15

Family

ID=9480466

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700348A EE03870B1 (et) 1995-06-28 1996-06-26 Neurotroopse ja neuroprotektiivse toimega 4-arüül-1-fenüülalküül-1,2,3,6-tetrahüdropüridiinid

Country Status (29)

Country Link
US (1) US5981754A (et)
EP (2) EP0837848B1 (et)
JP (2) JP3147906B2 (et)
KR (1) KR100460581B1 (et)
CN (1) CN1153765C (et)
AT (1) ATE223897T1 (et)
AU (1) AU715090B2 (et)
BR (1) BR9608662A (et)
CA (1) CA2225746C (et)
CY (1) CY2312B1 (et)
CZ (1) CZ291075B6 (et)
DE (1) DE69623631T2 (et)
DK (1) DK0837848T3 (et)
EE (1) EE03870B1 (et)
ES (1) ES2183965T3 (et)
FR (1) FR2736053B1 (et)
HU (1) HUP9900055A3 (et)
IL (1) IL122159A (et)
IS (1) IS1999B (et)
NO (1) NO310144B1 (et)
NZ (1) NZ312723A (et)
PL (2) PL187087B1 (et)
PT (1) PT837848E (et)
RU (1) RU2163237C2 (et)
SK (2) SK285433B6 (et)
TR (1) TR199701710T1 (et)
UA (1) UA62914C2 (et)
WO (1) WO1997001536A1 (et)
ZA (1) ZA965527B (et)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2762514B1 (fr) * 1997-04-29 1999-10-22 Sanofi Sa Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
FR2763847B1 (fr) 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
FR2771007B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
CO4980891A1 (es) * 1997-11-14 2000-11-27 Sanofi Sa Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer
FR2771006B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
CA2334677A1 (en) * 1998-06-19 1999-12-23 Vincent Patrick Rocco Preparation of heteroaryl compounds
FR2803593B1 (fr) * 2000-01-06 2002-02-15 Sanofi Synthelabo Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
DE60220779T2 (de) * 2001-04-20 2008-03-06 Sanofi-Aventis Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten
FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2840896B1 (fr) * 2002-06-18 2005-04-08 Sanofi Synthelabo Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant
CA2510170C (en) * 2002-12-16 2011-05-24 Mitsubishi Pharma Corporation 3-substituted-4-pyrimidone derivatives
EP2426120A1 (en) 2003-08-18 2012-03-07 Fujifilm Finechemicals Co., Ltd. Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
WO2006002350A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
WO2006012226A2 (en) 2004-06-24 2006-02-02 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
JP2008504280A (ja) * 2004-06-24 2008-02-14 インサイト・コーポレイション ２−メチルプロパンアミドおよびその医薬としての使用
CA2569507A1 (en) * 2004-06-24 2006-02-02 Incyte Corporation Amido compounds and their use as pharmaceuticals
US20060009471A1 (en) * 2004-06-24 2006-01-12 Wenqing Yao Amido compounds and their use as pharmaceuticals
CN101080226A (zh) * 2004-08-10 2007-11-28 因塞特公司 酰氨基化合物及它们作为药物的用途
US8110581B2 (en) * 2004-11-10 2012-02-07 Incyte Corporation Lactam compounds and their use as pharmaceuticals
US20060116382A1 (en) * 2004-11-10 2006-06-01 Wenqing Yao Lactam compounds and their use as pharmaceuticals
KR20070097441A (ko) * 2004-11-18 2007-10-04 인사이트 산 디에고 인코포레이티드 11-β 하이드록실 스테로이드 데하이드로게나제 유형 1의억제제 및 이를 사용하는 방법
FR2883285B1 (fr) * 2005-03-17 2007-05-18 Sanofi Aventis Sa Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique
JP4864342B2 (ja) * 2005-04-27 2012-02-01 北興化学工業株式会社 ビアリール化合物の製造方法
WO2007038138A2 (en) * 2005-09-21 2007-04-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
EP1957494A2 (en) * 2005-12-05 2008-08-20 Incyte Corporation Lactam compounds and methods of using the same
US7998959B2 (en) * 2006-01-12 2011-08-16 Incyte Corporation Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
KR20080091503A (ko) * 2006-01-31 2008-10-13 인사이트 코포레이션 아미도 화합물 및 약제로서의 이의 용도
TW200808807A (en) * 2006-03-02 2008-02-16 Incyte Corp Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US20070208001A1 (en) * 2006-03-03 2007-09-06 Jincong Zhuo Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
WO2007130898A1 (en) * 2006-05-01 2007-11-15 Incyte Corporation TETRASUBSTITUTED UREAS AS MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1
WO2007137066A2 (en) * 2006-05-17 2007-11-29 Incyte Corporation HETEROCYCLIC INHIBITORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME
CL2008001839A1 (es) * 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
WO2009086277A1 (en) 2007-12-20 2009-07-09 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
ES2546487T3 (es) * 2010-01-19 2015-09-24 Bayer Intellectual Property Gmbh Procedimiento para la preparación de derivados de ácido aril- y heteroarilacético
US10858351B2 (en) 2017-04-26 2020-12-08 Alberta Research Chemicals Inc. Substituted tetrahydropyridine derivatives as IDO-1 inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
FR2650505B1 (fr) * 1989-08-07 1994-06-03 Midy Spa Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
DE4325855A1 (de) * 1993-08-02 1995-02-09 Boehringer Ingelheim Kg Neue Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
FR2736053A1 (fr) 1997-01-03
TR199701710T1 (xx) 1998-05-21
HUP9900055A2 (hu) 1999-04-28
WO1997001536A1 (fr) 1997-01-16
CZ291075B6 (cs) 2002-12-11
RU2163237C2 (ru) 2001-02-20
DE69623631D1 (en) 2002-10-17
CA2225746C (en) 2004-05-18
HUP9900055A3 (en) 1999-11-29
IS4641A (is) 1997-12-23
NO976079D0 (no) 1997-12-23
KR100460581B1 (ko) 2005-04-14
CN1189154A (zh) 1998-07-29
CN1153765C (zh) 2004-06-16
CA2225746A1 (en) 1997-01-16
SK283707B6 (sk) 2003-12-02
PL187087B1 (pl) 2004-05-31
JP3147906B2 (ja) 2001-03-19
FR2736053B1 (fr) 1997-09-19
IS1999B (is) 2005-04-15
IL122159A (en) 2001-06-14
EP0837848B1 (fr) 2002-09-11
NO310144B1 (no) 2001-05-28
ZA965527B (en) 1997-01-24
AU715090B2 (en) 2000-01-13
IL122159A0 (en) 1998-04-05
AU6461996A (en) 1997-01-30
PL192353B1 (pl) 2006-10-31
US5981754A (en) 1999-11-09
SK285433B6 (sk) 2007-01-04
CZ422297A3 (cs) 1998-04-15
SK178197A3 (en) 1998-07-08
MX9710472A (es) 1998-03-31
EE03870B1 (et) 2002-10-15
PT837848E (pt) 2002-12-31
PL324216A1 (en) 1998-05-11
JPH11506118A (ja) 1999-06-02
HK1014952A1 (en) 1999-10-08
CY2312B1 (en) 2003-11-14
EP1216996A3 (fr) 2003-10-15
BR9608662A (pt) 1999-05-04
NO976079L (no) 1997-12-23
JP2001114763A (ja) 2001-04-24
DK0837848T3 (da) 2003-01-06
ATE223897T1 (de) 2002-09-15
ES2183965T3 (es) 2003-04-01
JP3302351B2 (ja) 2002-07-15
EP0837848A1 (fr) 1998-04-29
EP1216996A2 (fr) 2002-06-26
KR19990028431A (ko) 1999-04-15
NZ312723A (en) 1999-10-28
UA62914C2 (en) 2004-01-15
DE69623631T2 (de) 2003-08-07

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