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EE9600030A - N- (3-benzofuranyl) urea derivatives, process for their preparation, use in the manufacture of medicaments, medicaments containing these compounds and a process for their preparation - Google Patents

N- (3-benzofuranyl) urea derivatives, process for their preparation, use in the manufacture of medicaments, medicaments containing these compounds and a process for their preparation

Info

Publication number
EE9600030A
EE9600030A EE9600030A EE9600030A EE9600030A EE 9600030 A EE9600030 A EE 9600030A EE 9600030 A EE9600030 A EE 9600030A EE 9600030 A EE9600030 A EE 9600030A EE 9600030 A EE9600030 A EE 9600030A
Authority
EE
Estonia
Prior art keywords
preparation
medicaments
benzofuranyl
compounds
manufacture
Prior art date
Application number
EE9600030A
Other languages
Estonian (et)
Other versions
EE03921B1 (en
Inventor
Br�unlich Gabriele
Fischer Rdiger
Es-Sayed Mazen
Henning Rolf
Sperzel Michael
Schlemmer Karl-Heinz
Nielsch Ulrich
Tudhope Stephen
Sturton Graham
S. Abram Trevor
F. Fitzgerald Mary
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of EE9600030A publication Critical patent/EE9600030A/en
Publication of EE03921B1 publication Critical patent/EE03921B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Cosmetics (AREA)
EE9600030A 1995-03-06 1996-03-05 N- (3-benzofuranyl) urea derivatives, process for their preparation and use EE03921B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9504460.8A GB9504460D0 (en) 1995-03-06 1995-03-06 N-(3-Benzofuranyl)urea-derivatives

Publications (2)

Publication Number Publication Date
EE9600030A true EE9600030A (en) 1996-10-15
EE03921B1 EE03921B1 (en) 2002-12-16

Family

ID=10770709

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9600030A EE03921B1 (en) 1995-03-06 1996-03-05 N- (3-benzofuranyl) urea derivatives, process for their preparation and use

Country Status (41)

Country Link
US (2) US6399657B1 (en)
EP (1) EP0731099B1 (en)
JP (1) JP3204901B2 (en)
KR (2) KR100405579B1 (en)
CN (2) CN1134419A (en)
AR (1) AR002710A1 (en)
AT (1) ATE193704T1 (en)
BG (2) BG100396A (en)
BR (1) BR9600930A (en)
CA (1) CA2170824A1 (en)
CO (1) CO4370145A1 (en)
CZ (1) CZ66796A3 (en)
DE (1) DE69608721T2 (en)
DK (1) DK0731099T3 (en)
DZ (1) DZ1998A1 (en)
EE (1) EE03921B1 (en)
ES (1) ES2147320T3 (en)
FI (1) FI960998A7 (en)
GB (1) GB9504460D0 (en)
GR (1) GR3034240T3 (en)
HR (1) HRP960071B1 (en)
HU (1) HU222282B1 (en)
IL (1) IL117349A (en)
MA (1) MA23815A1 (en)
MY (1) MY117526A (en)
NO (1) NO313672B1 (en)
NZ (1) NZ286107A (en)
PE (1) PE43597A1 (en)
PL (1) PL189206B1 (en)
PT (1) PT731099E (en)
RO (1) RO116622B1 (en)
RU (1) RU2162845C2 (en)
SI (1) SI0731099T1 (en)
SK (1) SK281817B6 (en)
SV (1) SV1996000015A (en)
TN (1) TNSN96035A1 (en)
TR (1) TR199600177A2 (en)
TW (1) TW336934B (en)
UA (1) UA46714C2 (en)
YU (1) YU49359B (en)
ZA (1) ZA961774B (en)

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* Cited by examiner, † Cited by third party
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GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
GB9504460D0 (en) * 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
GB9525262D0 (en) * 1995-12-11 1996-02-07 Bayer Ag Heterocyclylcarbonyl substituted benzofuranyl-ureas
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
GB9614718D0 (en) 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
JPH10168095A (en) 1996-12-10 1998-06-23 Cci Corp Preventing and therapeutic agent for inflammatory intestinal disease
JP2002529444A (en) * 1998-11-12 2002-09-10 アリアド・ファーマシューティカルズ・インコーポレイテッド Bicyclic signaling inhibitors, compositions containing them and uses thereof
GB2350109A (en) * 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active benzofuranyl sulfonates
GB2350110A (en) * 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active benzofurans
GB2350111A (en) * 1999-05-17 2000-11-22 Bayer Ag Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives
GB2350112A (en) * 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active cycloalkyl ketones
US7144885B2 (en) 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
HK1080467B (en) 2002-02-22 2008-02-01 Bayer Healthcare Llc Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
EA200500846A1 (en) * 2002-11-19 2005-12-29 Ачиллион Фармасьютикалз, Инк. SUBSTITUTED ARYLTIOMOCHAMINES AND RELATED COMPOUNDS; VIRAL REPLICATION INHIBITORS
WO2004063181A1 (en) * 2003-01-03 2004-07-29 Genzyme Corporation Urea derivatives and their use as anti-inflammatory agents
TW200528459A (en) * 2004-01-06 2005-09-01 Achillion Pharmaceuticals Inc Azabenzofuran substituted thioureas; inhibitors of viral replication
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
JPWO2006137350A1 (en) * 2005-06-22 2009-01-15 キッセイ薬品工業株式会社 Novel furopyridine derivatives, pharmaceutical compositions containing them and their use
ES2378281T3 (en) 2006-07-05 2012-04-10 Nycomed Gmbh Combination of atorvastatin with a phosphodiesterase 4 inhibitor for the treatment of inflammatory pneumopathies
US20140057978A1 (en) 2011-03-17 2014-02-27 Algiax Pharmaceuticals Gmbh Novel use of benzofuranylsulfonates
WO2013156232A1 (en) * 2012-04-16 2013-10-24 Algiax Pharmaceuticals Gmbh Use of benzofuranylsulfonates in neuropathic pain
US10472324B2 (en) 2014-03-18 2019-11-12 Algiax Pharmaceuticals Gmbh 2-cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives
EP3165224A1 (en) 2015-11-09 2017-05-10 Albert-Ludwigs-Universität Freiburg Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
JP6788966B2 (en) * 2015-12-24 2020-11-25 丸善製薬株式会社 Cosmetics
EP4020024A1 (en) 2020-12-22 2022-06-29 Paul Scherrer Institut Method for producing high aspect ratio fan-shaped optics

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GB1382742A (en) * 1972-09-19 1975-02-05 Labaz Benzofuran derivatives and process for preparing the same
GB1464242A (en) * 1974-04-18 1977-02-09 Smithkline Corp Benzoyl benzofurans and compositions comprising them
ZA824343B (en) * 1981-07-01 1983-04-27 Upjohn Co Pyridinyl- and imidazolyl-benzofurane and benzothiophenes
US4933351A (en) * 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4822803A (en) * 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US5087638A (en) * 1984-06-20 1992-02-11 Merck Frosst Canada, Inc. Benzofuran derivatives
US4703053A (en) * 1985-10-28 1987-10-27 Warner-Lambert Company Benzothiophenes and benzofurans and antiallergic use thereof
GB9200623D0 (en) * 1992-01-13 1992-03-11 Bayer Ag Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives
GB9309324D0 (en) * 1993-05-06 1993-06-16 Bayer Ag Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
GB9504460D0 (en) * 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives

Also Published As

Publication number Publication date
NZ286107A (en) 1998-08-26
MA23815A1 (en) 1996-10-01
RU2162845C2 (en) 2001-02-10
SI0731099T1 (en) 2000-08-31
AU705667B2 (en) 1999-05-27
CN1176651C (en) 2004-11-24
IL117349A0 (en) 1996-07-23
US20030109578A1 (en) 2003-06-12
HU222282B1 (en) 2003-05-28
HUP9600549A3 (en) 1998-04-28
US6677372B2 (en) 2004-01-13
HK1013285A1 (en) 1999-08-20
KR960034194A (en) 1996-10-22
FI960998L (en) 1996-09-07
PE43597A1 (en) 1997-12-26
EP0731099A1 (en) 1996-09-11
HU9600549D0 (en) 1996-04-29
UA46714C2 (en) 2002-06-17
IL117349A (en) 2002-09-12
CA2170824A1 (en) 1996-09-07
DK0731099T3 (en) 2000-09-25
BG100396A (en) 1996-12-31
CN1134419A (en) 1996-10-30
KR100405579B1 (en) 2004-03-19
GB9504460D0 (en) 1995-04-26
AU4582896A (en) 1996-09-19
US6399657B1 (en) 2002-06-04
GR3034240T3 (en) 2000-12-29
CZ66796A3 (en) 1996-09-11
YU49359B (en) 2005-09-19
EE03921B1 (en) 2002-12-16
SK29796A3 (en) 1996-10-02
PT731099E (en) 2000-11-30
BR9600930A (en) 1997-12-30
NO960884L (en) 1996-09-09
FI960998A7 (en) 1996-09-07
ATE193704T1 (en) 2000-06-15
DZ1998A1 (en) 2002-07-20
PL189206B1 (en) 2005-07-29
JPH08253466A (en) 1996-10-01
TR199600177A2 (en) 1996-10-21
TNSN96035A1 (en) 2005-03-15
DE69608721T2 (en) 2000-10-05
FI960998A0 (en) 1996-03-04
SK281817B6 (en) 2001-08-06
SV1996000015A (en) 1997-02-17
NO960884D0 (en) 1996-03-05
DE69608721D1 (en) 2000-07-13
ES2147320T3 (en) 2000-09-01
NO313672B1 (en) 2002-11-11
ZA961774B (en) 1996-09-17
CN1313284A (en) 2001-09-19
MY117526A (en) 2004-07-31
PL313070A1 (en) 1996-09-16
JP3204901B2 (en) 2001-09-04
TW336934B (en) 1998-07-21
HRP960071B1 (en) 2001-04-30
HRP960071A2 (en) 1997-12-31
EP0731099B1 (en) 2000-06-07
RO116622B1 (en) 2001-04-30
CO4370145A1 (en) 1996-10-07
KR100438633B1 (en) 2004-07-02
YU13396A (en) 1999-06-15
HUP9600549A2 (en) 1997-07-28
AR002710A1 (en) 1998-04-29
BG62732B1 (en) 2000-06-30

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

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Effective date: 20070305