[go: up one dir, main page]

EE200300106A - Farmatseutiline kompositsioon kui süsteemne analgeetikum - Google Patents

Farmatseutiline kompositsioon kui süsteemne analgeetikum

Info

Publication number
EE200300106A
EE200300106A EEP200300106A EEP200300106A EE200300106A EE 200300106 A EE200300106 A EE 200300106A EE P200300106 A EEP200300106 A EE P200300106A EE P200300106 A EEP200300106 A EE P200300106A EE 200300106 A EE200300106 A EE 200300106A
Authority
EE
Estonia
Prior art keywords
pharmaceutical composition
systemic analgesic
systemic
analgesic
anolgs
Prior art date
Application number
EEP200300106A
Other languages
English (en)
Inventor
Dong Qingbin
Haykong Shum Frank
Original Assignee
Wex Medical Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wex Medical Limited filed Critical Wex Medical Limited
Publication of EE200300106A publication Critical patent/EE200300106A/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Laser Surgery Devices (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EEP200300106A 2000-09-18 2001-09-11 Farmatseutiline kompositsioon kui süsteemne analgeetikum EE200300106A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB001245171A CN1284536C (zh) 2000-09-18 2000-09-18 河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用
PCT/CN2001/001391 WO2002022129A1 (en) 2000-09-18 2001-09-11 A method of analgesia

Publications (1)

Publication Number Publication Date
EE200300106A true EE200300106A (et) 2005-04-15

Family

ID=4590472

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300106A EE200300106A (et) 2000-09-18 2001-09-11 Farmatseutiline kompositsioon kui süsteemne analgeetikum

Country Status (26)

Country Link
US (1) US6407088B1 (et)
EP (3) EP1320369B1 (et)
JP (1) JP2004508404A (et)
KR (2) KR20070112864A (et)
CN (1) CN1284536C (et)
AT (2) ATE447959T1 (et)
AU (1) AU2002213785A1 (et)
BG (1) BG107690A (et)
BR (1) BR0113961A (et)
CA (1) CA2421562C (et)
DE (1) DE60140466D1 (et)
EA (1) EA004870B1 (et)
EE (1) EE200300106A (et)
ES (1) ES2435463T3 (et)
HR (1) HRP20030202A2 (et)
HU (1) HUP0302677A3 (et)
IL (1) IL154342A0 (et)
IS (1) IS6719A (et)
MX (1) MXPA03002389A (et)
NO (1) NO323960B1 (et)
PL (1) PL360616A1 (et)
SK (1) SK3732003A3 (et)
UA (1) UA76960C2 (et)
WO (1) WO2002022129A1 (et)
YU (1) YU17103A (et)
ZA (1) ZA200301852B (et)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9809288A (pt) 1997-04-22 2001-08-07 Cocensys Inc Semicarbazonas e tiosemicarbazonas substituìdas carbocìclicas e heterocìclicas e utilização das mesmas
CN1236773C (zh) * 2000-11-22 2006-01-18 南宁枫叶药业有限公司 用于镇痛、麻醉或治疗药物依赖性的制剂
US7119062B1 (en) 2001-02-23 2006-10-10 Neucoll, Inc. Methods and compositions for improved articular surgery using collagen
CN1269482C (zh) * 2001-05-18 2006-08-16 威克斯医药有限公司 钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用
CN1203860C (zh) * 2001-06-22 2005-06-01 威克斯医药有限公司 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用
EA006739B1 (ru) 2001-11-15 2006-04-28 Майкроу Элджи Корпорейшн Фармацевтические композиции, содержащие 3,4-пропинопергидропурины, и их применение для блокирования нейронной передачи
WO2004013637A1 (en) * 2002-08-01 2004-02-12 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 37 (gpr37)
US20040209960A1 (en) * 2003-01-30 2004-10-21 Dynogen Pharmaceuticals, Inc. Methods of treating lower urinary tract disorders using sodium channell modulators
CN1568999A (zh) * 2003-07-14 2005-01-26 南宁枫叶药业有限公司 稳定的医药用河豚毒素冷冻干燥制剂
JP2005154368A (ja) * 2003-11-27 2005-06-16 Teikoku Seiyaku Co Ltd ジソピラミド含有神経因性疼痛の鎮痛剤
CA2821239C (en) * 2004-05-07 2016-04-12 Phytotox Limited Phycotoxins and uses thereof
MXPA06012960A (es) * 2004-05-07 2007-06-12 Phytotox Ltd Administracion transdermal de ficotoxinas.
US20050282836A1 (en) * 2004-06-22 2005-12-22 Weiyang Lin Solid orally ingestible formulations of tetrodotoxin
US20060034823A1 (en) * 2004-08-13 2006-02-16 Paul Reid Method of production and use of crotoxin as an analgesic
CN100363006C (zh) * 2004-08-20 2008-01-23 厦门朝阳生物工程有限公司 一种戒毒制剂及其制备方法
JP2008513407A (ja) * 2004-09-21 2008-05-01 ウェックス ファーマシューティカルズ インコーポレイテッド 中枢神経由来の神経障害性疼痛の治療用テトロドトキシンおよびその誘導体
JP2008513528A (ja) * 2004-09-22 2008-05-01 ウェックス ファーマシューティカルズ インコーポレイテッド 末梢神経由来の神経障害性疼痛の治療用テトロドトキシンおよびその誘導体
WO2006084765A1 (en) * 2005-02-11 2006-08-17 Wex Pharmaceuticals, Inc. Use of sodium channel blockers and their analogues for the treatment of nicotine dependency
EP1690541A1 (en) * 2005-02-11 2006-08-16 Laboratorios Del Dr. Esteve, S.A. Use of a sodium channel blocker and their analogues for the treatment of nicotine dependency
EP1714655A1 (en) * 2005-04-22 2006-10-25 Laboratorios Del Dr. Esteve, S.A. Use of sodium channel blockers and their analogues for the treatment of nicotine dependency
EP1702627A1 (en) * 2005-03-18 2006-09-20 Laboratorios Del Dr. Esteve, S.A. Analgesic combination of sodium channel blockers with opioid antagonists
WO2007025213A2 (en) * 2005-08-25 2007-03-01 Wex Pharmaceuticals, Inc. Use of sodium channel blockers for the management of musculoskeletal pain
US20100144767A1 (en) * 2005-08-25 2010-06-10 Wex Pharmaceuticals, Inc. Use of sodium channel blockers for the treatment of visceral pain or pain caused by cancer treatment
US20070148159A1 (en) * 2005-12-22 2007-06-28 Reid Paul F Use of crotoxin as an analgesic - CIP
GB0603008D0 (en) * 2006-02-14 2006-03-29 Portela & Ca Sa Method
EP1844781A1 (en) 2006-02-22 2007-10-17 Wex Pharmaceuticals Inc. Use of sodium channel blockers for the treatment of preterm labor
WO2007110220A1 (en) * 2006-03-27 2007-10-04 Wex Pharmaceuticals Inc. USE OF 4,9-ANHYDRO-TETRODOTOXIN FOR THE TREATMENT OF DISEASES RELATED TO THE VOLTAGE-GATED SODIUM CHANNEL α SUBUNIT NAV 1.6
CA2647235C (en) 2006-03-27 2019-03-12 Wex Pharmaceuticals Inc. Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy
EP1844782A1 (en) * 2006-03-27 2007-10-17 Wex Pharmaceuticals, Inc Use of 4,9-anhydro-tetrodotoxin for the treatment of diseases related to the voltage-gated sodium channel subunit Nav1.6
EP1844783A1 (en) * 2006-03-27 2007-10-17 Wex Pharmaceuticals, Inc Use of 4,9-anhydro-tetrodotoxin for the treatment of diseases related to the voltage-gated sodium channel - subunit Nav1.6
CN100438873C (zh) * 2006-06-26 2008-12-03 黄致强 将河鲀毒素作为镇痛药的耐受抑制剂在制备复方镇痛制剂中的应用
EP1882692A1 (en) * 2006-07-28 2008-01-30 Wex Pharmaceuticals Inc. Dimethano-[1,3]dioxocino[6,5-D]pyrimidine-spiro derivatives of tetrodotoxin, process for their synthesis and uses thereof in the treatment of pain
KR20100047860A (ko) * 2007-07-06 2010-05-10 누온 테라피우틱스, 아이엔씨. 신경병증 통증의 치료
CN101352422B (zh) * 2008-09-17 2011-04-20 厦门朝阳生物工程有限公司 河豚毒素冻干粉针制剂及其制备方法
US8957207B2 (en) 2009-03-24 2015-02-17 Proteus S.A. Methods for producing phycotoxins
WO2010117996A1 (en) * 2009-04-08 2010-10-14 Children's Medical Center Corporation Prolonged duration local anesthesia with minimal toxicity
EP2533785B1 (en) 2010-02-10 2014-04-23 Phytotox Limited Treatment of loss of sense of touch with saxitoxin derivatives
AU2011336467A1 (en) 2010-12-01 2013-07-04 Spinal Modulation, Inc. Agent delivery systems for selective neuromodulation
US10072076B2 (en) 2013-03-14 2018-09-11 Regeneron Pharmaceuticals, Inc. Human antibodies to NAv1.7
HRP20190419T1 (hr) * 2013-03-15 2019-05-03 The Children's Medical Center Corporation Kombinacijske formulacije neosaksitoksina za produženu lokalnu anesteziju
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
EP3471754A1 (en) 2016-06-20 2019-04-24 Kymab Limited Anti-pd-l1 antibodies
WO2018083248A1 (en) 2016-11-03 2018-05-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
CN107198689A (zh) * 2017-07-11 2017-09-26 东新皓特（北京）生化科技有限公司 用于治疗疼痛病症的河豚毒素药物组合物及外用药
JP2024518821A (ja) 2021-04-23 2024-05-07 ウェクス ファーマシューティカルズ インコーポレイテッド テトロドトキシン液体製剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022899A (en) 1973-06-12 1977-05-10 Astra Pharmaceutical Products, Inc. Synergistic local anesthetic compositions
US4029793A (en) 1973-06-12 1977-06-14 Astra Pharmaceutical Products, Inc. Synergistic local anesthetic compositions
EP0750909B1 (en) * 1994-03-17 2002-12-11 Nanning Maple Leaf Pharmaceutical Co., Ltd. The use of amino hydrogenated quinazoline compounds and derivatives thereof for abstaining from drug dependence
CN1072486C (zh) * 1996-09-24 2001-10-10 王维国 用于戒毒、镇痛的药剂及其制法
WO1998043619A2 (en) * 1997-04-02 1998-10-08 The Regents Of The University Of California Method of local anesthesia
US6326020B1 (en) * 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations
CN1236773C (zh) * 2000-11-22 2006-01-18 南宁枫叶药业有限公司 用于镇痛、麻醉或治疗药物依赖性的制剂
CN1269482C (zh) * 2001-05-18 2006-08-16 威克斯医药有限公司 钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用

Also Published As

Publication number Publication date
EA200300172A1 (ru) 2003-12-25
IS6719A (is) 2003-02-14
WO2002022129A1 (en) 2002-03-21
EP1563839A1 (en) 2005-08-17
UA76960C2 (en) 2006-10-16
EP1320369B1 (en) 2009-11-11
EP2298306B1 (en) 2013-09-11
ATE447959T1 (de) 2009-11-15
CA2421562C (en) 2011-05-24
BR0113961A (pt) 2004-01-13
NO20030915D0 (no) 2003-02-27
US6407088B1 (en) 2002-06-18
ATE542534T1 (de) 2012-02-15
NO20030915L (no) 2003-04-25
YU17103A (sh) 2006-03-03
PL360616A1 (en) 2004-09-20
IL154342A0 (en) 2003-09-17
EP1320369A1 (en) 2003-06-25
HUP0302677A3 (en) 2005-01-28
ZA200301852B (en) 2004-06-21
CA2421562A1 (en) 2002-03-21
BG107690A (bg) 2004-01-30
CN1284536C (zh) 2006-11-15
CN1356104A (zh) 2002-07-03
KR20030034181A (ko) 2003-05-01
HRP20030202A2 (en) 2005-02-28
KR20070112864A (ko) 2007-11-27
KR100891568B1 (ko) 2009-04-03
HUP0302677A2 (hu) 2003-11-28
SK3732003A3 (sk) 2005-05-05
AU2002213785A1 (en) 2002-03-26
DE60140466D1 (de) 2009-12-24
NO323960B1 (no) 2007-07-23
JP2004508404A (ja) 2004-03-18
EP1563839B1 (en) 2012-01-25
EP2298306A1 (en) 2011-03-23
EP1320369A4 (en) 2003-07-02
MXPA03002389A (es) 2004-03-12
ES2435463T3 (es) 2013-12-19
EA004870B1 (ru) 2004-08-26

Similar Documents

Publication Publication Date Title
EE200300106A (et) Farmatseutiline kompositsioon kui süsteemne analgeetikum
WO2002042462A3 (en) Therapeutic agents and methods of use thereof for treating an amyloidogenic disease
DK1341542T3 (da) Indanylderivater til behandling af luftvejssygdomme
DE60232417D1 (de) Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
IL151671A0 (en) Intradermal-penetration agents for topical local anesthetic administration
EA200600566A1 (ru) Быстрорастворимая лекарственная форма соединения, действующего на кальциевый рецептор
WO2004032909A3 (en) Stabilized pharmaceutical composition containing basic excipients
WO2002088100A3 (de) Deuterierte 3-piperidinopropiophenone sowie diese verbindungen enthaltende arzneimittel
AR034900A1 (es) Uso de una cantidad eficaz de un inhibidor de pde4 y un agente anticolinergico, bien en forma combinada sola o por separado, composiciones farmaceuticas que los comprenden, metodo para prepararlas, y uso de una composicion que comprende una cantidad eficaz de un inhibidor de pde4, una cantidad efica
LT2001119A (en) Pharmaceutical formulations comprising intranasal morphine and use thereof
MX2007015480A (es) Formulaciones de dosificacion solida de medicamentos narcoticos que tienen adsorcion bucal mejorada.
TW200603787A (en) Topical preparations containing ambroxol
WO2002007678A3 (en) Mu-conopeptides
SE9902267D0 (sv) New compounds
EP1262197A3 (en) Combination treatment for sleep disorders including sleep apnea
DE60236077D1 (de) Analgetische zusammensetzung enthaltend ein opioid und einen natriumkanalblocker
NO20031410L (no) Anvendelse av distamycinderivater for fremstilling av medikamenter
CA2432177A1 (en) Drug for prevention and/or therapy of endometriosis
NZ523606A (en) Pharmaceutical compositions and methods for use
IL168704A (en) Calcilytic compounds, pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising them and their use in the preparation of medicaments for treating disease or disorder characterized by abnormal bone or mineral homeostasis
SE0000303D0 (sv) Novel compounds
EE200100193A (et) 3-(1H-imidasool-4-ülmetüül)-indaan-5-ol'i kasutamine intraspinaalselt, teekasiseselt või epiduraalselt manustatava ravimi tootmises
BR0207271A (pt) Composição farmacêutica