EE200200606A - Imidasopürimidiini derivaadid ja triasolopürimidiini derivaadid - Google Patents

Imidasopürimidiini derivaadid ja triasolopürimidiini derivaadid

Info

Publication number: EE200200606A
Authority: EE; Estonia
Prior art keywords: derivatives; imidazopyrimidine; triazolopyrimidine; triazolopyrimidine derivatives; imidazopyrimidine derivatives
Prior art date: 2000-04-28

Application number

EEP200200606A

Other languages

English (en)

Estonian (et)

Inventor

Yura Takeshi

B. Concepcion Arnel

Han Gyoonhee

Marumo Makiko

Katsumata Hiroko

Kawamura Norihiro

Kokubo Toshio

Komura Hiroshi

Li Yingfu

B. Lowinger Timothy

Mogi Muneto

Yamamoto Noriyuki

Yoshida Nagahiro

Miller Scott

A. Popp Margaret

M. Redmann Aniko

E. Rodriguez Martha

J. Scott William

Wang Ming

Original Assignee

Bayer Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-28

Filing date

2001-04-17

Publication date

2004-04-15

2001-04-17 Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft

2004-04-15 Publication of EE200200606A publication Critical patent/EE200200606A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Hematology (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Otolaryngology (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Transplantation (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

EEP200200606A 2000-04-28 2001-04-17 Imidasopürimidiini derivaadid ja triasolopürimidiini derivaadid EE200200606A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2000128870A JP2001302667A (ja)	2000-04-28	2000-04-28	イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
PCT/EP2001/004357 WO2001083485A1 (en)	2000-04-28	2001-04-17	Imidazopyrimidine derivatives and triazolopyrimidine derivatives

Publications (1)

Publication Number	Publication Date
EE200200606A true EE200200606A (et)	2004-04-15

Family

ID=18638240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200606A EE200200606A (et)	2000-04-28	2001-04-17	Imidasopürimidiini derivaadid ja triasolopürimidiini derivaadid

Country Status (37)

Country	Link
US (1)	US6911443B2 (xx)
EP (1)	EP1278750B1 (xx)
JP (2)	JP2001302667A (xx)
KR (1)	KR20030009456A (xx)
CN (1)	CN1263756C (xx)
AR (1)	AR033367A1 (xx)
AT (1)	ATE272639T1 (xx)
AU (1)	AU783043B2 (xx)
BG (1)	BG107166A (xx)
BR (1)	BR0110404A (xx)
CA (1)	CA2407531A1 (xx)
CZ (1)	CZ20023551A3 (xx)
DE (1)	DE60104671T2 (xx)
DK (1)	DK1278750T3 (xx)
DO (1)	DOP2001000151A (xx)
EE (1)	EE200200606A (xx)
ES (1)	ES2225546T3 (xx)
HR (1)	HRP20020943A2 (xx)
HU (1)	HUP0300846A2 (xx)
IL (1)	IL151919A0 (xx)
MA (1)	MA25746A1 (xx)
MX (1)	MXPA02010579A (xx)
MY (1)	MY141578A (xx)
NO (1)	NO20025154D0 (xx)
NZ (2)	NZ522241A (xx)
PE (1)	PE20011287A1 (xx)
PL (1)	PL358106A1 (xx)
PT (1)	PT1278750E (xx)
RU (1)	RU2306313C2 (xx)
SI (1)	SI1278750T1 (xx)
SK (1)	SK15332002A3 (xx)
SV (1)	SV2001000416A (xx)
TR (1)	TR200402300T4 (xx)
TW (1)	TWI222974B (xx)
UA (1)	UA72615C2 (xx)
WO (1)	WO2001083485A1 (xx)
ZA (1)	ZA200207676B (xx)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002081443A1 (en)	2001-04-09	2002-10-17	Chiron Corporation	Novel guanidino compounds
PT1471057E (pt)	2003-04-25	2006-05-31	Actimis Pharmaceuticals Inc	Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2
US20070129383A1 (en) *	2003-10-17	2007-06-07	Hiroshi Kuramochi	Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof
WO2005061519A1 (en)	2003-12-19	2005-07-07	Takeda San Diego, Inc.	Kinase inhibitors
ATE433452T1 (de) *	2004-01-31	2009-06-15	Actimis Pharmaceuticals Inc	Imidazoä1,2-cüpyrimidinylessigsäurederivate
JP2008504294A (ja) *	2004-06-25	2008-02-14	アムジエン・インコーポレーテツド	サイトカイン介在疾患および他の疾患の治療において有用な縮合トリアゾールおよびインダゾール
US7550598B2 (en)	2004-08-18	2009-06-23	Takeda Pharmaceutical Company Limited	Kinase inhibitors
BRPI0514549A (pt)	2004-08-23	2008-06-17	Wyeth Corp	ácidos de pirrol-naftila como inibidores de pai-1
WO2006023866A2 (en)	2004-08-23	2006-03-02	Wyeth	Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1
JP2008510815A (ja)	2004-08-23	2008-04-10	ワイス	血栓症および心臓血管疾患の治療にて有用な調節剤であるプラスミノゲン活性化因子阻害剤１型（ｐａｉ−１）としてのオキサゾロ−ナフチル酸
ATE479687T1 (de)	2004-10-15	2010-09-15	Takeda Pharmaceutical	Kinaseinhibitoren
WO2006093247A1 (ja)	2005-02-28	2006-09-08	Japan Tobacco Inc.	Ｓｙｋ阻害活性を有する新規なアミノピリジン化合物
US7442700B2 (en)	2005-07-01	2008-10-28	Bristol-Myers Squibb Company	Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US8119655B2 (en) *	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
EA200800664A1 (ru) *	2005-10-13	2009-02-27	Глаксо Груп Лимитед	Производные пирролопиримидина в качестве ингибиторов syk
CL2007002617A1 (es) *	2006-09-11	2008-05-16	Sanofi Aventis	Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
GEP20135728B (en)	2006-10-09	2013-01-25	Takeda Pharmaceuticals Co	Kinase inhibitors
EP2223925A1 (en) *	2006-10-09	2010-09-01	Takeda Pharmaceutical Company Limited	Kinase inhibitors
EP3443958A1 (en) *	2006-11-22	2019-02-20	Incyte Holdings Corporation	Imidazotriazines and imidazopyrimidines as kinase inhibitors
US20100298557A1 (en)	2006-12-28	2010-11-25	Taisho Pharmaceutical Co., Ltd	Pyrazolopyrimidine compound
DE102007012645A1 (de)	2007-03-16	2008-09-18	Bayer Healthcare Ag	Substituierte Imidazo- und Triazolopyrimidine
CN101874023A (zh)	2007-09-25	2010-10-27	艾克提麦斯医药品有限公司	作为crth2拮抗剂的烷硫基嘧啶
CN101874024A (zh)	2007-09-25	2010-10-27	艾克提麦斯医药品有限公司	作为crth2拮抗剂的2-s-苄基取代的嘧啶
DE102008023801A1 (de)	2008-05-15	2009-11-19	Bayer Schering Pharma Aktiengesellschaft	Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine
NZ593460A (en)	2008-12-08	2013-11-29	Gilead Connecticut Inc	Imidazopyrazine syk inhibitors
TWI529172B (zh)	2008-12-08	2016-04-11	吉李德康乃狄克公司	作爲脾臟酪胺酸激酶（Ｓｙｋ）抑制劑之咪唑並吡化合物
ES2632220T3 (es) *	2009-06-15	2017-09-11	Rigel Pharmaceuticals, Inc.	Inhibidores de moléculas pequeñas de tirosina cinasa del bazo (SYK)
US8440689B2 (en)	2009-12-23	2013-05-14	Takeda Pharmaceutical Company Limited	Fused heteroaromatic pyrrolidinones
CN103168039B (zh)	2010-03-11	2016-08-03	吉利德康涅狄格公司	咪唑并吡啶类syk抑制剂
CA2796388A1 (en) *	2010-04-14	2011-10-20	Array Biopharma Inc.	5, 7-substituted-imidazo [1, 2-c] pyrimidines as inhibitors of jak kinases
JP2014513686A (ja)	2011-05-10	2014-06-05	メルク・シャープ・アンド・ドーム・コーポレーション	Ｓｙｋ阻害薬としてのアミノピリミジン
EP2706852B1 (en)	2011-05-10	2018-08-22	Merck Sharp & Dohme Corp.	Bipyridylaminopyridines as syk inhibitors
WO2012154520A1 (en)	2011-05-10	2012-11-15	Merck Sharp & Dohme Corp.	Pyridyl aminopyridines as syk inhibitors
WO2012167423A1 (en)	2011-06-08	2012-12-13	Hutchison Medipharma Limited	Substituted pyridopyrazines as novel syk inhibitors
EP2723739B1 (en)	2011-06-22	2016-08-24	Takeda Pharmaceutical Company Limited	Substituted 6-aza-isoindolin-1-one derivatives
US9199975B2 (en)	2011-09-30	2015-12-01	Asana Biosciences, Llc	Biaryl imidazole derivatives for regulating CYP17
EP2763976B1 (en)	2011-10-05	2016-05-18	Merck Sharp & Dohme Corp.	2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
US8987456B2 (en)	2011-10-05	2015-03-24	Merck Sharp & Dohme Corp.	3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
EP2763974B1 (en)	2011-10-05	2016-09-14	Merck Sharp & Dohme Corp.	Phenyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
BR112014008865A2 (pt) *	2011-10-12	2017-04-25	Array Biopharma Inc	imidazo[1,2-c]pirimidinas 5,7-substituídas
RU2576623C2 (ru) *	2011-12-28	2016-03-10	Фуджифилм Корпорэйшн	Новое производное никотинамида или его соль
WO2013192125A1 (en)	2012-06-20	2013-12-27	Merck Sharp & Dohme Corp.	Pyrazolyl derivatives as syk inhibitors
WO2013192128A1 (en)	2012-06-20	2013-12-27	Merck Sharp & Dohme Corp.	Imidazolyl analogs as syk inhibitors
WO2013192088A1 (en)	2012-06-22	2013-12-27	Merck Sharp & Dohme Corp.	SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS
US9376418B2 (en)	2012-06-22	2016-06-28	Merck Sharp & Dohme Corp.	Substituted pyridine spleen tyrosine kinase (SYK) inhibitors
WO2014031438A2 (en)	2012-08-20	2014-02-27	Merck Sharp & Dohme Corp.	SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS
EP2900665B1 (en)	2012-09-28	2018-01-03	Merck Sharp & Dohme Corp.	Triazolyl derivatives as syk inhibitors
EP2931281B1 (en)	2012-12-12	2018-01-17	Merck Sharp & Dohme Corp.	Amino-pyrimidine-containing spleen tyrosine kinase inhibitors
WO2014100314A1 (en)	2012-12-21	2014-06-26	Merck Sharp & Dohme Corp.	Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
EP2988744A4 (en)	2013-04-26	2016-11-02	Merck Sharp & Dohme	THIAZOLSUBSTITUTED AMINOHETEROARYLE AS MILZTYROSINKINASE INHIBITOR
WO2014176216A1 (en)	2013-04-26	2014-10-30	Merck Sharp & Dohme Corp.	Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
KR20160036590A (ko)	2013-07-30	2016-04-04	질레드 코네티컷 인코포레이티드	Ｓｙｋ 억제제의 제제
ES2822285T3 (es)	2013-07-30	2021-04-30	Kronos Bio Inc	Polimorfo de inhibidores de SYK
MX2016007311A (es)	2013-12-04	2016-09-07	Gilead Sciences Inc	Metodos para tratar canceres.
WO2015095445A1 (en)	2013-12-20	2015-06-25	Merck Sharp & Dohme Corp.	Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
US9670196B2 (en)	2013-12-20	2017-06-06	Merck Sharp & Dohme Corp.	Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors
US9783531B2 (en)	2013-12-20	2017-10-10	Merck Sharp & Dohme Corp.	Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
US9290505B2 (en)	2013-12-23	2016-03-22	Gilead Sciences, Inc.	Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
TWI735853B (zh)	2013-12-23	2021-08-11	美商克洛諾斯生技有限公司	脾酪胺酸激酶抑制劑
WO2015138273A1 (en)	2014-03-13	2015-09-17	Merck Sharp & Dohme Corp.	2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
JP6416275B2 (ja)	2014-03-19	2018-10-31	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ヘテロアリールｓｙｋ阻害剤
CN106687139A (zh)	2014-07-14	2017-05-17	吉利德科学公司	用于治疗癌症的组合
EP3347353B1 (en)	2015-09-11	2019-07-17	Boehringer Ingelheim International GmbH	Pyrazolyl-substituted heteroaryls and their use as medicaments
US11384082B2 (en)	2017-08-25	2022-07-12	Kronos Bio, Inc.	Hydrates of polymorphs of 6-(1H-indazol-6-YL)-N-(4-morpholinophenyl)-2,3-dihydroimidazo[1,2-A]pyrazin-8-amine bisemsylate as Syk inhibitors
SG11202002475TA (en)	2017-10-19	2020-04-29	Bayer Animal Health Gmbh	Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals
WO2019099564A1 (en)	2017-11-14	2019-05-23	Children's Medical Center Corporation	Novel imidazopyrimidine compounds and uses thereof
JP7382316B2 (ja) *	2017-11-14	2023-11-16	ザチルドレンズメディカルセンターコーポレーション	ヒト免疫応答をモジュレートするためのイミダゾピリミジンの使用
WO2019235572A1 (ja) *	2018-06-06	2019-12-12	富士フイルム株式会社	固形がんの処置剤および医薬組成物
WO2019235571A1 (ja) *	2018-06-06	2019-12-12	富士フイルム株式会社	血液がんの処置剤および医薬組成物
JP7370079B2 (ja) *	2018-06-06	2023-10-27	国立大学法人北海道大学	グリオーマの処置剤および医薬組成物
CR20210215A (es)	2018-10-31	2021-06-17	Gilead Sciences Inc	Compuestos de 6-azabencimidazol sustituidos como inhibidores de hpk1
CN117105933A (zh)	2018-10-31	2023-11-24	吉利德科学公司	具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物
CA3130848A1 (en)	2019-02-22	2020-08-27	Kronos Bio, Inc.	Solid forms of condensed pyrazines as syk inhibitors
CN114364798A (zh)	2019-03-21	2022-04-15	欧恩科斯欧公司	用于治疗癌症的Dbait分子与激酶抑制剂的组合
US11453681B2 (en)	2019-05-23	2022-09-27	Gilead Sciences, Inc.	Substituted eneoxindoles and uses thereof
JP2023500906A (ja)	2019-11-08	2023-01-11	インサーム（インスティテュナシオナルドゥラサンテエドゥラルシェルシェメディカル）	キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
WO2021173476A1 (en) *	2020-02-24	2021-09-02	The Trustees Of Columbia University In The City Of New York	Compounds, pharmaceutical formulations, and methods for treatment of cancer
WO2022104079A1 (en) *	2020-11-13	2022-05-19	Biogen Ma Inc.	Pyrazolo[1,5-a]pyrazine derivatives as btk inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4483987A (en) *	1983-06-20	1984-11-20	G. D. Searle & Co.	8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides
FR2549834B1 (fr) *	1983-07-25	1985-10-18	Sanofi Sa	Derives de triazolo-pyrimidine, leur procede de preparation et leur application therapeutique en tant que tonicardiaques
EP1017682A4 (en)	1997-09-26	2000-11-08	Merck & Co Inc	NEW ANGIOGENESIS INHIBITORS
JP4135318B2 (ja)	1997-12-15	2008-08-20	アステラス製薬株式会社	新規なピリミジン−５−カルボキサミド誘導体
US6673564B2 (en) *	1999-10-18	2004-01-06	Millennium Pharmaceuticals, Inc.	Methods for using 22045, a human cyclic nucleotide phosphodiesterase

2000
- 2000-04-28 JP JP2000128870A patent/JP2001302667A/ja active Pending
2001
- 2001-04-17 US US10/258,628 patent/US6911443B2/en not_active Expired - Fee Related
- 2001-04-17 JP JP2002500795A patent/JP2003535067A/ja active Pending
- 2001-04-17 CZ CZ20023551A patent/CZ20023551A3/cs unknown
- 2001-04-17 SK SK1533-2002A patent/SK15332002A3/sk unknown
- 2001-04-17 AU AU62204/01A patent/AU783043B2/en not_active Ceased
- 2001-04-17 HR HR20020943A patent/HRP20020943A2/hr not_active Application Discontinuation
- 2001-04-17 DK DK01936242T patent/DK1278750T3/da active
- 2001-04-17 DE DE60104671T patent/DE60104671T2/de not_active Expired - Fee Related
- 2001-04-17 BR BR0110404-7A patent/BR0110404A/pt not_active IP Right Cessation
- 2001-04-17 KR KR1020027014441A patent/KR20030009456A/ko not_active Ceased
- 2001-04-17 HU HU0300846A patent/HUP0300846A2/hu unknown
- 2001-04-17 PT PT01936242T patent/PT1278750E/pt unknown
- 2001-04-17 PL PL01358106A patent/PL358106A1/xx not_active Application Discontinuation
- 2001-04-17 AT AT01936242T patent/ATE272639T1/de not_active IP Right Cessation
- 2001-04-17 CA CA002407531A patent/CA2407531A1/en not_active Abandoned
- 2001-04-17 WO PCT/EP2001/004357 patent/WO2001083485A1/en not_active Ceased
- 2001-04-17 EP EP01936242A patent/EP1278750B1/en not_active Expired - Lifetime
- 2001-04-17 RU RU2002132193/04A patent/RU2306313C2/ru not_active IP Right Cessation
- 2001-04-17 SI SI200130178T patent/SI1278750T1/xx unknown
- 2001-04-17 IL IL15191901A patent/IL151919A0/xx unknown
- 2001-04-17 TR TR2004/02300T patent/TR200402300T4/xx unknown
- 2001-04-17 EE EEP200200606A patent/EE200200606A/xx unknown
- 2001-04-17 CN CNB018117201A patent/CN1263756C/zh not_active Expired - Fee Related
- 2001-04-17 NZ NZ522241A patent/NZ522241A/en unknown
- 2001-04-17 UA UA2002119418A patent/UA72615C2/uk unknown
- 2001-04-17 ES ES01936242T patent/ES2225546T3/es not_active Expired - Lifetime
- 2001-04-17 NZ NZ526221A patent/NZ526221A/en unknown
- 2001-04-17 MX MXPA02010579A patent/MXPA02010579A/es active IP Right Grant
- 2001-04-25 DO DO2001000151A patent/DOP2001000151A/es unknown
- 2001-04-26 MY MYPI20011983A patent/MY141578A/en unknown
- 2001-04-27 PE PE2001000382A patent/PE20011287A1/es not_active Application Discontinuation
- 2001-04-27 TW TW090110055A patent/TWI222974B/zh not_active IP Right Cessation
- 2001-04-27 AR ARP010102006A patent/AR033367A1/es not_active Application Discontinuation
- 2001-04-27 SV SV2001000416A patent/SV2001000416A/es not_active Application Discontinuation
2002
- 2002-09-25 ZA ZA200207676A patent/ZA200207676B/xx unknown
- 2002-10-03 BG BG107166A patent/BG107166A/bg unknown
- 2002-10-25 NO NO20025154A patent/NO20025154D0/no not_active Application Discontinuation
- 2002-10-28 MA MA26885A patent/MA25746A1/fr unknown

Also Published As

Publication number	Publication date
AU6220401A (en)	2001-11-12
ZA200207676B (en)	2003-09-25
MA25746A1 (fr)	2003-04-01
EP1278750B1 (en)	2004-08-04
DE60104671D1 (de)	2004-09-09
CA2407531A1 (en)	2001-10-25
CN1263756C (zh)	2006-07-12
BG107166A (bg)	2003-06-30
JP2003535067A (ja)	2003-11-25
HK1058362A1 (en)	2004-05-14
HRP20020943A2 (en)	2005-02-28
BR0110404A (pt)	2003-02-11
ATE272639T1 (de)	2004-08-15
SK15332002A3 (sk)	2003-06-03
MXPA02010579A (es)	2003-05-14
EP1278750A1 (en)	2003-01-29
US6911443B2 (en)	2005-06-28
DE60104671T2 (de)	2005-12-29
AU783043B2 (en)	2005-09-22
DK1278750T3 (da)	2004-11-22
RU2306313C2 (ru)	2007-09-20
KR20030009456A (ko)	2003-01-29
TR200402300T4 (tr)	2004-12-21
SV2001000416A (es)	2001-07-03
CZ20023551A3 (cs)	2003-01-15
PL358106A1 (en)	2004-08-09
MY141578A (en)	2010-05-14
UA72615C2 (en)	2005-03-15
DOP2001000151A (es)	2002-05-15
IL151919A0 (en)	2003-04-10
NZ526221A (en)	2005-01-28
NO20025154L (no)	2002-10-25
NZ522241A (en)	2004-04-30
TWI222974B (en)	2004-11-01
ES2225546T3 (es)	2005-03-16
NO20025154D0 (no)	2002-10-25
PT1278750E (pt)	2004-11-30
JP2001302667A (ja)	2001-10-31
SI1278750T1 (en)	2005-02-28
AR033367A1 (es)	2003-12-17
US20040054179A1 (en)	2004-03-18
WO2001083485A1 (en)	2001-11-08
CN1439009A (zh)	2003-08-27
PE20011287A1 (es)	2002-02-27
HUP0300846A2 (hu)	2003-08-28

Publication	Publication Date	Title
EE200200606A (et)	2004-04-15	Imidasopürimidiini derivaadid ja triasolopürimidiini derivaadid
MA26612A1 (fr)	2004-12-20	Pyrazolopyrimidines et pyrazolotriazines
DE60026297D1 (de)	2006-04-27	Pyrrolotriazin kinasehemmer
EE200200251A (et)	2003-06-16	Uued N-asabitsükloamiidi derivaadid ja nende kasutamine
FI20000819L (fi)	2002-01-25	Menetelmä vastaanottimessa ja vastaanotin
NO20025227L (no)	2002-10-31	Tropanderivater nyttige i terapi
EE200200080A (et)	2003-06-16	Imidaso[1,2a]püridiini ja pürasolo[2,3a]püridiiniderivaadid
DE60026861D1 (de)	2006-05-11	Purin-derivate
ATE238336T1 (de)	2003-05-15	Purin-derivate
IS6196A (is)	2001-12-11	Púrín afleiður
DE60027759D1 (de)	2006-06-08	Absorbierender artikel
DE60020536D1 (de)	2005-07-07	Absorbierender artikel
ATE325807T1 (de)	2006-06-15	Purinderivate
DE60039814D1 (de)	2008-09-25	Absorbierender Artikel
DE60018133D1 (de)	2005-03-24	Absorbierender Artikel
DE60030038D1 (de)	2006-09-28	Absorbierender Artikel
DE60103537D1 (de)	2004-07-01	Purinderivate
FI19992753L (fi)	2001-06-22	Menetelmä vastaanottimessa ja vastaanotin
DE60038972D1 (de)	2008-07-03	Absorbierender artikel
DE60044183D1 (de)	2010-05-27	Absorbierender artikel
DE60032898D1 (de)	2007-02-22	Arylthiazolidindion- und aryloxazolidinderivate
DE60103909D1 (de)	2004-07-22	2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on- und 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5 1honderivate
NO20025510L (no)	2003-01-14	Dibenzoazulen-derivater samt anvendelse derav
DE50208341D1 (de)	2006-11-16	Triazolopyrimidine
NO20004072D0 (no)	2000-08-15	Absorberende artikkel

Legal Events

Date	Code	Title	Description
2006-04-17	GB1A	Change in the ownership or in the address of the owner