EE200200405A - Pyrido [2,3-d] pyrimidine-2,7-diamines as kinase inhibitors - Google Patents

Pyrido [2,3-d] pyrimidine-2,7-diamines as kinase inhibitors

Info

Publication number: EE200200405A
Authority: EE; Estonia
Prior art keywords: pyrido; diamines; pyrimidine; kinase inhibitors; kinase
Prior art date: 2000-01-25

Application number

EEP200200405A

Other languages

Estonian (et)

Inventor

Laurence Toogood Peter

John Booth Richard

Myra Dobrusin Ellen

Prasad Venkata Nagendra Josyula Vara

Joseph Mcnamara Dennis

Original Assignee

Warner-Lambert Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2003-12-15

2001-01-23 Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company

2003-12-15 Publication of EE200200405A publication Critical patent/EE200200405A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

EEP200200405A 2000-01-25 2001-01-23 Pyrido [2,3-d] pyrimidine-2,7-diamines as kinase inhibitors EE200200405A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25
PCT/IB2001/000069 WO2001055147A1 (en)	2000-01-25	2001-01-23	PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS

Publications (1)

Publication Number	Publication Date
EE200200405A true EE200200405A (en)	2003-12-15

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200405A EE200200405A (en)	2000-01-25	2001-01-23	Pyrido [2,3-d] pyrimidine-2,7-diamines as kinase inhibitors

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (en)
JP (1)	JP4047010B2 (en)
KR (1)	KR20020065939A (en)
CN (1)	CN1395578A (en)
AP (1)	AP2002002586A0 (en)
AR (1)	AR030044A1 (en)
AU (1)	AU2542501A (en)
BG (1)	BG106850A (en)
BR (1)	BR0107751A (en)
CA (1)	CA2397961C (en)
CO (1)	CO5261549A1 (en)
CR (1)	CR6706A (en)
CZ (1)	CZ20022475A3 (en)
DZ (1)	DZ3266A1 (en)
EA (1)	EA200200643A1 (en)
EE (1)	EE200200405A (en)
GT (1)	GT200100016A (en)
HN (1)	HN2001000013A (en)
HU (1)	HUP0204141A3 (en)
IL (1)	IL150545A0 (en)
IS (1)	IS6443A (en)
MA (1)	MA26868A1 (en)
MX (1)	MXPA02007221A (en)
NO (1)	NO20023527L (en)
OA (1)	OA12161A (en)
PA (1)	PA8510701A1 (en)
PE (1)	PE20011066A1 (en)
PL (1)	PL356802A1 (en)
SK (1)	SK10632002A3 (en)
SV (1)	SV2002000294A (en)
TN (1)	TNSN01014A1 (en)
WO (1)	WO2001055147A1 (en)
YU (1)	YU50402A (en)
ZA (1)	ZA200205879B (en)

Families Citing this family (30)

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Publication number	Priority date	Publication date	Assignee	Title
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
WO2002059083A2 (en)	2000-10-23	2002-08-01	Smithkline Beecham Corporation	Novel compounds
PE20030008A1 (en) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	DUAL INHIBITORS OF PDE 7 AND PDE 4
JP4603268B2 (en)	2002-04-19	2010-12-22	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー	New compounds
RS20050363A (en) *	2002-11-28	2007-11-15	Schering Aktiengesellschaft,	Chk-,pdk-and akt-inhibitory pyrimidines,their production an use as pharmaceutical agents
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en)	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (en)	2004-07-15	2007-11-23	Sanofi Synthelabo	PYRIDO-PYRIMIDINE DERIVATIVES, THEIR APPLICATION IN THERAPEUTICS
CA2579406A1 (en) *	2004-09-21	2006-03-30	F.Hoffmann-La Roche Ag	6-(2-alkyl-phenyl) - pyrido[2,3-d] pyrimidines useful as protein kinase inhibitors
UY29439A1 (en)	2005-03-25	2006-10-02	Glaxo Group Ltd	NEW COMPOUNDS
US20090137550A1 (en)	2005-03-25	2009-05-28	Glaxo Group Limited	Novel Compounds
SG160438A1 (en)	2005-03-25	2010-04-29	Glaxo Group Ltd	Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5- d]pyrimidin-2(1h)-one derivatives
PE20100737A1 (en)	2005-03-25	2010-11-27	Glaxo Group Ltd	NEW COMPOUNDS
FR2887882B1 (en)	2005-07-01	2007-09-07	Sanofi Aventis Sa	PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
CA2614443C (en) *	2005-07-21	2011-03-22	F. Hoffmann-La Roche Ag	Pyrido [2,3-d] pyrimidine-2,4-diamine compounds as ptp1b inhibitors
BRPI0614804A2 (en)	2005-08-09	2011-04-12	Irm Llc	compounds and compositions as protein kinase inhibitors
FR2896246B1 (en)	2006-01-13	2008-08-15	Sanofi Aventis Sa	PYRIDO-PYRIMIDONE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
EP1914234A1 (en)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (en)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	MAPK/ERK Kinase Inhibitors
FR2910813B1 (en)	2006-12-28	2009-02-06	Sanofi Aventis Sa	NEW THERAPEUTIC USE FOR THE TREATMENT OF LEUKEMIA
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
JP5697601B2 (en) *	2008-12-01	2015-04-08	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	2,5-Diamino-substituted pyrido [4,3-D] pyrimidines as autotaxin inhibitors against cancer
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
EP2968331B1 (en) *	2013-03-14	2020-07-01	Icahn School of Medicine at Mount Sinai	Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (en) *	2014-09-02	2016-11-02	한국원자력의학원	Pyrimidine derivatives having anti-cancer effect, combination therapeutic effect with radiation, and anti-diabetic effect, and PPAR activity, and medical use thereof
CN107286180B (en) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	Heteropyridopyrimidinone derivatives as CDK inhibitors and their applications
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE190978T1 (en) *	1994-11-14	2000-04-15	Warner Lambert Co	6-ARYL-PYRIDO(2,3-D)PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING CELL PRODUCTION CAUSED BY PROTEIN TYROSINE KINASE
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
KR20010043829A (en) *	1998-05-26	2001-05-25	로즈 암스트롱, 크리스틴 에이. 트러트웨인	Bicyclic Pyrimidines and Bicyclic 3,4-Dihydropyrimidines as Inhibitors of Cellular Proliferation

2001
- 2001-01-23 CN CN01804048A patent/CN1395578A/en active Pending
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/en unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/en unknown
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/en not_active IP Right Cessation
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/en not_active Application Discontinuation
- 2001-01-23 YU YU50402A patent/YU50402A/en unknown
- 2001-01-23 AR ARP010100285A patent/AR030044A1/en not_active Application Discontinuation
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/en not_active Application Discontinuation
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/en not_active Expired - Fee Related
- 2001-01-23 EA EA200200643A patent/EA200200643A1/en unknown
- 2001-01-23 IL IL15054501A patent/IL150545A0/en unknown
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/en not_active Application Discontinuation
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/en active
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/en unknown
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/en not_active Ceased
- 2001-01-23 GT GT200100016A patent/GT200100016A/en unknown
- 2001-01-23 EP EP01900591A patent/EP1254137A1/en not_active Withdrawn
- 2001-01-23 PL PL01356802A patent/PL356802A1/en not_active Application Discontinuation
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/en not_active Ceased
- 2001-01-23 EE EEP200200405A patent/EE200200405A/en unknown
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 CA CA002397961A patent/CA2397961C/en not_active Expired - Fee Related
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/en not_active Application Discontinuation
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/en unknown
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/en unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/en not_active Application Discontinuation
2002
- 2002-06-20 BG BG106850A patent/BG106850A/en unknown
- 2002-06-25 IS IS6443A patent/IS6443A/en unknown
- 2002-07-17 CR CR6706A patent/CR6706A/en not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/en unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2397961C (en)	2008-08-26
AU2542501A (en)	2001-08-07
PE20011066A1 (en)	2001-10-22
NO20023527L (en)	2002-09-10
CA2397961A1 (en)	2001-08-02
YU50402A (en)	2005-11-28
OA12161A (en)	2006-05-08
EP1254137A1 (en)	2002-11-06
CZ20022475A3 (en)	2003-03-12
HUP0204141A3 (en)	2005-03-29
MA26868A1 (en)	2004-12-20
TNSN01014A1 (en)	2005-11-10
CR6706A (en)	2005-04-04
BG106850A (en)	2003-02-28
JP2003523357A (en)	2003-08-05
ZA200205879B (en)	2003-09-29
SV2002000294A (en)	2002-07-16
JP4047010B2 (en)	2008-02-13
IL150545A0 (en)	2003-02-12
DZ3266A1 (en)	2001-08-02
BR0107751A (en)	2002-11-12
AR030044A1 (en)	2003-08-13
IS6443A (en)	2002-06-25
EA200200643A1 (en)	2002-12-26
HUP0204141A2 (en)	2003-04-28
MXPA02007221A (en)	2002-11-29
CO5261549A1 (en)	2003-03-31
GT200100016A (en)	2001-10-19
CN1395578A (en)	2003-02-05
AP2002002586A0 (en)	2002-09-30
WO2001055147A1 (en)	2001-08-02
KR20020065939A (en)	2002-08-14
HN2001000013A (en)	2001-06-18
SK10632002A3 (en)	2003-06-03
PA8510701A1 (en)	2002-12-11
PL356802A1 (en)	2004-07-12
NO20023527D0 (en)	2002-07-24

Publication	Publication Date	Title
EE200200405A (en)	2003-12-15	Pyrido [2,3-d] pyrimidine-2,7-diamines as kinase inhibitors
EE200200506A (en)	2004-02-16	5-alkylpyrido [2,3-d] pyrimidines as tyrosine kinase inhibitors
DK1235830T3 (en)	2004-03-29	Pyrrolo [2,3-d] pyrimidine compounds as protein kinase inhibitors
IL181957A0 (en)	2009-02-11	Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
DK1416935T3 (en)	2008-07-07	4-Amino-6-phenyl-pyrrolo [2,3-d] pyrimidine derivatives
NO20021694L (en)	2002-05-27	Pyrazolo [4,3-d] pyrimidine
DK1697356T3 (en)	2009-01-12	Pyrido [2,3-d] pyrimidine-2,4-diamines as PDE 2 inhibitors
EE200200192A (en)	2003-06-16	5- (2-Substituted-5-heterocyclylsulfonylpyrid-3-yl) dihydropyrazolo [4,3-d] pyrimidin-7-ones as phosphodiesterase inhibitors
IL148614A0 (en)	2002-09-12	Pteridinones as kinase inhibitors
AU2000240570A1 (en)	2001-10-08	Pyrrolopyrimidines as tyrosine kinase inhibitors
DE50001191D1 (en)	2003-03-06	PYRAZOLO [4, 3-D] PYRIMIDINE
DE50103649D1 (en)	2004-10-21	2-aminoalkyl-THIENO [2,3-D] PYRIMIDINES
PT1326866E (en)	2005-08-31	SUBSTITUTED 3,4-DIHYDROPYRIDO [1,2-A] PYRIMIDINES
ZA200206528B (en)	2003-03-13	Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors.
DK1326866T3 (en)	2005-08-01	Substituted 3,4-dihydro-pyrido [1,2-a] pyrimidines