EE200200129A - Levosimendani farmatseutilised lahused - Google Patents

Levosimendani farmatseutilised lahused

Info

Publication number: EE200200129A
Authority: EE; Estonia
Prior art keywords: pharmaceutical solutions; levosimendan; levosimendan pharmaceutical; solutions; pharmaceutical
Prior art date: 1999-09-10

Application number

EEP200200129A

Other languages

English (en)

Inventor

B�Ckstr�M Reijo

Granvik P�ivi

Haikala Ritva

Pelttari Sirpa

Saukko Eva

Yrj�l� Reija

Original Assignee

Orion Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-10

Filing date

2000-09-08

Publication date

2003-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8555263&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE200200129(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-09-08 Application filed by Orion Corporation filed Critical Orion Corporation

2003-04-15 Publication of EE200200129A publication Critical patent/EE200200129A/et

2011-02-15 Publication of EE05375B1 publication Critical patent/EE05375B1/et

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

EEP200200129A 1999-09-10 2000-09-08 LevosimendaniÁfarmatseutilineÁlahus EE05375B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI991925A FI109659B (fi)	1999-09-10	1999-09-10	Levosimendaanin farmaseuttisia liuoksia
PCT/FI2000/000761 WO2001019334A2 (en)	1999-09-10	2000-09-08	Pharmaceutical solutions of levosimendan

Publications (2)

Publication Number	Publication Date
EE200200129A true EE200200129A (et)	2003-04-15
EE05375B1 EE05375B1 (et)	2011-02-15

Family

ID=8555263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200129A EE05375B1 (et)	1999-09-10	2000-09-08	LevosimendaniÁfarmatseutilineÁlahus

Country Status (39)

Country	Link
US (2)	US6730673B1 (et)
EP (1)	EP1210085B1 (et)
JP (1)	JP4708648B2 (et)
KR (1)	KR100869752B1 (et)
CN (1)	CN1203855C (et)
AR (1)	AR025449A1 (et)
AT (1)	ATE315937T1 (et)
AU (1)	AU771027B2 (et)
BG (1)	BG65827B1 (et)
BR (1)	BRPI0013924B8 (et)
CA (1)	CA2382013C (et)
CO (1)	CO5180582A1 (et)
CZ (1)	CZ303095B6 (et)
DE (1)	DE60025627T2 (et)
DK (1)	DK1210085T3 (et)
EA (1)	EA005067B1 (et)
EE (1)	EE05375B1 (et)
ES (1)	ES2256034T3 (et)
FI (1)	FI109659B (et)
HK (1)	HK1049282B (et)
HR (1)	HRP20020298B1 (et)
HU (1)	HU228340B1 (et)
IL (2)	IL148379A0 (et)
IS (1)	IS2244B (et)
ME (1)	ME00523B (et)
MX (1)	MXPA02002423A (et)
MY (1)	MY125984A (et)
NO (1)	NO331989B1 (et)
NZ (1)	NZ517605A (et)
PL (1)	PL202356B1 (et)
PT (1)	PT1210085E (et)
RS (1)	RS50445B (et)
SI (1)	SI1210085T1 (et)
SK (1)	SK287154B6 (et)
TR (1)	TR200200620T2 (et)
TW (1)	TWI242434B (et)
UA (1)	UA73954C2 (et)
WO (1)	WO2001019334A2 (et)
ZA (1)	ZA200201828B (et)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI109659B (fi) *	1999-09-10	2002-09-30	Orion Yhtymae Oyj	Levosimendaanin farmaseuttisia liuoksia
FI20010233A0 (fi) *	2001-02-08	2001-02-08	Orion Corp	Menetelmä sydämen vajaatoiminnan hoitoon
CN100428937C (zh) *	2003-10-30	2008-10-29	北京海合天科技开发有限公司	左西孟旦冷冻干燥组合物
CN100367964C (zh) *	2004-04-29	2008-02-13	王思清	左西孟旦-β环糊精包含物制剂
WO2006087420A2 (en) *	2005-02-18	2006-08-24	Orion Corporation	A method for treating heart failure
JP2010514778A (ja) *	2006-12-28	2010-05-06	オリオンコーポレーション	非経口投与のためのレボシメンダン製剤
US10046081B2 (en)	2008-04-11	2018-08-14	The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc.	Electrospun dextran fibers and devices formed therefrom
WO2012093404A2 (en) *	2011-01-03	2012-07-12	Gufic Biosciences Limited	Parenteral formulations of levosimendan
US20130096479A1 (en) *	2011-10-18	2013-04-18	St. Teresa Medical, Inc.	Method of forming hemostatic products
JP2015516441A (ja) *	2012-05-18	2015-06-11	ルオダファーマピーティーワイリミテッド	液体配合剤
CN105106113B (zh) *	2015-09-30	2019-07-26	济南康和医药科技有限公司	一种左西孟旦注射液及其制备方法
DK3370693T3 (da) *	2015-11-06	2020-03-23	Carinopharm Gmbh	Forbedrede formuleringer af levosimendan til intravenøs indgivelse som infusion eller injektion og af infusionskoncentrat
US10828387B2 (en)	2015-11-12	2020-11-10	St. Teresa Medical, Inc.	Method of sealing a durotomy
CN108261398A (zh) *	2016-12-30	2018-07-10	齐鲁制药有限公司	一种含有左西孟旦的供注射用药物制剂及其制备方法
US10953128B2 (en)	2017-11-02	2021-03-23	St. Teresa Medical, Inc.	Fibrin sealant products
CN111474289A (zh) *	2019-10-31	2020-07-31	武汉嘉诺康医药技术有限公司	一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
WO2021126884A1 (en) *	2019-12-16	2021-06-24	Tenax Therapeutics, Inc.	LEVOSIMENDAN FOR TREATING PULMONARY HYPERTENSION WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (PH-HF-pEF)
CN111514147B (zh) *	2020-05-12	2021-09-17	成都欣捷高新技术开发股份有限公司	用于急性失代偿心力衰竭症状的左西孟旦钠药用组合物及制备方法
US11760730B2 (en)	2021-01-11	2023-09-19	Navinta, Llc	Process for the preparation of high purity Levosimendan
TR2021013305A2 (tr) *	2021-08-23	2023-03-21	Tüm Eki̇p İlaç Anoni̇m Şi̇rketi̇	Li̇yofi̇li̇ze levosi̇mendan formülasyonlari
CN115518037A (zh) *	2022-10-14	2022-12-27	上药东英（江苏）药业有限公司	一种安全质量稳定的左西孟旦注射剂组合物及其制备方法
CN116473930B (zh) *	2023-05-17	2023-12-15	山东泰合医药科技有限公司	一种注射用左西孟旦及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2251615B (en)	1991-01-03	1995-02-08	Orion Yhtymae Oy	(-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en)	1992-05-06	1993-11-17	Orion Yhtymae Oy	Compounds for use as anti-ischemic medicaments
GB9606474D0 (en)	1996-03-27	1996-06-05	Orion Yhytmo Oy	Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) *	1996-07-05	1996-09-04	Orion Yhtymae Oy	Transdermal delivery of levosimendan
FI980902A7 (fi) *	1998-04-23	1999-10-24	Orion Yhtymae Oyj	Levosimendaanin stabiileja koostumuksia
FI109659B (fi) *	1999-09-10	2002-09-30	Orion Yhtymae Oyj	Levosimendaanin farmaseuttisia liuoksia

1999
- 1999-09-10 FI FI991925A patent/FI109659B/fi active
2000
- 2000-08-09 UA UA2002042873A patent/UA73954C2/uk unknown
- 2000-08-11 MY MYPI20003682A patent/MY125984A/en unknown
- 2000-08-30 AR ARP000104525A patent/AR025449A1/es not_active Application Discontinuation
- 2000-08-30 TW TW089117581A patent/TWI242434B/zh not_active IP Right Cessation
- 2000-09-06 CO CO00067212A patent/CO5180582A1/es active IP Right Grant
- 2000-09-08 MX MXPA02002423A patent/MXPA02002423A/es active IP Right Grant
- 2000-09-08 ME MEP-2008-866A patent/ME00523B/me unknown
- 2000-09-08 AT AT00958562T patent/ATE315937T1/de active
- 2000-09-08 NZ NZ517605A patent/NZ517605A/en not_active IP Right Cessation
- 2000-09-08 CA CA002382013A patent/CA2382013C/en not_active Expired - Lifetime
- 2000-09-08 TR TR2002/00620T patent/TR200200620T2/xx unknown
- 2000-09-08 EP EP00958562A patent/EP1210085B1/en not_active Expired - Lifetime
- 2000-09-08 HU HU0202749A patent/HU228340B1/hu unknown
- 2000-09-08 JP JP2001522969A patent/JP4708648B2/ja not_active Expired - Lifetime
- 2000-09-08 ES ES00958562T patent/ES2256034T3/es not_active Expired - Lifetime
- 2000-09-08 HR HR20020298A patent/HRP20020298B1/xx not_active IP Right Cessation
- 2000-09-08 PL PL354028A patent/PL202356B1/pl unknown
- 2000-09-08 BR BRPI0013924A patent/BRPI0013924B8/pt not_active IP Right Cessation
- 2000-09-08 RS YUP-169/02A patent/RS50445B/sr unknown
- 2000-09-08 IL IL14837900A patent/IL148379A0/xx active IP Right Grant
- 2000-09-08 DE DE60025627T patent/DE60025627T2/de not_active Expired - Lifetime
- 2000-09-08 AU AU70044/00A patent/AU771027B2/en not_active Expired
- 2000-09-08 SI SI200030801T patent/SI1210085T1/sl unknown
- 2000-09-08 SK SK327-2002A patent/SK287154B6/sk not_active IP Right Cessation
- 2000-09-08 EE EEP200200129A patent/EE05375B1/et unknown
- 2000-09-08 US US10/070,689 patent/US6730673B1/en not_active Expired - Lifetime
- 2000-09-08 CN CNB008126453A patent/CN1203855C/zh not_active Expired - Lifetime
- 2000-09-08 PT PT00958562T patent/PT1210085E/pt unknown
- 2000-09-08 HK HK03101189.6A patent/HK1049282B/zh not_active IP Right Cessation
- 2000-09-08 DK DK00958562T patent/DK1210085T3/da active
- 2000-09-08 EA EA200200348A patent/EA005067B1/ru not_active IP Right Cessation
- 2000-09-08 CZ CZ20020788A patent/CZ303095B6/cs not_active IP Right Cessation
- 2000-09-08 WO PCT/FI2000/000761 patent/WO2001019334A2/en not_active Ceased
- 2000-09-08 KR KR20027002923A patent/KR100869752B1/ko not_active Expired - Lifetime
2002
- 2002-02-26 IL IL148379A patent/IL148379A/en unknown
- 2002-03-05 ZA ZA200201828A patent/ZA200201828B/xx unknown
- 2002-03-05 NO NO20021090A patent/NO331989B1/no not_active IP Right Cessation
- 2002-03-06 IS IS6296A patent/IS2244B/is unknown
- 2002-04-05 BG BG106589A patent/BG65827B1/bg unknown
2003
- 2003-11-10 US US10/703,565 patent/US6943164B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN1373665A (zh)	2002-10-09
US6943164B2 (en)	2005-09-13
CZ2002788A3 (cs)	2002-11-13
RS50445B (sr)	2010-03-02
SK3272002A3 (en)	2002-12-03
EP1210085B1 (en)	2006-01-18
ME00523B (me)	2011-10-10
PT1210085E (pt)	2006-05-31
CN1203855C (zh)	2005-06-01
DK1210085T3 (da)	2006-05-08
DE60025627T2 (de)	2006-11-16
NO20021090L (no)	2002-03-05
SI1210085T1 (sl)	2006-04-30
CA2382013A1 (en)	2001-03-22
WO2001019334A2 (en)	2001-03-22
BR0013924A (pt)	2002-05-21
BG65827B1 (bg)	2010-02-26
EA005067B1 (ru)	2004-10-28
CA2382013C (en)	2009-08-11
SK287154B6 (sk)	2010-01-07
HK1049282B (zh)	2005-12-30
FI19991925L (fi)	2001-03-10
HK1049282A1 (en)	2003-05-09
EP1210085A2 (en)	2002-06-05
AU7004400A (en)	2001-04-17
YU16902A (sh)	2004-09-03
US6730673B1 (en)	2004-05-04
BRPI0013924B8 (pt)	2021-05-25
ATE315937T1 (de)	2006-02-15
PL354028A1 (pl)	2003-12-15
IL148379A0 (en)	2002-09-12
US20040106617A1 (en)	2004-06-03
ES2256034T3 (es)	2006-07-16
ZA200201828B (en)	2003-08-27
HUP0202749A3 (en)	2003-03-28
IS6296A (is)	2002-03-06
HUP0202749A2 (hu)	2003-02-28
IL148379A (en)	2006-12-10
CO5180582A1 (es)	2002-07-30
KR20020048400A (ko)	2002-06-22
PL202356B1 (pl)	2009-06-30
DE60025627D1 (de)	2006-04-06
BR0013924B1 (pt)	2013-09-24
HU228340B1 (en)	2013-03-28
TR200200620T2 (tr)	2002-09-23
EE05375B1 (et)	2011-02-15
NZ517605A (en)	2003-08-29
KR100869752B1 (ko)	2008-11-21
JP2003509351A (ja)	2003-03-11
MXPA02002423A (es)	2002-08-12
MY125984A (en)	2006-09-29
CZ303095B6 (cs)	2012-03-28
IS2244B (is)	2007-05-15
FI109659B (fi)	2002-09-30
WO2001019334A3 (en)	2001-11-15
UA73954C2 (uk)	2005-10-17
HRP20020298A2 (en)	2003-06-30
EA200200348A1 (ru)	2002-08-29
HRP20020298B1 (hr)	2007-02-28
NO20021090D0 (no)	2002-03-05
AU771027B2 (en)	2004-03-11
NO331989B1 (no)	2012-05-21
AR025449A1 (es)	2002-11-27
TWI242434B (en)	2005-11-01
BG106589A (bg)	2002-11-29
JP4708648B2 (ja)	2011-06-22

Publication	Publication Date	Title
FI19991925L (fi)	2001-03-10	Levosimendaanin farmaseuttisia liuoksia
NO2010019I2 (no)	2012-08-27	6-per-deoksy-6-per-(2-karboksetyl)tio-y-cyklodextrin
DE60002992D1 (de)	2003-07-03	Dreiphasenabscheider
DE50002834D1 (de)	2003-08-14	Handstempel
DE60004192D1 (de)	2003-09-04	Kompositverschlusskappe
ID23735A (id)	2000-05-11	Tablet trovafloksasin mesilat
NO20022606L (no)	2002-07-11	Farmasöytiske kombinasjoner
DK1275397T3 (da)	2014-09-22	Lægemiddel til lokal anvendelse
DE60037233D1 (de)	2008-01-10	Hämofiltrationsvorrichtung
DE59909346D1 (de)	2004-06-03	Zylinderkopfdichtung
DE60001649D1 (de)	2003-04-17	Ziprasidonsuspension
DE50007953D1 (de)	2004-11-04	Beleuchtungsanordung
NO20014926L (no)	2001-12-13	Farmasöytiske forbindelser
NO20004717D0 (no)	2000-09-21	Sikkerhetskile-lukkehode
DE50016100D1 (de)	2011-06-09	Gabtriebs
NO20016430L (no)	2002-02-26	Farmasöytisk kompleks
DE10082008D2 (de)	2002-12-19	Ausbeulgerät
DE50006829D1 (de)	2004-07-22	Benzoylpyridazine
SE9902945D0 (sv)	1999-08-18	Pharmaceuticals
SE9902941D0 (sv)	1999-08-18	Pharmaceuticals
SE9902940D0 (sv)	1999-08-18	Pharmaceuticals
SE9902939D0 (sv)	1999-08-18	Pharmaceuticals
FI4492U1 (fi)	2000-07-20	Jalas
UA2855S (uk)	1999-07-19	Таблетка фармацевтична
FI19991830L (fi)	2001-02-28	Permeabiliteettilääke

Legal Events

Date	Code	Title	Description
2007-08-15	GB1A	Change in the ownership or in the address of the owner
2016-02-15	HH1A	Change of representative