EE200100219A - Esters of (+) - alpha (2,3-dimethoxyphenyl) -1- [2- (4-fluorophenyl) ethyl] -4-piperidinemethanol, process for their preparation, use and pharmaceutical composition - Google Patents

Esters of (+) - alpha (2,3-dimethoxyphenyl) -1- [2- (4-fluorophenyl) ethyl] -4-piperidinemethanol, process for their preparation, use and pharmaceutical composition

Info

Publication number: EE200100219A
Authority: EE; Estonia
Prior art keywords: piperidinemethanol; dimethoxyphenyl; fluorophenyl; alpha; esters
Prior art date: 1998-10-14

Application number

EEP200100219A

Other languages

Estonian (et)

Inventor

A. Carr Albert

E. Van Hijfte Luc

W. Kosley Raymond Jr.

Original Assignee

Aventis Pharmaceuticals Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-14

Filing date

1998-10-14

Publication date

2002-08-15

1998-10-14 Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.

2002-08-15 Publication of EE200100219A publication Critical patent/EE200100219A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Addiction (AREA)
Epidemiology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EEP200100219A 1998-10-14 1998-10-14 Esters of (+) - alpha (2,3-dimethoxyphenyl) -1- [2- (4-fluorophenyl) ethyl] -4-piperidinemethanol, process for their preparation, use and pharmaceutical composition EE200100219A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1998/021608 WO2000021930A1 (en)	1998-10-14	1998-10-14	Esters of (+)-alpha-( 2,3- dimethoxyphenyl) -1-[2-(4- fluorophenyl) ethyl]-4- piperidinemethanol and their use as prodrugs of the 5ht2a receptor antagonist mdl 110,907

Publications (1)

Publication Number	Publication Date
EE200100219A true EE200100219A (en)	2002-08-15

Family

ID=22268079

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100219A EE200100219A (en)	1998-10-14	1998-10-14	Esters of (+) - alpha (2,3-dimethoxyphenyl) -1- [2- (4-fluorophenyl) ethyl] -4-piperidinemethanol, process for their preparation, use and pharmaceutical composition

Country Status (20)

Country	Link
EP (1)	EP1121345A1 (en)
JP (1)	JP2002527422A (en)
KR (1)	KR100515429B1 (en)
CN (1)	CN1160333C (en)
AU (1)	AU1083099A (en)
BR (1)	BR9816049A (en)
CA (1)	CA2347469C (en)
CZ (1)	CZ20011331A3 (en)
EA (1)	EA003667B1 (en)
EE (1)	EE200100219A (en)
HR (1)	HRP20010278A2 (en)
HU (1)	HUP0200517A3 (en)
IL (2)	IL142479A0 (en)
NO (1)	NO320417B1 (en)
NZ (1)	NZ510631A (en)
PL (1)	PL193306B1 (en)
SK (1)	SK5082001A3 (en)
TR (1)	TR200101047T2 (en)
UA (1)	UA57859C2 (en)
WO (1)	WO2000021930A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20020099076A1 (en) *	2000-05-25	2002-07-25	Richard Scheyer D.	Use of (+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol or its prodrug in the treatment of symptoms of dementia and dopamine induced psychosis
CN102241667B (en) *	2010-05-14	2013-10-23	中国人民解放军军事医学科学院毒物药物研究所	1-[(4-hydroxypiperidine-4-yl) methyl] pyridine-2(1H)-one derivatives, preparation method and use thereof
CN106892897A (en) *	2015-12-21	2017-06-27	上海科胜药物研发有限公司	A kind of hydroxyl piperazine pyrrone free alkali novel crystal forms and preparation method thereof
CN106928187A (en) *	2015-12-31	2017-07-07	上海奥博生物医药技术有限公司	A kind of hydrochloric acid hydroxyl piperazine pyrrone novel crystal forms and preparation method thereof
US20220273628A1 (en) *	2021-02-19	2022-09-01	Universitätsspital Basel	Effects of lysergic acid diethylamide (lsd) and of lsd analogs to assist psychotherapy for generalized anxiety disorder or other anxiety not related to life-threatening illness
WO2022232093A1 (en)	2021-04-30	2022-11-03	Mind Medicine, Inc.	Lsd salt crystal forms
AU2022331317B2 (en)	2021-08-19	2025-09-11	Definium Therapeutics US, Inc.	IMMEDIATE RELEASE FORMULATIONS OF d-LYSERGIC ACID DIETHYLAMIDE FOR THERAPEUTIC APPLICATIONS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0531410T3 (en) *	1990-06-01	1995-01-30	Merrell Dow Pharma	(+) - alpha- (2,3-Demethoxyphenyl) -1- (2- (4-fluorophenyl) ethyl) -4-piperidinemethanol

1998
- 1998-10-14 NZ NZ510631A patent/NZ510631A/en active IP Right Revival
- 1998-10-14 SK SK508-2001A patent/SK5082001A3/en not_active Application Discontinuation
- 1998-10-14 HR HR20010278A patent/HRP20010278A2/en not_active Application Discontinuation
- 1998-10-14 UA UA2001042522A patent/UA57859C2/en unknown
- 1998-10-14 CA CA002347469A patent/CA2347469C/en not_active Expired - Fee Related
- 1998-10-14 EP EP98953458A patent/EP1121345A1/en not_active Withdrawn
- 1998-10-14 PL PL347318A patent/PL193306B1/en not_active IP Right Cessation
- 1998-10-14 AU AU10830/99A patent/AU1083099A/en not_active Abandoned
- 1998-10-14 BR BR9816049-4A patent/BR9816049A/en not_active Application Discontinuation
- 1998-10-14 JP JP2000575839A patent/JP2002527422A/en active Pending
- 1998-10-14 WO PCT/US1998/021608 patent/WO2000021930A1/en not_active Ceased
- 1998-10-14 CZ CZ20011331A patent/CZ20011331A3/en unknown
- 1998-10-14 TR TR2001/01047T patent/TR200101047T2/en unknown
- 1998-10-14 KR KR10-2001-7004703A patent/KR100515429B1/en not_active Expired - Fee Related
- 1998-10-14 HU HU0200517A patent/HUP0200517A3/en unknown
- 1998-10-14 EA EA200100361A patent/EA003667B1/en not_active IP Right Cessation
- 1998-10-14 EE EEP200100219A patent/EE200100219A/en unknown
- 1998-10-14 IL IL14247998A patent/IL142479A0/en active IP Right Grant
- 1998-10-14 CN CNB988142740A patent/CN1160333C/en not_active Expired - Fee Related
2001
- 2001-04-05 IL IL142479A patent/IL142479A/en not_active IP Right Cessation
- 2001-04-09 NO NO20011805A patent/NO320417B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL142479A (en)	2006-06-11
UA57859C2 (en)	2003-07-15
EP1121345A1 (en)	2001-08-08
CA2347469C (en)	2006-02-28
EA200100361A1 (en)	2001-10-22
KR100515429B1 (en)	2005-09-20
CN1314887A (en)	2001-09-26
NO20011805D0 (en)	2001-04-09
SK5082001A3 (en)	2001-11-06
JP2002527422A (en)	2002-08-27
CN1160333C (en)	2004-08-04
EA003667B1 (en)	2003-08-28
AU1083099A (en)	2000-05-01
HK1039332A1 (en)	2002-04-19
PL193306B1 (en)	2007-01-31
KR20010106517A (en)	2001-11-29
BR9816049A (en)	2001-07-03
HRP20010278A2 (en)	2002-06-30
HUP0200517A3 (en)	2002-12-28
CZ20011331A3 (en)	2001-08-15
IL142479A0 (en)	2002-03-10
WO2000021930A1 (en)	2000-04-20
CA2347469A1 (en)	2000-04-20
NO20011805L (en)	2001-06-08
TR200101047T2 (en)	2001-08-21
NZ510631A (en)	2003-07-25
PL347318A1 (en)	2002-03-25
HUP0200517A2 (en)	2002-06-29
NO320417B1 (en)	2005-12-05

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