EE200000584A - Viirusevastase bensimidasoolühendi kristallilisedvormid - Google Patents

Viirusevastase bensimidasoolühendi kristallilisedvormid

Info

Publication number: EE200000584A
Authority: EE; Estonia
Prior art keywords: crystalline forms; benzimidazole compound; antiviral; antiviral benzimidazole; compound
Prior art date: 1998-04-07

Application number

EEP200000584A

Other languages

English (en)

Inventor

Howard Carter Barry

Neal Glover Bobby

Huang Lian-Feng

William Lancaster Robert

Todd Long Stacey

Catherine Rizzolio Michele

Allen Schmitt Eric

Riddle Sickles Barry

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-07

Filing date

1999-04-01

Publication date

2002-04-15

1999-04-01 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2002-04-15 Publication of EE200000584A publication Critical patent/EE200000584A/et

2003-08-15 Publication of EE04120B1 publication Critical patent/EE04120B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

EEP200000584A 1998-04-07 1999-04-01 Viirusevastase bensimidasoolühendi kristallilisedvormid EE04120B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9807354.7A GB9807354D0 (en)	1998-04-07	1998-04-07	Antiviral compound
PCT/EP1999/002214 WO1999051618A1 (en)	1998-04-07	1999-04-01	Novel crystalline forms of an antiviral benzimidazole compound

Publications (2)

Publication Number	Publication Date
EE200000584A true EE200000584A (et)	2002-04-15
EE04120B1 EE04120B1 (et)	2003-08-15

Family

ID=10829932

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000584A EE04120B1 (et)	1998-04-07	1999-04-01	Viirusevastase bensimidasoolühendi kristallilisedvormid

Country Status (28)

Country	Link
US (9)	US6469160B1 (et)
EP (1)	EP1071693B1 (et)
JP (1)	JP2002510703A (et)
KR (1)	KR20010074472A (et)
CN (1)	CN1303390A (et)
AP (1)	AP2000001947A0 (et)
AT (1)	ATE261452T1 (et)
AU (1)	AU752877B2 (et)
BR (1)	BR9909474A (et)
CA (1)	CA2327494C (et)
DE (1)	DE69915461T2 (et)
EA (1)	EA002970B1 (et)
EE (1)	EE04120B1 (et)
ES (1)	ES2216503T3 (et)
GB (1)	GB9807354D0 (et)
HR (1)	HRP20000669A2 (et)
HU (1)	HUP0101669A3 (et)
ID (1)	ID27109A (et)
IL (1)	IL138697A0 (et)
IS (1)	IS5640A (et)
NO (1)	NO20005005L (et)
NZ (1)	NZ507173A (et)
PL (1)	PL343397A1 (et)
SK (1)	SK14832000A3 (et)
TR (1)	TR200002860T2 (et)
WO (1)	WO1999051618A1 (et)
YU (1)	YU60900A (et)
ZA (1)	ZA200005153B (et)

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* Cited by examiner, † Cited by third party
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GB9807355D0 (en)	1998-04-07	1998-06-03	Glaxo Group Ltd	Antiviral compound
GB9807354D0 (en) *	1998-04-07	1998-06-03	Glaxo Group Ltd	Antiviral compound
GB0008939D0 (en) *	2000-04-11	2000-05-31	Glaxo Group Ltd	Process for preparing substituted benzimidazole compounds
CA2485834C (en)	2002-05-16	2007-07-17	Tibotec Pharmaceuticals Ltd.	Pseudopolymorphic forms of a hiv protease inhibitor
WO2005118586A1 (en) *	2004-06-02	2005-12-15	Sandoz Ag	Meropenem intermediate in crystalline form
US7750153B2 (en) *	2005-07-05	2010-07-06	Hetero Drugs Limited	Process for the preparation of didanosine using novel intermediates
WO2007052289A2 (en) *	2005-07-22	2007-05-10	Rubicon Research Pvt Ltd.	Novel dispersible tablet composition
US8188138B2 (en) *	2005-09-21	2012-05-29	4Sc Ag	Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
EA201001799A1 (ru) *	2005-10-31	2011-06-30	Янссен Фармацевтика Н.В.	Новые способы получения пиперазинильных и диазепанильных производных бензамида
CA2656057C (en) *	2006-06-16	2012-10-02	H. Lundbeck A/S	Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
US7919598B2 (en) *	2006-06-28	2011-04-05	Bristol-Myers Squibb Company	Crystal structures of SGLT2 inhibitors and processes for preparing same
NZ598071A (en) *	2006-10-27	2013-08-30	Signal Pharm Llc	Uses of and pharmaceutical compositions comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol compounds
EP2085397A1 (en) *	2008-01-21	2009-08-05	Esteve Quimica, S.A.	Crystalline form of abacavir
US7935817B2 (en) *	2008-03-31	2011-05-03	Apotex Pharmachem Inc.	Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
AR071318A1 (es) *	2008-04-15	2010-06-09	Basilea Pharmaceutica Ag	Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
US8097719B2 (en) *	2008-07-15	2012-01-17	Genesen Labs	Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
KR101043794B1 (ko) *	2009-04-13	2011-06-27	청우산업 주식회사	황토판재로 제공되는 기능성 황토방
KR101512548B1 (ko)	2010-03-12	2015-04-15	오메로스 코포레이션	Pde10 억제제 및 관련 조성물 및 방법
MX2013002421A (es) *	2010-09-01	2013-05-17	Arena Pharm Inc	Sales no hidroscopicas de agonistas de 5-ht2c.
US8940707B2 (en)	2010-10-28	2015-01-27	Viropharma Incorporated	Maribavir isomers, compositions, methods of making and methods of using
US8541391B2 (en)	2010-10-28	2013-09-24	Viropharma Incorporated	Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8546344B2 (en)	2010-10-28	2013-10-01	Viropharma Incorporated	Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
WO2013044816A1 (en) *	2011-09-30	2013-04-04	Sunshine Lake Pharma Co., Ltd.	Crystalline forms of azilsartan and preparation and uses thereof
NZ630803A (en) *	2014-04-28	2016-03-31	Omeros Corp	Optically active pde10 inhibitor
NZ716494A (en)	2014-04-28	2017-07-28	Omeros Corp	Processes and intermediates for the preparation of a pde10 inhibitor
AU2016250843A1 (en)	2015-04-24	2017-10-12	Omeros Corporation	PDE10 inhibitors and related compositions and methods
WO2017079678A1 (en)	2015-11-04	2017-05-11	Omeros Corporation	Solid state forms of a pde10 inhibitor
EP3870292A4 (en)	2018-10-26	2022-11-09	The Research Foundation for The State University of New York	COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
CN111303230B (zh) *	2020-03-09	2021-07-13	中国食品药品检定研究院	一种黄体酮共晶物及其制备方法和用途
CN119751358A (zh)	2022-10-12	2025-04-04	武田药品工业株式会社	制备马立巴韦的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3399987A (en) *	1965-08-02	1968-09-03	United States Borax Chem	2-alkylaminobenzimidazoles as herbicides
CH443777A (de) *	1965-08-06	1968-02-15	Agripat Sa	Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) *	1970-07-30	1972-04-11	Merck & Co Inc	Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
SE9003151D0 (sv) *	1990-10-02	1990-10-02	Medivir Ab	Nucleoside derivatives
US5248672A (en) *	1990-11-01	1993-09-28	The Regents Of The University Of Michigan	Polysubstituted benzimidazole nucleosides as antiviral agents
WO1994008456A1 (en) *	1992-10-21	1994-04-28	The Regents Of The University Of Michigan	Polysubstituted benzimidazoles as antiviral agents
GB9413724D0 (en) *	1994-07-07	1994-08-24	Wellcome Found	Therapeutic nucleosides
GB9600143D0 (en)	1996-01-05	1996-03-06	Wellcome Found	Therapeutic compounds
GB9807354D0 (en) *	1998-04-07	1998-06-03	Glaxo Group Ltd	Antiviral compound
GB9807355D0 (en)	1998-04-07	1998-06-03	Glaxo Group Ltd	Antiviral compound

1998
- 1998-04-07 GB GBGB9807354.7A patent/GB9807354D0/en not_active Ceased
1999
- 1999-04-01 AP APAP/P/2000/001947A patent/AP2000001947A0/en unknown
- 1999-04-01 HU HU0101669A patent/HUP0101669A3/hu unknown
- 1999-04-01 CN CN99806894A patent/CN1303390A/zh active Pending
- 1999-04-01 EA EA200000911A patent/EA002970B1/ru not_active IP Right Cessation
- 1999-04-01 CA CA2327494A patent/CA2327494C/en not_active Expired - Lifetime
- 1999-04-01 US US09/647,962 patent/US6469160B1/en not_active Expired - Lifetime
- 1999-04-01 BR BR9909474-6A patent/BR9909474A/pt not_active IP Right Cessation
- 1999-04-01 IL IL13869799A patent/IL138697A0/xx unknown
- 1999-04-01 EP EP99917935A patent/EP1071693B1/en not_active Expired - Lifetime
- 1999-04-01 AT AT99917935T patent/ATE261452T1/de not_active IP Right Cessation
- 1999-04-01 WO PCT/EP1999/002214 patent/WO1999051618A1/en not_active Ceased
- 1999-04-01 ID IDW20002036A patent/ID27109A/id unknown
- 1999-04-01 AU AU36034/99A patent/AU752877B2/en not_active Ceased
- 1999-04-01 YU YU60900A patent/YU60900A/sh unknown
- 1999-04-01 SK SK1483-2000A patent/SK14832000A3/sk unknown
- 1999-04-01 PL PL99343397A patent/PL343397A1/xx unknown
- 1999-04-01 KR KR1020007011089A patent/KR20010074472A/ko not_active Withdrawn
- 1999-04-01 ES ES99917935T patent/ES2216503T3/es not_active Expired - Lifetime
- 1999-04-01 JP JP2000542339A patent/JP2002510703A/ja active Pending
- 1999-04-01 HR HR20000669A patent/HRP20000669A2/hr not_active Application Discontinuation
- 1999-04-01 EE EEP200000584A patent/EE04120B1/et not_active IP Right Cessation
- 1999-04-01 TR TR2000/02860T patent/TR200002860T2/xx unknown
- 1999-04-01 NZ NZ507173A patent/NZ507173A/en unknown
- 1999-04-01 DE DE69915461T patent/DE69915461T2/de not_active Expired - Lifetime
2000
- 2000-09-26 ZA ZA200005153A patent/ZA200005153B/en unknown
- 2000-09-26 IS IS5640A patent/IS5640A/is unknown
- 2000-10-04 NO NO20005005A patent/NO20005005L/no not_active Application Discontinuation
2001
- 2001-10-29 US US10/007,272 patent/US7297683B2/en not_active Expired - Fee Related
2007
- 2007-10-25 US US11/924,204 patent/US7714123B2/en not_active Expired - Fee Related
2010
- 2010-03-26 US US12/732,302 patent/US20100179101A1/en not_active Abandoned
2011
- 2011-01-25 US US13/012,924 patent/US9163052B2/en not_active Expired - Fee Related
2013
- 2013-02-01 US US13/756,612 patent/US20130261294A1/en not_active Abandoned
2015
- 2015-10-12 US US14/880,600 patent/US20160030460A1/en not_active Abandoned
2016
- 2016-09-19 US US15/268,949 patent/US20170002035A1/en not_active Abandoned
2017
- 2017-10-05 US US15/725,785 patent/US20180044366A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US7297683B2 (en)	2007-11-20
AU3603499A (en)	1999-10-25
EP1071693B1 (en)	2004-03-10
EA002970B1 (ru)	2002-12-26
IL138697A0 (en)	2001-10-31
ES2216503T3 (es)	2004-10-16
HRP20000669A2 (en)	2001-08-31
US20100179101A1 (en)	2010-07-15
US20180044366A1 (en)	2018-02-15
ATE261452T1 (de)	2004-03-15
US7714123B2 (en)	2010-05-11
DE69915461T2 (de)	2005-03-03
WO1999051618A1 (en)	1999-10-14
US6469160B1 (en)	2002-10-22
CN1303390A (zh)	2001-07-11
GB9807354D0 (en)	1998-06-03
KR20010074472A (ko)	2001-08-04
JP2002510703A (ja)	2002-04-09
ZA200005153B (en)	2001-09-26
ID27109A (id)	2001-03-01
IS5640A (is)	2000-09-26
HUP0101669A3 (en)	2003-07-28
EA200000911A1 (ru)	2001-04-23
US20080103186A1 (en)	2008-05-01
AP2000001947A0 (en)	2000-12-31
BR9909474A (pt)	2000-12-19
CA2327494C (en)	2010-10-26
AU752877B2 (en)	2002-10-03
PL343397A1 (en)	2001-08-13
NO20005005D0 (no)	2000-10-04
TR200002860T2 (tr)	2000-12-21
EE04120B1 (et)	2003-08-15
HUP0101669A2 (hu)	2001-10-28
US20160030460A1 (en)	2016-02-04
EP1071693A1 (en)	2001-01-31
US20110118203A1 (en)	2011-05-19
YU60900A (sh)	2003-07-07
SK14832000A3 (sk)	2001-07-10
CA2327494A1 (en)	1999-10-14
US20020177703A1 (en)	2002-11-28
US20170002035A1 (en)	2017-01-05
DE69915461D1 (de)	2004-04-15
US20130261294A1 (en)	2013-10-03
NO20005005L (no)	2000-12-06
NZ507173A (en)	2003-07-25
US9163052B2 (en)	2015-10-20

Publication	Publication Date	Title
EE200000584A (et)	2002-04-15	Viirusevastase bensimidasoolühendi kristallilisedvormid
LTPA2009006I1 (lt)	2022-03-10	Trombopoetino junginiai
ATE229954T1 (de)	2003-01-15	Betacarbolinverbindungen
ID28266A (id)	2001-05-10	Senyawa-senyawa amidin
NO20015536D0 (no)	2001-11-13	FAP-aktiverte anti-tumor-forbindelser
NO20011745L (no)	2001-06-06	Forbindelser
EE200100135A (et)	2002-06-17	EtO2C-CH2-(R)Cgl-Aze-Pab-OH kristalsed vormid
NO20005795D0 (no)	2000-11-16	Antivirale forbindelser
NO20020030D0 (no)	2002-01-04	Krystallinske 1-metylcarbapenemforbindelser
NO20005006L (no)	2000-10-04	Kalsilytiske forbindelser
NO20013684D0 (no)	2001-07-26	Substituerte fenetylaminderivater
ID30516A (id)	2001-12-13	Senyawa-senyawa (aminoiminometil atau aminometil) benzoheteroaril tersubstitusi
NO20006662D0 (no)	2000-12-27	Fluorfenylresin-forbindelser
DK1054867T3 (da)	2004-08-09	Antivirale midler
IS5821A (is)	2001-01-23	Kristalluð form af ósanetant
FI982378A0 (fi)	1998-11-03	Järjestely kohteen tutkimiseen
PT1175417E (pt)	2004-04-30	Compostos substituidos de benzolactamas
DE60024760D1 (de)	2006-01-19	Einlagerungsverbindung
DE59910977D1 (de)	2004-12-09	Motorradverkleidung
IT250476Y1 (it)	2003-09-10	Struttura di elemento di aggancio particolarmente per la connessionereciproca di due parti
ITMI982758A1 (it)	2000-06-22	Procedimento per la purificazione di 7-glutaril aca
HK1032973A (en)	2001-08-10	Novel crystalline forms of an antiviral benzimidazole compound
IT1302547B1 (it)	2000-09-05	Struttura multistrato per la realizzazione di elementi diprotezione
IDP000021799A (id)	1999-07-29	Senyawa-senyawa pirolum tersubstitusi
SE9904417D0 (sv)	1999-12-03	Crystalline form

Legal Events

Date	Code	Title	Description
2003-08-15	HD1A	Correction of address
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2005-12-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20050401