EE04282B1 - Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon - Google Patents

Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon

Info

Publication number: EE04282B1
Authority: EE; Estonia
Prior art keywords: pharmaceutical; preparation; composition containing; pyrimidines; pyrazole
Prior art date: 1996-02-07

Application number

EE9800124A

Other languages

English (en)

Estonian (et)

Other versions

EE9800124A (et

Inventor

R. Webb Thomas

R. Mccarthy James

J. Moran Terence

M. Wilcoxen Keith

Chen Chen

Huang Charles

Original Assignee

Janssen Pharmaceutica N.V.

Neurocrine Biosciences Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-07

Filing date

1997-01-30

Publication date

2004-04-15

1997-01-30 Application filed by Janssen Pharmaceutica N.V., Neurocrine Biosciences Inc. filed Critical Janssen Pharmaceutica N.V.

1998-10-15 Publication of EE9800124A publication Critical patent/EE9800124A/xx

2004-04-15 Publication of EE04282B1 publication Critical patent/EE04282B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Addiction (AREA)
Obesity (AREA)
Rheumatology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Nutrition Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

EE9800124A 1996-02-07 1997-01-30 Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon EE04282B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1127996P	1996-02-07	1996-02-07
US2768896P	1996-10-08	1996-10-08
PCT/EP1997/000459 WO1997029109A1 (en)	1996-02-07	1997-01-30	Pyrazolopyrimidines as crf receptor antagonists

Publications (2)

Publication Number	Publication Date
EE9800124A EE9800124A (et)	1998-10-15
EE04282B1 true EE04282B1 (et)	2004-04-15

Family

ID=26682204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800124A EE04282B1 (et)	1996-02-07	1997-01-30	Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon

Country Status (27)

Country	Link
EP (1)	EP0880523B1 (xx)
JP (2)	JP3356291B2 (xx)
KR (1)	KR100421626B1 (xx)
CN (1)	CN1090189C (xx)
AR (1)	AR008577A1 (xx)
AT (1)	ATE336495T1 (xx)
AU (1)	AU713673B2 (xx)
BG (1)	BG102349A (xx)
BR (1)	BR9707391A (xx)
CA (1)	CA2233285C (xx)
CZ (1)	CZ244598A3 (xx)
DE (2)	DE69736513T2 (xx)
DK (1)	DK0880523T3 (xx)
EA (1)	EA000803B1 (xx)
EE (1)	EE04282B1 (xx)
ES (1)	ES2168237T3 (xx)
HU (1)	HUP9900575A3 (xx)
ID (1)	ID15905A (xx)
IL (1)	IL123835A0 (xx)
NO (1)	NO310292B1 (xx)
NZ (1)	NZ330119A (xx)
PL (1)	PL191271B1 (xx)
PT (1)	PT880523E (xx)
SK (1)	SK106398A3 (xx)
TR (1)	TR199800792T2 (xx)
TW (1)	TW449599B (xx)
WO (1)	WO1997029109A1 (xx)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6060478A (en) *	1996-07-24	2000-05-09	Dupont Pharmaceuticals	Azolo triazines and pyrimidines
US7094782B1 (en)	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
US6124289A (en) *	1996-07-24	2000-09-26	Dupont Pharmaceuticals Co.	Azolo triazines and pyrimidines
US6313124B1 (en)	1997-07-23	2001-11-06	Dupont Pharmaceuticals Company	Tetrazine bicyclic compounds
US6191131B1 (en)	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
PT915880E (pt) *	1996-07-24	2007-12-31	Bristol Myers Squibb Pharma Co	Azol triazinas e pirimidinas
PL331602A1 (en)	1996-08-06	1999-08-02	Pfizer	Pyrido- or pyrimido-substituted 6,6- or 6,7-bicyclic derivatives
US5723608A (en)	1996-12-31	1998-03-03	Neurogen Corporation	3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
AU6279598A (en) *	1997-02-18	1998-09-08	Neurocrine Biosciences, Inc.	Biazacyclic CRF antagonists
CA2291709A1 (en) *	1997-05-30	1998-12-03	Merck & Co., Inc.	Novel angiogenesis inhibitors
US6235741B1 (en) *	1997-05-30	2001-05-22	Merck & Co., Inc.	Angiogenesis inhibitors
NL1010018C2 (nl) *	1997-09-09	1999-03-10	Duphar Int Res	Chinoline en chinazoline derivaten met corticotropine releasing factor (CRF) antagonistische werking.
US6380203B1 (en)	1998-01-14	2002-04-30	Merck & Co., Inc.	Angiogenesis inhibitors
ATE301657T1 (de) *	1998-01-28	2005-08-15	Bristol Myers Squibb Pharma Co	Azolo-pyrimidine
WO1999045007A1 (en) *	1998-03-06	1999-09-10	Janssen Pharmaceutica N.V.	Crf antagonistic pyrazolo[4,3-b]pyridines
US6472402B1 (en)	1998-04-02	2002-10-29	Neurogen Corporation	Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives
EP1068205A1 (en)	1998-04-02	2001-01-17	Neurogen Corporation	Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino 2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino 4,5-b]indole derivatives: crf1 specific ligands
CA2359041A1 (en) *	1999-01-29	2000-08-03	Sumitomo Chemical Co., Ltd.	Fat accumulation inhibitory agents
WO2000059907A2 (en)	1999-04-06	2000-10-12	Du Pont Pharmaceuticals Company	Pyrazolotriazines as crf antagonists
WO2000059908A2 (en)	1999-04-06	2000-10-12	Du Pont Pharmaceuticals Company	Pyrazolopyrimidines as crf antagonists
US6432989B1 (en)	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
PL354675A1 (en)	1999-09-30	2004-02-09	Neurogen Corporation	Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines
CO5271670A1 (es)	1999-10-29	2003-04-30	Pfizer Prod Inc	Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas
TWI271406B (en)	1999-12-13	2007-01-21	Eisai Co Ltd	Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
EP1293213A1 (en) *	2000-02-14	2003-03-19	Japan Tobacco Inc.	Preventives/remedies for postoperative stress
US6888004B2 (en)	2001-01-26	2005-05-03	Bristol-Myers Squibb Company	Imidazolyl derivatives as corticotropin releasing factor inhibitors
TWI312347B (en)	2001-02-08	2009-07-21	Eisai R&D Man Co Ltd	Bicyclic nitrogen-containing condensed ring compounds
HUP0401292A3 (en) *	2001-04-27	2011-01-28	Eisai R & D Man Co	Pyrazolo[1,5-a]pyridines, pharmaceutical compositions containing the same and process for preparation thereof
US6872827B2 (en)	2002-04-26	2005-03-29	Chembridge Research Laboratories, Inc.	Somatostatin analogue compounds
US7161003B1 (en) *	2002-09-04	2007-01-09	Schering Corporation	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
SI1555265T1 (sl)	2002-10-22	2009-06-30	Eisai R&D Man Co Ltd	7-fenil pirazolopiridinske spojine
US7176216B2 (en)	2002-10-22	2007-02-13	Eisai Co., Ltd.	7-phenylpyrazolopyridine compounds
NZ540612A (en)	2003-01-14	2008-02-29	Arena Pharm Inc	1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
WO2004087707A1 (en) *	2003-03-31	2004-10-14	Vernalis (Cambridge) Limited	Pyrazolopyrimidine compounds and their use in medicine
AR045047A1 (es)	2003-07-11	2005-10-12	Arena Pharm Inc	Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
EA010023B1 (ru) *	2003-07-14	2008-06-30	Арена Фармасьютикалз, Инк.	Конденсированные арильные и гетероарильные производные в качестве модуляторов метаболизма и для профилактики и лечения расстройств, связанных с нарушением метаболизма
US7329662B2 (en) *	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
CN1938309B (zh) *	2003-12-22	2011-11-09	史密斯克莱.比奇曼（科克）有限公司	Crf受体拮抗剂及其相关方法
US20070293511A1 (en) *	2003-12-22	2007-12-20	Sb Pharmco Puerto Rico Inc. And Neurocrine Biosciences, Inc., A Corporation	Crf Receptor Antagonists and Methods
EP1722826A2 (en) *	2004-02-13	2006-11-22	SB Pharmco Puerto Rico Inc.	Crf receptor antagonists, their preparations, their pharmaceutical composition and their uses
GB0519957D0 (en)	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
BRPI0607927A2 (pt)	2005-02-11	2009-10-20	Hoffmann La Roche	derivados de pirazol-pirimidina
PL1869049T3 (pl) *	2005-03-21	2009-07-31	Lilly Co Eli	Związki imidazopirydazyny
BRPI0609719B8 (pt)	2005-03-23	2021-05-25	Hoffmann La Roche	derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2
EP1879896A1 (en) *	2005-04-05	2008-01-23	Eli Lilly And Company	Imidazopyridazine compounds
WO2007017678A1 (en) *	2005-08-09	2007-02-15	Eirx Therapeutics Limited	Pyrazolo[1,5-a] pyrimidine compounds and pharmaceutical compositions containing them
EP1934214B1 (en)	2005-09-27	2010-04-07	F.Hoffmann-La Roche Ag	Oxadiazolyl pyrazolo-pyrimidines as mglur2 antagonists
CA2662000C (en) *	2006-09-20	2013-01-08	Eli Lilly And Company	Thiophene pyrazolopyrimidine compounds
AU2007297421B2 (en) *	2006-09-20	2012-03-08	Eli Lilly And Company	Thiazole pyrazolopyrimidines as CRF1 receptor antagonists
BRPI0813625A2 (pt)	2007-07-26	2014-12-23	Novartis Ag	Imidazo-[1,2b]-piridozinas 2,3,7-substituídos para tratamento de doenças mediadas por alzk4 ou alk5
MY152687A (en)	2008-04-15	2014-10-31	Eisai R&D Man Co Ltd	3-phenylpyrazolo[5,1-b]thiazole compound
AR078521A1 (es)	2009-10-08	2011-11-16	Eisai R&D Man Co Ltd	Compuesto pirazolotiazol
CN103221410B (zh)	2010-09-22	2017-09-15	艾尼纳制药公司	Gpr119受体调节剂和对与其相关的障碍的治疗
GB201210686D0 (en)	2012-06-15	2012-08-01	Holsboermaschmeyer Neurochemie Gmbh	V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
GB201310782D0 (en)	2013-06-17	2013-07-31	Max Planck Innovation Gmbh	Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
EP4445956A3 (en)	2015-01-06	2024-12-04	Arena Pharmaceuticals, Inc.	Compound for use in treating conditions related to the s1p1 receptor
PL236355B1 (pl) *	2015-04-02	2021-01-11	Celon Pharma Spolka Akcyjna	Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3
PL3310760T3 (pl)	2015-06-22	2023-03-06	Arena Pharmaceuticals, Inc.	Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
CN116478131A (zh)	2016-07-12	2023-07-25	锐新医药公司	作为变构shp2抑制剂的2,5-双取代型及2,5,6-三取代型3-甲基吡嗪
CN110446709B (zh)	2017-01-23	2023-09-12	锐新医药公司	作为变构shp2抑制剂的二环化合物
EP4230623A3 (en)	2017-01-23	2023-10-11	Revolution Medicines, Inc.	Pyridine compounds as allosteric shp2 inhibitors
CN110996943A (zh)	2017-08-14	2020-04-10	云杉生物科学公司	促肾上腺皮质激素释放因子受体拮抗剂
CA3064445A1 (en) *	2017-08-14	2019-02-21	Spruce Biosciences, Inc.	Corticotropin releasing factor receptor antagonists
MX2020002608A (es)	2017-09-07	2020-09-18	Revolution Medicines Inc	Composiciones que comprenden inhibidores de shp2 y metodos para tratar el cáncer.
EP3694848A1 (en)	2017-10-12	2020-08-19	Revolution Medicines, Inc.	Pyridine, pyrazine, and triazine compounds as allosteric shp2 inhibitors
AU2018385713A1 (en)	2017-12-15	2020-06-18	Revolution Medicines, Inc.	Polycyclic compounds as allosteric SHP2 inhibitors
ES2987794T3 (es)	2018-06-06	2024-11-18	Arena Pharm Inc	Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1
KR20240023691A (ko)	2020-08-12	2024-02-22	스프루스 바이오사이언시스 인코포레이티드	다낭성 난소 증후군을 치료하기 위한 방법 및 조성물
US11708372B2 (en)	2021-11-19	2023-07-25	Spruce Biosciences, Inc.	Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4211753Y1 (xx) *	1964-06-06	1967-06-30
JPS6157587A (ja) *	1984-08-29	1986-03-24	Shionogi & Co Ltd	縮合複素環誘導体および抗潰瘍剤
JPH0211753A (ja) *	1988-06-29	1990-01-16	Raimuzu:Kk	ＴｉＡｌ系複合部材及びその製造方法
TW370529B (en) *	1992-12-17	1999-09-21	Pfizer	Pyrazolopyrimidines

1997
- 1997-01-30 ES ES97902295T patent/ES2168237T3/es not_active Expired - Lifetime
- 1997-01-30 EE EE9800124A patent/EE04282B1/xx not_active IP Right Cessation
- 1997-01-30 DE DE69736513T patent/DE69736513T2/de not_active Expired - Lifetime
- 1997-01-30 WO PCT/EP1997/000459 patent/WO1997029109A1/en not_active Ceased
- 1997-01-30 AU AU15991/97A patent/AU713673B2/en not_active Ceased
- 1997-01-30 IL IL12383597A patent/IL123835A0/xx active IP Right Grant
- 1997-01-30 CN CN97191382A patent/CN1090189C/zh not_active Expired - Fee Related
- 1997-01-30 DE DE0880523T patent/DE880523T1/de active Pending
- 1997-01-30 EP EP97902295A patent/EP0880523B1/en not_active Expired - Lifetime
- 1997-01-30 PL PL327284A patent/PL191271B1/pl not_active IP Right Cessation
- 1997-01-30 PT PT97902295T patent/PT880523E/pt unknown
- 1997-01-30 EA EA199800394A patent/EA000803B1/ru not_active IP Right Cessation
- 1997-01-30 AT AT97902295T patent/ATE336495T1/de active
- 1997-01-30 BR BR9707391A patent/BR9707391A/pt not_active Application Discontinuation
- 1997-01-30 DK DK97902295T patent/DK0880523T3/da active
- 1997-01-30 NZ NZ330119A patent/NZ330119A/en not_active IP Right Cessation
- 1997-01-30 KR KR10-1998-0703401A patent/KR100421626B1/ko not_active Expired - Fee Related
- 1997-01-30 SK SK1063-98A patent/SK106398A3/sk unknown
- 1997-01-30 CA CA002233285A patent/CA2233285C/en not_active Expired - Fee Related
- 1997-01-30 CZ CZ982445A patent/CZ244598A3/cs unknown
- 1997-01-30 TR TR1998/00792T patent/TR199800792T2/xx unknown
- 1997-01-30 HU HU9900575A patent/HUP9900575A3/hu unknown
- 1997-01-30 JP JP52812397A patent/JP3356291B2/ja not_active Expired - Fee Related
- 1997-02-05 TW TW086101373A patent/TW449599B/zh not_active IP Right Cessation
- 1997-02-06 AR ARP970100473A patent/AR008577A1/es not_active Application Discontinuation
- 1997-02-07 ID IDP970392A patent/ID15905A/id unknown
1998
- 1998-03-25 BG BG102349A patent/BG102349A/xx unknown
- 1998-03-25 NO NO19981357A patent/NO310292B1/no not_active IP Right Cessation
2001
- 2001-09-03 JP JP2001265611A patent/JP2002121194A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
BG102349A (en)	1999-02-26
NO310292B1 (no)	2001-06-18
EA000803B1 (ru)	2000-04-24
DK0880523T3 (da)	2007-03-26
EP0880523B1 (en)	2006-08-16
ES2168237T3 (es)	2007-04-01
HUP9900575A3 (en)	2001-11-28
PL191271B1 (pl)	2006-04-28
SK106398A3 (en)	1998-12-02
JP2000503661A (ja)	2000-03-28
DE69736513D1 (de)	2006-09-28
HUP9900575A2 (hu)	1999-06-28
CN1090189C (zh)	2002-09-04
NO981357D0 (no)	1998-03-25
JP3356291B2 (ja)	2002-12-16
WO1997029109A1 (en)	1997-08-14
TW449599B (en)	2001-08-11
AU1599197A (en)	1997-08-28
NO981357L (no)	1998-08-03
PL327284A1 (en)	1998-12-07
PT880523E (pt)	2007-01-31
KR19990067391A (ko)	1999-08-16
IL123835A0 (en)	1998-10-30
EE9800124A (et)	1998-10-15
NZ330119A (en)	2000-02-28
ID15905A (id)	1997-08-14
TR199800792T2 (xx)	1998-07-21
AU713673B2 (en)	1999-12-09
CZ244598A3 (cs)	1998-10-14
CA2233285C (en)	2006-07-04
BR9707391A (pt)	1999-07-20
EP0880523A1 (en)	1998-12-02
JP2002121194A (ja)	2002-04-23
EA199800394A1 (ru)	1998-10-29
DE69736513T2 (de)	2007-04-05
ATE336495T1 (de)	2006-09-15
KR100421626B1 (ko)	2004-05-20
CA2233285A1 (en)	1997-08-14
ES2168237T1 (es)	2002-06-16
AR008577A1 (es)	2000-02-09
CN1205009A (zh)	1999-01-13
DE880523T1 (de)	2002-07-04

Publication	Publication Date	Title
EE04282B1 (et)	2004-04-15	Pürasoolpürimidiinid, nende valmistamine ja kasutamine ravimina ning neid sisaldav kompositsioon
EE200000168A (et)	2001-04-16	Karboksamidotiasoolderivaadid, nende valmistamine ja neid sisaldavad farmatseutilised kompositsioonid
EE05183B1 (et)	2009-06-15	Asabitsklilised hendid, nende valmistamine ja kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
EE9800028A (et)	1998-08-17	Iprotroopiumsoolad, neid sisaldavad ravimkompositsioonid ja nende kasutamine
EE04673B1 (et)	2006-08-15	Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
HUP9701169A3 (en)	1999-07-28	Cycloalkano-pyridine derivatives, intermediates, preparation and use thereof, pharmaceutical compositions containing these compounds
EE200200138A (et)	2003-06-16	Kinolüülpropüülpiperidiini derivaadid, nende valmistamine ja neid sisaldavad kompositsioonid
HUP0002272A3 (en)	2002-03-28	Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use
SI0918059T1 (en)	2003-12-31	Substituted imidazoline derivatives, their preparation, their use, and pharmaceutical compositions containing them
HUP9801900A3 (en)	2001-02-28	2-methoxybenzophenone derivatives, intermediates, preparation thereof and fungicide compositions containing them
HUP9901243A3 (en)	2001-11-28	Quinazoline derivatives, preparation and use thereof, pharmaceutical compositions containing these compounds
IL190216A0 (en)	2008-11-03	Novel substituted imidazole compounds, their preparation and pharmaceutical compositions comprising them
EE200200065A (et)	2003-04-15	3-aminopürasooli derivaadid, nende valmistamine ja kasutamine vähivastaste toimeainetena ning neid sisaldav farmatseutiline kompositsioon
IL112384A0 (en)	1995-03-30	Tetracyclic derivatives, their preparation and pharmaceutical compositions containing them
EE04399B1 (et)	2004-12-15	Spiroasabitsüklilised heterotsüklilised ühendid, nende valmistamise protsess, neid sisaldavad ravimkoostised ja nende kasutamine ravis
HUP0102102A3 (en)	2002-06-28	Pyrazoline derivatives, their preparation, pharmaceutical compositions containing them and their use
EE200000037A (et)	2000-10-16	Atsüülpiperasinüülpürimidiinide derivaadid, nende valmistamine ja kasutamine ravimitena
HUP0103884A3 (en)	2002-11-28	Arylsulfonanilide urea-derivatives, pharmaceutical compositions containing them and their use
EE04276B1 (et)	2004-04-15	Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid
ATE240315T1 (de)	2003-05-15	Substituierte 4-amino-2-aryl-pyrimidine, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
EE9900015A (et)	1999-08-16	Sünteetilised polüsahhariidid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
HUP9904694A3 (en)	2001-12-28	Spiropyrrolidine derivatives, their use and pharmaceutical compositions containing them
IL122740A (en)	2003-09-17	16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
HUP0101960A3 (en)	2003-03-28	Metabolites of ecteinascidin 743, their use and pharmaceutical compositions containing them
IL112443A0 (en)	1995-03-30	Heterocyclic compounds, their preparation and pharmaceutical compositions containing them

Legal Events

Date	Code	Title	Description
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2005-10-17	MM4A	Lapsed by not paying the annual fees	Effective date: 20050130