EE04750B1 - HIV-proteaasi inhibiitorite valmistamismeetod - Google Patents
HIV-proteaasi inhibiitorite valmistamismeetodInfo
- Publication number
- EE04750B1 EE04750B1 EEP200000568A EEP200000568A EE04750B1 EE 04750 B1 EE04750 B1 EE 04750B1 EE P200000568 A EEP200000568 A EE P200000568A EE P200000568 A EEP200000568 A EE P200000568A EE 04750 B1 EE04750 B1 EE 04750B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- protease inhibitors
- hiv protease
- hiv
- inhibitors
- Prior art date
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805898.5A GB9805898D0 (en) | 1998-03-20 | 1998-03-20 | Process for the sythesis of hiv protease inhibitors |
| PCT/GB1999/000852 WO1999048885A1 (en) | 1998-03-20 | 1999-03-18 | Process for the synthesis of hiv protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200000568A EE200000568A (et) | 2002-02-15 |
| EE04750B1 true EE04750B1 (et) | 2006-12-15 |
Family
ID=10828884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000568A EE04750B1 (et) | 1998-03-20 | 1999-03-18 | HIV-proteaasi inhibiitorite valmistamismeetod |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6281367B1 (et) |
| EP (1) | EP1066276B1 (et) |
| JP (1) | JP3363439B2 (et) |
| KR (1) | KR100555278B1 (et) |
| CN (1) | CN1308319C (et) |
| AP (1) | AP1226A (et) |
| AT (1) | ATE242772T1 (et) |
| AU (1) | AU751534B2 (et) |
| BR (1) | BR9908970A (et) |
| CA (1) | CA2324217C (et) |
| CZ (1) | CZ299193B6 (et) |
| DE (1) | DE69908761T2 (et) |
| DK (1) | DK1066276T3 (et) |
| EA (1) | EA003022B1 (et) |
| EE (1) | EE04750B1 (et) |
| ES (1) | ES2203090T3 (et) |
| GB (1) | GB9805898D0 (et) |
| HR (1) | HRP20000609B1 (et) |
| HU (1) | HUP0105439A3 (et) |
| ID (1) | ID26587A (et) |
| IL (1) | IL138127A (et) |
| IS (1) | IS2273B (et) |
| NO (1) | NO317648B1 (et) |
| NZ (1) | NZ506563A (et) |
| PL (1) | PL201810B1 (et) |
| PT (1) | PT1066276E (et) |
| RS (1) | RS49954B (et) |
| SK (1) | SK283939B6 (et) |
| TR (1) | TR200002698T2 (et) |
| WO (1) | WO1999048885A1 (et) |
| ZA (1) | ZA200004482B (et) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2177868T3 (es) | 1992-08-25 | 2002-12-16 | Searle & Co | Hidroxietilaminosulfonamidas de alfa- y beta-aminoacidos utiles como inhibidores de proteasas retroviricas. |
| DE60039533D1 (de) * | 1999-12-23 | 2008-08-28 | Ampac Fine Chemicals Llc | Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin |
| US6548706B2 (en) * | 1999-12-23 | 2003-04-15 | Aerojet Fine Chemicals Llc | Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
| CA2485834C (en) | 2002-05-16 | 2007-07-17 | Tibotec Pharmaceuticals Ltd. | Pseudopolymorphic forms of a hiv protease inhibitor |
| DK1725566T3 (da) * | 2003-12-23 | 2009-10-05 | Tibotec Pharm Ltd | Fremgangsmåde til fremstilling af (3R,3AS, 6AR)-hexahydrofuro [2,3.B] furan-3-yl (1S,2R)-3-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamat |
| JP4818124B2 (ja) * | 2003-12-23 | 2011-11-16 | テイボテク・フアーマシユーチカルズ・リミテツド | （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法 |
| TWI482775B (zh) | 2008-09-01 | 2015-05-01 | Tibotec Pharm Ltd | 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法 |
| PH12012501537A1 (en) | 2010-01-27 | 2018-02-07 | Viiv Healthcare Co | Antiviral therapy |
| US8877947B2 (en) | 2010-09-10 | 2014-11-04 | Lupin Limited | Process for preparation of substantially pure fosamprenavir calcium and its intermediates |
| CN111233794A (zh) * | 2020-03-27 | 2020-06-05 | 江巨东 | 一种安普那韦的精制方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
| ES2177868T3 (es) * | 1992-08-25 | 2002-12-16 | Searle & Co | Hidroxietilaminosulfonamidas de alfa- y beta-aminoacidos utiles como inhibidores de proteasas retroviricas. |
| US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
-
1998
- 1998-03-20 GB GBGB9805898.5A patent/GB9805898D0/en not_active Ceased
-
1999
- 1999-03-18 DE DE69908761T patent/DE69908761T2/de not_active Expired - Lifetime
- 1999-03-18 HR HR20000609A patent/HRP20000609B1/xx not_active IP Right Cessation
- 1999-03-18 PT PT99910543T patent/PT1066276E/pt unknown
- 1999-03-18 AT AT99910543T patent/ATE242772T1/de not_active IP Right Cessation
- 1999-03-18 AU AU29475/99A patent/AU751534B2/en not_active Ceased
- 1999-03-18 WO PCT/GB1999/000852 patent/WO1999048885A1/en not_active Ceased
- 1999-03-18 CA CA002324217A patent/CA2324217C/en not_active Expired - Fee Related
- 1999-03-18 IL IL13812799A patent/IL138127A/xx not_active IP Right Cessation
- 1999-03-18 CN CNB998042242A patent/CN1308319C/zh not_active Expired - Fee Related
- 1999-03-18 DK DK99910543T patent/DK1066276T3/da active
- 1999-03-18 PL PL342602A patent/PL201810B1/pl not_active IP Right Cessation
- 1999-03-18 HU HU0105439A patent/HUP0105439A3/hu unknown
- 1999-03-18 EA EA200000859A patent/EA003022B1/ru unknown
- 1999-03-18 EE EEP200000568A patent/EE04750B1/et not_active IP Right Cessation
- 1999-03-18 ES ES99910543T patent/ES2203090T3/es not_active Expired - Lifetime
- 1999-03-18 RS YUP-559/00A patent/RS49954B/sr unknown
- 1999-03-18 BR BR9908970-0A patent/BR9908970A/pt not_active Application Discontinuation
- 1999-03-18 ID IDW20001857A patent/ID26587A/id unknown
- 1999-03-18 EP EP99910543A patent/EP1066276B1/en not_active Expired - Lifetime
- 1999-03-18 SK SK1373-2000A patent/SK283939B6/sk not_active IP Right Cessation
- 1999-03-18 TR TR2000/02698T patent/TR200002698T2/xx unknown
- 1999-03-18 KR KR1020007010359A patent/KR100555278B1/ko not_active Expired - Fee Related
- 1999-03-18 NZ NZ506563A patent/NZ506563A/en unknown
- 1999-03-18 CZ CZ20003457A patent/CZ299193B6/cs not_active IP Right Cessation
- 1999-03-18 US US09/646,277 patent/US6281367B1/en not_active Expired - Lifetime
- 1999-03-18 JP JP2000537868A patent/JP3363439B2/ja not_active Expired - Lifetime
- 1999-03-18 AP APAP/P/2000/001911A patent/AP1226A/en active
-
2000
- 2000-08-29 IS IS5605A patent/IS2273B/is unknown
- 2000-08-29 ZA ZA200004482A patent/ZA200004482B/en unknown
- 2000-09-19 NO NO20004664A patent/NO317648B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HK1A | Erratum in gazette | ||
| KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20100318 |