EE04642B1 - (1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod - Google Patents

(1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod

Info

Publication number: EE04642B1
Authority: EE; Estonia
Prior art keywords: quinolizin; benzo; derivatives; synthesis; compounds
Prior art date: 1998-08-03

Application number

EEP200100060A

Other languages

English (en)

Inventor

Guarna Antonio

Serio Mario

Giovanni Occhiato Ernesto

Original Assignee

Applied Research Systems Ars Holding N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-03

Filing date

1999-07-23

Publication date

2006-06-15

1999-07-23 Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.

2002-06-17 Publication of EE200100060A publication Critical patent/EE200100060A/et

2006-06-15 Publication of EE04642B1 publication Critical patent/EE04642B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Carbon And Carbon Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EEP200100060A 1998-08-03 1999-07-23 (1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod EE04642B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98114524		1998-08-03
PCT/EP1999/005277 WO2000008019A1 (en)	1998-08-03	1999-07-23	Process for the synthesis of (1h)-benzo[c]quinolizin-3-ones derivatives

Publications (2)

Publication Number	Publication Date
EE200100060A EE200100060A (et)	2002-06-17
EE04642B1 true EE04642B1 (et)	2006-06-15

Family

ID=8232396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100060A EE04642B1 (et)	1998-08-03	1999-07-23	(1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod

Country Status (28)

Country	Link
US (1)	US6723850B1 (et)
EP (1)	EP1102765B1 (et)
JP (1)	JP2002522435A (et)
KR (1)	KR100624239B1 (et)
CN (1)	CN1128148C (et)
AT (1)	ATE250057T1 (et)
AU (1)	AU751873B2 (et)
BG (1)	BG65062B1 (et)
BR (1)	BR9912870A (et)
CA (1)	CA2338498C (et)
CZ (1)	CZ291648B6 (et)
DE (1)	DE69911430T2 (et)
DK (1)	DK1102765T3 (et)
EA (1)	EA003997B1 (et)
EE (1)	EE04642B1 (et)
ES (1)	ES2203169T3 (et)
HU (1)	HUP0103241A3 (et)
IL (2)	IL141212A0 (et)
NO (1)	NO20010559L (et)
NZ (1)	NZ509243A (et)
PL (1)	PL198963B1 (et)
PT (1)	PT1102765E (et)
SI (1)	SI1102765T1 (et)
SK (1)	SK285438B6 (et)
TR (1)	TR200100286T2 (et)
UA (1)	UA67787C2 (et)
WO (1)	WO2000008019A1 (et)
ZA (1)	ZA200100365B (et)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2810655C (en)	2004-06-24	2013-12-10	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
US8354427B2 (en) *	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
JP2009521468A (ja) *	2005-12-24	2009-06-04	バーテックスファーマシューティカルズインコーポレイテッド	Ａｂｃ輸送体の調節因子としてのキノリン−４−オン誘導体
DK1993360T3 (en)	2005-12-28	2017-05-22	Vertex Pharma	SOLID FORMS OF N- [2,4-BIS (1,1-DIMETHYLETHYL) -5-HYDROXYPHENYL] -1,4-DIHYDRO-4-OXOQUINOLIN-3-CARBOXAMIDE
US12458635B2 (en)	2008-08-13	2025-11-04	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
HRP20151137T1 (hr)	2009-03-20	2015-11-20	Vertex Pharmaceuticals Incorporated	Postupak za dobivanje modulatora transmembranskog regulatora vodljivosti cistiäśne fibroze
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
PT2651890E (pt) *	2010-12-14	2014-12-09	Syngenta Participations Ag	Derivados de estrigolactama e sua utilização como reguladores do crescimento das plantas
IL265430B2 (en)	2012-02-27	2024-08-01	Vertex Pharma	Pharmaceutical compositions containing a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamode and uses thereof
CN107250113B (zh)	2014-10-07	2019-03-29	弗特克斯药品有限公司	囊性纤维化跨膜传导调节蛋白的调节剂的共晶
CN105001216B (zh) *	2015-07-08	2017-03-01	中国科学院兰州化学物理研究所	一种喹嗪酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5064961A (en) *	1989-12-18	1991-11-12	E. R. Squibb & Sons, Inc.	Process for preparing an optically active cyclobutane nucleoside
FR2696465B1 (fr) *	1992-10-02	1994-12-23	Adir	Nouveaux dérivés d'ellipticine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
IT1286545B1 (it) *	1996-02-09	1998-07-15	Antonio Guarna	Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
JPH09316076A (ja) *	1996-05-24	1997-12-09	Nippon Paper Ind Co Ltd	９−置換プリン誘導体及びその抗ウイルス剤としての用途

1999
- 1999-07-23 DK DK99941269T patent/DK1102765T3/da active
- 1999-07-23 PL PL345802A patent/PL198963B1/pl not_active IP Right Cessation
- 1999-07-23 SK SK167-2001A patent/SK285438B6/sk not_active IP Right Cessation
- 1999-07-23 CA CA002338498A patent/CA2338498C/en not_active Expired - Fee Related
- 1999-07-23 BR BR9912870-5A patent/BR9912870A/pt not_active Application Discontinuation
- 1999-07-23 AT AT99941269T patent/ATE250057T1/de not_active IP Right Cessation
- 1999-07-23 EA EA200100213A patent/EA003997B1/ru not_active IP Right Cessation
- 1999-07-23 KR KR1020017000325A patent/KR100624239B1/ko not_active Expired - Fee Related
- 1999-07-23 SI SI9930419T patent/SI1102765T1/xx unknown
- 1999-07-23 UA UA2001020777A patent/UA67787C2/uk unknown
- 1999-07-23 NZ NZ509243A patent/NZ509243A/xx not_active IP Right Cessation
- 1999-07-23 EP EP99941269A patent/EP1102765B1/en not_active Expired - Lifetime
- 1999-07-23 DE DE69911430T patent/DE69911430T2/de not_active Expired - Fee Related
- 1999-07-23 EE EEP200100060A patent/EE04642B1/et not_active IP Right Cessation
- 1999-07-23 TR TR2001/00286T patent/TR200100286T2/xx unknown
- 1999-07-23 US US09/743,373 patent/US6723850B1/en not_active Expired - Fee Related
- 1999-07-23 PT PT99941269T patent/PT1102765E/pt unknown
- 1999-07-23 CZ CZ2001434A patent/CZ291648B6/cs not_active IP Right Cessation
- 1999-07-23 HU HU0103241A patent/HUP0103241A3/hu unknown
- 1999-07-23 IL IL14121299A patent/IL141212A0/xx active IP Right Grant
- 1999-07-23 WO PCT/EP1999/005277 patent/WO2000008019A1/en not_active Ceased
- 1999-07-23 ES ES99941269T patent/ES2203169T3/es not_active Expired - Lifetime
- 1999-07-23 AU AU63123/99A patent/AU751873B2/en not_active Ceased
- 1999-07-23 JP JP2000563652A patent/JP2002522435A/ja active Pending
- 1999-07-23 CN CN99809204A patent/CN1128148C/zh not_active Expired - Fee Related
2001
- 2001-01-12 ZA ZA200100365A patent/ZA200100365B/en unknown
- 2001-01-30 BG BG105198A patent/BG65062B1/bg unknown
- 2001-02-01 IL IL141212A patent/IL141212A/en not_active IP Right Cessation
- 2001-02-01 NO NO20010559A patent/NO20010559L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2002522435A (ja)	2002-07-23
CN1311788A (zh)	2001-09-05
PL198963B1 (pl)	2008-08-29
IL141212A (en)	2006-12-31
KR100624239B1 (ko)	2006-09-13
NO20010559D0 (no)	2001-02-01
US6723850B1 (en)	2004-04-20
HK1037368A1 (en)	2002-02-08
SK285438B6 (sk)	2007-01-04
HUP0103241A2 (hu)	2002-01-28
DE69911430T2 (de)	2004-07-22
SI1102765T1 (en)	2003-12-31
DE69911430D1 (de)	2003-10-23
ZA200100365B (en)	2001-07-26
EA003997B1 (ru)	2003-12-25
BG105198A (en)	2001-12-29
TR200100286T2 (tr)	2001-07-23
ATE250057T1 (de)	2003-10-15
CZ2001434A3 (cs)	2001-08-15
DK1102765T3 (da)	2004-02-02
CN1128148C (zh)	2003-11-19
NO20010559L (no)	2001-02-01
EP1102765A1 (en)	2001-05-30
UA67787C2 (uk)	2004-07-15
PT1102765E (pt)	2003-12-31
CA2338498C (en)	2009-05-19
WO2000008019A1 (en)	2000-02-17
EA200100213A1 (ru)	2001-08-27
EP1102765B1 (en)	2003-09-17
BR9912870A (pt)	2001-10-16
AU751873B2 (en)	2002-08-29
ES2203169T3 (es)	2004-04-01
CZ291648B6 (cs)	2003-04-16
PL345802A1 (en)	2002-01-02
IL141212A0 (en)	2002-03-10
EE200100060A (et)	2002-06-17
BG65062B1 (bg)	2007-01-31
KR20010074684A (ko)	2001-08-09
CA2338498A1 (en)	2000-02-17
NZ509243A (en)	2002-11-26
AU6312399A (en)	2000-02-28
SK1672001A3 (en)	2001-08-06
HUP0103241A3 (en)	2002-10-28

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Legal Events

Date	Code	Title	Description
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2007-10-15	GB1A	Change in the ownership or in the address of the owner
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2011-04-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20100723