EE03687B1 - Furandiarylmethylidene derivatives, method of their preparation and use in therapy - Google Patents

Furandiarylmethylidene derivatives, method of their preparation and use in therapy

Info

Publication number: EE03687B1
Authority: EE; Estonia
Prior art keywords: furandiarylmethylidene; therapy; derivatives; preparation; furandiarylmethylidene derivatives
Prior art date: 1996-04-04

Application number

EE9800333A

Other languages

Estonian (et)

Other versions

EE9800333A (en

Inventor

Nicolai Eric

Teulon Jean-Marie

Original Assignee

Laboratoires Upsa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-04

Filing date

1997-04-03

Publication date

2002-04-15

1997-04-03 Application filed by Laboratoires Upsa filed Critical Laboratoires Upsa

1999-04-15 Publication of EE9800333A publication Critical patent/EE9800333A/en

2002-04-15 Publication of EE03687B1 publication Critical patent/EE03687B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

EE9800333A 1996-04-04 1997-04-03 Furandiarylmethylidene derivatives, method of their preparation and use in therapy EE03687B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9604236A FR2747123B1 (en)	1996-04-04	1996-04-04	NOVEL DIARYLMETHYLIDENE TETRAHYDROFURANE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THERAPEUTIC USES
FR9607922A FR2747124B1 (en)	1996-04-04	1996-06-26	NOVEL FURANIC DIARYLMETHYLIDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
PCT/FR1997/000602 WO1997037984A1 (en)	1996-04-04	1997-04-03	Novel furan diarylmethylidene derivatives, method for their preparation and therapeutical uses thereof

Publications (2)

Publication Number	Publication Date
EE9800333A EE9800333A (en)	1999-04-15
EE03687B1 true EE03687B1 (en)	2002-04-15

Family

ID=9490907

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800333A EE03687B1 (en)	1996-04-04	1997-04-03	Furandiarylmethylidene derivatives, method of their preparation and use in therapy

Country Status (28)

Country	Link
EP (1)	EP0891345B1 (en)
JP (1)	JP2000508638A (en)
KR (1)	KR20000005146A (en)
CN (1)	CN1215396A (en)
AR (1)	AR006539A1 (en)
AT (1)	ATE204268T1 (en)
AU (1)	AU717146B2 (en)
BG (1)	BG62808B1 (en)
BR (1)	BR9708510A (en)
CA (1)	CA2248949A1 (en)
CZ (1)	CZ318898A3 (en)
DE (1)	DE69706157T2 (en)
DK (1)	DK0891345T3 (en)
EE (1)	EE03687B1 (en)
ES (1)	ES2162678T3 (en)
FR (2)	FR2747123B1 (en)
GE (1)	GEP20032924B (en)
IL (1)	IL126105A (en)
NO (1)	NO984624L (en)
NZ (1)	NZ331672A (en)
PL (1)	PL329213A1 (en)
PT (1)	PT891345E (en)
RU (1)	RU2189979C2 (en)
SI (1)	SI0891345T1 (en)
SK (1)	SK283292B6 (en)
TW (1)	TW353660B (en)
WO (1)	WO1997037984A1 (en)
ZA (1)	ZA972894B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6180651B1 (en) *	1996-04-04	2001-01-30	Bristol-Myers Squibb	Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
US6026814A (en)	1997-03-06	2000-02-22	Scimed Life Systems, Inc.	System and method for percutaneous coronary artery bypass
WO1998043966A1 (en) *	1997-04-02	1998-10-08	Merck Frosst Canada & Co.	Alpha-methylene gamma lactones as selective cyclooxygenase-2 inhibitors
FR2775477B1 (en) *	1998-02-27	2000-05-19	Union Pharma Scient Appl	NOVEL HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
CN1106392C (en) *	2000-10-24	2003-04-23	中国科学院上海有机化学研究所	Butenolide containing no substituent at beta position and its synthesis process
AR038957A1 (en)	2001-08-15	2005-02-02	Pharmacia Corp	COMBINATION THERAPY FOR CANCER TREATMENT
EP1562930A4 (en) *	2002-11-05	2008-12-10	Magnachem Int Lab Inc	Synthetic lactone formulations and method of use
CA2524568C (en) *	2003-03-31	2012-07-17	Council Of Scientific & Industrial Research	Mercapto-phenyl-naphthyl-methane derivatives and preparation thereof
DE602004002832T2 (en)	2003-05-07	2007-06-06	Osteologix A/S	TREATMENT OF CARTILAGE / BONE DISEASES WITH WATER-SOLUBLE STRONTIUM SALTS
US8779168B2 (en) *	2010-12-16	2014-07-15	Transitions Optical, Inc.	Lactone compounds and materials made therefrom
WO2022195579A1 (en)	2021-03-15	2022-09-22	Saul Yedgar	Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2111288T3 (en) *	1993-01-15	1998-03-01	Searle & Co	NEW 3,4-DIARYL THIOPHENES AND ANALOGS OF THE SAME USEFUL AS ANTI-INFLAMMATORY AGENTS.
US5474995A (en) *	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
IL112249A (en) *	1994-01-25	2001-11-25	Warner Lambert Co	Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5585504A (en) *	1994-09-16	1996-12-17	Merck & Co., Inc.	Process of making cox-2 inhibitors having a lactone bridge

1996
- 1996-04-04 FR FR9604236A patent/FR2747123B1/en not_active Expired - Fee Related
- 1996-06-26 FR FR9607922A patent/FR2747124B1/en not_active Expired - Lifetime
1997
- 1997-03-24 TW TW086103701A patent/TW353660B/en active
- 1997-04-03 NZ NZ331672A patent/NZ331672A/en unknown
- 1997-04-03 KR KR1019980707808A patent/KR20000005146A/en not_active Ceased
- 1997-04-03 AT AT97919476T patent/ATE204268T1/en active
- 1997-04-03 EP EP97919476A patent/EP0891345B1/en not_active Expired - Lifetime
- 1997-04-03 IL IL12610597A patent/IL126105A/en not_active IP Right Cessation
- 1997-04-03 AU AU23933/97A patent/AU717146B2/en not_active Ceased
- 1997-04-03 JP JP9535910A patent/JP2000508638A/en active Pending
- 1997-04-03 CA CA002248949A patent/CA2248949A1/en not_active Abandoned
- 1997-04-03 CN CN97193543A patent/CN1215396A/en active Pending
- 1997-04-03 WO PCT/FR1997/000602 patent/WO1997037984A1/en not_active Ceased
- 1997-04-03 CZ CZ983188A patent/CZ318898A3/en unknown
- 1997-04-03 DE DE69706157T patent/DE69706157T2/en not_active Expired - Lifetime
- 1997-04-03 GE GEAP19974555A patent/GEP20032924B/en unknown
- 1997-04-03 PT PT97919476T patent/PT891345E/en unknown
- 1997-04-03 BR BR9708510A patent/BR9708510A/en not_active IP Right Cessation
- 1997-04-03 ES ES97919476T patent/ES2162678T3/en not_active Expired - Lifetime
- 1997-04-03 DK DK97919476T patent/DK0891345T3/en active
- 1997-04-03 SI SI9730222T patent/SI0891345T1/en unknown
- 1997-04-03 PL PL97329213A patent/PL329213A1/en unknown
- 1997-04-03 SK SK1375-98A patent/SK283292B6/en not_active IP Right Cessation
- 1997-04-03 EE EE9800333A patent/EE03687B1/en unknown
- 1997-04-03 RU RU98119887/04A patent/RU2189979C2/en not_active IP Right Cessation
- 1997-04-04 ZA ZA9702894A patent/ZA972894B/en unknown
- 1997-04-04 AR ARP970101359A patent/AR006539A1/en not_active Application Discontinuation
1998
- 1998-09-16 BG BG102771A patent/BG62808B1/en unknown
- 1998-10-02 NO NO984624A patent/NO984624L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
FR2747124A1 (en)	1997-10-10
FR2747124B1 (en)	1998-06-26
GEP20032924B (en)	2003-03-25
SK283292B6 (en)	2003-05-02
AR006539A1 (en)	1999-09-08
EP0891345A1 (en)	1999-01-20
TW353660B (en)	1999-03-01
WO1997037984A1 (en)	1997-10-16
PL329213A1 (en)	1999-03-15
IL126105A (en)	2001-08-26
NO984624D0 (en)	1998-10-02
SK137598A3 (en)	1999-02-11
IL126105A0 (en)	1999-05-09
ATE204268T1 (en)	2001-09-15
BG102771A (en)	1999-06-30
DE69706157D1 (en)	2001-09-20
CN1215396A (en)	1999-04-28
DE69706157T2 (en)	2002-04-11
AU2393397A (en)	1997-10-29
NO984624L (en)	1998-11-30
BG62808B1 (en)	2000-08-31
CZ318898A3 (en)	1999-01-13
DK0891345T3 (en)	2001-12-03
JP2000508638A (en)	2000-07-11
RU2189979C2 (en)	2002-09-27
SI0891345T1 (en)	2002-02-28
ZA972894B (en)	1997-11-04
ES2162678T3 (en)	2002-01-01
PT891345E (en)	2002-02-28
EE9800333A (en)	1999-04-15
FR2747123A1 (en)	1997-10-10
KR20000005146A (en)	2000-01-25
NZ331672A (en)	2000-02-28
AU717146B2 (en)	2000-03-16
EP0891345B1 (en)	2001-08-16
BR9708510A (en)	1999-08-03
CA2248949A1 (en)	1997-10-16
FR2747123B1 (en)	1998-06-26

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Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231