[go: up one dir, main page]

ECSP23048136A - Compuestos de indazol como inhibidores de cinasas - Google Patents

Compuestos de indazol como inhibidores de cinasas

Info

Publication number
ECSP23048136A
ECSP23048136A ECSENADI202348136A ECDI202348136A ECSP23048136A EC SP23048136 A ECSP23048136 A EC SP23048136A EC SENADI202348136 A ECSENADI202348136 A EC SENADI202348136A EC DI202348136 A ECDI202348136 A EC DI202348136A EC SP23048136 A ECSP23048136 A EC SP23048136A
Authority
EC
Ecuador
Prior art keywords
kinase inhibitors
indazole compounds
compounds
indazole
disclosed
Prior art date
Application number
ECSENADI202348136A
Other languages
English (en)
Inventor
Robert Hudkins
Daniel Bensen
Original Assignee
Tyra Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tyra Biosciences Inc filed Critical Tyra Biosciences Inc
Publication of ECSP23048136A publication Critical patent/ECSP23048136A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

En el presente documento se divulgan compuestos y métodos para tratar enfermedades y/o afecciones asociadas con la inhibición de FGFR.
ECSENADI202348136A 2020-12-30 2023-06-26 Compuestos de indazol como inhibidores de cinasas ECSP23048136A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063132031P 2020-12-30 2020-12-30
US202163216879P 2021-06-30 2021-06-30

Publications (1)

Publication Number Publication Date
ECSP23048136A true ECSP23048136A (es) 2023-09-29

Family

ID=80168316

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202348136A ECSP23048136A (es) 2020-12-30 2023-06-26 Compuestos de indazol como inhibidores de cinasas

Country Status (16)

Country Link
US (3) US12264149B2 (es)
EP (1) EP4271673A1 (es)
JP (1) JP7791196B2 (es)
KR (1) KR20230152654A (es)
AU (1) AU2021411587B2 (es)
CA (1) CA3205986A1 (es)
CL (1) CL2023001951A1 (es)
CO (1) CO2023008689A2 (es)
CR (1) CR20230325A (es)
EC (1) ECSP23048136A (es)
IL (1) IL304014A (es)
MX (1) MX2023007793A (es)
PE (1) PE20240687A1 (es)
TW (1) TW202241906A (es)
WO (1) WO2022147246A1 (es)
ZA (1) ZA202306559B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
CR20230325A (es) 2020-12-30 2023-12-11 Tyra Biosciences Inc Compuestos de indazol como inhibidores de cinasas
AU2023300357A1 (en) * 2022-06-29 2025-01-09 Tyra Biosciences, Inc. Polymorphic compounds and uses thereof
US20250368666A1 (en) * 2022-06-29 2025-12-04 Tyra Biosciences, Inc. Indazole compounds
EP4580629A1 (en) 2022-08-30 2025-07-09 Tyra Biosciences, Inc. Methods of treating solid tumors having activating fgfr3 gene alterations
WO2024104922A1 (en) 2022-11-14 2024-05-23 Ascendis Pharma Growth Disorders A/S Method of improving skeletal muscle function
WO2024137742A1 (en) 2022-12-20 2024-06-27 Blueprint Medicines Corporation Compounds and compositions as fgfr3 degraders and uses thereof
WO2024138112A1 (en) * 2022-12-22 2024-06-27 Tyra Biosciences, Inc. Indazole compounds
CN120265624A (zh) * 2022-12-30 2025-07-04 江苏亚虹医药科技股份有限公司 吡唑稠环化合物及其制备方法和用途
KR20250162619A (ko) 2023-03-20 2025-11-18 아센디스 파마 그로우쓰 디스오더스 에이/에스 연골무형성증을 가진 인간 대상에서의 흉요추 변형의 치료 방법
CN119306723A (zh) * 2023-07-13 2025-01-14 长春金赛药业有限责任公司 吲唑类fgfr2/3选择性抑制剂、药物组合物及其应用
WO2025021033A1 (zh) * 2023-07-21 2025-01-30 长春金赛药业有限责任公司 成纤维细胞生长因子受体抑制剂、药物组合物及其应用
WO2025021997A1 (en) 2023-07-27 2025-01-30 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts New map4k1 inhibitors
WO2025061029A1 (en) * 2023-09-18 2025-03-27 3H Pharmaceuticals Co., Ltd. Fgfr inhibitors and methods of use thereof
WO2025064744A1 (en) 2023-09-22 2025-03-27 Tyra Biosciences, Inc. Tyra-300 (5-[(1r)-1-(3,5-dichloro-4-pyridyl)ethoxy]-3-[6-(2-methylsulfonyl-2,6-diazaspiro[3.3]heptan-6-yl)-3-pyridyl]-1h-indazole ) in combination with a pd-1 or pd-l1 antagonist for use in the treatment of cancer
WO2025129014A1 (en) * 2023-12-15 2025-06-19 Tyra Biosciences, Inc. Indazole compounds for the treatment of cancer
WO2025170959A1 (en) 2024-02-05 2025-08-14 Tyra Biosciences, Inc. Combination of the fgfr 3 inhibitor tyra-300 and a nectin-4 targeting agent-drug conjugate for use in the treatment of cancer
WO2025199217A1 (en) 2024-03-19 2025-09-25 Tyra Biosciences, Inc. Pharmaceutical compositions
WO2026020109A1 (en) * 2024-07-19 2026-01-22 Tyra Biosciences, Inc. Combination treatment comprising a fgfr3 inhibitor and a pd-1/pd-l1 inhibitor for use in the treatment of cancer

Family Cites Families (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3657744A (en) 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
JPS62135835A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62135834A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62135830A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料及びその処理方法
JPS62135832A (ja) 1985-12-09 1987-06-18 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料の処理方法
JPS62136651A (ja) 1985-12-10 1987-06-19 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料の処理方法
JPS62136654A (ja) 1985-12-10 1987-06-19 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料の処理方法
JPS62136650A (ja) 1985-12-11 1987-06-19 Fuji Photo Film Co Ltd ハロゲン化銀カラ−写真感光材料及びその処理方法
US5040548A (en) 1989-06-01 1991-08-20 Yock Paul G Angioplasty mehtod
US5350395A (en) 1986-04-15 1994-09-27 Yock Paul G Angioplasty apparatus facilitating rapid exchanges
US5061273A (en) 1989-06-01 1991-10-29 Yock Paul G Angioplasty apparatus facilitating rapid exchanges
US4748982A (en) 1987-01-06 1988-06-07 Advanced Cardiovascular Systems, Inc. Reinforced balloon dilatation catheter with slitted exchange sleeve and method
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
GB8808433D0 (en) 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
CA1322628C (en) 1988-10-04 1993-10-05 Richard A. Schatz Expandable intraluminal graft
US6344053B1 (en) 1993-12-22 2002-02-05 Medtronic Ave, Inc. Endovascular support device and method
US5674278A (en) 1989-08-24 1997-10-07 Arterial Vascular Engineering, Inc. Endovascular support device
US5292331A (en) 1989-08-24 1994-03-08 Applied Vascular Engineering, Inc. Endovascular support device
US5041453A (en) 1990-05-30 1991-08-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4
US6063930A (en) 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
JP2000507955A (ja) 1996-04-03 2000-06-27 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
YU25400A (sh) 1997-11-04 2003-07-07 Pfizer Products Inc. Terapeutski aktivna jedinjenja sa indazolom
SK6252000A3 (en) 1997-11-04 2001-11-06 Pfizer Prod Inc Indazole bioisostere replacement of catechol in therapeutically active compounds
EP1046631A1 (en) 1999-04-19 2000-10-25 Rolic AG Liquid crystalline compounds
GB9908934D0 (en) 1999-04-19 1999-06-16 Rolic Ag Liquid crystalline compounds
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
AU2001273040A1 (en) 2000-06-27 2002-01-08 Du Pont Pharmaceuticals Company Factor xa inhibitors
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
KR20040007497A (ko) 2001-04-16 2004-01-24 에자이 가부시키가이샤 신규 1ｈ-인다졸 화합물
US6995144B2 (en) 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
CA2482838A1 (en) 2002-05-31 2003-12-11 Eisai Co., Ltd. Pyrazole compounds and pharmaceutical compositions containing the compound
JP2006501217A (ja) 2002-08-12 2006-01-12 スージェン・インコーポレーテッド 新規キナーゼ阻害剤としての３−ピロリル−ピリドピラゾールおよび３−ピロリル−インダゾール
BRPI0410348A (pt) 2003-05-14 2006-05-30 Torreypines Therapeutics Inc compostos e usos dos mesmos na modulação de amilóide-beta
JP2007510629A (ja) 2003-10-22 2007-04-26 イーライ リリー アンド カンパニー 新規ｍｃｈ受容体アンタゴニスト
WO2005060958A1 (en) 2003-12-19 2005-07-07 Kalypsys, Inc. (5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes
US7880002B2 (en) 2004-12-29 2011-02-01 Millennium Pharmaceuticals, Inc. Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists
US7635698B2 (en) 2004-12-29 2009-12-22 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
CN102584754B (zh) 2005-03-04 2016-02-03 默沙东公司 具有抗糖尿病活性的稠合芳香化合物
WO2007044085A2 (en) 2005-05-19 2007-04-19 Xenon Pharmaceuticals Inc. Heteroaryl compounds and their uses as therapeutic agents
WO2007050124A1 (en) 2005-05-19 2007-05-03 Xenon Pharmaceuticals Inc. Fused piperidine derivatives and their uses as therapeutic agents
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
JP5255559B2 (ja) 2006-03-31 2013-08-07 アボット・ラボラトリーズ インダゾール化合物
DE102006030479A1 (de) 2006-07-01 2008-03-20 Merck Patent Gmbh Indazolderivate
US20080027052A1 (en) 2006-07-10 2008-01-31 Sharon Moe Methods for treating cystic kidney disease
US20110008347A1 (en) 2006-12-01 2011-01-13 Agency For Science ,Technology And Research Cancer-related protein kinases
CN101687789A (zh) 2007-02-12 2010-03-31 因特蒙公司 C型肝炎病毒复制的新颖抑制剂
MX2009011579A (es) 2007-04-25 2009-11-11 Exelixis Inc Pirimidinonas como moduladores de caseina cinasa ii (ck2).
EP2155187B1 (en) 2007-05-07 2016-05-25 Merck Sharp & Dohme Corp. Method of treatment using fused aromatic compounds having anti-diabetic activity
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
JP2010111624A (ja) 2008-11-06 2010-05-20 Shionogi & Co Ltd Ｔｔｋ阻害作用を有するインダゾール誘導体
WO2010065681A1 (en) 2008-12-03 2010-06-10 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
AR074760A1 (es) 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
EP2379563B1 (en) 2008-12-22 2014-07-16 Merck Sharp & Dohme Corp. Gamma secretase modulators
WO2010075273A1 (en) 2008-12-23 2010-07-01 Schering Corporation Bicyclic heterocycle derivatives and methods of use thereof
WO2010088518A2 (en) 2009-01-31 2010-08-05 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
WO2010096777A1 (en) 2009-02-23 2010-08-26 Presidio Pharmaceuticals, Inc. Inhibitors of hcv ns5a
US8455516B2 (en) 2010-01-15 2013-06-04 Touro University HIV-1 fusion inhibitors and methods
KR101483215B1 (ko) 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
EP2368876A1 (en) 2010-03-01 2011-09-28 Sanofi Derivatives of aminoindanes, their preparation and their application in therapeutics
WO2011109551A2 (en) 2010-03-03 2011-09-09 Calcimedica Inc. Compounds that modulate intracellular calcium
JP5763937B2 (ja) 2010-03-10 2015-08-12 Ａｇｃセイミケミカル株式会社 液晶化合物、その製造方法、液晶組成物および液晶電気光学素子
WO2011143365A1 (en) 2010-05-13 2011-11-17 Amgen Inc. Nitrogen heterocyclic compounds useful as pde10 inhibitors
EA025611B1 (ru) 2010-07-29 2017-01-30 Райджел Фармасьютикалз, Инк. Активирующие ampk гетероциклические соединения и способы их использования
JO3062B1 (ar) * 2010-10-05 2017-03-15 Lilly Co Eli R)-(e)-2-(4-(2-(5-(1-(3، 5-داي كلورو بيريدين-4-يل)إيثوكسي)-1h-إندازول-3-يل)?ينيل)-1h-بيرازول-1-يل)إيثانول بلوري
WO2012068589A2 (en) 2010-11-19 2012-05-24 Constellation Pharmaceuticals Modulators of methyl modifying enzymes, compositions and uses thereof
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
TWI450891B (zh) 2010-12-29 2014-09-01 Dev Center Biotechnology 新穎微管蛋白抑制劑
WO2012129562A2 (en) 2011-03-24 2012-09-27 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
US9340489B2 (en) 2011-05-23 2016-05-17 Sanofi Process for the preparation of deuterated compounds containing N-alkyl groups
CN102243505B (zh) 2011-07-07 2013-08-14 矽力杰半导体技术(杭州)有限公司 一种低失调、快速响应的电压控制电流源、控制方法以及应用其的电源电路
WO2013021950A1 (ja) 2011-08-05 2013-02-14 アステラス製薬株式会社 新規ｆｇｆｒ４変異体の検出法
JP2014525932A (ja) 2011-08-15 2014-10-02 インターミューン， インコーポレイテッド リゾホスファチド酸レセプターアンタゴニスト
CA2844730A1 (en) 2011-09-01 2013-03-07 F. Hoffmann-La Roche Ag Pyrrolopyrazine kinase inhibitors
ES2731471T3 (es) 2011-09-09 2019-11-15 Lantheus Medical Imaging Inc Composiciones, métodos y sistemas para la síntesis y el uso de agentes de obtención de imágenes
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
US9254288B2 (en) 2012-05-07 2016-02-09 The Translational Genomics Research Institute Susceptibility of tumors to tyrosine kinase inhibitors and treatment thereof
CN103420906B (zh) 2012-05-21 2015-09-09 南京圣和药业股份有限公司 新型酪氨酸蛋白激酶抑制剂
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
US9013997B2 (en) 2012-06-01 2015-04-21 Broadcom Corporation System for performing distributed data cut-through
EP4223770A3 (en) 2012-11-05 2023-10-18 Foundation Medicine, Inc. Novel fusion molecules and uses thereof
US20140213538A1 (en) 2013-01-15 2014-07-31 Intermune, Inc. Lysophosphatidic acid receptor antagonists
AU2014207342C1 (en) 2013-01-18 2019-04-04 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
KR101648141B1 (ko) 2013-06-11 2016-08-12 제일모직 주식회사 화합물, 이를 포함하는 유기 광전자 소자 및 상기 유기 광전자 소자를 포함하는 표시장치
EP3023101B1 (en) 2013-07-18 2020-08-19 Taiho Pharmaceutical Co., Ltd. Therapeutic agent for fgfr inhibitor-resistant cancer
WO2015035415A1 (en) 2013-09-09 2015-03-12 Nantomics, Llc Method of detecting suceptibility to breast cancer through mutations in the fgfr3 and tp53 genes
US20150087673A1 (en) 2013-09-26 2015-03-26 Rigel Pharmaceuticals, Inc. Methods for using and biomarkers for ampk-activating compounds
JP6749234B2 (ja) 2013-09-27 2020-09-02 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 皮膚修復のための化合物及び方法
EP3082802B1 (en) 2013-12-03 2020-02-26 Iomet Pharma Ltd. Tryptophan-2,3-dioxygenase (tdo) and/or indolamine-2,3-dioxygenase (ido) inhibitors and their use
IL300974A (en) 2013-12-11 2023-04-01 Accuragen Holdings Ltd Preparations and methods for the detection of rare sequence variants
ES2756175T3 (es) 2013-12-27 2020-04-27 Chugai Pharmaceutical Co Ltd Genes mutantes guardián de fgfr y fármacos que se dirigen a los mismos
WO2015103527A1 (en) 2014-01-06 2015-07-09 The Scripps Research Institute Modulators of rev-erb
US20160340742A1 (en) 2014-02-04 2016-11-24 Mayo Foundation For Medical Education And Research Method of Identifying Tyrosine Kinase Receptor Rearrangements in Patients
US10703798B2 (en) 2014-03-31 2020-07-07 Debiopharm International Sa Methods of cancer therapy by inhibiting fusion polypeptides comprising fibroblast growth factor receptor 2 (FGFR2) and vinculin (VCL)
WO2015154169A1 (en) 2014-04-09 2015-10-15 The University Of British Columbia Binding function3 (bf3) site compounds as therapeutics and methods for their use
US10550326B2 (en) 2014-05-09 2020-02-04 Merck Patent Gmbh Liquid-crystalline medium and high-frequency components comprising same
JP6616786B2 (ja) 2014-05-19 2019-12-04 メリアル インコーポレイテッド 駆虫性化合物
WO2016022446A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [5,6]-fused bicyclic antidiabetic compounds
JP2017529332A (ja) 2014-08-28 2017-10-05 オンコエシックス ゲーエムベーハー チエノトリアゾロジアゼピン化合物を含む医薬組成物を用いる急性骨髄性白血病又は急性リンパ性白血病の治療方法
JP2017535646A (ja) 2014-11-11 2017-11-30 メルク・パテント・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ ＧｍｂＨ ビメソゲン化合物及びメソゲン媒体
JP2018027019A (ja) 2014-11-26 2018-02-22 国立研究開発法人国立がん研究センター 胆道がんにおける新規治療標的融合遺伝子
WO2016105503A1 (en) 2014-12-24 2016-06-30 Genentech, Inc. Therapeutic, diagnostic and prognostic methods for cancer of the bladder
WO2016139227A1 (en) 2015-03-03 2016-09-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Fgfr3 antagonists
KR101663277B1 (ko) 2015-03-30 2016-10-06 주식회사 녹십자 TNIK, IKKε 및 TBK1 억제제로서의 피라졸계 유도체 및 이를 포함하는 약학적 조성물
WO2016172631A2 (en) 2015-04-24 2016-10-27 President And Fellows Of Harvard College Substrate selective inhibitors of insulin-degrading enzyme (ide) and uses thereof
CN106317023A (zh) * 2015-07-10 2017-01-11 中国科学院上海药物研究所 吲唑类化合物的制备方法和用途
WO2017024968A1 (zh) 2015-08-07 2017-02-16 南京明德新药研发股份有限公司 作为fgfr和vegfr抑制剂的乙烯基化合物
CA3001857A1 (en) 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
US20180305331A1 (en) 2015-10-22 2018-10-25 Selvita S.A. Pyridone derivatives and their use as kinase inhibitors
EP3425004A4 (en) 2016-03-02 2019-10-16 JNC Corporation COMPOSITION FOR ELEMENTS WITH LOW THERMAL EXPANSION, ITEM WITH LOW THERMAL EXPANSION, ELECTRONIC DEVICE AND METHOD FOR PRODUCING AN ELEMENT WITH LOW THERMAL EXPANSION
CN108712965A (zh) 2016-03-02 2018-10-26 捷恩智株式会社 层叠体、电子机器、层叠体的制造方法
TWI747889B (zh) 2016-03-16 2021-12-01 美商庫拉腫瘤技術股份有限公司 經取代之menin-mll抑制劑及使用方法
EP3455328B1 (en) 2016-05-12 2020-03-04 Merck Patent GmbH Bimesogenic compounds and mesogenic media
BR112019003659B1 (pt) 2016-08-30 2022-05-03 Dow Global Technologies Llc Método para produzir uma mistura tratada, mistura tratada e artigo fabricado
JP6589795B2 (ja) 2016-09-27 2019-10-16 信越化学工業株式会社 スルホニウム塩、レジスト組成物及びパターン形成方法
WO2018226976A1 (en) 2017-06-08 2018-12-13 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
WO2019018795A1 (en) 2017-07-20 2019-01-24 Yumanity Therapeutics COMPOUNDS AND USES THEREOF
WO2019036562A1 (en) 2017-08-18 2019-02-21 Saint Louis University ERR INVERSE AGONISTS
CN109400522B (zh) 2017-08-18 2023-04-28 上海轶诺药业有限公司 一种具有pd-l1抑制活性的化合物、其制备方法及用途
WO2019209948A1 (en) 2018-04-25 2019-10-31 Yumanity Therapeutics, Inc. Compounds and uses thereof
KR20210071976A (ko) 2018-09-04 2021-06-16 마젠타 테라퓨틱스 인코포레이티드 아릴 하이드로카본 수용체 길항제 및 사용 방법
KR102127006B1 (ko) 2018-12-06 2020-06-25 한국생산기술연구원 피리미딘계 작용기 함유 단분자 화합물, 상기 화합물의 광가교물을 포함한 유기물층 및 이를 포함하는 유기전자소자
CA3124970A1 (en) 2018-12-28 2020-07-02 Cedars-Sinai Medical Center Methods of treating inflammatory bowel diseases that target ripk2
CN111434655A (zh) 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 溶血磷脂酸受体拮抗剂及其制备方法
IN201941011265A (es) * 2019-03-22 2020-09-25
TW202108582A (zh) 2019-05-14 2021-03-01 大陸商上海翰森生物醫藥科技有限公司 含二並環類衍生物抑制劑、其製備方法和應用
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CN112409331B (zh) 2019-08-21 2024-02-20 上海翰森生物医药科技有限公司 杂环类衍生物抑制剂、其制备方法和应用
WO2021067374A1 (en) * 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP7675711B2 (ja) 2019-10-14 2025-05-13 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての二環式複素環
CN112812014B (zh) 2019-11-15 2024-05-10 石家庄诚志永华显示材料有限公司 化合物、液晶组合物、液晶显示器
CN113179640B (zh) 2019-11-26 2024-06-25 上海翰森生物医药科技有限公司 含氮多环类衍生物抑制剂、其制备方法和应用
TW202136253A (zh) 2019-12-19 2021-10-01 美商卡司馬療法公司 Ｔｒｐｍｌ調節劑
US12441707B2 (en) * 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
US20230128972A1 (en) 2020-01-31 2023-04-27 Atomwise Inc. Anat Inhibitors and Methods of Use Thereof
AU2021219370A1 (en) 2020-02-12 2022-08-25 Curadev Pharma Pvt. Ltd. Small molecule STING antagonists
US20230148214A1 (en) 2020-03-06 2023-05-11 ESCAPE Bio, Inc. Indazoles and azaindazoles as lrrk2 inhibitors
US20230140941A1 (en) 2020-03-13 2023-05-11 University Of Maryland, Baltimore Non-atp/catalytic site p38 mitogen activated protein kinase inhibitors
CR20220561A (es) 2020-05-06 2023-02-17 Servier Lab Nuevos inhibidores macrocíclicos de la quinasa de lrrk2
CR20230325A (es) 2020-12-30 2023-12-11 Tyra Biosciences Inc Compuestos de indazol como inhibidores de cinasas
CA3213388A1 (en) 2021-03-18 2022-09-22 Les Laboratoires Servier Macrocyclic lrrk2 kinase inhibitors
EP4308557A1 (en) 2021-03-19 2024-01-24 Arvinas Operations, Inc. Indazole based compounds and associated methods of use
WO2023279041A1 (en) 2021-06-30 2023-01-05 Tyra Biosciences, Inc. Indazole compounds
CN119183452A (zh) 2022-04-04 2024-12-24 布雷宁疗法公司 Lrrk2抑制剂
AU2023300357A1 (en) 2022-06-29 2025-01-09 Tyra Biosciences, Inc. Polymorphic compounds and uses thereof
US20250368666A1 (en) 2022-06-29 2025-12-04 Tyra Biosciences, Inc. Indazole compounds
EP4580629A1 (en) 2022-08-30 2025-07-09 Tyra Biosciences, Inc. Methods of treating solid tumors having activating fgfr3 gene alterations

Also Published As

Publication number Publication date
US12071428B2 (en) 2024-08-27
US20240208941A1 (en) 2024-06-27
CO2023008689A2 (es) 2023-09-29
PE20240687A1 (es) 2024-04-10
TW202241906A (zh) 2022-11-01
AU2021411587A1 (en) 2023-07-06
US20250340533A1 (en) 2025-11-06
KR20230152654A (ko) 2023-11-03
IL304014A (en) 2023-08-01
WO2022147246A1 (en) 2022-07-07
JP7791196B2 (ja) 2025-12-23
MX2023007793A (es) 2023-09-22
CA3205986A1 (en) 2022-07-07
JP2024502433A (ja) 2024-01-19
CR20230325A (es) 2023-12-11
AU2021411587B2 (en) 2024-10-10
CL2023001951A1 (es) 2023-12-01
US12264149B2 (en) 2025-04-01
ZA202306559B (en) 2025-09-25
EP4271673A1 (en) 2023-11-08
US20240109865A1 (en) 2024-04-04

Similar Documents

Publication Publication Date Title
CL2023001951A1 (es) Compuestos de indazol como inhibidores de cinasas
CO2020013599A2 (es) Piridazinonas como inhibidoras de parp7
CO2021008224A2 (es) Inhibidores de kif18a
CL2020002146A1 (es) Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida y compuestos relacionados como inhibidores hpki para tratar el cáncer.
ECSP22011692A (es) Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2
CU20180006A7 (es) Compuestos de indazaol y azaindazol como inhibidores de irak-4
CL2018003511A1 (es) Derivados de pirazolopirimidina como inhibidor de quinasa.
MX2020000386A (es) Inhibidores heterociclicos de la cinasa atr.
CO2018008846A2 (es) Derivados de carboxamida útiles como inhibidores de rsk
MX2017000806A (es) Derivados de 2-h-indazol como inhibidores de kinasas dependientes de ciclinas (cdk) y usos terapeuticos de los mismos.
MX2024004162A (es) Inhibidores de proteinas quinasas activadas por mitogeno p38 en sitio no atp/catalitico.
CL2019002557A1 (es) Pirimidopirimidinonas útiles como inhibidores de la quinasa wee-1.
CL2021000292A1 (es) Benzimidazoles sustituidos como inhibidores de pad4.
CO2022018806A2 (es) Inhibidores de las cinasas receptoras del receptor del factor de crecimiento de fibroblastos
MX2024015477A (es) Compuestos de indazol
MX383930B (es) Compuestos de pirazol sustituidos como inhibidores de serina proteasa.
MX2022003671A (es) Inhibidores de proteina cinasa i de interaccion con receptores para el tratamiento de enfermedades.
MX2022004270A (es) Inhibidores de aldosa reductasa para el tratamiento de la deficiencia de fosfomannomutasa 2.
MX2017009246A (es) Farmaco de combinacion.
CO2025003263A2 (es) Inhibidores de kif18a y usos de estos
CL2024001535A1 (es) Quinolinas y azaquinolinas como inhibidores de cd38
CO2024009144A2 (es) Inhibidores de cinasa met
MX2022002443A (es) Compuestos inhibidores de perk.
EA202192575A1 (ru) Соединения dbait в сочетании с ингибиторами киназ для лечения рака
BR112019008622A2 (pt) método para tratar uma condição