ECSP20020949A - Conjugados de fármaco-anticuerpo (adc) anti-egfr y sus usos - Google Patents
Conjugados de fármaco-anticuerpo (adc) anti-egfr y sus usosInfo
- Publication number
- ECSP20020949A ECSP20020949A ECSENADI202020949A ECDI202020949A ECSP20020949A EC SP20020949 A ECSP20020949 A EC SP20020949A EC SENADI202020949 A ECSENADI202020949 A EC SENADI202020949A EC DI202020949 A ECDI202020949 A EC DI202020949A EC SP20020949 A ECSP20020949 A EC SP20020949A
- Authority
- EC
- Ecuador
- Prior art keywords
- adcs
- egfr
- heavy chain
- constant region
- antibody conjugates
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 2
- 101000851181 Homo sapiens Epidermal growth factor receptor Proteins 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 102000045108 human EGFR Human genes 0.000 abstract 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68035—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a pyrrolobenzodiazepine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente divulgación proporciona conjugados fármaco-anticuerpo (ADC)que comprenden un agente citotóxico o citoestático ligados a un anticuerpo anti-EGFR mediante un ligador, composiciones que comprenden los ADC, métodos de elaboración de los ADC, y métodos para tratar un tipo de cáncer que comprenden administrar los ADC a un sujeto que tiene cáncer. La presente divulgación proporciona ADC que se fijan específicamente al EGFR y, en particular, al EGFR humano (hEGFR). El Ab anti-EGFR descrito en la presente comprende una mutación S239C en una región constante de la cadena pesada, en donde la numeración es de acuerdo con Kabat. En ciertas formas de realización, la región constante de la cadena pesada del anticuerpo anti-EGFR carece de una lisina en el terminal C o comprende un aminoácido distinto a lisina en el terminal C de la región constante de la cadena pesada.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762553837P | 2017-09-02 | 2017-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP20020949A true ECSP20020949A (es) | 2020-05-29 |
Family
ID=65526126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202020949A ECSP20020949A (es) | 2017-09-02 | 2020-04-02 | Conjugados de fármaco-anticuerpo (adc) anti-egfr y sus usos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20200188525A1 (es) |
| EP (1) | EP3675907A4 (es) |
| JP (1) | JP2020532523A (es) |
| KR (1) | KR20200041998A (es) |
| CN (1) | CN111295201A (es) |
| AU (1) | AU2018326878A1 (es) |
| BR (1) | BR112020004212A2 (es) |
| CA (1) | CA3073560A1 (es) |
| CL (1) | CL2020000508A1 (es) |
| CO (1) | CO2020003512A2 (es) |
| CR (1) | CR20200145A (es) |
| DO (1) | DOP2020000045A (es) |
| EC (1) | ECSP20020949A (es) |
| IL (1) | IL272920A (es) |
| MX (1) | MX2020002268A (es) |
| PE (1) | PE20200721A1 (es) |
| PH (1) | PH12020500417A1 (es) |
| RU (1) | RU2020112280A (es) |
| SG (1) | SG11202001762RA (es) |
| WO (1) | WO2019046859A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11376317B2 (en) | 2017-08-30 | 2022-07-05 | University Of Maryland, College Park | FcRn-targeted mucosal vaccination against RSV |
| US11591371B2 (en) | 2018-04-02 | 2023-02-28 | University Of Maryland, College Park | FcRn-targeted mucosal vaccination against influenza infections |
| WO2021174128A1 (en) * | 2020-02-26 | 2021-09-02 | University Of Maryland, College Park | Compositions and methods for mucosal vaccination against sars-cov-2 |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| CA3232764A1 (en) | 2021-09-30 | 2023-04-06 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pyrrolo benzodiazepine derivative, and conjugate, preparation method and use thereof |
| KR20250129814A (ko) | 2023-01-18 | 2025-08-29 | 타이리간드 바이오사이언스 (상하이) 리미티드 | 항체-약물 접합체 및 이의 용도 |
| CN120957754A (zh) * | 2023-05-12 | 2025-11-14 | 四川科伦博泰生物医药股份有限公司 | 稠环化合物及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3461847T1 (sl) * | 2010-12-06 | 2021-03-31 | Seagen Inc. | Humanizirana protitelesa proti LIV-1 in njihova uporaba pri zdravljenju raka |
| ES2704411T3 (es) * | 2013-03-12 | 2019-03-18 | Biocon Ltd | Proteínas de fusión inmunomoduladoras y procedimientos de fabricación de las mismas |
| KR20220025946A (ko) * | 2014-03-21 | 2022-03-03 | 애브비 인코포레이티드 | 항-ｅｇｆｒ 항체 및 항체 약물 접합체 |
| ES2719584T3 (es) * | 2014-04-11 | 2019-07-11 | Medimmune Llc | Compuestos conjugados que comprenden anticuerpos modificados por ingeniería genética con cisteína |
| CA2947238A1 (en) * | 2014-05-22 | 2015-11-26 | Synthon Biopharmaceuticals B.V. | Site-specific conjugation of linker drugs to antibodies and resulting adcs |
| US20190083645A1 (en) * | 2015-12-04 | 2019-03-21 | Abbvie Stemcentrx Llc | Novel anti-claudin antibodies and methods of use |
-
2018
- 2018-09-04 AU AU2018326878A patent/AU2018326878A1/en not_active Abandoned
- 2018-09-04 PE PE2020000303A patent/PE20200721A1/es unknown
- 2018-09-04 CA CA3073560A patent/CA3073560A1/en not_active Abandoned
- 2018-09-04 BR BR112020004212-9A patent/BR112020004212A2/pt not_active Application Discontinuation
- 2018-09-04 US US16/643,527 patent/US20200188525A1/en not_active Abandoned
- 2018-09-04 MX MX2020002268A patent/MX2020002268A/es unknown
- 2018-09-04 SG SG11202001762RA patent/SG11202001762RA/en unknown
- 2018-09-04 CN CN201880070839.9A patent/CN111295201A/zh active Pending
- 2018-09-04 EP EP18852236.1A patent/EP3675907A4/en not_active Withdrawn
- 2018-09-04 RU RU2020112280A patent/RU2020112280A/ru unknown
- 2018-09-04 JP JP2020512352A patent/JP2020532523A/ja active Pending
- 2018-09-04 KR KR1020207009274A patent/KR20200041998A/ko not_active Withdrawn
- 2018-09-04 WO PCT/US2018/049412 patent/WO2019046859A1/en not_active Ceased
- 2018-09-04 CR CR20200145A patent/CR20200145A/es unknown
-
2020
- 2020-02-26 IL IL272920A patent/IL272920A/en unknown
- 2020-02-26 DO DO2020000045A patent/DOP2020000045A/es unknown
- 2020-03-02 CL CL2020000508A patent/CL2020000508A1/es unknown
- 2020-03-02 PH PH12020500417A patent/PH12020500417A1/en unknown
- 2020-03-25 CO CONC2020/0003512A patent/CO2020003512A2/es unknown
- 2020-04-02 EC ECSENADI202020949A patent/ECSP20020949A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020004212A2 (pt) | 2020-09-08 |
| CL2020000508A1 (es) | 2020-07-10 |
| CA3073560A1 (en) | 2019-03-07 |
| PE20200721A1 (es) | 2020-07-21 |
| IL272920A (en) | 2020-04-30 |
| KR20200041998A (ko) | 2020-04-22 |
| SG11202001762RA (en) | 2020-03-30 |
| AU2018326878A1 (en) | 2020-03-19 |
| PH12020500417A1 (en) | 2021-03-01 |
| DOP2020000045A (es) | 2020-09-15 |
| RU2020112280A (ru) | 2021-10-05 |
| CO2020003512A2 (es) | 2020-06-19 |
| CR20200145A (es) | 2020-08-03 |
| US20200188525A1 (en) | 2020-06-18 |
| MX2020002268A (es) | 2021-01-08 |
| JP2020532523A (ja) | 2020-11-12 |
| EP3675907A1 (en) | 2020-07-08 |
| EP3675907A4 (en) | 2021-05-12 |
| CN111295201A (zh) | 2020-06-16 |
| WO2019046859A1 (en) | 2019-03-07 |
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