ECSP19048477A - Inhibidores biciclo[1.1.1]pentano de la cinasa de cremallera de leucina dual (dlk) para el tratamiento de enfermedades - Google Patents
Inhibidores biciclo[1.1.1]pentano de la cinasa de cremallera de leucina dual (dlk) para el tratamiento de enfermedadesInfo
- Publication number
- ECSP19048477A ECSP19048477A ECSENADI201948477A ECDI201948477A ECSP19048477A EC SP19048477 A ECSP19048477 A EC SP19048477A EC SENADI201948477 A ECSENADI201948477 A EC SENADI201948477A EC DI201948477 A ECDI201948477 A EC DI201948477A EC SP19048477 A ECSP19048477 A EC SP19048477A
- Authority
- EC
- Ecuador
- Prior art keywords
- disease
- dlk
- resulting
- diseases
- leucine zipper
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 102000020233 phosphotransferase Human genes 0.000 title abstract 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 title abstract 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 230000009977 dual effect Effects 0.000 title abstract 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Biomedical Technology (AREA)
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- Epidemiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En este documento se dan a conocer compuestos que inhiben la actividad de cinasa de la cinasa de cremallera de leucina dual (DLK) (MAP3K12), composiciones farmacéuticas y métodos de tratamiento de enfermedades mediadas por DLK, tales como enfermedades neurológicas que resultan de lesión traumática al sistema nervioso central y neuronas del sistema nervioso periférico (por ejemplo, apoplejía, lesión cerebral traumática, lesión de médula espinal), o que resultan de un padecimiento neurodegenerativo crónico (por ejemplo, enfermedad de Alzheimer, demencia frontotemporal, enfermedad de Parkinson, enfermedad de Huntington, esclerosis lateral amiotrófica, ataxia espinocerebelar, parálisis supranuclear progresiva, enfermedad de cuerpos de Lewy, enfermedad de Kennedy y otros padecimientos relacionados), de neuropatías que resultan de daño neurológico (neuropatía periférica inducida por quimioterapia, neuropatía diabética y trastornos relacionados) y de trastornos cognitivos ocasionados por intervención farmacológica (por ejemplo, trastorno cognitivo inducido por quimioterapia, también conocido como quimiocerebro).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662431504P | 2016-12-08 | 2016-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP19048477A true ECSP19048477A (es) | 2019-07-31 |
Family
ID=62492159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI201948477A ECSP19048477A (es) | 2016-12-08 | 2019-07-08 | Inhibidores biciclo[1.1.1]pentano de la cinasa de cremallera de leucina dual (dlk) para el tratamiento de enfermedades |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10093664B2 (es) |
| EP (1) | EP3551610B1 (es) |
| JP (1) | JP7128816B2 (es) |
| KR (1) | KR20190087622A (es) |
| CN (1) | CN110191878B (es) |
| AU (1) | AU2017371084B2 (es) |
| BR (1) | BR112019011801A2 (es) |
| CA (1) | CA3045947A1 (es) |
| CL (1) | CL2019001539A1 (es) |
| CO (1) | CO2019006785A2 (es) |
| EA (1) | EA201991375A1 (es) |
| EC (1) | ECSP19048477A (es) |
| ES (1) | ES2895257T3 (es) |
| IL (1) | IL267121B (es) |
| MX (1) | MX386838B (es) |
| WO (1) | WO2018107072A1 (es) |
| ZA (1) | ZA201904402B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10093664B2 (en) | 2016-12-08 | 2018-10-09 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
| MA49858A (fr) | 2017-08-09 | 2021-04-28 | Denali Therapeutics Inc | Composés, compositions et procédés |
| WO2019046779A1 (en) | 2017-09-01 | 2019-03-07 | Denali Therapeutics Inc. | COMPOUNDS, COMPOSITIONS AND METHODS |
| WO2019241244A1 (en) * | 2018-06-13 | 2019-12-19 | Board Of Regents, The University Of Texas System | Salts of bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease |
| GB201811165D0 (en) * | 2018-07-06 | 2018-08-29 | Metrion Biosciences Ltd | Novel compounds |
| US11702425B2 (en) * | 2018-08-01 | 2023-07-18 | Agency For Science, Technology And Research | Bicyclic compounds as kinase modulators, methods and uses thereof |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| JP7212781B2 (ja) | 2018-12-19 | 2023-01-25 | ディスアーム セラピューティクス， インコーポレイテッド | 神経保護剤と組み合わせたｓａｒｍ１の阻害剤 |
| AU2020223228A1 (en) | 2019-02-13 | 2021-08-26 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| MA54959A (fr) | 2019-02-13 | 2021-12-22 | Denali Therapeutics Inc | Composés, compositions et procédés |
| IL291665B2 (en) * | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| US11560366B2 (en) * | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
| CA3193736A1 (en) * | 2020-09-02 | 2022-03-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Lzk-targeting degraders and methods of use |
| KR20240055041A (ko) | 2021-09-01 | 2024-04-26 | 더 유나이티드 스테이츠 오브 아메리카, 애즈 레프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 | 혼합 계통 키나제 억제제 및 억제제의 사용 방법 |
| CN115974795A (zh) * | 2022-12-26 | 2023-04-18 | 杭州师范大学 | 一种含全氟烷基和n杂环二取代双环[1.1.1]戊烷及其合成方法 |
| WO2025021997A1 (en) | 2023-07-27 | 2025-01-30 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | New map4k1 inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004096822A2 (en) | 2003-04-25 | 2004-11-11 | Chiron Corporation | Pyridyl substituted ketolide antibiotics |
| TW200944520A (en) | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
| US9073895B2 (en) | 2010-12-16 | 2015-07-07 | Boehringer Ingelheim International Gmbh | Biarylamide inhibitors of leukotriene production |
| JP6267193B2 (ja) | 2012-05-22 | 2018-01-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 置換ジピリジルアミン類及びそれらの使用 |
| CN104918934B (zh) | 2013-01-18 | 2017-12-22 | 霍夫曼-拉罗奇有限公司 | 3‑取代的吡唑及其作为dlk抑制剂的用途 |
| CN104119340A (zh) | 2013-01-22 | 2014-10-29 | 韩冰 | 一类蛋白酶抑制剂及其制备方法和用途 |
| MX2015014861A (es) | 2013-05-01 | 2016-03-09 | Hoffmann La Roche | Pirimidinas sustituidas con heterocicloalquilo c-enlazado y sus usos. |
| MY182082A (en) | 2013-05-01 | 2021-01-18 | Hoffmann La Roche | Biheteroaryl compounds and uses thereof |
| MX2016008110A (es) * | 2013-12-20 | 2016-08-19 | Hoffmann La Roche | Derivados de pirazol como inhibidores de la cinasa de cremallera de leucina dual (dlk) y usos de los mismos. |
| EP3114107B1 (en) | 2014-03-07 | 2020-07-22 | Recurium IP Holdings, LLC | Propellane derivates and synthesis |
| US9307840B2 (en) | 2014-07-01 | 2016-04-12 | Carlos Arturo Restrepo | Foldable and portable lounge chair having an integrated lockable storage compartment |
| ES2789331T3 (es) * | 2015-03-02 | 2020-10-26 | Rigel Pharmaceuticals Inc | Inhibidores de TGF-beta |
| KR20170132307A (ko) | 2015-04-03 | 2017-12-01 | 카리라 파마슈티컬스, 아이앤씨. | 스피로 고리 화합물 |
| JP2019528319A (ja) | 2016-08-29 | 2019-10-10 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 疾患の処置のための二重ロイシンジッパー（ｄｌｋ）キナーゼの阻害薬 |
| US10093664B2 (en) | 2016-12-08 | 2018-10-09 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
| US11560366B2 (en) * | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
-
2017
- 2017-12-08 US US15/836,442 patent/US10093664B2/en active Active
- 2017-12-08 WO PCT/US2017/065385 patent/WO2018107072A1/en not_active Ceased
- 2017-12-08 KR KR1020197019246A patent/KR20190087622A/ko not_active Abandoned
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- 2017-12-08 MX MX2019006645A patent/MX386838B/es unknown
- 2017-12-08 AU AU2017371084A patent/AU2017371084B2/en not_active Ceased
- 2017-12-08 EA EA201991375A patent/EA201991375A1/ru unknown
- 2017-12-08 EP EP17879488.9A patent/EP3551610B1/en active Active
- 2017-12-08 CN CN201780082917.2A patent/CN110191878B/zh not_active Expired - Fee Related
- 2017-12-08 CA CA3045947A patent/CA3045947A1/en active Pending
- 2017-12-08 JP JP2019530500A patent/JP7128816B2/ja active Active
- 2017-12-08 ES ES17879488T patent/ES2895257T3/es active Active
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2018
- 2018-09-04 US US16/121,198 patent/US10428057B2/en active Active
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2019
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- 2019-07-04 ZA ZA2019/04402A patent/ZA201904402B/en unknown
- 2019-07-08 EC ECSENADI201948477A patent/ECSP19048477A/es unknown
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2022
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| Publication number | Publication date |
|---|---|
| EA201991375A1 (ru) | 2020-01-20 |
| US10093664B2 (en) | 2018-10-09 |
| EP3551610A1 (en) | 2019-10-16 |
| CN110191878A (zh) | 2019-08-30 |
| US20180186781A1 (en) | 2018-07-05 |
| CO2019006785A2 (es) | 2019-07-10 |
| US10428057B2 (en) | 2019-10-01 |
| JP2020502092A (ja) | 2020-01-23 |
| AU2017371084A1 (en) | 2019-06-20 |
| EP3551610A4 (en) | 2020-04-22 |
| US20190092764A1 (en) | 2019-03-28 |
| IL267121A (en) | 2019-08-29 |
| KR20190087622A (ko) | 2019-07-24 |
| MX386838B (es) | 2025-03-19 |
| JP7128816B2 (ja) | 2022-08-31 |
| ES2895257T3 (es) | 2022-02-18 |
| EP3551610B1 (en) | 2021-08-11 |
| BR112019011801A2 (pt) | 2019-10-29 |
| IL267121B (en) | 2021-12-01 |
| US20220267311A1 (en) | 2022-08-25 |
| CN110191878B (zh) | 2023-05-26 |
| ZA201904402B (en) | 2020-12-23 |
| WO2018107072A1 (en) | 2018-06-14 |
| MX2019006645A (es) | 2019-08-26 |
| CA3045947A1 (en) | 2018-06-14 |
| CL2019001539A1 (es) | 2019-08-23 |
| AU2017371084B2 (en) | 2022-04-28 |
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