ECSP18019949A - CYCLIC DINUCLEOTIDE COMPOUNDS AS STING AGONISTS - Google Patents
CYCLIC DINUCLEOTIDE COMPOUNDS AS STING AGONISTSInfo
- Publication number
- ECSP18019949A ECSP18019949A ECIEPI201819949A ECPI201819949A ECSP18019949A EC SP18019949 A ECSP18019949 A EC SP18019949A EC IEPI201819949 A ECIEPI201819949 A EC IEPI201819949A EC PI201819949 A ECPI201819949 A EC PI201819949A EC SP18019949 A ECSP18019949 A EC SP18019949A
- Authority
- EC
- Ecuador
- Prior art keywords
- cyclic dinucleotide
- sting agonists
- compounds
- dinucleotide compounds
- general formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940044665 STING agonist Drugs 0.000 title 1
- 102000002227 Interferon Type I Human genes 0.000 abstract 1
- 108010014726 Interferon Type I Proteins 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se proporciona una clase de compuestos policíclicos de fórmula general (I), de fórmula general (I'), o de fórmula general (II''), en las que Base1 , Base2 , Y, Ya , Xa , Xa1, Xb , Xb1, Xc , Xc1 , X d , Xd1, R1 , R1a, R2 , R2a, R3 , R4 , R4a, R5 , R6 , R6a, R7 , R7a, R8 y R8a se definen en el presente documento, que pueden ser útiles como inductores de la producción de interferones de tipo I, específicamente como agentes activos de STING. También se proporcionan procesos de síntesis y de uso de compuestos.A class of polycyclic compounds of general formula (I), general formula (I '), or general formula (II' ') is provided, wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1 , Xc, Xc1, X d, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8 and R8a are defined herein, which may be useful as inducers of the production of type I interferons, specifically as active agents of STING. Processes for synthesis and use of compounds are also provided.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562204677P | 2015-08-13 | 2015-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP18019949A true ECSP18019949A (en) | 2018-07-31 |
Family
ID=60451227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201819949A ECSP18019949A (en) | 2015-08-13 | 2018-03-13 | CYCLIC DINUCLEOTIDE COMPOUNDS AS STING AGONISTS |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR105683A1 (en) |
| EC (1) | ECSP18019949A (en) |
-
2016
- 2016-08-11 AR ARP160102472A patent/AR105683A1/en not_active Application Discontinuation
-
2018
- 2018-03-13 EC ECIEPI201819949A patent/ECSP18019949A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR105683A1 (en) | 2017-11-01 |
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