ECSP18040250A - Composiciones y métodos para inhibir la actividad arginasa - Google Patents
Composiciones y métodos para inhibir la actividad arginasaInfo
- Publication number
- ECSP18040250A ECSP18040250A ECIEPI201840250A ECPI201840250A ECSP18040250A EC SP18040250 A ECSP18040250 A EC SP18040250A EC IEPI201840250 A ECIEPI201840250 A EC IEPI201840250A EC PI201840250 A ECPI201840250 A EC PI201840250A EC SP18040250 A ECSP18040250 A EC SP18040250A
- Authority
- EC
- Ecuador
- Prior art keywords
- methods
- compositions
- arginase activity
- inhibit arginase
- inhibit
- Prior art date
Links
- 102000004452 Arginase Human genes 0.000 title abstract 3
- 108700024123 Arginases Proteins 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La invención se refiere a una nueva clase de compuestos que exhiben actividad inhibidora de la actividad hacia la arginasa, y composiciones farmacéuticas que comprenden los compuestos de la invención. También se proporcionan en el presente documento los métodos para tratar el cáncer con los inhibidores de arginasa de la invención.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562248632P | 2015-10-30 | 2015-10-30 | |
| US201662281964P | 2016-01-22 | 2016-01-22 | |
| US201662323034P | 2016-04-15 | 2016-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP18040250A true ECSP18040250A (es) | 2018-10-31 |
Family
ID=58631120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECIEPI201840250A ECSP18040250A (es) | 2015-10-30 | 2018-05-28 | Composiciones y métodos para inhibir la actividad arginasa |
Country Status (36)
| Country | Link |
|---|---|
| US (4) | US10065974B2 (es) |
| EP (3) | EP4011887B1 (es) |
| JP (3) | JP6833844B2 (es) |
| KR (2) | KR20220118559A (es) |
| CN (4) | CN113150015A (es) |
| AU (3) | AU2016343656B2 (es) |
| BR (3) | BR122020022280B1 (es) |
| CA (1) | CA3003271A1 (es) |
| CL (4) | CL2018001134A1 (es) |
| CO (1) | CO2018004750A2 (es) |
| CR (3) | CR20210390A (es) |
| CY (1) | CY1123557T1 (es) |
| DK (2) | DK3368541T3 (es) |
| EA (1) | EA038276B1 (es) |
| EC (1) | ECSP18040250A (es) |
| ES (3) | ES2808988T3 (es) |
| HR (1) | HRP20201046T1 (es) |
| HU (1) | HUE054972T2 (es) |
| IL (3) | IL258731B (es) |
| LT (1) | LT3368541T (es) |
| MA (2) | MA43131B1 (es) |
| MD (1) | MD3368541T2 (es) |
| MX (1) | MX2018005294A (es) |
| MY (1) | MY201783A (es) |
| NZ (1) | NZ742742A (es) |
| PH (2) | PH12018500899B1 (es) |
| PL (1) | PL3368541T3 (es) |
| PT (1) | PT3368541T (es) |
| RS (1) | RS60695B1 (es) |
| SG (4) | SG10201911406TA (es) |
| SI (1) | SI3368541T1 (es) |
| SM (1) | SMT202000469T1 (es) |
| TW (3) | TWI734630B (es) |
| UA (1) | UA125289C2 (es) |
| WO (1) | WO2017075363A1 (es) |
| ZA (4) | ZA201803556B (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ603364A (en) | 2010-04-22 | 2015-06-26 | Mars Inc | Inhibitors of arginase and their therapeutic applications |
| JP5909239B2 (ja) | 2010-10-26 | 2016-04-26 | マーズ インコーポレイテッド | アルギナーゼ阻害剤としてのボロネート |
| ES2808988T3 (es) | 2015-10-30 | 2021-03-02 | Calithera Biosciences Inc | Composiciones y métodos para inhibir la actividad arginasa |
| PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| CA3042878A1 (en) | 2016-11-08 | 2018-05-17 | Calithera Biosciences, Inc. | Arginase inhibitor combination therapies |
| MX378460B (es) | 2016-12-22 | 2025-03-10 | Calithera Biosciences Inc | Composiciones y métodos para inhibir la actividad de la arginasa. |
| MX2019013533A (es) * | 2017-05-12 | 2020-08-03 | Calithera Biosciences Inc | Metodo para preparar (3r,4s)-3-acetamido-4-alil-n-(terc-butil)pirr olidina-3-carboxamida. |
| US11655260B2 (en) | 2017-12-22 | 2023-05-23 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heterocyclic compounds as arginase inhibitors |
| CN117186134A (zh) | 2018-02-17 | 2023-12-08 | 阿斯利康(瑞典)有限公司 | 精氨酸酶抑制剂及其使用方法 |
| MX2020009290A (es) | 2018-03-05 | 2020-09-28 | Arcus Biosciences Inc | Inhibidores de la arginasa. |
| EP3765006A4 (en) * | 2018-03-13 | 2022-02-23 | Merck Sharp & Dohme Corp. | ARGINASE INHIBITORS AND METHODS OF USE |
| TWI723366B (zh) | 2018-03-29 | 2021-04-01 | 波蘭商昂科艾倫迪治療法股份公司 | 二肽哌啶衍生物 |
| WO2019245890A1 (en) | 2018-06-20 | 2019-12-26 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| ES3034676T3 (en) | 2018-11-16 | 2025-08-21 | Arcus Biosciences Inc | Inhibitors of arg1 and/or arg2 |
| CN109364252B (zh) * | 2018-11-21 | 2021-09-28 | 南京大学 | 抑制ifn-i至arg1诱导通路在制备抗肿瘤药物组合物中的应用 |
| US12240867B2 (en) | 2018-12-18 | 2025-03-04 | Merck Sharp & Dohme Llc | Arginase inhibitors and methods of use |
| CN113614095B (zh) * | 2019-02-06 | 2024-08-23 | 广东新契生物医药科技有限公司 | 作为精氨酸酶抑制剂的烷基硼酸类化合物 |
| KR20220004726A (ko) * | 2019-05-02 | 2022-01-11 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | Jak 억제제로서의 치환된 피롤로피리딘 |
| MX2022000904A (es) * | 2019-07-23 | 2022-05-02 | Astrazeneca Ab | Inhibidores de arginasa y métodos de uso de estos. |
| CN110615753A (zh) * | 2019-09-02 | 2019-12-27 | 南京新酶合医药科技有限公司 | 一种(3r,4s)-1-取代-4-乙基吡咯-3-羧酸的合成方法 |
| CN110759843A (zh) * | 2019-09-30 | 2020-02-07 | 东北师范大学 | 一种氟叠氮取代的四元杂环化合物的制备和应用 |
| CN110734456A (zh) * | 2019-11-06 | 2020-01-31 | 南京谷睿生物科技有限公司 | 一种化合物及其制备方法和医药上的应用 |
| JP2023502182A (ja) | 2019-11-12 | 2023-01-20 | ナミ セラピューティクス， インコーポレイテッド | がんの処置において有用なｉｄｏアンタゴニストプロドラッグを含有する製剤化および／または共製剤化されたリポソーム組成物およびその方法 |
| US20230140132A1 (en) * | 2020-01-07 | 2023-05-04 | Merck Sharp & Dohme Llc | Arginase inhibitors and methods of use |
| US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| WO2022006456A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic pyridone compounds as jak2 v617f inhibitors |
| CA3188639A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| TW202216662A (zh) * | 2020-07-17 | 2022-05-01 | 美商英塞特公司 | 製備精胺酸酶抑制劑及其合成中間物之方法 |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| TW202228720A (zh) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
| EP4298099A1 (en) | 2021-02-25 | 2024-01-03 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
| JP2025509672A (ja) | 2022-03-17 | 2025-04-11 | インサイト・コーポレイション | Ｊａｋ２ ｖ６１７ｆ阻害剤としての三環式尿素化合物 |
| TW202416968A (zh) | 2022-10-21 | 2024-05-01 | 美商英塞特公司 | 作為ｊａｋ２ ｖ６１７ｆ抑制劑之三環脲化合物 |
| AU2024237095A1 (en) | 2023-03-13 | 2025-09-25 | Incyte Corporation | Bicyclic ureas as kinase inhibitors |
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| GB9217295D0 (en) | 1992-08-14 | 1992-09-30 | Wellcome Found | Controlled released tablets |
| US5541231A (en) | 1993-07-30 | 1996-07-30 | Glaxo Wellcome Inc. | Stabilized Pharmaceutical |
| GB9315856D0 (en) | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
| US5358970A (en) | 1993-08-12 | 1994-10-25 | Burroughs Wellcome Co. | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
| ES2206965T3 (es) | 1997-07-29 | 2004-05-16 | Alcon Laboratories, Inc. | Composiciones oftalmicas que contienen polimeros de galactomanana y borato. |
| EP1049660A1 (en) | 1997-10-10 | 2000-11-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for inhibiting arginase activity |
| US6110973A (en) | 1998-01-29 | 2000-08-29 | Sepracor | Methods for treating obesity and weight gain using optically pure (-)-bupropion |
| US20040063666A1 (en) | 1998-10-09 | 2004-04-01 | David Christianson | Compositions for inhibiting arginase activity |
| US8889112B2 (en) | 1999-09-16 | 2014-11-18 | Ocularis Pharma, Llc | Ophthalmic formulations including selective alpha 1 antagonists |
| WO2002004465A1 (en) | 2000-07-06 | 2002-01-17 | Fal Diagnostics | Methods and kits for the detection of arginine compounds |
| CA2431080A1 (en) | 2003-06-02 | 2004-12-02 | Catherine Adele O'brien | Enhancement of anticancer immunity through inhibition of arginase |
| US6933289B2 (en) | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
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| WO2009137378A2 (en) * | 2008-05-05 | 2009-11-12 | Schering Corporation | Sequential administration of chemotherapeutic agents for treatment of cancer |
| DK2389352T3 (da) * | 2009-01-26 | 2019-07-29 | Univ Pennsylvania | Arginaseinhibitorer og anvendelsesfremgangsmåder |
| NZ603364A (en) | 2010-04-22 | 2015-06-26 | Mars Inc | Inhibitors of arginase and their therapeutic applications |
| JP5909239B2 (ja) * | 2010-10-26 | 2016-04-26 | マーズ インコーポレイテッド | アルギナーゼ阻害剤としてのボロネート |
| CN104857005B (zh) * | 2010-12-31 | 2019-04-26 | 阿斯利康公司 | 精氨酸酶抑制剂及其使用方法 |
| WO2013059437A1 (en) | 2011-10-19 | 2013-04-25 | Mars, Incorporated | Inhibitors of arginase and their therapeutic applications |
| ES2627347T3 (es) | 2011-10-20 | 2017-07-27 | Glaxosmithkline Llc | Aza-heterociclos bicíclicos sustituidos y análogos como moduladores de sirtuina |
| EP2852598B3 (en) | 2012-04-18 | 2016-10-19 | Mars, Incorporated | Ring constrained analogs as arginase inhibitors |
| EP2914263A4 (en) * | 2012-11-02 | 2016-04-27 | Pharmacyclics Inc | ADJUVANT THERAPY WITH TEC FAMILY KINASE INHIBITOR |
| AU2014339816B2 (en) | 2013-10-25 | 2020-05-28 | Pharmacyclics Llc | Treatment using Bruton's tyrosine kinase inhibitors and immunotherapy |
| CN105879030A (zh) * | 2014-09-30 | 2016-08-24 | 复旦大学 | 治疗肿瘤的增效药物复合物及其制备方法 |
| KR20170129896A (ko) * | 2015-03-20 | 2017-11-27 | 새미 오유 오피요 | 악성 신생물에 대한 수라민 및 아르기나아제 억제제의 용도 |
| MA42269A (fr) * | 2015-06-23 | 2018-05-02 | Calithera Biosciences Inc | Compositions et procédés d'inhibition de l'activité de l'arginase |
| ES2808988T3 (es) | 2015-10-30 | 2021-03-02 | Calithera Biosciences Inc | Composiciones y métodos para inhibir la actividad arginasa |
| PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
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2016
- 2016-10-28 ES ES16860883T patent/ES2808988T3/es active Active
- 2016-10-28 CR CR20210390A patent/CR20210390A/es unknown
- 2016-10-28 CN CN202110097870.5A patent/CN113150015A/zh active Pending
- 2016-10-28 HR HRP20201046TT patent/HRP20201046T1/hr unknown
- 2016-10-28 SG SG10201911406TA patent/SG10201911406TA/en unknown
- 2016-10-28 UA UAA201805902A patent/UA125289C2/uk unknown
- 2016-10-28 CN CN202110099502.4A patent/CN113150016A/zh active Pending
- 2016-10-28 AU AU2016343656A patent/AU2016343656B2/en not_active Ceased
- 2016-10-28 PT PT168608834T patent/PT3368541T/pt unknown
- 2016-10-28 DK DK16860883.4T patent/DK3368541T3/da active
- 2016-10-28 CN CN201680063897.XA patent/CN108271371B/zh active Active
- 2016-10-28 PL PL16860883T patent/PL3368541T3/pl unknown
- 2016-10-28 SG SG10201911402YA patent/SG10201911402YA/en unknown
- 2016-10-28 BR BR122020022280-8A patent/BR122020022280B1/pt active IP Right Grant
- 2016-10-28 EP EP22150809.6A patent/EP4011887B1/en active Active
- 2016-10-28 MA MA43131A patent/MA43131B1/fr unknown
- 2016-10-28 MD MDE20180870T patent/MD3368541T2/ro unknown
- 2016-10-28 EP EP16860883.4A patent/EP3368541B1/en active Active
- 2016-10-28 MX MX2018005294A patent/MX2018005294A/es unknown
- 2016-10-28 ES ES20165627T patent/ES2910928T3/es active Active
- 2016-10-28 TW TW109135297A patent/TWI734630B/zh not_active IP Right Cessation
- 2016-10-28 WO PCT/US2016/059342 patent/WO2017075363A1/en not_active Ceased
- 2016-10-28 US US15/337,041 patent/US10065974B2/en active Active
- 2016-10-28 JP JP2018522126A patent/JP6833844B2/ja active Active
- 2016-10-28 CR CR20180282A patent/CR20180282A/es unknown
- 2016-10-28 MY MYPI2018701596A patent/MY201783A/en unknown
- 2016-10-28 LT LTEP16860883.4T patent/LT3368541T/lt unknown
- 2016-10-28 ES ES22150809T patent/ES2991555T3/es active Active
- 2016-10-28 DK DK22150809.6T patent/DK4011887T3/da active
- 2016-10-28 SG SG11201802961PA patent/SG11201802961PA/en unknown
- 2016-10-28 KR KR1020227028040A patent/KR20220118559A/ko active Pending
- 2016-10-28 SG SG10202003966RA patent/SG10202003966RA/en unknown
- 2016-10-28 HU HUE16860883A patent/HUE054972T2/hu unknown
- 2016-10-28 BR BR122020022275-1A patent/BR122020022275B1/pt active IP Right Grant
- 2016-10-28 PH PH1/2018/500899A patent/PH12018500899B1/en unknown
- 2016-10-28 TW TW110129153A patent/TWI775556B/zh not_active IP Right Cessation
- 2016-10-28 TW TW105135189A patent/TWI710565B/zh not_active IP Right Cessation
- 2016-10-28 BR BR112018008746-7A patent/BR112018008746B1/pt not_active IP Right Cessation
- 2016-10-28 SM SM20200469T patent/SMT202000469T1/it unknown
- 2016-10-28 CR CR20210389A patent/CR20210389A/es unknown
- 2016-10-28 CA CA3003271A patent/CA3003271A1/en active Pending
- 2016-10-28 EP EP20165627.9A patent/EP3693375B1/en active Active
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