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ECSP13013008A - IMIDAZOPIRIDAZINAS AS QUINASA AKT INHIBITORS - Google Patents

IMIDAZOPIRIDAZINAS AS QUINASA AKT INHIBITORS

Info

Publication number
ECSP13013008A
ECSP13013008A ECSP13013008A ECSP13013008A EC SP13013008 A ECSP13013008 A EC SP13013008A EC SP13013008 A ECSP13013008 A EC SP13013008A EC SP13013008 A ECSP13013008 A EC SP13013008A
Authority
EC
Ecuador
Prior art keywords
imidazopiridazinas
quinasa
akt inhibitors
akt
inhibitors
Prior art date
Application number
Other languages
Spanish (es)
Inventor
William J Scott
Lars Bärfacker
Hans Briem
Ulf Bömer
Andrea Hägebarth
Stuart Ince
Hartmut Rehwinkel
Oliver Politz
Roland Neuhaus
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of ECSP13013008A publication Critical patent/ECSP13013008A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Imidazopiridazinas de fórmula (I), un proceso para su producción y el uso las mismas.Imidazopyridazines of formula (I), a process for their production and use thereof.

ECSP13013008 2011-04-07 2013-11-04 IMIDAZOPIRIDAZINAS AS QUINASA AKT INHIBITORS ECSP13013008A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161472732P 2011-04-07 2011-04-07

Publications (1)

Publication Number Publication Date
ECSP13013008A true ECSP13013008A (en) 2013-12-31

Family

ID=45953129

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13013008 ECSP13013008A (en) 2011-04-07 2013-11-04 IMIDAZOPIRIDAZINAS AS QUINASA AKT INHIBITORS

Country Status (43)

Country Link
US (2) US9206185B2 (en)
EP (1) EP2694510B1 (en)
JP (1) JP5906303B2 (en)
KR (1) KR20140022057A (en)
CN (1) CN103596957B (en)
AP (1) AP3597A (en)
AR (1) AR087148A1 (en)
AU (1) AU2012238589B2 (en)
BR (1) BR112013025777A2 (en)
CA (1) CA2832374A1 (en)
CL (1) CL2013002878A1 (en)
CO (1) CO6862145A2 (en)
CR (1) CR20130515A (en)
CU (1) CU24263B1 (en)
CY (1) CY1117163T1 (en)
DK (1) DK2694510T3 (en)
DO (1) DOP2013000226A (en)
EA (1) EA024890B1 (en)
EC (1) ECSP13013008A (en)
ES (1) ES2558780T3 (en)
GT (1) GT201300238A (en)
HR (1) HRP20160011T1 (en)
HU (1) HUE026323T2 (en)
IL (1) IL228567A0 (en)
JO (1) JO3068B1 (en)
MA (1) MA35016B1 (en)
ME (1) ME02316B (en)
MX (1) MX336865B (en)
NI (1) NI201300105A (en)
PE (1) PE20141380A1 (en)
PH (1) PH12013502073A1 (en)
PL (1) PL2694510T3 (en)
PT (1) PT2694510E (en)
RS (1) RS54480B1 (en)
SG (1) SG193631A1 (en)
SI (1) SI2694510T1 (en)
SM (1) SMT201600001B (en)
TN (1) TN2013000400A1 (en)
TW (1) TWI535719B (en)
UA (1) UA111739C2 (en)
UY (1) UY34006A (en)
WO (1) WO2012136776A1 (en)
ZA (1) ZA201307223B (en)

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US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
JP5507552B2 (en) 2008-06-16 2014-05-28 ユニバーシティ オブ テネシー リサーチ ファウンデーション Compounds for treating cancer
JP5879273B2 (en) 2010-03-01 2016-03-08 ジーティーエックス・インコーポレイテッド Compounds for treating cancer
US11084811B2 (en) 2010-03-01 2021-08-10 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
WO2012136776A1 (en) * 2011-04-07 2012-10-11 Bayer Intellectual Property Gmbh Imidazopyridazines as akt kinase inhibitors
EP2802588B1 (en) * 2012-01-10 2016-05-25 Bayer Intellectual Property GmbH Substituted pyrazolopyrimidines as akt kinase inhibitors
EP2802586B1 (en) * 2012-01-10 2016-05-25 Bayer Intellectual Property GmbH Substituted imidazopyrazines as akt kinase inhibitors
US20150328320A1 (en) * 2012-11-30 2015-11-19 Glaxosmithkline Llc Novel Pharmaceutical Composition
JP6835472B2 (en) * 2013-03-05 2021-02-24 ユニバーシティ オブ テネシー リサーチ ファウンデーション Compositions for the treatment of cancer
WO2014158467A1 (en) * 2013-03-12 2014-10-02 Glaxosmithkline Llc Combination
US20160045531A1 (en) * 2013-03-14 2016-02-18 Epizyme, Inc. Combination therapy for treating cancer
CA2936024A1 (en) * 2014-01-09 2015-07-16 Bayer Pharma Aktiengesellschaft Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders
MA46888A (en) * 2016-11-28 2021-06-02 Bristol Myers Squibb Co GSK-3 INHIBITORS
EP3453706A1 (en) 2017-09-08 2019-03-13 Basf Se Pesticidal imidazole compounds
GB2600384A (en) 2020-09-30 2022-05-04 Vaderis Therapeutics Ag Allosteric AKT inhibitors for use in the treatment of hereditary hemorrhagic telangiectasia

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EP1268478B1 (en) 2000-03-31 2007-05-02 Ortho-McNeil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
JP3729343B2 (en) 2000-04-27 2005-12-21 アステラス製薬株式会社 Fused heteroaryl derivatives
EP1608628A2 (en) 2003-03-17 2005-12-28 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7579355B2 (en) 2003-04-24 2009-08-25 Merck & Co., Inc. Inhibitors of Akt activity
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DE602005026509D1 (en) 2004-04-09 2011-04-07 Merck Sharp & Dohme HEMMER OF ACT ACTIVITY
WO2006036395A2 (en) 2004-08-23 2006-04-06 Merck & Co., Inc. Inhibitors of akt activity
WO2006021303A1 (en) 2004-08-24 2006-03-02 Basf Aktiengesellschaft Imidazolium-methyl sulfites for use as starting compounds for producing ionic liquids
AU2005316826A1 (en) 2004-12-15 2006-06-22 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
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WO2012136776A1 (en) * 2011-04-07 2012-10-11 Bayer Intellectual Property Gmbh Imidazopyridazines as akt kinase inhibitors

Also Published As

Publication number Publication date
JP2014510127A (en) 2014-04-24
PT2694510E (en) 2016-02-08
CU20130135A7 (en) 2014-02-28
US20140113901A1 (en) 2014-04-24
DOP2013000226A (en) 2013-11-15
AU2012238589B2 (en) 2017-02-16
RS54480B1 (en) 2016-06-30
JP5906303B2 (en) 2016-04-20
NZ616270A (en) 2015-09-25
US9206185B2 (en) 2015-12-08
AP3597A (en) 2016-02-19
SI2694510T1 (en) 2016-02-29
CN103596957B (en) 2016-12-07
GT201300238A (en) 2015-04-06
PH12013502073A1 (en) 2014-01-13
CY1117163T1 (en) 2017-04-05
UA111739C2 (en) 2016-06-10
KR20140022057A (en) 2014-02-21
PE20141380A1 (en) 2014-10-18
SG193631A1 (en) 2013-11-29
EA201301130A1 (en) 2014-07-30
HUE026323T2 (en) 2016-05-30
CL2013002878A1 (en) 2014-05-02
AP2013007215A0 (en) 2013-10-31
ZA201307223B (en) 2014-12-23
US9604989B2 (en) 2017-03-28
MX2013011699A (en) 2014-01-31
MA35016B1 (en) 2014-04-03
EP2694510A1 (en) 2014-02-12
AU2012238589A1 (en) 2013-11-07
EP2694510B1 (en) 2015-10-14
CO6862145A2 (en) 2014-02-10
UY34006A (en) 2012-10-31
ME02316B (en) 2016-06-20
HRP20160011T1 (en) 2016-02-12
PL2694510T3 (en) 2016-03-31
JO3068B1 (en) 2017-03-15
CU24263B1 (en) 2017-07-04
ES2558780T3 (en) 2016-02-08
TW201245204A (en) 2012-11-16
CR20130515A (en) 2013-12-04
CN103596957A (en) 2014-02-19
US20150368250A1 (en) 2015-12-24
TN2013000400A1 (en) 2015-03-30
BR112013025777A2 (en) 2016-12-20
DK2694510T3 (en) 2016-01-18
IL228567A0 (en) 2013-12-31
WO2012136776A1 (en) 2012-10-11
AR087148A1 (en) 2014-02-26
MX336865B (en) 2016-02-04
CA2832374A1 (en) 2012-10-11
SMT201600001B (en) 2016-02-25
NI201300105A (en) 2014-07-14
EA024890B1 (en) 2016-10-31
TWI535719B (en) 2016-06-01

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