ECSP12012212A - Derivados de ariletinilo - Google Patents
Derivados de ariletiniloInfo
- Publication number
- ECSP12012212A ECSP12012212A ECSP12012212A ECSP12012212A EC SP12012212 A ECSP12012212 A EC SP12012212A EC SP12012212 A ECSP12012212 A EC SP12012212A EC SP12012212 A ECSP12012212 A EC SP12012212A
- Authority
- EC
- Ecuador
- Prior art keywords
- cycloalkyl
- hydrogen
- lower alkyl
- attached
- carbon atom
- Prior art date
Links
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a derivados de etinilo de la fórmula I; Ien la que:U es =N- o =C(R5)-;V es -CH= o -N=;W es =CH- o =N-;con la condición de que solamente uno de U, V o W pueda ser nitrógeno,R5 es hidrógeno, metilo o halógeno;Y es -N(R6)-, -O-, -C(R7')(R7)-, -CH2O- o -CH2S(O)2-;dicho R6 es hidrógeno o alquilo inferior y R7/R7' con independencia entre sí son hidrógeno, hidroxi, alquilo inferior o alcoxi inferior;R1 es fenilo o heteroarilo, que están opcionalmente sustituidos por uno o dos sustituyentes elegidos entre halógeno, alquilo inferior y alcoxi inferior;R2/R2' con independencia entre sí son hidrógeno, alquilo inferior, hidroxi, alcoxi inferior, cicloalquilo C3-C6, CH2-alcoxi inferior o junto con el átomo de carbono al que están unidos pueden formar un cicloalquilo C3-C6 o un anillo que contiene -CH2OCH2-;m es el número 0, 1 ó 2; en el caso de que m sea 1, R3/R3' con independencia entre sí son hidrógeno, alquilo inferior, CH2-alcoxi inferior o junto con el átomo de carbono al que están unidos pueden formar un cicloalquilo C3-C6;o R3 y R2 junto con el átomo de carbono al que están unidos pueden formar un cicloalquilo C3-6 o un anillo que contiene -(CH2)2OCH2-;n es el número 0 ó 1; en el caso de que n sea 1,R4/R4' con independencia entre sí son hidrógeno, alquilo inferior, CH2-alcoxi inferior o junto con el átomo de carbono al que están unidos pueden formar un cicloalquilo C3-C6; R4 y R2 junto con el átomo de carbono al que están unidos pueden formar un cicloalquilo C3-6;
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10159754 | 2010-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP12012212A true ECSP12012212A (es) | 2012-10-30 |
Family
ID=44140916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP12012212 ECSP12012212A (es) | 2010-04-13 | 2012-10-02 | Derivados de ariletinilo |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US8420661B2 (es) |
| EP (1) | EP2558457B1 (es) |
| JP (1) | JP5559418B2 (es) |
| KR (1) | KR101431367B1 (es) |
| CN (1) | CN102947289B (es) |
| AR (1) | AR080878A1 (es) |
| AU (1) | AU2011240131B2 (es) |
| BR (1) | BR112012026004A2 (es) |
| CA (1) | CA2786216C (es) |
| CL (1) | CL2012002771A1 (es) |
| CR (1) | CR20120480A (es) |
| CY (1) | CY1117441T1 (es) |
| DK (1) | DK2558457T3 (es) |
| EC (1) | ECSP12012212A (es) |
| ES (1) | ES2565761T3 (es) |
| HR (1) | HRP20160617T1 (es) |
| HU (1) | HUE027105T2 (es) |
| IL (1) | IL220982A (es) |
| MA (1) | MA34078B1 (es) |
| MX (1) | MX2012011841A (es) |
| MY (1) | MY160490A (es) |
| NZ (1) | NZ601024A (es) |
| PE (1) | PE20130155A1 (es) |
| PH (1) | PH12012501773A1 (es) |
| PL (1) | PL2558457T3 (es) |
| RS (1) | RS54708B1 (es) |
| RU (1) | RU2573560C2 (es) |
| SG (1) | SG183974A1 (es) |
| SI (1) | SI2558457T1 (es) |
| TW (1) | TWI445706B (es) |
| UA (1) | UA107491C2 (es) |
| WO (1) | WO2011128279A1 (es) |
| ZA (1) | ZA201207285B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8278316B2 (en) * | 2009-03-09 | 2012-10-02 | Bristol-Myers Squibb Company | Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| PL2702051T3 (pl) * | 2011-04-26 | 2015-08-31 | Hoffmann La Roche | Pochodne etynylu jako pozytywne allosteryczne modulatory mglur5 |
| US20130123254A1 (en) * | 2011-09-30 | 2013-05-16 | Barbara Biemans | Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification |
| UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
| ES2600133T3 (es) * | 2012-07-17 | 2017-02-07 | F. Hoffmann-La Roche Ag | Derivados de ariletinilo |
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| WO2014056710A1 (en) * | 2012-09-27 | 2014-04-17 | F. Hoffmann-La Roche Ag | Arylethynyl derivatives |
| UA116023C2 (uk) | 2013-07-08 | 2018-01-25 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як антагоністи метаботропного глутаматного рецептора |
| PL3049409T3 (pl) * | 2013-09-25 | 2017-09-29 | F.Hoffmann-La Roche Ag | Pochodne etynylowe |
| TWI649310B (zh) * | 2014-01-10 | 2019-02-01 | 赫孚孟拉羅股份公司 | 乙炔基衍生物 |
| EA029261B1 (ru) * | 2014-02-25 | 2018-02-28 | Ф. Хоффманн-Ля Рош Аг | Производные этинила |
| CN107207481B (zh) * | 2015-03-19 | 2020-03-03 | 豪夫迈·罗氏有限公司 | 作为mglur4的调节剂的3-(4-乙炔基苯基)六氢嘧啶-2,4-二酮衍生物 |
| AU2016273751B2 (en) * | 2015-06-03 | 2020-04-02 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| MA42442B1 (fr) | 2015-07-15 | 2019-07-31 | Hoffmann La Roche | Dérivés d'éthynyle comme modulateurs du récepteur métabotropique au glutamate |
| AR105556A1 (es) * | 2015-08-03 | 2017-10-18 | Hoffmann La Roche | Derivados de etinilo |
| CN106632243B (zh) * | 2015-10-28 | 2019-03-15 | 华领医药技术（上海）有限公司 | 吡咯烷衍生物 |
| CA3030788A1 (en) | 2016-07-18 | 2018-01-25 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| CN108947883A (zh) * | 2017-05-25 | 2018-12-07 | 北京万全德众医药生物技术有限公司 | 布瓦西坦的制备 |
| CN110753691B (zh) | 2017-06-02 | 2024-02-02 | 豪夫迈·罗氏有限公司 | 用于治疗性和/或预防性治疗癌症的化合物 |
| AR113299A1 (es) | 2017-06-02 | 2020-04-08 | Hoffmann La Roche | Compuestos de isoindolina |
| MA53003A (fr) | 2018-06-29 | 2021-05-05 | Hoffmann La Roche | Composés |
| CR20210056A (es) * | 2018-08-13 | 2021-03-02 | Hoffmann La Roche | Nuevos compuestos heterocíclicos como inhibidores de monoacilglicerol lipasa |
| CA3104928A1 (en) | 2018-08-13 | 2020-02-20 | F. Hoffmann-La Roche Ag | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
| WO2020048826A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds |
| CN113993873B (zh) | 2019-06-21 | 2024-08-02 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的egfr抑制剂 |
| TW202115070A (zh) | 2019-06-21 | 2021-04-16 | 瑞士商赫孚孟拉羅股份公司 | 新穎的egfr抑制劑 |
| KR20220062515A (ko) | 2019-09-12 | 2022-05-17 | 에프. 호프만-라 로슈 아게 | Magl 억제제로서 4,4a,5,7,8,8a-헥사피리도[4,3-b][1,4]옥사진-3-온 화합물 |
| CN114018880B (zh) * | 2021-10-22 | 2024-02-27 | 杭州食疗晶元生物科技有限公司 | 基于内源活性中间体对纯净水和天然矿泉水的鉴别方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI90869C (fi) * | 1986-11-14 | 1994-04-11 | Tanabe Seiyaku Co | Menetelmä lääkeaineena käyttökelpoisten imidatsolidinonijohdannaisten valmistamiseksi |
| GB9510744D0 (en) | 1995-05-26 | 1995-07-19 | Zeneca Ltd | Chemical process |
| DE19546462A1 (de) * | 1995-12-13 | 1997-06-19 | Bayer Ag | Diarylacetylenketone |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| EP1214303A1 (en) * | 1999-08-31 | 2002-06-19 | Merck & Co., Inc. | Heterocyclic compounds and methods of use thereof |
| CN100334085C (zh) * | 1999-09-28 | 2007-08-29 | 卫材R&D管理有限公司 | 奎宁环化合物和包含该化合物作为活性成分的药物 |
| EP1375496B1 (en) * | 2001-03-27 | 2007-07-04 | Eisai R&D Management Co., Ltd. | N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient |
| PE20050141A1 (es) * | 2003-04-23 | 2005-04-01 | Schering Corp | DERIVADOS DE 2-ALQUINIL-Y 2-ALQUENIL-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIDINA COMO ANTAGONISTAS DEL RECEPTOR A2a ADENOSINA |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| EP1729771B1 (en) * | 2004-03-22 | 2009-10-14 | Eli Lilly & Company | Pyridyl derivatives and their use as mglu5 receptor antagonists |
| WO2005108370A1 (ja) * | 2004-04-16 | 2005-11-17 | Ajinomoto Co., Inc. | ベンゼン化合物 |
| CA2583572C (en) * | 2004-10-07 | 2016-07-12 | Merck & Co., Inc. | Thiazolyl mglur5 antagonists and methods for their use |
| EP1809620B1 (en) | 2004-11-04 | 2010-12-29 | Addex Pharma SA | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| MX2009013169A (es) * | 2007-06-03 | 2010-04-30 | Univ Vanderbilt | Moduladores alostericos positivos del mglur5 benzamida y metodos de elaboracion y uso de los mismos. |
| US8853392B2 (en) | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
| WO2010063487A1 (en) * | 2008-12-05 | 2010-06-10 | Merz Pharma Gmbh & Co. Kgaa | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
| CN101544892B (zh) * | 2009-05-07 | 2012-10-03 | 石家庄诚志永华显示材料有限公司 | 一种合成二芳基乙炔类单体液晶的方法 |
| TW201116532A (en) * | 2009-08-05 | 2011-05-16 | Merz Pharma Gmbh & Co Kgaa | Metabotropic glutamate receptor modulators |
| US8389536B2 (en) | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
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2011
- 2011-04-05 US US13/066,044 patent/US8420661B2/en active Active
- 2011-04-11 SI SI201130777A patent/SI2558457T1/sl unknown
- 2011-04-11 BR BR112012026004A patent/BR112012026004A2/pt not_active Application Discontinuation
- 2011-04-11 PL PL11713288.6T patent/PL2558457T3/pl unknown
- 2011-04-11 MY MYPI2012004559A patent/MY160490A/en unknown
- 2011-04-11 RU RU2012145237/04A patent/RU2573560C2/ru not_active IP Right Cessation
- 2011-04-11 RS RS20160259A patent/RS54708B1/sr unknown
- 2011-04-11 AU AU2011240131A patent/AU2011240131B2/en not_active Ceased
- 2011-04-11 NZ NZ601024A patent/NZ601024A/en not_active IP Right Cessation
- 2011-04-11 MA MA35234A patent/MA34078B1/fr unknown
- 2011-04-11 PH PH1/2012/501773A patent/PH12012501773A1/en unknown
- 2011-04-11 ES ES11713288.6T patent/ES2565761T3/es active Active
- 2011-04-11 JP JP2013504215A patent/JP5559418B2/ja active Active
- 2011-04-11 DK DK11713288.6T patent/DK2558457T3/en active
- 2011-04-11 AR ARP110101210A patent/AR080878A1/es unknown
- 2011-04-11 CA CA2786216A patent/CA2786216C/en not_active Expired - Fee Related
- 2011-04-11 TW TW100112500A patent/TWI445706B/zh not_active IP Right Cessation
- 2011-04-11 SG SG2012066759A patent/SG183974A1/en unknown
- 2011-04-11 MX MX2012011841A patent/MX2012011841A/es active IP Right Grant
- 2011-04-11 HR HRP20160617TT patent/HRP20160617T1/hr unknown
- 2011-04-11 HU HUE11713288A patent/HUE027105T2/en unknown
- 2011-04-11 WO PCT/EP2011/055585 patent/WO2011128279A1/en not_active Ceased
- 2011-04-11 EP EP11713288.6A patent/EP2558457B1/en active Active
- 2011-04-11 PE PE2012002013A patent/PE20130155A1/es active IP Right Grant
- 2011-04-11 KR KR1020127029579A patent/KR101431367B1/ko not_active Expired - Fee Related
- 2011-04-11 CN CN201180015120.3A patent/CN102947289B/zh active Active
- 2011-11-04 UA UAA201212800A patent/UA107491C2/uk unknown
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2012
- 2012-07-16 IL IL220982A patent/IL220982A/en active IP Right Grant
- 2012-09-24 CR CR20120480A patent/CR20120480A/es unknown
- 2012-09-28 ZA ZA2012/07285A patent/ZA201207285B/en unknown
- 2012-10-02 EC ECSP12012212 patent/ECSP12012212A/es unknown
- 2012-10-03 CL CL2012002771A patent/CL2012002771A1/es unknown
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2013
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2016
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