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ECSP11011124A - Antagonistas de 4-azetidinil-1-heteroaril-ciclohexanol de ccr2 - Google Patents

Antagonistas de 4-azetidinil-1-heteroaril-ciclohexanol de ccr2

Info

Publication number
ECSP11011124A
ECSP11011124A EC2011011124A ECSP11011124A ECSP11011124A EC SP11011124 A ECSP11011124 A EC SP11011124A EC 2011011124 A EC2011011124 A EC 2011011124A EC SP11011124 A ECSP11011124 A EC SP11011124A EC SP11011124 A ECSP11011124 A EC SP11011124A
Authority
EC
Ecuador
Prior art keywords
ccr2
formula
ciclohexanol
azetidinil
heteroaril
Prior art date
Application number
EC2011011124A
Other languages
English (en)
Inventor
Dana L Johnson
Heather Rae Hufnagel
Zhihua Sui
Barry Fegely
Xuqing Zhang
Cuifen Hou
David Breslin
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41510894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11011124(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP11011124A publication Critical patent/ECSP11011124A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)

Abstract

La presente invención comprende los compuestos de la Fórmula (I). Fórmula (I).en donde: R1, R2, R3, y R4 son como se definió en la descripción. La invención comprende, además, las composiciones farmacéuticas que comprenden los compuestos de la Fórmula (I) y los métodos de prevenir, tratar o mejorar un síndrome, trastorno o enfermedad mediada por CCR2, por ejemplo, diabetes tipo II, obesidad o asma, al administrar los compuesto de la Fórmula (I).
EC2011011124A 2008-12-10 2011-06-10 Antagonistas de 4-azetidinil-1-heteroaril-ciclohexanol de ccr2 ECSP11011124A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12127208P 2008-12-10 2008-12-10
US16729509P 2009-04-07 2009-04-07

Publications (1)

Publication Number Publication Date
ECSP11011124A true ECSP11011124A (es) 2011-07-29

Family

ID=41510894

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011124A ECSP11011124A (es) 2008-12-10 2011-06-10 Antagonistas de 4-azetidinil-1-heteroaril-ciclohexanol de ccr2

Country Status (28)

Country Link
US (1) US8450304B2 (es)
EP (1) EP2376475B1 (es)
JP (1) JP5782381B2 (es)
KR (1) KR20110094325A (es)
CN (1) CN102317278B (es)
AR (1) AR074583A1 (es)
AU (1) AU2009324723B2 (es)
BR (1) BRPI0923237A2 (es)
CA (1) CA2745969C (es)
CL (1) CL2011001427A1 (es)
CO (1) CO6331470A2 (es)
CR (1) CR20110381A (es)
EA (1) EA018997B1 (es)
EC (1) ECSP11011124A (es)
ES (1) ES2555004T3 (es)
HN (1) HN2011001606A (es)
IL (1) IL213250A0 (es)
MX (1) MX2011006226A (es)
NI (1) NI201100117A (es)
NZ (1) NZ593172A (es)
PA (1) PA8853001A1 (es)
PE (1) PE20110928A1 (es)
SG (1) SG171998A1 (es)
SV (1) SV2011003944A (es)
TW (1) TW201033204A (es)
UY (1) UY32312A (es)
WO (1) WO2010068663A1 (es)
ZA (1) ZA201105056B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA018997B1 (ru) 2008-12-10 2013-12-30 Янссен Фармацевтика Нв Антагонисты ccr2 группы 4-азетидинил-1-гетероарилциклогексанола
AU2010236393B2 (en) * 2009-04-16 2014-11-13 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of CCR2
WO2010121046A1 (en) 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
ES2541607T3 (es) 2009-04-17 2015-07-22 Janssen Pharmaceutica Nv Antagonistas de CCR2 de ciclohexano unido a 4-azetidinilo-1-heteroátomo
TW201211027A (en) * 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
KR101743280B1 (ko) * 2010-06-17 2017-06-02 얀센 파마슈티카 엔.브이. Ccr2의 사이클로헥실-아제티디닐 길항제
EP2771484A1 (en) 2011-10-28 2014-09-03 Galderma Research & Development New leukocyte infiltrate markers for rosacea and uses thereof
MA42133A (fr) 2015-05-21 2021-06-02 Chemocentryx Inc Modulateurs du ccr2
BR112020005284A2 (pt) 2017-09-25 2020-09-24 Chemocentryx, Inc. terapia de combinação usando um antagonista do receptor de quimiocina 2 (ccr2) e um inibidor de pd-1/pd-l1
CN107793404A (zh) * 2017-11-07 2018-03-13 全椒先奇医药科技有限公司 一种治疗缺血性脑损伤药物组合物及其应用
IL275898B2 (en) 2018-01-08 2025-05-01 Chemocentryx Inc Methods for treating solid tumors with CCR2 antagonists
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037354A (en) * 1997-06-18 2000-03-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
CA2293408A1 (en) 1997-06-18 1998-12-23 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
CN1192773C (zh) * 1999-08-04 2005-03-16 帝人株式会社 环胺ccr3拮抗剂
CA2390531A1 (en) 1999-11-08 2001-05-17 Wyeth ¬(indol-3-yl)-cycloalkyl|-3-substituted azetidines for the treatment of central nervous system disorders
US6245799B1 (en) * 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
CA2432369A1 (en) * 2000-12-20 2002-08-08 Bristol-Myers Squibb Pharma Company Cyclic derivatives as modulators of chemokine receptor activity
KR100895968B1 (ko) * 2002-11-27 2009-05-07 인사이트 코포레이션 케모킨 수용체의 조절자로서의 3-아미노피롤리딘 유도체
CN1741994A (zh) * 2002-11-27 2006-03-01 因塞特公司 作为趋化因子受体调节剂的3－氨基吡咯烷衍生物
EP1696919B1 (en) 2003-12-18 2013-10-02 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
KR20070063562A (ko) * 2004-09-28 2007-06-19 얀센 파마슈티카 엔.브이. 치환 디피페리딘 ｃｃｒ２ 길항제
US20060073592A1 (en) * 2004-10-06 2006-04-06 Wendell Sun Methods of storing tissue matrices
PA8653301A1 (es) * 2004-11-22 2006-11-09 Incyte Corp Incyte Corp Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il) ciclohexil)pirrolidin
GB0513747D0 (en) 2005-07-06 2005-08-10 Merck Sharp & Dohme Therapeutic compounds
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US20070197590A1 (en) 2006-01-31 2007-08-23 Demong Duane E Substituted dipiperidine ccr2 antagonists
EA018997B1 (ru) 2008-12-10 2013-12-30 Янссен Фармацевтика Нв Антагонисты ccr2 группы 4-азетидинил-1-гетероарилциклогексанола
AU2010236393B2 (en) 2009-04-16 2014-11-13 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of CCR2
WO2010121046A1 (en) * 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
ES2541607T3 (es) 2009-04-17 2015-07-22 Janssen Pharmaceutica Nv Antagonistas de CCR2 de ciclohexano unido a 4-azetidinilo-1-heteroátomo

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EP2376475A1 (en) 2011-10-19
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