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ECSP11011118A - ESPIRO AZEPAN OXAZOLIDINONAS COMO BLOQUEADORES DEL CANAL DE POTASIO Kv1.3 - Google Patents

ESPIRO AZEPAN OXAZOLIDINONAS COMO BLOQUEADORES DEL CANAL DE POTASIO Kv1.3

Info

Publication number
ECSP11011118A
ECSP11011118A EC2011011118A ECSP11011118A ECSP11011118A EC SP11011118 A ECSP11011118 A EC SP11011118A EC 2011011118 A EC2011011118 A EC 2011011118A EC SP11011118 A ECSP11011118 A EC SP11011118A EC SP11011118 A ECSP11011118 A EC SP11011118A
Authority
EC
Ecuador
Prior art keywords
compounds
azepan
methods
blockers
oxazolidinonas
Prior art date
Application number
EC2011011118A
Other languages
English (en)
Inventor
Pieter Smid
Michael Mlinaric
H M Josephus Lange
F Konrad Koehler
Garcia Sara Nunez
Elmar Wegener
Original Assignee
Abbott Healthcare Products Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Healthcare Products Bv filed Critical Abbott Healthcare Products Bv
Publication of ECSP11011118A publication Critical patent/ECSP11011118A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta invención se refiere a espiro azepan oxazolidinonas como bloqueadores del canal de calcio Kv1.3 voltaje dependiente, a composiciones farmacéuticas que contienen estos compuestos, a métodos para preparar los compuestos, a métodos para preparar nuevos compuestos intermedios útiles para su síntesis, y a métodos para preparar composiciones. La invención también se refiere a los usos de tales compuestos y composiciones, particularmente a su uso para administrarlos a pacientes para lograr un efecto terapéutico en diabetes y neuropatías inflamatorias, incluyendo enfermedades autoinmunes en las cuales las células T actúan como mediador, tales como artritis reumatoide y esclerosis múltiple. Los compuestos tienen la fórmula (1):
EC2011011118A 2008-12-12 2011-06-09 ESPIRO AZEPAN OXAZOLIDINONAS COMO BLOQUEADORES DEL CANAL DE POTASIO Kv1.3 ECSP11011118A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12191308P 2008-12-12 2008-12-12
EP08171421 2008-12-12

Publications (1)

Publication Number Publication Date
ECSP11011118A true ECSP11011118A (es) 2011-07-29

Family

ID=40513443

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011118A ECSP11011118A (es) 2008-12-12 2011-06-09 ESPIRO AZEPAN OXAZOLIDINONAS COMO BLOQUEADORES DEL CANAL DE POTASIO Kv1.3

Country Status (20)

Country Link
US (1) US8575148B2 (es)
EP (1) EP2376501A1 (es)
JP (1) JP2012511546A (es)
KR (1) KR20110110165A (es)
CN (1) CN102333782A (es)
AR (1) AR074558A1 (es)
AU (1) AU2009324358A1 (es)
BR (1) BRPI0922714A2 (es)
CA (1) CA2743557A1 (es)
CO (1) CO6390036A2 (es)
CR (1) CR20110302A (es)
DO (1) DOP2011000164A (es)
EA (1) EA201170801A1 (es)
EC (1) ECSP11011118A (es)
IL (1) IL212948A0 (es)
MX (1) MX2011006221A (es)
PE (1) PE20110772A1 (es)
TW (1) TW201026708A (es)
WO (1) WO2010066840A1 (es)
ZA (1) ZA201104041B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1201048A1 (en) 2011-10-03 2015-08-21 The Regents Of The University Of California Treatment of obesity and obesity-related disorders by pharmacological targeting of kv1.3 potassium channels
KR20150075091A (ko) * 2012-10-29 2015-07-02 에프. 호프만-라 로슈 아게 3,4-이치환된 옥사졸리디논 유도체 및 칼슘 활성화 칼륨 채널의 억제제로서 이의 용도
TWI701249B (zh) 2015-03-13 2020-08-11 德商４Ｓｃ製藥公司 Ｋv１.３抑制劑及其醫學應用
TWI698438B (zh) 2015-03-13 2020-07-11 德商４Ｓｃ製藥公司 Ｋv１.３抑制劑及其醫學應用
CN109053751A (zh) * 2018-08-30 2018-12-21 成都海博锐药业有限公司 具有螺环结构的fxr调节剂
WO2020252130A1 (en) * 2019-06-12 2020-12-17 Lieber Institute, Inc. Kv11.1-3.1 inhibiting methods and compositions
KR20220079575A (ko) * 2019-10-07 2022-06-13 디.이. 쇼우 리서치, 엘엘씨 Kv1.3 칼륨 셰이커 채널 차단제로서의 아릴 헤테로비시클릭 화합물
WO2021071812A1 (en) * 2019-10-07 2021-04-15 D.E Shaw Research, Llc Arylmethylene heterocyclic compounds as kv1.3 potassium shaker channel blockers
JP7780440B2 (ja) * 2019-10-07 2025-12-04 ディー．イー．ショウ リサーチ，エルエルシー Ｋｖ１．３カリウムシェーカーチャネル遮断薬としてのアリール複素二環式化合物
CN111574537B (zh) * 2020-05-20 2022-11-15 成都药明康德新药开发有限公司 叔丁基-8-氧杂-3,11-二氮杂螺[5.6]十二烷-3-甲酸基酯的合成方法
AU2022364718A1 (en) * 2021-10-13 2024-05-16 Vanqua Bio, Inc. Small molecule modulators of glucocerebrosidase activity and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303637B1 (en) 1998-10-30 2001-10-16 Merck & Co., Inc. Heterocyclic potassium channel inhibitors

Also Published As

Publication number Publication date
US20110237569A1 (en) 2011-09-29
EA201170801A1 (ru) 2011-12-30
US8575148B2 (en) 2013-11-05
ZA201104041B (en) 2012-11-28
TW201026708A (en) 2010-07-16
CO6390036A2 (es) 2012-02-29
EP2376501A1 (en) 2011-10-19
AR074558A1 (es) 2011-01-26
KR20110110165A (ko) 2011-10-06
PE20110772A1 (es) 2011-10-19
WO2010066840A1 (en) 2010-06-17
MX2011006221A (es) 2011-06-28
DOP2011000164A (es) 2011-06-30
BRPI0922714A2 (pt) 2016-01-05
AU2009324358A1 (en) 2011-06-23
CR20110302A (es) 2011-10-27
IL212948A0 (en) 2011-07-31
CN102333782A (zh) 2012-01-25
CA2743557A1 (en) 2010-06-17
JP2012511546A (ja) 2012-05-24

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