ECSP10010427A - DERIVADOS DE IMIDAZO-[1,2-b]-PIRIDAZINA PARA EL TRATAMIENTO DE ENFERMEDAD MEDIADA POR CINASA DE TIROSINA C-MET - Google Patents
DERIVADOS DE IMIDAZO-[1,2-b]-PIRIDAZINA PARA EL TRATAMIENTO DE ENFERMEDAD MEDIADA POR CINASA DE TIROSINA C-METInfo
- Publication number
- ECSP10010427A ECSP10010427A EC2010010427A ECSP10010427A ECSP10010427A EC SP10010427 A ECSP10010427 A EC SP10010427A EC 2010010427 A EC2010010427 A EC 2010010427A EC SP10010427 A ECSP10010427 A EC SP10010427A EC SP10010427 A ECSP10010427 A EC SP10010427A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- met
- formula
- piridazine
- compound
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención se refiere a los compuestos de la fórmula (I) y sales de los mismos; en donde los sustituyentes son como se definen en la memoria descriptiva, a la aplicación de un compuesto de la fórmula (I) en un proceso para el tratamiento del cuerpo humano o animal, en particular con respecto una enfermedad mediada por la cinasa de tirosina c-Met; al uso de un compuesto de la fórmula (I) para la fabricación de un medicamento para el tratamiento de estas enfermedades; a composiciones farmacéuticas que comprenden un compuesto de la fórmula (I), opcionalmente en la presencia de un componente de combinación; y a procesos para la preparación de un compuesto de la fórmula (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08152068 | 2008-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP10010427A true ECSP10010427A (es) | 2010-09-30 |
Family
ID=39672115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2010010427A ECSP10010427A (es) | 2008-02-28 | 2010-08-27 | DERIVADOS DE IMIDAZO-[1,2-b]-PIRIDAZINA PARA EL TRATAMIENTO DE ENFERMEDAD MEDIADA POR CINASA DE TIROSINA C-MET |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8822468B2 (es) |
| EP (1) | EP2265614A1 (es) |
| JP (1) | JP5576802B2 (es) |
| KR (1) | KR20100128305A (es) |
| CN (1) | CN102015716B (es) |
| AR (1) | AR070487A1 (es) |
| AU (1) | AU2009218459A1 (es) |
| BR (1) | BRPI0908504A2 (es) |
| CA (1) | CA2717034A1 (es) |
| CL (1) | CL2009000443A1 (es) |
| CO (1) | CO6300957A2 (es) |
| CR (1) | CR11620A (es) |
| DO (1) | DOP2010000263A (es) |
| EA (1) | EA201001365A1 (es) |
| EC (1) | ECSP10010427A (es) |
| IL (1) | IL207434A0 (es) |
| MA (1) | MA32167B1 (es) |
| MX (1) | MX2010009414A (es) |
| NI (1) | NI201000145A (es) |
| PE (1) | PE20091468A1 (es) |
| SM (1) | SMAP201000112A (es) |
| TW (1) | TW200940545A (es) |
| UY (1) | UY31676A1 (es) |
| WO (1) | WO2009106577A1 (es) |
| ZA (1) | ZA201005602B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32049A (es) * | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
| US20110053968A1 (en) * | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
| US8389526B2 (en) * | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| BR112012003262A8 (pt) | 2009-08-12 | 2016-05-17 | Novartis Ag | compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação |
| BR112012008061A2 (pt) | 2009-08-20 | 2016-03-01 | Novartis Ag | compostos de oxima heterocíclica |
| PE20130375A1 (es) | 2009-12-31 | 2013-04-10 | Hutchison Medipharma Ltd | Compuestos de triazolopiridinas y triazolopirazinas inhibidores de c-met y composiciones de los mismos |
| US20110195066A1 (en) * | 2010-02-05 | 2011-08-11 | Auspex Pharmaceuticals, Inc. | Quinoline inhibitors of tyrosine kinase |
| WO2012003338A1 (en) * | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| AR085183A1 (es) | 2010-07-30 | 2013-09-18 | Lilly Co Eli | Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| WO2012175591A1 (en) * | 2011-06-22 | 2012-12-27 | Bayer Intellectual Property Gmbh | Heterocyclyl aminoimidazopyridazines |
| CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
| EP2755976B1 (en) | 2011-09-15 | 2018-07-18 | Novartis AG | 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors |
| CN103122000B (zh) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术(太仓)有限公司 | 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂 |
| RS56720B1 (sr) | 2012-11-19 | 2018-03-30 | Novartis Ag | Jedinjenja i kompozicije za lečenje parazitskih oboljenja |
| WO2014138692A1 (en) | 2013-03-07 | 2014-09-12 | Califia Bio, Inc. | Mixed lineage kinase inhibitors and method of treatments |
| AR097543A1 (es) * | 2013-09-06 | 2016-03-23 | Lexicon Pharmaceuticals Inc | COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO |
| CN105326793A (zh) * | 2014-08-06 | 2016-02-17 | 中美冠科生物技术(太仓)有限公司 | 一种包含c-Met激酶抑制剂的固体分散体及其制备方法和用途 |
| CN107108633B (zh) * | 2014-12-19 | 2020-05-12 | 詹森药业有限公司 | 作为PI3Kβ抑制剂的杂环基连接的咪唑并哒嗪衍生物 |
| US10087187B2 (en) * | 2014-12-19 | 2018-10-02 | Janssen Pharmaceutica Nv | Imidazopyridazine derivatives as PI3KB inhibitors |
| EP3512852B1 (en) * | 2016-09-16 | 2024-06-26 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Traf 6 inhibitors |
| EP3558304A2 (en) * | 2016-12-23 | 2019-10-30 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases |
| WO2018138050A1 (de) | 2017-01-26 | 2018-08-02 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| US11584744B2 (en) * | 2017-06-23 | 2023-02-21 | University Of Washington | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them |
| JP7296992B2 (ja) * | 2018-05-28 | 2023-06-23 | エフ. ホフマン-ラ ロシュ アーゲー | 細菌感染症の処置および予防のための新規オキソキノリジン化合物 |
| JP7712932B2 (ja) * | 2019-12-18 | 2025-07-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Lin28の阻害剤及びその使用方法 |
| CN119081395B (zh) * | 2024-09-07 | 2025-03-18 | 广东环塑众创实业有限公司 | 一种耐高温尼龙工程塑料及其制备方法 |
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| US3489755A (en) | 1966-08-03 | 1970-01-13 | Pfizer & Co C | Imidazo (1,2-b) pyridazines |
| GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
| FR2619818B1 (fr) | 1987-09-01 | 1990-01-12 | Sanofi Sa | Imidazo (1,2-b) pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| CA2057089A1 (en) | 1990-12-07 | 1992-06-08 | Eric E. Allen | Substituted pyrazolopyrimidines and imidazopyridazines as angiotensin ii antagonists |
| ATE300540T1 (de) | 2000-04-27 | 2005-08-15 | Yamanouchi Pharma Co Ltd | Imidazopyridin-derivate |
| TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
| AU2003297160A1 (en) | 2002-12-18 | 2004-07-22 | Vertex Pharmaceuticals Incorporated | Benzisoxazole derivatives useful as inhibitors of protein kinases |
| EP1641761A4 (en) | 2003-06-30 | 2008-05-14 | Merck & Co Inc | 17-ACETAMIDO-4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS |
| US7037909B2 (en) | 2003-07-02 | 2006-05-02 | Sugen, Inc. | Tetracyclic compounds as c-Met inhibitors |
| US7122548B2 (en) | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| EP1677799A4 (en) | 2003-10-21 | 2008-09-10 | Merck & Co Inc | TRIAZOLO-PYRIDAZINE COMPOUNDS AND DERIVATIVES THEREOF FOR THE TREATMENT OF NEUROPATHIC PAIN |
| EP2251327B1 (en) | 2003-11-19 | 2014-02-12 | Array Biopharma, Inc. | Heterocyclic inhibitors of mek |
| US7626030B2 (en) | 2004-01-23 | 2009-12-01 | Amgen Inc. | Compounds and methods of use |
| EP1713784A1 (en) | 2004-02-12 | 2006-10-25 | Neurogen Corporation | Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands |
| US7456289B2 (en) | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
| KR100973609B1 (ko) | 2005-03-23 | 2010-08-03 | 에프. 호프만-라 로슈 아게 | mGluR2 길항제로서 아세틸렌일-피라졸로-피리미딘유도체 |
| US20090156617A1 (en) | 2005-05-12 | 2009-06-18 | Northrup Alan B | Tyrosine kinase inhibitors |
| JP2009502734A (ja) * | 2005-07-29 | 2009-01-29 | アステラス製薬株式会社 | Lck阻害剤としての縮合複素環 |
| US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| EP1963329B1 (en) | 2005-11-30 | 2013-01-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-met and uses thereof |
| US7348325B2 (en) | 2005-11-30 | 2008-03-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| RS55630B1 (sr) | 2005-12-21 | 2017-06-30 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
| NL2000613C2 (nl) | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
| CA2651979A1 (en) | 2006-05-30 | 2007-12-06 | Pfizer Products Inc. | Triazolopyridazine derivatives |
| US8198448B2 (en) * | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
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| PE20121506A1 (es) * | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
| AU2007279595A1 (en) | 2006-08-04 | 2008-02-07 | Takeda Pharmaceutical Company Limited | Fused heterocyclic derivative and use thereof |
| JP2010500365A (ja) | 2006-08-07 | 2010-01-07 | インサイト・コーポレイション | キナーゼ阻害剤としてのトリアゾロトリアジン |
| WO2008030744A2 (en) | 2006-09-05 | 2008-03-13 | Board Of Regents, The University Of Texas System | Inhibitors of c-met and uses thereof |
| US20110021513A1 (en) | 2006-09-07 | 2011-01-27 | Biogen Idec Ma Inc. | Modulators of interleukin-1 receptor-associated kinase |
| BRPI0717317A2 (pt) | 2006-10-23 | 2013-10-22 | Sgx Pharmaceuticals Inc | Modularoes da proteína cinase triazalopiridazina |
| CN103288833B (zh) | 2006-11-22 | 2018-01-12 | 因塞特控股公司 | 作为激酶抑制剂的咪唑并三嗪和咪唑并嘧啶 |
| AR064420A1 (es) | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
| WO2009011954A2 (en) | 2007-04-27 | 2009-01-22 | Alaka'i Consulting & Engineering, Inc. | Laser spectroscopy system |
| EP2170894A1 (en) | 2007-06-21 | 2010-04-07 | Janssen Pharmaceutica N.V. | Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline |
| EP2217601A1 (en) * | 2007-11-08 | 2010-08-18 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Imidazopyridazines for use as protein kinase inhibitors |
| US20110097189A1 (en) | 2007-12-31 | 2011-04-28 | Aaron Sandoval | Boundary layer effect turbine |
| JP2009227599A (ja) | 2008-03-21 | 2009-10-08 | Daiichi Sankyo Co Ltd | イミダゾピリダジン誘導体 |
-
2009
- 2009-02-26 AU AU2009218459A patent/AU2009218459A1/en not_active Abandoned
- 2009-02-26 PE PE2009000287A patent/PE20091468A1/es not_active Application Discontinuation
- 2009-02-26 CN CN200980114928.XA patent/CN102015716B/zh not_active Expired - Fee Related
- 2009-02-26 WO PCT/EP2009/052302 patent/WO2009106577A1/en not_active Ceased
- 2009-02-26 AR ARP090100659A patent/AR070487A1/es unknown
- 2009-02-26 KR KR1020107021426A patent/KR20100128305A/ko not_active Ceased
- 2009-02-26 CA CA2717034A patent/CA2717034A1/en not_active Abandoned
- 2009-02-26 BR BRPI0908504-1A patent/BRPI0908504A2/pt not_active IP Right Cessation
- 2009-02-26 UY UY031676A patent/UY31676A1/es not_active Application Discontinuation
- 2009-02-26 EA EA201001365A patent/EA201001365A1/ru unknown
- 2009-02-26 EP EP09714429A patent/EP2265614A1/en not_active Withdrawn
- 2009-02-26 JP JP2010548110A patent/JP5576802B2/ja not_active Expired - Fee Related
- 2009-02-26 MX MX2010009414A patent/MX2010009414A/es not_active Application Discontinuation
- 2009-02-27 CL CL2009000443A patent/CL2009000443A1/es unknown
- 2009-02-27 TW TW098106564A patent/TW200940545A/zh unknown
- 2009-03-02 US US12/396,137 patent/US8822468B2/en not_active Expired - Fee Related
-
2010
- 2010-08-05 IL IL207434A patent/IL207434A0/en unknown
- 2010-08-05 ZA ZA2010/05602A patent/ZA201005602B/en unknown
- 2010-08-06 CR CR11620A patent/CR11620A/es not_active Application Discontinuation
- 2010-08-27 DO DO2010000263A patent/DOP2010000263A/es unknown
- 2010-08-27 NI NI201000145A patent/NI201000145A/es unknown
- 2010-08-27 EC EC2010010427A patent/ECSP10010427A/es unknown
- 2010-08-27 CO CO10106017A patent/CO6300957A2/es not_active Application Discontinuation
- 2010-09-24 MA MA33198A patent/MA32167B1/fr unknown
- 2010-09-28 SM SM201000112T patent/SMAP201000112A/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5576802B2 (ja) | 2014-08-20 |
| AR070487A1 (es) | 2010-04-07 |
| BRPI0908504A2 (pt) | 2015-08-11 |
| US20090264406A1 (en) | 2009-10-22 |
| SMAP201000112A (it) | 2010-11-12 |
| MX2010009414A (es) | 2010-09-24 |
| AU2009218459A1 (en) | 2009-09-03 |
| TW200940545A (en) | 2009-10-01 |
| EA201001365A1 (ru) | 2011-04-29 |
| UY31676A1 (es) | 2009-09-30 |
| NI201000145A (es) | 2011-03-02 |
| CR11620A (es) | 2010-10-08 |
| IL207434A0 (en) | 2010-12-30 |
| ZA201005602B (en) | 2011-04-28 |
| WO2009106577A1 (en) | 2009-09-03 |
| EP2265614A1 (en) | 2010-12-29 |
| CO6300957A2 (es) | 2011-07-21 |
| JP2011513279A (ja) | 2011-04-28 |
| CN102015716A (zh) | 2011-04-13 |
| DOP2010000263A (es) | 2010-09-30 |
| CN102015716B (zh) | 2014-09-17 |
| KR20100128305A (ko) | 2010-12-07 |
| PE20091468A1 (es) | 2009-10-22 |
| MA32167B1 (fr) | 2011-03-01 |
| US8822468B2 (en) | 2014-09-02 |
| CA2717034A1 (en) | 2009-09-03 |
| CL2009000443A1 (es) | 2010-09-10 |
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