EA201892814A1 - Радиофармацевтические комплексы - Google Patents
Радиофармацевтические комплексыInfo
- Publication number
- EA201892814A1 EA201892814A1 EA201892814A EA201892814A EA201892814A1 EA 201892814 A1 EA201892814 A1 EA 201892814A1 EA 201892814 A EA201892814 A EA 201892814A EA 201892814 A EA201892814 A EA 201892814A EA 201892814 A1 EA201892814 A1 EA 201892814A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tissue
- specific
- complexing agent
- thorium
- complex
- Prior art date
Links
- 229940121896 radiopharmaceutical Drugs 0.000 title 1
- 239000012217 radiopharmaceutical Substances 0.000 title 1
- 230000002799 radiopharmaceutical effect Effects 0.000 title 1
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 abstract 3
- 229910052776 Thorium Inorganic materials 0.000 abstract 3
- 239000008139 complexing agent Substances 0.000 abstract 3
- SNUSZUYTMHKCPM-UHFFFAOYSA-N 1-hydroxypyridin-2-one Chemical compound ON1C=CC=CC1=O SNUSZUYTMHKCPM-UHFFFAOYSA-N 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 102000005593 Endopeptidases Human genes 0.000 abstract 1
- 108010059378 Endopeptidases Proteins 0.000 abstract 1
- LBDSXVIYZYSRII-IGMARMGPSA-N alpha-particle Chemical compound [4He+2] LBDSXVIYZYSRII-IGMARMGPSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 206010020718 hyperplasia Diseases 0.000 abstract 1
- 230000002390 hyperplastic effect Effects 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1075—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being against an enzyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретение обеспечивает способ образования тканеспецифического ториевого комплекса, причём вышеуказанный способ включает а) образование октадентатного комплексообразователя, который включает четыре гидроксипиридиноновых (HOPO) фрагмента, замещенных в N-положении метильной группой, и связующий фрагмент, который заканчивается карбоновокислотной группой; б) соединение вышеуказанного октадентатного комплексообразователя по крайней мере с одним тканеспецифическим фрагментом, направленным на FAP пропилэндопептидазы; и в) контактирование вышеуказанного тканеспецифического комплексообразователя с водным раствором, который включает ион по крайней мере одного излучающего α-частицы изотопа тория. Также обеспечивается способ лечения неопластического или гиперпластического заболевания, который включает введение такого тканеспецифического ториевого комплекса, а также комплекс и соответствующие фармацевтические композиции.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16173874 | 2016-06-10 | ||
| PCT/EP2017/063689 WO2017211809A1 (en) | 2016-06-10 | 2017-06-06 | Radio-pharmaceutical complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201892814A1 true EA201892814A1 (ru) | 2019-06-28 |
Family
ID=56132786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201892814A EA201892814A1 (ru) | 2016-06-10 | 2017-06-06 | Радиофармацевтические комплексы |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20190298865A1 (ru) |
| EP (1) | EP3468619A1 (ru) |
| JP (1) | JP2019517547A (ru) |
| KR (1) | KR20190016544A (ru) |
| CN (1) | CN109689115A (ru) |
| AR (1) | AR110466A1 (ru) |
| AU (1) | AU2017277463A1 (ru) |
| BR (1) | BR112018075554A2 (ru) |
| CA (1) | CA3026900A1 (ru) |
| CL (1) | CL2018003550A1 (ru) |
| CO (1) | CO2018013359A2 (ru) |
| CR (1) | CR20180581A (ru) |
| CU (1) | CU20180149A7 (ru) |
| DO (1) | DOP2018000277A (ru) |
| EA (1) | EA201892814A1 (ru) |
| EC (1) | ECSP18091468A (ru) |
| IL (1) | IL263538A (ru) |
| MA (1) | MA45225A (ru) |
| MX (1) | MX2018015340A (ru) |
| NI (1) | NI201800136A (ru) |
| PE (1) | PE20190327A1 (ru) |
| PH (1) | PH12018502605A1 (ru) |
| SG (1) | SG11201810967VA (ru) |
| TW (1) | TW201805025A (ru) |
| UY (1) | UY37286A (ru) |
| WO (1) | WO2017211809A1 (ru) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| CN109069488B (zh) | 2016-03-07 | 2021-09-07 | 英安塔制药有限公司 | 乙型肝炎抗病毒剂 |
| EP3675637A4 (en) | 2017-08-28 | 2021-05-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2019143902A2 (en) | 2018-01-22 | 2019-07-25 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| MX2021003253A (es) | 2018-09-21 | 2021-08-11 | Enanta Pharm Inc | Heterociclos funcionalizados como agentes antivirales. |
| SG11202105007TA (en) | 2018-11-21 | 2021-06-29 | Enanta Pharm Inc | Functionalized heterocycles as antiviral agents |
| US11236111B2 (en) | 2019-06-03 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| CN118406106A (zh) | 2019-07-08 | 2024-07-30 | 3B制药有限公司 | 包含成纤维细胞活化蛋白配体的化合物及其用途 |
| BR112022000144A2 (pt) | 2019-07-08 | 2022-02-22 | 3B Pharmaceuticals Gmbh | Compostos que compreendem um ligante de proteína de ativação de fibroblastos e uso dos mesmos |
| EP3763726A1 (en) | 2019-07-08 | 2021-01-13 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US20230072421A1 (en) | 2019-07-25 | 2023-03-09 | Bayer As | Targeted radiopharmaceuticals for the diagnosis and treatment of prostate cancer |
| US11236108B2 (en) | 2019-09-17 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| IL301285A (en) | 2020-09-10 | 2023-05-01 | Precirix N V | A portion of an antibody against FAP |
| IL303925A (en) | 2021-01-07 | 2023-08-01 | 3B Pharmaceuticals Gmbh | Compounds comprising a fibroblast activation protein ligand and use thereof |
| EP4050018A1 (en) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| WO2023213801A1 (en) | 2022-05-02 | 2023-11-09 | Precirix N.V. | Pre-targeting |
| US20250186630A1 (en) | 2023-12-12 | 2025-06-12 | Viewpoint Molecular Targeting, Inc. | Fibroblast activation protein targeting peptides |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| US4880615A (en) | 1988-11-25 | 1989-11-14 | Merck & Co., Inc. | Stabilized radiopharmaceutical compositions |
| US5624901A (en) | 1994-04-15 | 1997-04-29 | The Regents Of The University Of California | 3-hydroxy-2(1H)-pyridinone chelating agents |
| NO312708B1 (no) | 2000-02-21 | 2002-06-24 | Anticancer Therapeutic Inv Sa | Radioaktive liposomer til terapi |
| NO313180B1 (no) | 2000-07-04 | 2002-08-26 | Anticancer Therapeutic Inv Sa | Bensökende alfapartikkel emitterende radiofarmasöytika |
| GB0308731D0 (en) | 2003-04-15 | 2003-05-21 | Anticancer Therapeutic Inv Sa | Method of radiotherapy |
| WO2008063721A2 (en) | 2006-08-15 | 2008-05-29 | The Regents Of The University Of California | Luminescent macrocyclic lanthanide complexes |
| AU2010301105A1 (en) * | 2009-10-02 | 2012-04-19 | Ludwig Institute For Cancer Research Ltd. | Anti-fibroblast activation protein antibodies and methods and uses thereof |
| WO2011079291A1 (en) * | 2009-12-24 | 2011-06-30 | Lumiphore, Inc. | Radiopharmaceutical complexes |
| GB201002508D0 (en) * | 2010-02-12 | 2010-03-31 | Algeta As | Product |
| GB201208309D0 (en) | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
| NL2009131C2 (en) * | 2012-07-05 | 2014-01-07 | Stichting Vu Vumc | Compound and use of compound to prepare a radiollabelled compound. |
| MA41176A (fr) * | 2014-12-17 | 2017-10-24 | Bayer As | Complexes radio-pharmaceutiques |
-
2017
- 2017-06-06 EP EP17729086.3A patent/EP3468619A1/en not_active Withdrawn
- 2017-06-06 CU CU2018000149A patent/CU20180149A7/es unknown
- 2017-06-06 BR BR112018075554A patent/BR112018075554A2/pt not_active Application Discontinuation
- 2017-06-06 AU AU2017277463A patent/AU2017277463A1/en not_active Abandoned
- 2017-06-06 US US16/308,307 patent/US20190298865A1/en not_active Abandoned
- 2017-06-06 SG SG11201810967VA patent/SG11201810967VA/en unknown
- 2017-06-06 EA EA201892814A patent/EA201892814A1/ru unknown
- 2017-06-06 MA MA045225A patent/MA45225A/fr unknown
- 2017-06-06 PE PE2018003200A patent/PE20190327A1/es unknown
- 2017-06-06 WO PCT/EP2017/063689 patent/WO2017211809A1/en not_active Ceased
- 2017-06-06 CA CA3026900A patent/CA3026900A1/en not_active Abandoned
- 2017-06-06 CN CN201780049257.8A patent/CN109689115A/zh active Pending
- 2017-06-06 MX MX2018015340A patent/MX2018015340A/es unknown
- 2017-06-06 CR CR20180581A patent/CR20180581A/es unknown
- 2017-06-06 KR KR1020197000406A patent/KR20190016544A/ko not_active Withdrawn
- 2017-06-06 JP JP2018564263A patent/JP2019517547A/ja active Pending
- 2017-06-09 TW TW106119188A patent/TW201805025A/zh unknown
- 2017-06-09 UY UY0001037286A patent/UY37286A/es not_active Application Discontinuation
- 2017-06-09 AR ARP170101585A patent/AR110466A1/es unknown
-
2018
- 2018-12-06 IL IL263538A patent/IL263538A/en unknown
- 2018-12-10 NI NI201800136A patent/NI201800136A/es unknown
- 2018-12-10 DO DO2018000277A patent/DOP2018000277A/es unknown
- 2018-12-10 CL CL2018003550A patent/CL2018003550A1/es unknown
- 2018-12-10 EC ECSENADI201891468A patent/ECSP18091468A/es unknown
- 2018-12-10 CO CONC2018/0013359A patent/CO2018013359A2/es unknown
- 2018-12-10 PH PH12018502605A patent/PH12018502605A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12018502605A1 (en) | 2019-10-21 |
| CN109689115A (zh) | 2019-04-26 |
| DOP2018000277A (es) | 2018-12-31 |
| BR112018075554A2 (pt) | 2019-10-01 |
| AR110466A1 (es) | 2019-04-03 |
| TW201805025A (zh) | 2018-02-16 |
| WO2017211809A1 (en) | 2017-12-14 |
| MX2018015340A (es) | 2019-03-28 |
| IL263538A (en) | 2019-01-31 |
| EP3468619A1 (en) | 2019-04-17 |
| US20190298865A1 (en) | 2019-10-03 |
| CU20180149A7 (es) | 2019-07-04 |
| JP2019517547A (ja) | 2019-06-24 |
| PE20190327A1 (es) | 2019-03-05 |
| CR20180581A (es) | 2019-02-11 |
| KR20190016544A (ko) | 2019-02-18 |
| UY37286A (es) | 2018-01-31 |
| CL2018003550A1 (es) | 2019-02-01 |
| NI201800136A (es) | 2019-04-29 |
| CO2018013359A2 (es) | 2018-12-14 |
| AU2017277463A1 (en) | 2019-01-03 |
| ECSP18091468A (es) | 2018-12-31 |
| MA45225A (fr) | 2019-04-17 |
| CA3026900A1 (en) | 2017-12-14 |
| SG11201810967VA (en) | 2019-01-30 |
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