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EA201890817A1 - Кристаллические формы бета-никотинамида мононуклеотида - Google Patents

Кристаллические формы бета-никотинамида мононуклеотида

Info

Publication number
EA201890817A1
EA201890817A1 EA201890817A EA201890817A EA201890817A1 EA 201890817 A1 EA201890817 A1 EA 201890817A1 EA 201890817 A EA201890817 A EA 201890817A EA 201890817 A EA201890817 A EA 201890817A EA 201890817 A1 EA201890817 A1 EA 201890817A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mononucleotide
nicotinamide
beta
crystal forms
relates
Prior art date
Application number
EA201890817A
Other languages
English (en)
Other versions
EA037104B1 (ru
Inventor
Эндрю Карр
Филипп Фернандес
Дэвид Дж. Ливингстон
Original Assignee
МЕТРО ИНТЕРНЭШНЛ БАЙОТЕК, ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by МЕТРО ИНТЕРНЭШНЛ БАЙОТЕК, ЭлЭлСи filed Critical МЕТРО ИНТЕРНЭШНЛ БАЙОТЕК, ЭлЭлСи
Publication of EA201890817A1 publication Critical patent/EA201890817A1/ru
Publication of EA037104B1 publication Critical patent/EA037104B1/ru

Links

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048Pyridine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Изобретение относится к кристаллическим формам β-никотинамида мононуклеотида, способам их получения и их соответствующим фармацевтическим препаратам. Изобретение также относится к препаратам, подходящим для нутрицевтических, ветеринарных и сельскохозяйственных нужд.
EA201890817A 2015-10-02 2016-09-30 Кристаллические формы -никотинамида мононуклеотида EA037104B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562236657P 2015-10-02 2015-10-02
PCT/US2016/054776 WO2017059249A1 (en) 2015-10-02 2016-09-30 Crystal forms of beta-nicotinamide mononucleotide

Publications (2)

Publication Number Publication Date
EA201890817A1 true EA201890817A1 (ru) 2018-10-31
EA037104B1 EA037104B1 (ru) 2021-02-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890817A EA037104B1 (ru) 2015-10-02 2016-09-30 Кристаллические формы -никотинамида мононуклеотида

Country Status (14)

Country Link
US (6) US10392415B2 (ru)
EP (2) EP3355895A4 (ru)
JP (4) JP2018534265A (ru)
KR (1) KR102779733B1 (ru)
CN (1) CN108697722B (ru)
AU (1) AU2016331918B2 (ru)
BR (1) BR112018006243A2 (ru)
CA (1) CA3000744C (ru)
EA (1) EA037104B1 (ru)
GB (1) GB2542881B (ru)
IL (1) IL258276B (ru)
MX (1) MX390064B (ru)
WO (1) WO2017059249A1 (ru)
ZA (1) ZA201802657B (ru)

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