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EA201400701A1 - Замещенные соединения пиразоло[1,5-a]пиридина в качестве ингибиторов тропомиозинрецепторной киназы (trk) - Google Patents

Замещенные соединения пиразоло[1,5-a]пиридина в качестве ингибиторов тропомиозинрецепторной киназы (trk)

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Publication number
EA201400701A1
EA201400701A1 EA201400701A EA201400701A EA201400701A1 EA 201400701 A1 EA201400701 A1 EA 201400701A1 EA 201400701 A EA201400701 A EA 201400701A EA 201400701 A EA201400701 A EA 201400701A EA 201400701 A1 EA201400701 A1 EA 201400701A1
Authority
EA
Eurasian Patent Office
Prior art keywords
trk
pyridine
pyrazolo
tripomyosinreceptor
kinase inhibitors
Prior art date
Application number
EA201400701A
Other languages
English (en)
Other versions
EA025352B1 (ru
Inventor
Прадип Кумар Сасмал
Шахадат Ахмед
Ашок Техим
Видьядхар Парадкар
Прасанна М. Даттатрея
Нанйеговда Йагадееш Мавинахалли
Original Assignee
Др. Редди'С Лабораториз Лтд.
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Publication date
Application filed by Др. Редди'С Лабораториз Лтд. filed Critical Др. Редди'С Лабораториз Лтд.
Publication of EA201400701A1 publication Critical patent/EA201400701A1/ru
Publication of EA025352B1 publication Critical patent/EA025352B1/ru

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

Изобретение относится к сериям замещенных пиразоло[1,5-а]пиридиновых соединений, их применению в качестве ингибиторов протеинкиназ семейства тропомиозинрецепторной киназы (Trk), способу получения и фармацевтическим композициям, содержащим такие соединения.
EA201400701A 2011-12-12 2012-12-12 ЗАМЕЩЕННЫЕ СОЕДИНЕНИЯ ПИРАЗОЛО[1,5-a]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ТРОПОМИОЗИН-РЕЦЕПТОРНОЙ КИНАЗЫ (Trk) EA025352B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4329CH2011 2011-12-12
PCT/IB2012/003012 WO2013088256A1 (en) 2011-12-12 2012-12-12 Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (trk) inhibitors

Publications (2)

Publication Number Publication Date
EA201400701A1 true EA201400701A1 (ru) 2014-11-28
EA025352B1 EA025352B1 (ru) 2016-12-30

Family

ID=47902312

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400701A EA025352B1 (ru) 2011-12-12 2012-12-12 ЗАМЕЩЕННЫЕ СОЕДИНЕНИЯ ПИРАЗОЛО[1,5-a]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ТРОПОМИОЗИН-РЕЦЕПТОРНОЙ КИНАЗЫ (Trk)

Country Status (16)

Country Link
US (7) US9045479B2 (ru)
EP (2) EP2791138B1 (ru)
JP (1) JP5990595B2 (ru)
KR (2) KR20140105508A (ru)
CN (1) CN104114553B (ru)
AU (1) AU2012351748B2 (ru)
BR (1) BR112014014276A2 (ru)
CA (1) CA2858958C (ru)
CL (1) CL2014001529A1 (ru)
CO (1) CO7071124A2 (ru)
DK (1) DK2791138T3 (ru)
EA (1) EA025352B1 (ru)
ES (1) ES2686501T3 (ru)
IL (1) IL233067B (ru)
MX (1) MX356401B (ru)
WO (2) WO2013088256A1 (ru)

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PT3372605T (pt) 2008-10-22 2021-12-09 Array Biopharma Inc Compostos de pirazolo[1,5-a]pirimidina substituídos como inibidores de quinase trk
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
SMT201900203T1 (it) 2010-05-20 2019-05-10 Array Biopharma Inc Composti macrociclici come inibitori di trk chinasi
WO2013088256A1 (en) * 2011-12-12 2013-06-20 Dr. Reddy's Laboratories Ltd. Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (trk) inhibitors
TWI731317B (zh) 2013-12-10 2021-06-21 美商健臻公司 原肌球蛋白相關之激酶（ｔｒｋ）抑制劑
EP3083602A1 (en) 2013-12-20 2016-10-26 Pfizer Limited N-acylpiperidine ether tropomyosin-related kinase inhibitors
CN103819343B (zh) * 2014-02-17 2016-03-23 青岛农业大学 化合物2-烯丙基-4-氟-6-硝基苯酚的制备方法和农用生物活性
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
WO2015159175A1 (en) 2014-04-15 2015-10-22 Pfizer Inc. Tropomyosin-related kinase inhibitors containing both a 1h-pyrazole and a pyrimidine moiety
WO2015170218A1 (en) 2014-05-07 2015-11-12 Pfizer Inc. Tropomyosin-related kinase inhibitors
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US9394305B2 (en) 2014-06-23 2016-07-19 Dr. Reddy's Laboratories Ltd. Substituted imidazo[1,2-a]pyridine compounds as tropomyosin receptor kinase a (TrkA) inhibitors
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