[go: up one dir, main page]

EA201391703A1 - INTRANASAL BIOADGEUSIVE TESTOSTERONIC COMPOSITIONS IN THE FORM OF GELS AND THEIR APPLICATION FOR THE TREATMENT OF MALE HYPOGONADISM - Google Patents

INTRANASAL BIOADGEUSIVE TESTOSTERONIC COMPOSITIONS IN THE FORM OF GELS AND THEIR APPLICATION FOR THE TREATMENT OF MALE HYPOGONADISM

Info

Publication number
EA201391703A1
EA201391703A1 EA201391703A EA201391703A EA201391703A1 EA 201391703 A1 EA201391703 A1 EA 201391703A1 EA 201391703 A EA201391703 A EA 201391703A EA 201391703 A EA201391703 A EA 201391703A EA 201391703 A1 EA201391703 A1 EA 201391703A1
Authority
EA
Eurasian Patent Office
Prior art keywords
gels
intranasal
treatment
testosterone
testosteronic
Prior art date
Application number
EA201391703A
Other languages
Russian (ru)
Other versions
EA039080B1 (en
Inventor
Уэйн Креппнер
Шивон Фогарти
Вернер Обереггер
Пол Хосе Пьер Мари Маэс
Original Assignee
Тримел Биофарма Срл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тримел Биофарма Срл filed Critical Тримел Биофарма Срл
Priority claimed from PCT/IB2012/001112 external-priority patent/WO2012156820A1/en
Publication of EA201391703A1 publication Critical patent/EA201391703A1/en
Publication of EA039080B1 publication Critical patent/EA039080B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gynecology & Obstetrics (AREA)
  • Otolaryngology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к перназальным биоадгезивным тестостероновым составам в виде гелей для интраназального введения и способам заместительной терапии тестостероном для применения указанных перназальных тестостероновых биоадгезивных составов в виде гелей с обеспечением замедленной интраназальной доставки тестостерона у мужчин с дефицитом тестостерона для лечения, например субъектов мужского пола с диагностированным гипогонадизмом.The invention relates to pernasal bioadhesive testosterone formulations in the form of gels for intranasal administration and methods of testosterone replacement therapy for the use of said pernasal testosterone bioadhesive formulations in the form of gels to ensure delayed intranasal delivery of testosterone in men with testosterone deficiency for treatment, for example, male hypogonitis with a diagnosis.

EA201391703A 2011-05-16 2012-05-15 Intranasal testosterone bio-adhesive gel formulations and use thereof for treating male hypogonadism EA039080B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161486634P 2011-05-16 2011-05-16
PCT/IB2012/001112 WO2012156820A1 (en) 2011-05-15 2012-05-15 Intranasal testosterone bio-adhesive gel formulations and use thereof for treating male hypogonadism

Publications (2)

Publication Number Publication Date
EA201391703A1 true EA201391703A1 (en) 2016-01-29
EA039080B1 EA039080B1 (en) 2021-12-01

Family

ID=80631211

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201391703A EA039080B1 (en) 2011-05-16 2012-05-15 Intranasal testosterone bio-adhesive gel formulations and use thereof for treating male hypogonadism
EA202192397A EA202192397A3 (en) 2011-05-16 2012-05-15 INTRANASAL BIOADHESIVE TESTOSTERONE COMPOSITIONS IN THE FORM OF GELS AND THEIR USE FOR THE TREATMENT OF MALE HYPOGONADISM

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202192397A EA202192397A3 (en) 2011-05-16 2012-05-15 INTRANASAL BIOADHESIVE TESTOSTERONE COMPOSITIONS IN THE FORM OF GELS AND THEIR USE FOR THE TREATMENT OF MALE HYPOGONADISM

Country Status (1)

Country Link
EA (2) EA039080B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE319426T1 (en) * 2003-11-11 2006-03-15 Mattern Udo NASAL FORMULATION WITH CONTROLLED RELEASE OF SEXUAL HORMONES
EP2191833B1 (en) * 2007-09-20 2013-02-13 Shiseido Company, Ltd. Transdermally absorbable preparation

Also Published As

Publication number Publication date
EA039080B1 (en) 2021-12-01
EA202192397A3 (en) 2022-03-31
EA202192397A2 (en) 2021-12-31

Similar Documents

Publication Publication Date Title
CY1124499T1 (en) LIPIDS FOR THERAPEUTIC AGENT DELIVERY COMPOSITIONS
CY1124311T1 (en) DNA-PK INHIBITORS
GB201118656D0 (en) New compounds
NZ630805A (en) Pharmaceutical combinations comprising a thionucleotide analog
AR081681A1 (en) METHODS AND COMPOSITIONS FOR THE INTRATECAL ADMINISTRATION OF b-GALACTOCEREBROSIDASA
MX349004B (en) New compounds.
EA201390804A1 (en) DOSAGE FORM LACOSAMIDE FOR ADMISSION ONCE IN DAY
GB201106750D0 (en) Novel compounds
EA201500314A1 (en) DOSAGE FORMS OF ENZALUTAMIDE
IN2012MN02591A (en)
MX348495B (en) Methods and compositions for weed control.
MX366899B (en) New compounds.
PH12014501273A1 (en) Intranasal dexmedetomidine compositions and methods of use thereof
HN2011003011A (en) SUBLINGUAL COMPOSITIONS OF DEXMEDETOMIDINE AND METHODS OF USE OF THEM
EP4414376A3 (en) Novel depsipeptide and uses thereof
NZ708821A (en) Lfa-1 inhibitor formulations
MX2013013649A (en) Quinone compounds for treating ape1 mediated diseases.
MX367926B (en) Pharmaceutical composition for a sustained release of lanreotide.
PH12016500495A1 (en) Compositions for the treatment of hypertension and/or fibrosis
EA201391702A1 (en) INTRANASAL TESTOSTERONIC COMPOSITIONS WITH REDUCED DOSAGE IN THE FORM OF GEL AND THEIR USE FOR THE TREATMENT OF ANORGASMASIS OR HYPOACTIVE DISORDER
PH12016500497A1 (en) Compositions for the treatment of hypertension and/or fibrosis
MX363385B (en) Treatment of sickle cell disease and inflammatory conditions.
UA117567C2 (en) Galactagogue compositions based on phosphatidylserine
WO2014104989A8 (en) Pharmaceutical compositions comprising aripiprazole
EA201391703A1 (en) INTRANASAL BIOADGEUSIVE TESTOSTERONIC COMPOSITIONS IN THE FORM OF GELS AND THEIR APPLICATION FOR THE TREATMENT OF MALE HYPOGONADISM