EA201390716A1 - Комбинированная терапия внеклеточным доменом fgfr1 - Google Patents
Комбинированная терапия внеклеточным доменом fgfr1Info
- Publication number
- EA201390716A1 EA201390716A1 EA201390716A EA201390716A EA201390716A1 EA 201390716 A1 EA201390716 A1 EA 201390716A1 EA 201390716 A EA201390716 A EA 201390716A EA 201390716 A EA201390716 A EA 201390716A EA 201390716 A1 EA201390716 A1 EA 201390716A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- fgfr1
- fgfr1 ecd
- extracellular domain
- therapeutic agent
- additional therapeutic
- Prior art date
Links
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 title 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 title 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 4
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 4
- 229960002949 fluorouracil Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 3
- 230000004927 fusion Effects 0.000 abstract 3
- 229940124597 therapeutic agent Drugs 0.000 abstract 3
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 abstract 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 2
- 229930012538 Paclitaxel Natural products 0.000 abstract 2
- 229960000397 bevacizumab Drugs 0.000 abstract 2
- 229960004562 carboplatin Drugs 0.000 abstract 2
- 190000008236 carboplatin Chemical compound 0.000 abstract 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 2
- 229960004316 cisplatin Drugs 0.000 abstract 2
- 229960003668 docetaxel Drugs 0.000 abstract 2
- 229960004679 doxorubicin Drugs 0.000 abstract 2
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 abstract 2
- 235000008191 folinic acid Nutrition 0.000 abstract 2
- 239000011672 folinic acid Substances 0.000 abstract 2
- 229960001691 leucovorin Drugs 0.000 abstract 2
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 abstract 2
- 229960001756 oxaliplatin Drugs 0.000 abstract 2
- 229960001592 paclitaxel Drugs 0.000 abstract 2
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 abstract 2
- 229960005079 pemetrexed Drugs 0.000 abstract 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 abstract 2
- 229960004528 vincristine Drugs 0.000 abstract 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 abstract 2
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 abstract 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940029303 fibroblast growth factor-1 Drugs 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Описаны способы лечения рака, включающие введение внеклеточного домена (ECD) рецептора фактора роста фибробластов 1 (FGFR1) и/или молекулы слияния FGFR1 ECD в комбинации по меньшей мере с одним дополнительным терапевтическим агентом, выбираемым из доцетакселя, паклитакселя, винкристина, карбоплатина, цисплатина, оксалиплатина, доксорубицина, 5-фторурацила (5-ФУ), лейковорина, пеметрекседа и бевацизумаба. Также описаны упаковки дозы, включающие FGFR1 ECD и/или молекулу слияния FGFR1 ECD и/или по меньшей мере один дополнительный терапевтический агент, выбираемый из доцетакселя, паклитакселя, винкристина, карбоплатина, цисплатина, оксалиплатина, доксорубицина, 5-фторурацила (5-ФУ), лейковорина, пеметрекседа и бевацизумаба В некоторых вариантах воплощения изобретения упаковка дозы включает инструкции по введению FGFR1 ECD и/или молекулы слияния FGFR1 ECD по меньшей мере с одним дополнительным терапевтическим агентом.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41394010P | 2010-11-15 | 2010-11-15 | |
| US42146210P | 2010-12-09 | 2010-12-09 | |
| PCT/US2011/060666 WO2012068032A1 (en) | 2010-11-15 | 2011-11-14 | Fgfr1 extracellular domain combination therapies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201390716A1 true EA201390716A1 (ru) | 2014-02-28 |
| EA025828B1 EA025828B1 (ru) | 2017-02-28 |
Family
ID=44993965
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201390716A EA025828B1 (ru) | 2010-11-15 | 2011-11-14 | Комбинированная терапия внеклеточным доменом fgfr1 |
| EA201390722A EA201390722A1 (ru) | 2010-11-15 | 2011-11-14 | Лечение рака повышенными дозами растворимых белков слияния fgfr1 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201390722A EA201390722A1 (ru) | 2010-11-15 | 2011-11-14 | Лечение рака повышенными дозами растворимых белков слияния fgfr1 |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP2640406A1 (ru) |
| JP (4) | JP6178240B2 (ru) |
| KR (3) | KR20130124513A (ru) |
| CN (2) | CN107050426A (ru) |
| AU (2) | AU2011329125B2 (ru) |
| BR (2) | BR112013012041A2 (ru) |
| CA (2) | CA2817583A1 (ru) |
| EA (2) | EA025828B1 (ru) |
| IL (2) | IL226248A0 (ru) |
| MX (2) | MX349293B (ru) |
| NZ (4) | NZ610487A (ru) |
| SG (2) | SG190788A1 (ru) |
| WO (2) | WO2012068032A1 (ru) |
| ZA (2) | ZA201303501B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
| HK1202240A1 (en) | 2011-11-14 | 2015-09-25 | 戊瑞治疗有限公司 | Methods of treating cancer |
| CA2908391A1 (en) * | 2013-05-01 | 2014-11-06 | Five Prime Therapeutics, Inc. | Methods of treating cancer |
| BR112015029145A2 (pt) | 2013-05-23 | 2017-09-19 | Glaxosmithkline Ip No 2 Ltd | Usos de um domínio extracelular (ecd) de receptor de fator de crescimento de fibroblastos 1 (fgfr1) e métodos de identificação de pacientes |
| CN117717569A (zh) * | 2013-07-05 | 2024-03-19 | 恒星生物群落有限公司 | 口服组合物 |
| WO2015066452A2 (en) * | 2013-11-01 | 2015-05-07 | Foundation Medicine, Inc. | Methods of treating pediatric cancers |
| EP3411399A4 (en) * | 2016-02-04 | 2019-10-16 | Jinsong Ni | TECHNOLOGY FOR ANTIBODY-ACTIVE SYNERGISM FOR THE TREATMENT OF DISEASES |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
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