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EA201201179A1 - Способ получения изоксазолиновых производных - Google Patents

Способ получения изоксазолиновых производных

Info

Publication number
EA201201179A1
EA201201179A1 EA201201179A EA201201179A EA201201179A1 EA 201201179 A1 EA201201179 A1 EA 201201179A1 EA 201201179 A EA201201179 A EA 201201179A EA 201201179 A EA201201179 A EA 201201179A EA 201201179 A1 EA201201179 A1 EA 201201179A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
producing
isoxasoline
derivatives
compounds
Prior art date
Application number
EA201201179A
Other languages
English (en)
Inventor
Николас Филлип Малхолленд
Эдуар Годино
Жером Ив Кассер
Петер Ренольд
Мирием Эль-Касеми
Гийом Револь
Original Assignee
Зингента Партисипейшнс Аг
Зингента Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1007689.1A external-priority patent/GB201007689D0/en
Application filed by Зингента Партисипейшнс Аг, Зингента Лимитед filed Critical Зингента Партисипейшнс Аг
Publication of EA201201179A1 publication Critical patent/EA201201179A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0271—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds also containing elements or functional groups covered by B01J31/0201 - B01J31/0231
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к способу получения соединений формулы (IB)где A, A, A, A, L, Y, Y, R, R, R, Rи Rявляются такими, как определено в формуле изобретения, включающему реакцию соединения формулы (II)где Y, Y, L, A, A, R, R, R, Rи Rявляются такими, как определено для соединения формулы (I); с гидроксиламином в присутствии воды, основания и хирального катализатора межфазового переноса, причем хиральный катализатор межфазового переноса представляет собой хининовое производное. Изобретение также относится к соединениям формулы (IB) и энантиомерно обогащенным смесям, содержащим соединения формулы (IB).
EA201201179A 2010-02-25 2011-02-03 Способ получения изоксазолиновых производных EA201201179A1 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP10250337 2010-02-25
EP10250336 2010-02-25
GBGB1007689.1A GB201007689D0 (en) 2010-05-07 2010-05-07 Process
EP10164234 2010-05-28
EP10164231 2010-05-28
EP10187269 2010-10-12
PCT/EP2011/051513 WO2011104089A1 (en) 2010-02-25 2011-02-03 Process for the preparation of isoxazoline derivatives

Publications (1)

Publication Number Publication Date
EA201201179A1 true EA201201179A1 (ru) 2013-04-30

Family

ID=43856171

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201179A EA201201179A1 (ru) 2010-02-25 2011-02-03 Способ получения изоксазолиновых производных

Country Status (16)

Country Link
US (1) US20140206633A1 (ru)
EP (1) EP2539335B1 (ru)
JP (1) JP2013520456A (ru)
KR (1) KR20120133401A (ru)
CN (1) CN102822168B (ru)
AU (1) AU2011220041A1 (ru)
BR (1) BR112012020983A2 (ru)
CA (1) CA2790963A1 (ru)
CL (1) CL2012002345A1 (ru)
EA (1) EA201201179A1 (ru)
IL (1) IL221392A0 (ru)
MX (1) MX2012009707A (ru)
PH (1) PH12012501625A1 (ru)
UY (1) UY33249A (ru)
WO (1) WO2011104089A1 (ru)
ZA (1) ZA201206095B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2614978C2 (ru) * 2012-08-31 2017-03-31 Зоэтис Сервисиз Ллс Кристаллические формы 1-(5'-(5-(3,5-дихлоро-4-фторфенил)-5-(трифторметил)-4,5-дигидроизоксазол-3-ил)-3'н-спиро[азетидин-3,1'-изобензофуран]-1-ил)-2-(метилсульфонил)этанона

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010149506A1 (en) 2009-06-22 2010-12-29 Syngenta Participations Ag Insecticidal compounds
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
US20130085064A1 (en) * 2010-02-25 2013-04-04 Syngenta Crop Protection Llc Pesticidal mixtures containing isoxazoline derivatives and insecticide or nematoicidal biological agent
JP2014028758A (ja) 2010-11-19 2014-02-13 Nissan Chem Ind Ltd 寄生虫及び衛生害虫防除剤
CA2826059A1 (en) 2011-02-09 2012-08-16 Pierre Joseph Marcel Jung Insecticidal compounds
WO2012117021A2 (en) 2011-03-03 2012-09-07 Syngenta Participations Ag Novel microbiocidal oxime ethers
WO2012120399A1 (en) 2011-03-10 2012-09-13 Pfizer Inc. Spirocyclic isoxazoline derivatives as antiparasitic agents
WO2012126881A1 (en) 2011-03-22 2012-09-27 Syngenta Participations Ag Insecticidal compounds
WO2012143395A1 (en) 2011-04-20 2012-10-26 Syngenta Participations Ag 4,5-dihydro-isoxazole derivatives as fungicides
KR20140034798A (ko) 2011-05-18 2014-03-20 신젠타 파티서페이션즈 아게 아릴티오아세트아미드 유도체에 기반한 살곤충 화합물
WO2012175474A1 (en) 2011-06-20 2012-12-27 Syngenta Participations Ag 1,2,3 triazole pesticides
WO2013007550A1 (en) 2011-07-08 2013-01-17 Syngenta Participations Ag Fungicide mixtures
WO2013011010A1 (en) 2011-07-19 2013-01-24 Syngenta Participations Ag Fungizide mixtures
WO2013026900A1 (en) 2011-08-23 2013-02-28 Syngenta Participations Ag Pyridine derivatives as microbiocides
AU2012298448A1 (en) * 2011-08-25 2014-03-06 Syngenta Participations Ag Isoxazoline derivatives as insecticidal compounds
WO2013050317A1 (en) 2011-10-03 2013-04-11 Syngenta Limited Polymorphs of an isoxazoline derivative
JP6075563B2 (ja) * 2011-11-08 2017-02-08 日産化学工業株式会社 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物
WO2013092460A1 (en) 2011-12-20 2013-06-27 Syngenta Participations Ag Cyclic bisoxime microbicides
AU2013215374A1 (en) 2012-02-03 2014-08-21 Zoetis Services Llc Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents
ES2720201T3 (es) 2012-02-06 2019-07-18 Merial Inc Composiciones parasiticidas orales veterinarias que comprenden agentes activos de acción sistémica y usos de las mismas
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
EP2641901A1 (en) 2012-03-22 2013-09-25 Syngenta Participations AG. Novel microbiocides
WO2014019951A1 (en) 2012-08-03 2014-02-06 Syngenta Participations Ag Methods of controlling insects
WO2015055764A1 (en) 2013-10-18 2015-04-23 Syngenta Participations Ag 3-methanimidamid-pyridine derivatives as fungicides
SG11201603430XA (en) 2013-11-01 2016-05-30 Merial Ltd Antiparasitic and pesticidal isoxazoline compounds
AU2015247463B2 (en) 2014-04-17 2018-03-29 Basf, Se Use of malononitrile compounds for protecting animals from parasites
WO2016023787A1 (en) 2014-08-11 2016-02-18 Syngenta Participations Ag Process for the preparation of optically active isoxazoline compounds
ES2827477T3 (es) 2015-01-16 2021-05-21 Avista Pharma Solutions Inc Compuestos antiparasitarios
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
SG10202103403SA (en) 2015-05-20 2021-05-28 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic depsipeptide compounds
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
HRP20211979T1 (hr) * 2016-04-06 2022-04-01 Boehringer Ingelheim Animal Health USA Inc. Postupak za pripravu enantiomerno obogaćenih spojeva izoksazolina – kristalnog toluen solvata (s)-afoksolanera
WO2018071535A1 (en) 2016-10-14 2018-04-19 Merial, Inc. Pesticidal and parasiticidal vinyl isoxazoline compounds
US11382949B2 (en) 2016-11-16 2022-07-12 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
WO2019036407A1 (en) 2017-08-14 2019-02-21 Merial, Inc. PYRAZOLE-ISOXAZOLINE COMPOUNDS WITH PESTICIDE AND PARASITICIDE ACTIVITY
JP2021503465A (ja) 2017-11-16 2021-02-12 アビスタ ファーマ ソリューションズ，インコーポレーテッド 単一エナンチオマーの抗寄生生物化合物
IL279977B2 (en) 2018-07-09 2024-06-01 Boehringer Ingelheim Animal Health Usa Inc Heterocyclic anthelmintic compounds
US11773066B2 (en) 2018-11-20 2023-10-03 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
CN109553528A (zh) * 2018-12-21 2019-04-02 荆门医药工业技术研究院 一种2-甲基-4-乙酰基苯甲酸甲酯的合成方法
US11560388B2 (en) 2019-03-19 2023-01-24 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic aza-benzothiophene and aza-benzofuran compounds
WO2021197880A1 (en) 2020-03-31 2021-10-07 Basf Se Process for preparation of optically enriched isoxazolines
CA3183100A1 (en) 2020-05-29 2021-12-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelmintic heterocyclic compounds
AU2021311722A1 (en) 2020-07-24 2023-02-02 Elanco Us Inc. Process for making an isoxazoline compound and intermediate thereof
US20240116854A1 (en) 2021-01-27 2024-04-11 Intervet Inc. Cyclopropylamide compounds against parasites in fish
CA3209562A1 (en) 2021-01-27 2022-08-04 Intervet International B.V. Cyclopropylamide compounds against parasites in fish
MX2023014962A (es) 2021-08-11 2024-02-13 Elanco Us Inc Proceso para elaborar derivado de diaril isoxazolina.
CN116478057A (zh) * 2022-01-17 2023-07-25 洛阳惠中兽药有限公司 一种氟雷拉纳中间体的制备方法
JP2025507585A (ja) 2022-02-17 2025-03-21 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー 流体製品メーラーを提供する方法及びシステム
WO2024012527A1 (zh) 2022-07-13 2024-01-18 安徽圣丰生化有限公司 一种含吡唑结构的化合物和应用以及杀虫剂
CN115477577B (zh) * 2022-10-25 2024-03-15 台州臻挚生物科技有限公司 一种制备2-甲基-4-乙酰基苯甲酸及其衍生物的新方法
WO2025003945A1 (en) * 2023-06-30 2025-01-02 Hikal Limited An improved process for the preparation of 4-acetyl-2-methyl-benzonitrile
NO20240925A1 (en) 2023-09-15 2025-03-17 Evah Atlantic Inc Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish
CN120774881A (zh) * 2024-04-01 2025-10-14 山东康乔生物科技有限公司 一种含砜五元杂环基的异噁唑啉类化合物的制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61107392A (ja) 1984-10-31 1986-05-26 株式会社東芝 画像処理システム
AU613521B2 (en) 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
US5015630A (en) 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
NO176766C (no) 1989-02-07 1995-05-24 Meiji Seika Kaisha Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
JPH085894B2 (ja) 1990-03-01 1996-01-24 三共株式会社 ミルベマイシンエーテル誘導体
JPH0570366A (ja) 1991-03-08 1993-03-23 Meiji Seika Kaisha Ltd 薬用組成物
ATE211466T1 (de) 1992-03-17 2002-01-15 Fujisawa Pharmaceutical Co Depsipeptide, herstellung und anwendung
UA39936C2 (ru) 1992-04-28 2001-07-16 Йашима Кемікал Індастрі Ко., Лтд 2-(2, 6-дифторфенил)-4-(2-етокси-4-трет-бутилфенил)- 2-оксазолин, способ митицидной обработки и митицидная композиция
DE4317458A1 (de) 1992-06-11 1993-12-16 Bayer Ag Verwendung von cyclischen Depsipeptiden mit 18 Ringatomen zur Bekämpfung von Endoparasiten, neue cyclische Depsipeptide mit 18 Ringatomen und Verfahren zu ihrer Herstellung
AU666750B2 (en) 1992-09-01 1996-02-22 Novartis Animal Health K.K. Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
KR100309091B1 (ko) 1993-02-19 2001-12-28 이치로 키타사토 환상 데프시펩티드 pf 1022의 유도체
DE4317457A1 (de) 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
JP2767161B2 (ja) 1994-01-14 1998-06-18 ファイザー製薬株式会社 抗寄生虫活性ピロロベンゾキサジン化合物
GB9402916D0 (en) 1994-02-16 1994-04-06 Pfizer Ltd Antiparasitic agents
DE4437198A1 (de) 1994-10-18 1996-04-25 Bayer Ag Verfahren zur Sulfonylierung, Sulfenylierung und Phosphorylierung von cyclischen Depsipeptiden
DE4440193A1 (de) 1994-11-10 1996-05-15 Bayer Ag Verwendung von Dioxomorpholinen zur Bekämpfung von Endoparasiten, neue Dioxomorpholine und Verfahren zur ihrer Herstellung
US6406690B1 (en) 1995-04-17 2002-06-18 Minrav Industries Ltd. Bacillus firmus CNCM I-1582 or Bacillus cereus CNCM I-1562 for controlling nematodes
DE19520936A1 (de) 1995-06-08 1996-12-12 Bayer Ag Ektoparasitizide Mittel
TW200724033A (en) 2001-09-21 2007-07-01 Du Pont Anthranilamide arthropodicide treatment
GB0303439D0 (en) 2003-02-14 2003-03-19 Pfizer Ltd Antiparasitic terpene alkaloids
DE102006015467A1 (de) 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
WO2009063910A1 (ja) * 2007-11-12 2009-05-22 Nissan Chemical Industries, Ltd. 光学活性イソキサゾリン化合物の触媒的不斉合成方法
TWI411395B (zh) * 2007-12-24 2013-10-11 Syngenta Participations Ag 殺蟲化合物
WO2010025998A1 (en) * 2008-09-04 2010-03-11 Syngenta Participations Ag Insecticidal compounds
TWI487486B (zh) * 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
US20130085064A1 (en) * 2010-02-25 2013-04-04 Syngenta Crop Protection Llc Pesticidal mixtures containing isoxazoline derivatives and insecticide or nematoicidal biological agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2614978C2 (ru) * 2012-08-31 2017-03-31 Зоэтис Сервисиз Ллс Кристаллические формы 1-(5'-(5-(3,5-дихлоро-4-фторфенил)-5-(трифторметил)-4,5-дигидроизоксазол-3-ил)-3'н-спиро[азетидин-3,1'-изобензофуран]-1-ил)-2-(метилсульфонил)этанона

Also Published As

Publication number Publication date
MX2012009707A (es) 2012-09-12
UY33249A (es) 2011-09-30
JP2013520456A (ja) 2013-06-06
ZA201206095B (en) 2015-04-29
US20140206633A1 (en) 2014-07-24
AU2011220041A1 (en) 2012-08-23
EP2539335A1 (en) 2013-01-02
PH12012501625A1 (en) 2012-10-22
CN102822168B (zh) 2016-10-26
KR20120133401A (ko) 2012-12-10
IL221392A0 (en) 2012-10-31
WO2011104089A1 (en) 2011-09-01
CL2012002345A1 (es) 2013-01-18
BR112012020983A2 (pt) 2016-11-01
CN102822168A (zh) 2012-12-12
EP2539335B1 (en) 2016-12-21
CA2790963A1 (en) 2011-09-01

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