EA201200574A1 - Терапия пирфенидоном и индукторы цитохрома р450 - Google Patents
Терапия пирфенидоном и индукторы цитохрома р450Info
- Publication number
- EA201200574A1 EA201200574A1 EA201200574A EA201200574A EA201200574A1 EA 201200574 A1 EA201200574 A1 EA 201200574A1 EA 201200574 A EA201200574 A EA 201200574A EA 201200574 A EA201200574 A EA 201200574A EA 201200574 A1 EA201200574 A1 EA 201200574A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrphenidone
- cytochrome
- inductors
- therapy
- pirfenidone
- Prior art date
Links
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 title 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 206010013710 Drug interaction Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 abstract 1
- 229960003073 pirfenidone Drugs 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000391 smoking effect Effects 0.000 abstract 1
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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Abstract
Настоящее изобретение относится к способам, включающим предотвращение неблагоприятного лекарственного взаимодействия пирфенидона и индукторов CYP, таких как курение.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26675309P | 2009-12-04 | 2009-12-04 | |
| US12/684,543 US8084475B2 (en) | 2009-12-04 | 2010-01-08 | Pirfenidone therapy and inducers of cytochrome P450 |
| EP10250378A EP2308491B1 (en) | 2009-12-04 | 2010-03-03 | Pirfenidone therapy and inducers of cytochrome P450 |
| US31057510P | 2010-03-04 | 2010-03-04 | |
| CA2710014A CA2710014C (en) | 2009-12-04 | 2010-08-17 | Pirfenidone therapy and inducers of cytochrome p450 |
| PCT/US2010/058936 WO2011069089A1 (en) | 2009-12-04 | 2010-12-03 | Pirfenidone therapy and inducers of cytochrome p450 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201200574A1 true EA201200574A1 (ru) | 2012-10-30 |
| EA026869B1 EA026869B1 (ru) | 2017-05-31 |
Family
ID=42077364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201200574A EA026869B1 (ru) | 2009-12-04 | 2010-12-03 | Способ лечения идиопатического легочного фиброза |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8084475B2 (ru) |
| EP (3) | EP2377537A1 (ru) |
| JP (3) | JP5753094B2 (ru) |
| KR (2) | KR101762465B1 (ru) |
| AT (1) | ATE523197T1 (ru) |
| AU (1) | AU2010212488B2 (ru) |
| CA (1) | CA2710014C (ru) |
| CY (1) | CY1112075T1 (ru) |
| DK (1) | DK2308491T3 (ru) |
| EA (1) | EA026869B1 (ru) |
| ES (1) | ES2395159T3 (ru) |
| GE (1) | GEP20166426B (ru) |
| HR (1) | HRP20110853T1 (ru) |
| IL (1) | IL219056A (ru) |
| MX (1) | MX2012004528A (ru) |
| NZ (1) | NZ599246A (ru) |
| PE (1) | PE20121348A1 (ru) |
| PL (1) | PL2308491T3 (ru) |
| PT (1) | PT2308491E (ru) |
| RS (1) | RS51976B (ru) |
| SG (1) | SG181128A1 (ru) |
| SI (1) | SI2308491T1 (ru) |
| SM (1) | SMT201200003B (ru) |
| TW (2) | TWI440459B (ru) |
| WO (1) | WO2011069089A1 (ru) |
| ZA (1) | ZA201202553B (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8084475B2 (en) | 2009-12-04 | 2011-12-27 | Intermune, Inc. | Pirfenidone therapy and inducers of cytochrome P450 |
| US7816383B1 (en) | 2009-12-04 | 2010-10-19 | Intermune, Inc. | Methods of administering pirfenidone therapy |
| US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| US10092552B2 (en) | 2011-01-31 | 2018-10-09 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| CA2819967C (en) | 2012-08-31 | 2016-03-22 | Intermune, Inc. | Use of pirfenidone concomitantly with ciprofloxacin |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP2919718B1 (en) | 2012-11-16 | 2020-11-04 | In Queue Innovations, LLC | Oblique expanding fusion cage device |
| WO2014151517A1 (en) * | 2013-03-15 | 2014-09-25 | Intermune, Inc. | Methods of improving microvascular integrity |
| US10039650B2 (en) | 2013-03-15 | 2018-08-07 | In Queue Innovations, Llc | Expandable fusion cage system |
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