EA201070813A1 - Производные n-гетероциклоимидазо[1,2-а]пиридин-2-карбоксамидов, их получение и применение в терапии - Google Patents
Производные n-гетероциклоимидазо[1,2-а]пиридин-2-карбоксамидов, их получение и применение в терапииInfo
- Publication number
- EA201070813A1 EA201070813A1 EA201070813A EA201070813A EA201070813A1 EA 201070813 A1 EA201070813 A1 EA 201070813A1 EA 201070813 A EA201070813 A EA 201070813A EA 201070813 A EA201070813 A EA 201070813A EA 201070813 A1 EA201070813 A1 EA 201070813A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- hydrogen atom
- therapy
- group
- nrr
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Соединения формулы (I), где Х означает гетероцикл; Rпредставляет собой атом водорода, атом галогена, (C-С)алкоксигруппу, (С-С)алкил, группу NRaRb; Rпредставляет собой атом водорода, замещенный при необходимости (C-C)алкил, замещенную при необходимости (C-C)алкоксигруппу, (С-С)алкенил, (С-С)алкинил, -CO-R, -CO-NRR, -CO-O-R, -NR-CO-R, -NRR, -N=CH-NRaRb, атом галогена, циано-, нитрогруппу, гидроксииминоалкил, алкоксииминоалкил, (C-C)алкилтиогруппу, (C-С) алкилсульфинил, (C-C)алкилсульфонил, ((C-С)алкил))силилэтинил, -SO-NRR, замещенный при необходимости фенил; Rпредставляет собой атом водорода, (С-С)алкил, (C-С)алкоксигруппу или атом галогена; Rпредставляет собой атом водорода, (C-C)алкил, (C-C)алкоксигруппу или атом фтора; в виде основания или кислотно-аддитивной соли. Применение в терапии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800003A FR2925901B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES DE N-HETEROCYCLIQUE-IMIDAZO°1,2-a!PYRIDINE-2- CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| PCT/FR2008/001834 WO2009106749A2 (fr) | 2008-01-02 | 2008-12-31 | Dérivés de n-heterocyclique-imidazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201070813A1 true EA201070813A1 (ru) | 2010-12-30 |
Family
ID=39712153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201070813A EA201070813A1 (ru) | 2008-01-02 | 2008-12-31 | Производные n-гетероциклоимидазо[1,2-а]пиридин-2-карбоксамидов, их получение и применение в терапии |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20100317673A1 (ru) |
| EP (1) | EP2225242A2 (ru) |
| JP (1) | JP2011509250A (ru) |
| KR (1) | KR20100099244A (ru) |
| CN (1) | CN101910172A (ru) |
| AR (1) | AR070072A1 (ru) |
| AU (1) | AU2008351927A1 (ru) |
| BR (1) | BRPI0821992A2 (ru) |
| CA (1) | CA2710860A1 (ru) |
| CL (1) | CL2008003933A1 (ru) |
| CO (1) | CO6331306A2 (ru) |
| EA (1) | EA201070813A1 (ru) |
| FR (1) | FR2925901B1 (ru) |
| IL (1) | IL206671A0 (ru) |
| MA (1) | MA32059B1 (ru) |
| MX (1) | MX2010007349A (ru) |
| TW (1) | TW200934777A (ru) |
| UY (2) | UY3816Q (ru) |
| WO (1) | WO2009106749A2 (ru) |
| ZA (1) | ZA201004643B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
| TWI527813B (zh) | 2010-12-13 | 2016-04-01 | 亞雷生物製藥股份有限公司 | 作為III型受體酪胺酸激酶抑制劑之經取代Ｎ－（１Ｈ－吲唑－４－基）咪唑并 ［１，２－ａ］吡啶－３－甲醯胺化合物 |
| WO2012147890A1 (ja) * | 2011-04-27 | 2012-11-01 | 持田製薬株式会社 | 新規アゾール誘導体 |
| JP6284490B2 (ja) | 2012-12-28 | 2018-02-28 | 株式会社新日本科学 | イミダゾピリジン誘導体を有効成分として含むｏｃｔ３活性阻害剤又はｏｃｔ３検出剤 |
| EP3946618A1 (en) | 2019-04-05 | 2022-02-09 | Storm Therapeutics Ltd | Mettl3 inhibitory compounds |
| WO2022074379A1 (en) * | 2020-10-06 | 2022-04-14 | Storm Therapeutics Limited | Mettl3 inhibitory compounds |
| EP4596548A1 (en) * | 2024-02-05 | 2025-08-06 | Ludwig-Maximilians-Universität | Nurr1 modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260303A (en) * | 1991-03-07 | 1993-11-09 | G. D. Searle & Co. | Imidazopyridines as serotonergic 5-HT3 antagonists |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| JP5358962B2 (ja) * | 2007-02-06 | 2013-12-04 | 住友化学株式会社 | 組成物及び該組成物を用いてなる発光素子 |
| WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
-
2008
- 2008-01-02 FR FR0800003A patent/FR2925901B1/fr not_active Expired - Fee Related
- 2008-06-12 UY UY3816F patent/UY3816Q/es not_active IP Right Cessation
- 2008-12-30 AR ARP080105777A patent/AR070072A1/es unknown
- 2008-12-30 UY UY31587A patent/UY31587A1/es not_active Application Discontinuation
- 2008-12-30 CL CL2008003933A patent/CL2008003933A1/es unknown
- 2008-12-31 AU AU2008351927A patent/AU2008351927A1/en not_active Abandoned
- 2008-12-31 EA EA201070813A patent/EA201070813A1/ru unknown
- 2008-12-31 TW TW097151676A patent/TW200934777A/zh unknown
- 2008-12-31 JP JP2010541083A patent/JP2011509250A/ja not_active Withdrawn
- 2008-12-31 MX MX2010007349A patent/MX2010007349A/es not_active Application Discontinuation
- 2008-12-31 WO PCT/FR2008/001834 patent/WO2009106749A2/fr not_active Ceased
- 2008-12-31 CN CN2008801238170A patent/CN101910172A/zh active Pending
- 2008-12-31 BR BRPI0821992-3A patent/BRPI0821992A2/pt not_active IP Right Cessation
- 2008-12-31 CA CA2710860A patent/CA2710860A1/fr not_active Abandoned
- 2008-12-31 KR KR1020107014639A patent/KR20100099244A/ko not_active Withdrawn
- 2008-12-31 EP EP08872909A patent/EP2225242A2/fr not_active Withdrawn
-
2010
- 2010-06-28 IL IL206671A patent/IL206671A0/en unknown
- 2010-07-01 ZA ZA2010/04643A patent/ZA201004643B/en unknown
- 2010-07-01 US US12/828,370 patent/US20100317673A1/en not_active Abandoned
- 2010-07-02 CO CO10080861A patent/CO6331306A2/es not_active Application Discontinuation
- 2010-08-02 MA MA33057A patent/MA32059B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA32059B1 (fr) | 2011-02-01 |
| EP2225242A2 (fr) | 2010-09-08 |
| US20100317673A1 (en) | 2010-12-16 |
| CL2008003933A1 (es) | 2010-02-12 |
| JP2011509250A (ja) | 2011-03-24 |
| ZA201004643B (en) | 2011-09-28 |
| WO2009106749A2 (fr) | 2009-09-03 |
| CO6331306A2 (es) | 2011-10-20 |
| WO2009106749A3 (fr) | 2010-05-06 |
| AR070072A1 (es) | 2010-03-10 |
| BRPI0821992A2 (pt) | 2015-06-23 |
| MX2010007349A (es) | 2010-08-18 |
| IL206671A0 (en) | 2010-12-30 |
| UY31587A1 (es) | 2009-08-03 |
| AU2008351927A1 (en) | 2009-09-03 |
| CN101910172A (zh) | 2010-12-08 |
| CA2710860A1 (fr) | 2009-09-03 |
| FR2925901B1 (fr) | 2011-03-04 |
| FR2925901A1 (fr) | 2009-07-03 |
| UY3816Q (es) | 2008-09-30 |
| KR20100099244A (ko) | 2010-09-10 |
| TW200934777A (en) | 2009-08-16 |
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