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EA201000563A1 - Триазолпиридиновые ингибиторы 11-бета- гидроксистероид - дегидрогеназы типа i - Google Patents

Триазолпиридиновые ингибиторы 11-бета- гидроксистероид - дегидрогеназы типа i

Info

Publication number
EA201000563A1
EA201000563A1 EA201000563A EA201000563A EA201000563A1 EA 201000563 A1 EA201000563 A1 EA 201000563A1 EA 201000563 A EA201000563 A EA 201000563A EA 201000563 A EA201000563 A EA 201000563A EA 201000563 A1 EA201000563 A1 EA 201000563A1
Authority
EA
Eurasian Patent Office
Prior art keywords
beta
inhibitors
hydroxysteroid
triazolpyridine
dehydrogenase type
Prior art date
Application number
EA201000563A
Other languages
English (en)
Other versions
EA019706B1 (ru
Inventor
Цзюнь Ли
Джеффри А. Робл
Джеймс Дж. Ли
Лоуренс Дж. Кеннеди
Хайся Ван
Цзе Джек Ли
Синьхуа Цянь
Раджендра П. Дешпанде
Лаксма Колла
Реджинальд О. Канн
Ченку Вэй
Майкл Галелла
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40523804&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201000563(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA201000563A1 publication Critical patent/EA201000563A1/ru
Publication of EA019706B1 publication Critical patent/EA019706B1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Предложены новые соединения, которые представляют собой ингибиторы 11-бета-гидроксистероиддегидрогеназы типа I. Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа I пригодны для лечения, профилактики или замедления развития болезней, требующих применения терапии с использованием 11-бета-гидроксистероиддегидрогеназы. Эти новые соединения имеют формулу (I), или являются стереомерами, или фармацевтически приемлемыми солями этих соединений, где G, Q, X, Y, R, Rи Rопределены в описании.
EA201000563A 2007-10-01 2008-09-19 Триазолпиридиновые ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа i EA019706B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97650607P 2007-10-01 2007-10-01
US12/206,801 US8119658B2 (en) 2007-10-01 2008-09-09 Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
PCT/US2008/076984 WO2009045753A1 (en) 2007-10-01 2008-09-19 Triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors

Publications (2)

Publication Number Publication Date
EA201000563A1 true EA201000563A1 (ru) 2010-10-29
EA019706B1 EA019706B1 (ru) 2014-05-30

Family

ID=40523804

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201391705A EA201391705A1 (ru) 2007-10-01 2008-09-19 Триазолпиридиновые ингибиторы 11-бета-гидроксистероиддегидрогеназы типа i
EA201000563A EA019706B1 (ru) 2007-10-01 2008-09-19 Триазолпиридиновые ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа i

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201391705A EA201391705A1 (ru) 2007-10-01 2008-09-19 Триазолпиридиновые ингибиторы 11-бета-гидроксистероиддегидрогеназы типа i

Country Status (20)

Country Link
US (2) US8119658B2 (ru)
EP (1) EP2205598A1 (ru)
JP (1) JP5611044B2 (ru)
KR (1) KR20100085081A (ru)
CN (1) CN101883772B (ru)
AR (1) AR068601A1 (ru)
AU (1) AU2008309101B2 (ru)
BR (1) BRPI0817656A2 (ru)
CA (1) CA2701355A1 (ru)
CL (1) CL2008002916A1 (ru)
CO (1) CO6280485A2 (ru)
EA (2) EA201391705A1 (ru)
IL (1) IL204799A (ru)
MX (1) MX2010003565A (ru)
NZ (1) NZ584386A (ru)
PE (2) PE20121704A1 (ru)
SG (1) SG190638A1 (ru)
TW (1) TW200916470A (ru)
WO (1) WO2009045753A1 (ru)
ZA (1) ZA201002043B (ru)

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