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EA201000032A1 - Синтетическая дезоксихолевая кислота и композиция на ее основе, соединения и способ получения дезоксихолевой кислоты, способ удаления жировых отложений - Google Patents

Синтетическая дезоксихолевая кислота и композиция на ее основе, соединения и способ получения дезоксихолевой кислоты, способ удаления жировых отложений

Info

Publication number
EA201000032A1
EA201000032A1 EA201000032A EA201000032A EA201000032A1 EA 201000032 A1 EA201000032 A1 EA 201000032A1 EA 201000032 A EA201000032 A EA 201000032A EA 201000032 A EA201000032 A EA 201000032A EA 201000032 A1 EA201000032 A1 EA 201000032A1
Authority
EA
Eurasian Patent Office
Prior art keywords
acid
dezoxy
synthetic
compounds
composition based
Prior art date
Application number
EA201000032A
Other languages
English (en)
Other versions
EA020806B1 (ru
Inventor
Роберт М. Мориарти
Натаниэл Е. Дэвид
Надир Ахмедуддин Махмуд
Ачампета Ратан Прасад
Рой А. Джей Сваринген
Джон Грегори Рейд
Акила Кумар Саху
Original Assignee
Кайсэрэ Байэуфамэсьютиклз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41226994&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201000032(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US12/035,339 external-priority patent/US20080318870A1/en
Priority claimed from GB0807615A external-priority patent/GB2452358C/en
Application filed by Кайсэрэ Байэуфамэсьютиклз, Инк. filed Critical Кайсэрэ Байэуфамэсьютиклз, Инк.
Publication of EA201000032A1 publication Critical patent/EA201000032A1/ru
Publication of EA020806B1 publication Critical patent/EA020806B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Описаны желчные кислоты и родственные композиции, а также способы синтеза и применение. В частности, предложены дезоксихолевая кислота и родственные композиции, причем указанные композиции свободны от всех примесей животной природы и свободны от пирогенных примесей.
EA201000032A 2007-06-19 2008-06-18 Способ получения дезоксихолевой кислоты (варианты), дезоксихолевая кислота, полученная указанным способом, фармацевтическая композиция, ее содержащая, способ удаления жировых отложений EA020806B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US94503507P 2007-06-19 2007-06-19
US95687507P 2007-08-20 2007-08-20
US12/035,339 US20080318870A1 (en) 2007-06-19 2008-02-21 Synthetic bile acid compositions and methods
GB0807615A GB2452358C (en) 2008-04-25 2008-04-25 Preparation of bile acids.
US12/153,446 US7902387B2 (en) 2008-04-25 2008-05-16 Preparation of bile acids and intermediates thereof
PCT/US2008/067391 WO2008157635A2 (en) 2007-06-19 2008-06-18 Synthetic bile acid composition, method, and preparation

Publications (2)

Publication Number Publication Date
EA201000032A1 true EA201000032A1 (ru) 2010-04-30
EA020806B1 EA020806B1 (ru) 2015-01-30

Family

ID=41226994

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000032A EA020806B1 (ru) 2007-06-19 2008-06-18 Способ получения дезоксихолевой кислоты (варианты), дезоксихолевая кислота, полученная указанным способом, фармацевтическая композиция, ее содержащая, способ удаления жировых отложений

Country Status (28)

Country Link
EP (3) EP2407475B1 (ru)
JP (2) JP2010530876A (ru)
KR (7) KR101598402B1 (ru)
CN (4) CN106146594A (ru)
AR (1) AR067440A1 (ru)
AU (1) AU2008265721B2 (ru)
BR (1) BRPI0813140C1 (ru)
CA (2) CA2690841C (ru)
CR (2) CR20170070A (ru)
CY (1) CY1116700T1 (ru)
DK (1) DK2407475T3 (ru)
EA (1) EA020806B1 (ru)
ES (2) ES2826429T3 (ru)
HR (1) HRP20150879T1 (ru)
HU (1) HUE025909T2 (ru)
IL (1) IL202203B (ru)
JO (1) JO3172B1 (ru)
MX (2) MX2009013664A (ru)
MY (1) MY160040A (ru)
NZ (1) NZ581081A (ru)
PH (1) PH12013500364A1 (ru)
PL (1) PL2407475T3 (ru)
PT (1) PT2407475E (ru)
SI (1) SI2407475T1 (ru)
SM (1) SMP201000003B (ru)
TW (2) TWI503396B (ru)
WO (1) WO2008157635A2 (ru)
ZA (1) ZA200907928B (ru)

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US8242294B2 (en) 2007-06-19 2012-08-14 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
JOP20180077A1 (ar) 2007-06-19 2019-01-30 Kythera Biopharmaceuticals Inc تركيبات وطرق لحمض صفراوي تخليقي
BRPI0813140C1 (pt) * 2007-06-19 2021-05-25 Kythera Biopharmaceuticals Inc método para a preparação de ácido desoxicólico (dca) ou um éster desse ou um sal farmaceuticamente aceitável desse e composto intermediário
US20080318870A1 (en) 2007-06-19 2008-12-25 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
GB2480632A (en) * 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
MX2013001704A (es) * 2010-08-12 2013-06-28 Kythera Biopharmaceuticals Inc Composiciones sinteticas de acido biliar y metodos.
EP3138850B8 (en) * 2011-06-16 2019-09-11 Allergan Sales, LLC Compositions containing deoxycholic acid and 10% deionized water in ethanol, directed to the purification of deoxycholic acid
US20130102580A1 (en) * 2011-09-22 2013-04-25 Kythera Biopharmaceuticals, Inc. Compositions and methods related to deoxycholic acid and its polymorphs
US10081592B2 (en) 2012-03-23 2018-09-25 The Board Of Trustees Of The University Of Illinois Complex and structurally diverse compounds
CN103059087B (zh) * 2012-12-30 2015-10-14 中山百灵生物技术有限公司 一种脱氧胆酸的合成方法
KR101447901B1 (ko) * 2013-04-16 2014-10-16 한양대학교 산학협력단 지방세포 표적 비바이러스성 유전자 전달체
MA43066A (fr) * 2015-07-30 2018-06-06 Intercept Pharmaceuticals Inc Procédés de préparation d'acides biliaires et de leurs dérivés
CN108366975A (zh) * 2015-11-04 2018-08-03 凯瑟拉生物制药有限公司 使用脱氧胆酸和其盐对堆积的脂肪的治疗
KR102527103B1 (ko) * 2016-06-06 2023-04-28 크리스탈 파마 에스.에이.유. 디옥시콜린산 제조방법 및 디옥시콜린산의 제조에 유용한 중간물
CN111328332B (zh) * 2017-08-03 2023-01-24 玫帝托克斯股份有限公司 用于制备胆汁酸类的方法
WO2019081586A1 (en) 2017-10-24 2019-05-02 Bionice, S.L.U. PREPARATION OF DEOXYCHOLIC ACID
RU2705314C1 (ru) * 2019-03-18 2019-11-06 Федеральное бюджетное учреждение науки "Государственный научный центр прикладной микробиологии и биотехнологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ПМБ) Способ производства сухих очищенных солей желчных кислот для бактериологии
KR102456989B1 (ko) * 2020-06-12 2022-10-21 (주)케어젠 항비만 활성을 가지는 디옥시콜산-펩타이드 결합체 및 이의 용도
EP4215540A4 (en) * 2020-09-18 2025-01-15 Seoul National University R & DB Foundation METHOD FOR MASS PRODUCTION OF SODIUM TAURODEOXYCHOLATE
JP2024525831A (ja) 2021-07-16 2024-07-12 スカイ・セラピューティクス・カンパニー・リミテッド 胆汁酸または胆汁酸塩の分子会合体及びこれを含む局所脂肪除去用の医薬組成物
CN117979950A (zh) 2021-07-16 2024-05-03 思凯制药有限公司 包含胆汁酸或胆汁酸盐的分子聚集体的化妆品组合物
CN114478676B (zh) * 2022-02-18 2024-05-10 国药集团化学试剂有限公司 一种脱氧胆酸钠的制备方法
CN115974949B (zh) * 2022-10-26 2023-12-22 湖南科瑞生物制药股份有限公司 一种植物源脱氧胆酸中间体的制备方法
CN118344420A (zh) * 2023-01-16 2024-07-16 北京诺博特生物科技有限公司 一种脱氧胆酸的制备方法
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Also Published As

Publication number Publication date
AU2008265721A1 (en) 2008-12-24
KR20180061401A (ko) 2018-06-07
KR101863131B1 (ko) 2018-06-01
AR067440A1 (es) 2009-10-14
TW201534684A (zh) 2015-09-16
PL2407475T3 (pl) 2015-12-31
CR11174A (es) 2010-03-23
IL202203A0 (en) 2010-06-16
CN106083969B (zh) 2018-02-27
IL202203B (en) 2018-04-30
JP2013075918A (ja) 2013-04-25
KR20100031512A (ko) 2010-03-22
CN108191940B (zh) 2021-02-09
DK2407475T3 (en) 2015-10-26
JP2010530876A (ja) 2010-09-16
CA2690841A1 (en) 2008-12-24
HRP20150879T1 (hr) 2015-09-25
NZ581081A (en) 2012-12-21
SMAP201000003A (it) 2010-03-01
BRPI0813140A2 (pt) 2014-12-23
TW200918550A (en) 2009-05-01
BRPI0813140C1 (pt) 2021-05-25
PT2407475E (pt) 2015-11-20
PH12013500364A1 (en) 2014-04-28
EP2407475A2 (en) 2012-01-18
SMP201000003B (it) 2010-11-12
TWI503396B (zh) 2015-10-11
EP3002290A3 (en) 2016-06-29
HK1223372A1 (en) 2017-07-28
EP2407475A3 (en) 2012-06-13
KR20160025044A (ko) 2016-03-07
CR20170070A (es) 2017-04-27
MY160040A (en) 2017-02-15
JO3172B1 (ar) 2018-03-08
AU2008265721B2 (en) 2014-03-20
KR20180122483A (ko) 2018-11-12
CA2690841C (en) 2012-11-27
CN106083969A (zh) 2016-11-09
EA020806B1 (ru) 2015-01-30
EP2069383A2 (en) 2009-06-17
HK1165807A1 (en) 2012-10-12
EP3002290B1 (en) 2020-09-09
BRPI0813140B1 (pt) 2019-02-05
KR101916024B1 (ko) 2018-11-08
WO2008157635A2 (en) 2008-12-24
CA2789109C (en) 2015-10-06
KR20130133881A (ko) 2013-12-09
WO2008157635A3 (en) 2009-06-04
CN106146594A (zh) 2016-11-23
TWI503327B (zh) 2015-10-11
KR101598402B1 (ko) 2016-03-03
KR20160150646A (ko) 2016-12-30
HUE025909T2 (en) 2016-04-28
KR102061001B1 (ko) 2020-01-03
ZA200907928B (en) 2011-05-28
KR20150013305A (ko) 2015-02-04
EP3002290A2 (en) 2016-04-06
CN108191940A (zh) 2018-06-22
SI2407475T1 (sl) 2016-03-31
ES2826429T3 (es) 2021-05-18
CN101711254A (zh) 2010-05-19
MX360094B (es) 2018-10-19
CY1116700T1 (el) 2017-03-15
EP2407475B1 (en) 2015-08-12
JP5589102B2 (ja) 2014-09-10
CA2789109A1 (en) 2008-12-24
MX2009013664A (es) 2010-04-07
ES2550504T3 (es) 2015-11-10

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