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EA200970203A1 - Новый способ получения эфира 3-амино-5-фтор-4-диалкоксипентановой кислоты - Google Patents

Новый способ получения эфира 3-амино-5-фтор-4-диалкоксипентановой кислоты

Info

Publication number
EA200970203A1
EA200970203A1 EA200970203A EA200970203A EA200970203A1 EA 200970203 A1 EA200970203 A1 EA 200970203A1 EA 200970203 A EA200970203 A EA 200970203A EA 200970203 A EA200970203 A EA 200970203A EA 200970203 A1 EA200970203 A1 EA 200970203A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amino
dialcoxypentanic
ftor
obtaining
new method
Prior art date
Application number
EA200970203A
Other languages
English (en)
Other versions
EA016854B1 (ru
Inventor
Хиун Ик Шин
Хиеонг Воок Чои
Дзае Хоон Ли
Киу Воонг Ли
Original Assignee
Эл Джи Лайф Сайенсиз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эл Джи Лайф Сайенсиз Лтд. filed Critical Эл Джи Лайф Сайенсиз Лтд.
Publication of EA200970203A1 publication Critical patent/EA200970203A1/ru
Publication of EA016854B1 publication Critical patent/EA016854B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Данное изобретение относится к новому способу получения эфира 3-амино-5-фтор-4-диалкоксипентановой кислоты, применимого в качестве предшественника 3-амино-5-фтор-4-оксопентановой кислоты, представленной следующей формулой (1), в которой R1 и R2 определены в описании.
EA200970203A 2006-08-16 2007-08-09 Новый способ получения эфира 3-амино-5-фтор-4-диалкоксипентановой кислоты EA016854B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020060077360A KR101299720B1 (ko) 2006-08-16 2006-08-16 3-아미노-5-플루오로-4-디알콕시펜탄산 에스테르의 새로운제조방법
PCT/KR2007/003822 WO2008020691A1 (en) 2006-08-16 2007-08-09 A novel process for preparing 3-amino-5-fluoro-4-dialkoxypentanoic acid ester

Publications (2)

Publication Number Publication Date
EA200970203A1 true EA200970203A1 (ru) 2009-08-28
EA016854B1 EA016854B1 (ru) 2012-08-30

Family

ID=39082197

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970203A EA016854B1 (ru) 2006-08-16 2007-08-09 Новый способ получения эфира 3-амино-5-фтор-4-диалкоксипентановой кислоты

Country Status (13)

Country Link
US (1) US7906676B2 (ru)
EP (1) EP2051959A4 (ru)
JP (1) JP4956614B2 (ru)
KR (1) KR101299720B1 (ru)
CN (1) CN101506146B (ru)
AU (1) AU2007285155B2 (ru)
BR (1) BRPI0716662A2 (ru)
CA (1) CA2660348C (ru)
CO (1) CO6160223A2 (ru)
EA (1) EA016854B1 (ru)
MX (1) MX2009001508A (ru)
NZ (1) NZ574792A (ru)
WO (1) WO2008020691A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008245A (zh) * 2016-05-31 2016-10-12 北京华清科创科技开发有限公司 基于触媒法的氨基酮戊酸的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5770847A (en) * 1980-10-21 1982-05-01 Microbial Chem Res Found Preparation of 3-aminoglutaric acid dialkyl ester
DE3343531A1 (de) * 1983-12-01 1985-06-13 Bayer Ag, 5090 Leverkusen Substituierte acetylenketone
JPS6191160A (ja) * 1984-10-09 1986-05-09 Nisshin Flour Milling Co Ltd Ｌ−カルニチンの製造法
JP2620533B2 (ja) * 1985-12-28 1997-06-18 住友製薬株式会社 新規なアミノ酸誘導体
JPH0742258B2 (ja) * 1989-04-14 1995-05-10 宇部興産株式会社 ３―置換アミノアクリル酸エステル類の製造法
JP2891740B2 (ja) * 1990-03-30 1999-05-17 塩野義製薬株式会社 光学活性ノルボルナン系アミン誘導体の製造方法
US6200969B1 (en) 1996-09-12 2001-03-13 Idun Pharmaceuticals, Inc. Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
JP2001522825A (ja) * 1997-11-07 2001-11-20 ゾルファイ フルーオル ウント デリヴァーテ ゲゼルシャフト ミット ベシュレンクテル ハフツング アミノハロゲンクロトネートの製造方法
DE69925268T2 (de) 1998-03-16 2006-03-23 Cytovia, Inc., San Diego Dipeptid-Caspase-Inhibitoren und deren Verwendung
JP3632069B2 (ja) * 1999-09-03 2005-03-23 国立大学法人東北大学 含フッ素モノマーおよびその合成方法
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
EP1463699A2 (en) * 2001-07-03 2004-10-06 ALTANA Pharma AG Process for the production of 3-phenylisoserine
CA2519220A1 (en) * 2003-03-18 2004-09-30 Merck & Co., Inc. Amino cyclobutylamide modulators of chemokine receptor activity
KR100594544B1 (ko) * 2003-08-27 2006-06-30 주식회사 엘지생명과학 이소옥사졸린 구조를 갖는 캐스파제 저해제
KR20080019732A (ko) * 2004-07-09 2008-03-04 워너-램버트 캄파니 엘엘씨 알파-2-델타 단백질에 대한 친화도를 갖는 베타-아미노산의제조 방법
KR100774999B1 (ko) * 2005-02-26 2007-11-09 주식회사 엘지생명과학 이소옥사졸린 유도체 및 그의 제조 방법

Also Published As

Publication number Publication date
EP2051959A4 (en) 2011-04-13
US20100036158A1 (en) 2010-02-11
EA016854B1 (ru) 2012-08-30
CN101506146B (zh) 2013-06-12
BRPI0716662A2 (pt) 2013-09-17
JP4956614B2 (ja) 2012-06-20
US7906676B2 (en) 2011-03-15
NZ574792A (en) 2011-12-22
CA2660348C (en) 2013-03-12
KR20080015692A (ko) 2008-02-20
JP2010500403A (ja) 2010-01-07
CN101506146A (zh) 2009-08-12
KR101299720B1 (ko) 2013-08-28
WO2008020691A1 (en) 2008-02-21
AU2007285155A1 (en) 2008-02-21
AU2007285155B2 (en) 2012-05-31
CA2660348A1 (en) 2008-02-21
CO6160223A2 (es) 2010-05-20
MX2009001508A (es) 2009-02-18
EP2051959A1 (en) 2009-04-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU