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EA200901423A1 - Бензимидазолы и содержащие их фармацевтические композиции - Google Patents

Бензимидазолы и содержащие их фармацевтические композиции

Info

Publication number
EA200901423A1
EA200901423A1 EA200901423A EA200901423A EA200901423A1 EA 200901423 A1 EA200901423 A1 EA 200901423A1 EA 200901423 A EA200901423 A EA 200901423A EA 200901423 A EA200901423 A EA 200901423A EA 200901423 A1 EA200901423 A1 EA 200901423A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzimidazoly
pharmaceutical compositions
pharmaceutically acceptable
relates
patient
Prior art date
Application number
EA200901423A
Other languages
English (en)
Other versions
EA016726B1 (ru
Inventor
Ивао Оджима
Шонг-юб Ли
Original Assignee
Дзе Рисёч Фаундейшн Оф Стейт Юнивесити Оф Нью Йорк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Рисёч Фаундейшн Оф Стейт Юнивесити Оф Нью Йорк filed Critical Дзе Рисёч Фаундейшн Оф Стейт Юнивесити Оф Нью Йорк
Publication of EA200901423A1 publication Critical patent/EA200901423A1/ru
Publication of EA016726B1 publication Critical patent/EA016726B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым производным бензимидазола и их фармацевтически приемлемым солям. Другой аспект изобретения относится к лечению пациента, инфицированного Mycobacterium tuberculosis или Francisella tulerensis путем введения пациенту производного бензимидазола или его фармацевтически приемлемой соли.
EA200901423A 2007-04-20 2008-04-21 Бензимидазолы и содержащие их фармацевтические композиции EA016726B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91298007P 2007-04-20 2007-04-20
PCT/US2008/005084 WO2008130669A1 (en) 2007-04-20 2008-04-21 Benzimidazoles and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
EA200901423A1 true EA200901423A1 (ru) 2010-06-30
EA016726B1 EA016726B1 (ru) 2012-07-30

Family

ID=39875833

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901423A EA016726B1 (ru) 2007-04-20 2008-04-21 Бензимидазолы и содержащие их фармацевтические композиции

Country Status (17)

Country Link
US (1) US8232410B2 (ru)
EP (1) EP2154966B1 (ru)
JP (1) JP5400032B2 (ru)
CN (1) CN101677553A (ru)
AU (1) AU2008242488B2 (ru)
BR (1) BRPI0810244A2 (ru)
CA (1) CA2684594C (ru)
DK (1) DK2154966T3 (ru)
EA (1) EA016726B1 (ru)
ES (1) ES2434693T3 (ru)
HR (1) HRP20131103T1 (ru)
IN (1) IN2009KN03959A (ru)
MX (1) MX2009011281A (ru)
PL (1) PL2154966T3 (ru)
PT (1) PT2154966E (ru)
SI (1) SI2154966T1 (ru)
WO (1) WO2008130669A1 (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232310B2 (en) 2006-12-29 2012-07-31 Georgetown University Targeting of EWS-FLI1 as anti-tumor therapy
US8039502B2 (en) 2007-07-24 2011-10-18 The Ohio State University Research Foundation Anti-infective agents against intracellular pathogens
US20120108823A1 (en) 2009-04-22 2012-05-03 The Ohio State University Research Foundation Anti-francisella agents
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
WO2013116823A1 (en) * 2012-02-02 2013-08-08 The Research Foundation Of State University Of New York Benzimidazoles and uses thereof
WO2013142326A1 (en) * 2012-03-23 2013-09-26 The Research Foundation Of State University Of New York 5-carbonylamino-/(sulfonamido-) substituted benz imidazoles and use thereof treatment of tuberculosis
IN2014DN09228A (ru) * 2012-04-12 2015-07-10 Univ Georgetown
CN103333170B (zh) * 2013-06-14 2016-08-10 清华大学 苯并咪唑类化合物及其用途
EP3060207A4 (en) 2013-10-24 2017-04-12 Georgetown University Methods and compositions for treating cancer
CN106061951A (zh) * 2013-11-22 2016-10-26 纽约州立大学研究基金会 苯并咪唑及其在结核病治疗中的用途
US10287617B2 (en) 2014-03-11 2019-05-14 Colorado State University Research Foundation Methods for in vitro—in vivo efficacy determination
EP3157904B1 (en) * 2014-06-20 2020-11-18 Institut Pasteur Korea Anti-infective compounds
US9604927B2 (en) 2014-10-09 2017-03-28 Oncternal Therapeutics, Inc. Indolinone compounds and uses thereof
ES2823190T3 (es) 2016-03-31 2021-05-06 Oncternal Therapeutics Inc Análogos de indolina y usos de los mismos
US10159660B2 (en) 2016-07-29 2018-12-25 Oncternal Therapeutics, Inc. Uses of indolinone compounds
CN111303092B (zh) * 2020-04-07 2021-05-25 山东昌邑灶户盐化有限公司 2,4-二硝基-6-氯苯胺衍生物、合成方法及其应用
WO2023283425A1 (en) 2021-07-09 2023-01-12 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61170732A (ja) * 1985-01-25 1986-08-01 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
EP1805147B1 (en) * 2004-09-30 2014-08-13 Janssen Pharmaceutica NV Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
EP2008210A1 (en) 2006-03-15 2008-12-31 Csir Modulation of phosphoryl transferase activity of glutamine synthetase

Also Published As

Publication number Publication date
EP2154966A4 (en) 2010-12-15
CN101677553A (zh) 2010-03-24
ES2434693T3 (es) 2013-12-17
EP2154966A1 (en) 2010-02-24
US20100256203A1 (en) 2010-10-07
BRPI0810244A2 (pt) 2014-09-30
EP2154966B1 (en) 2013-08-21
HRP20131103T1 (hr) 2013-12-20
JP5400032B2 (ja) 2014-01-29
IN2009KN03959A (ru) 2015-08-28
PL2154966T3 (pl) 2014-03-31
AU2008242488A1 (en) 2008-10-30
US8232410B2 (en) 2012-07-31
MX2009011281A (es) 2010-03-08
AU2008242488B2 (en) 2014-10-30
DK2154966T3 (da) 2013-11-18
SI2154966T1 (sl) 2014-02-28
PT2154966E (pt) 2013-11-13
CA2684594C (en) 2015-10-06
EA016726B1 (ru) 2012-07-30
CA2684594A1 (en) 2008-10-30
JP2010524947A (ja) 2010-07-22
WO2008130669A1 (en) 2008-10-30

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU