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EA200801402A1 - Карбаматные соединения в качестве агонистов рецептора 5-нт - Google Patents

Карбаматные соединения в качестве агонистов рецептора 5-нт

Info

Publication number
EA200801402A1
EA200801402A1 EA200801402A EA200801402A EA200801402A1 EA 200801402 A1 EA200801402 A1 EA 200801402A1 EA 200801402 A EA200801402 A EA 200801402A EA 200801402 A EA200801402 A EA 200801402A EA 200801402 A1 EA200801402 A1 EA 200801402A1
Authority
EA
Eurasian Patent Office
Prior art keywords
agonists
receptor
carbamatic
compounds
creation
Prior art date
Application number
EA200801402A
Other languages
English (en)
Other versions
EA014819B1 (ru
Inventor
Дэниэл Лонг
Сеок-Ки Чои
Пол Р. Фазери
Адам Голдблум
Дэниэл Маркесс
Original Assignee
Тереванс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тереванс, Инк. filed Critical Тереванс, Инк.
Publication of EA200801402A1 publication Critical patent/EA200801402A1/ru
Publication of EA014819B1 publication Critical patent/EA014819B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение обеспечивает создание новых агонистов рецептора 5-НТ
EA200801402A 2005-11-22 2006-11-21 Карбаматные соединения в качестве агонистов рецептора 5-ht EA014819B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73870205P 2005-11-22 2005-11-22
PCT/US2006/045099 WO2007062058A2 (en) 2005-11-22 2006-11-21 Carbamate compounds as 5-ht4 receptor agonists

Publications (2)

Publication Number Publication Date
EA200801402A1 true EA200801402A1 (ru) 2008-10-30
EA014819B1 EA014819B1 (ru) 2011-02-28

Family

ID=38067868

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801402A EA014819B1 (ru) 2005-11-22 2006-11-21 Карбаматные соединения в качестве агонистов рецептора 5-ht

Country Status (20)

Country Link
US (2) US7329752B2 (ru)
EP (1) EP1960396B1 (ru)
JP (1) JP2009516745A (ru)
KR (1) KR20080072727A (ru)
CN (1) CN101312967B (ru)
AR (1) AR057627A1 (ru)
AT (1) ATE448224T1 (ru)
AU (1) AU2006318507A1 (ru)
BR (1) BRPI0618835A2 (ru)
CA (1) CA2630222A1 (ru)
DE (1) DE602006010432D1 (ru)
EA (1) EA014819B1 (ru)
ES (1) ES2336952T3 (ru)
MY (1) MY143574A (ru)
NO (1) NO20082597L (ru)
NZ (1) NZ567653A (ru)
PE (1) PE20070954A1 (ru)
TW (1) TW200804366A (ru)
WO (1) WO2007062058A2 (ru)
ZA (1) ZA200804010B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7446114B2 (en) * 2005-03-02 2008-11-04 Theravance, Inc. Quinolinone compounds as 5-HT4 receptor agonists
ATE509021T1 (de) * 2006-02-16 2011-05-15 Theravance Inc Verfahren zur herstellung von zwischenverbindungen zu 5-ht4-rezeptoragonist- verbindungen

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223511A (en) 1987-09-23 1993-06-29 Boehringer Ingelheim Italia S.P.A. Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists
IT1231413B (it) 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
JP3829879B2 (ja) 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
US6069152A (en) 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
IT1298271B1 (it) 1998-02-18 1999-12-20 Boehringer Ingelheim Italia Esteri ed ammidi dell'acido 2-oxo-2,3-diidro-benzimidazol-1- carbossilico
CN1461216A (zh) 1999-04-28 2003-12-10 呼吸器有限公司 用作治疗有关支气管收缩的机能障碍的药物的化合物
IT1313625B1 (it) 1999-09-22 2002-09-09 Boehringer Ingelheim Italia Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina.
JP4181847B2 (ja) * 2002-10-25 2008-11-19 エルピーダメモリ株式会社 タイミング調整回路、半導体装置及びタイミング調整方法
DK1664036T3 (da) 2003-09-03 2012-02-13 Pfizer Benzimidazolonforbindelser med 5-HT4-receptoragonistisk virkning
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
ATE441646T1 (de) 2004-11-05 2009-09-15 Theravance Inc 5-ht4-rezeptoragonistenverbindungen
JP5042028B2 (ja) 2004-11-05 2012-10-03 セラヴァンス， インコーポレーテッド キノリノン−カルボキサミド化合物
CA2588037A1 (en) 2004-12-22 2006-06-29 Theravance, Inc. Indazole-carboxamide compounds
US7446114B2 (en) * 2005-03-02 2008-11-04 Theravance, Inc. Quinolinone compounds as 5-HT4 receptor agonists
US7351304B2 (en) * 2005-05-24 2008-04-01 General Electric Company Method and apparatus for reducing surface defects
US7317022B2 (en) 2005-06-07 2008-01-08 Theravance, Inc. Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists

Also Published As

Publication number Publication date
EP1960396B1 (en) 2009-11-11
TW200804366A (en) 2008-01-16
JP2009516745A (ja) 2009-04-23
MY143574A (en) 2011-05-31
US7851467B2 (en) 2010-12-14
KR20080072727A (ko) 2008-08-06
ATE448224T1 (de) 2009-11-15
NZ567653A (en) 2011-06-30
CN101312967B (zh) 2011-08-24
US20070117796A1 (en) 2007-05-24
CA2630222A1 (en) 2007-05-31
WO2007062058A2 (en) 2007-05-31
EA014819B1 (ru) 2011-02-28
NO20082597L (no) 2008-06-10
EP1960396A2 (en) 2008-08-27
AU2006318507A1 (en) 2007-05-31
WO2007062058A3 (en) 2007-09-07
US20080090811A1 (en) 2008-04-17
PE20070954A1 (es) 2007-09-10
US7329752B2 (en) 2008-02-12
ES2336952T3 (es) 2010-04-19
AR057627A1 (es) 2007-12-05
ZA200804010B (en) 2009-02-25
CN101312967A (zh) 2008-11-26
DE602006010432D1 (de) 2009-12-24
BRPI0618835A2 (pt) 2011-09-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU