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EA200700876A1 - AGENTS SPECIFICALLY BINDING ANGIOPOETIN-2 - Google Patents

AGENTS SPECIFICALLY BINDING ANGIOPOETIN-2

Info

Publication number
EA200700876A1
EA200700876A1 EA200700876A EA200700876A EA200700876A1 EA 200700876 A1 EA200700876 A1 EA 200700876A1 EA 200700876 A EA200700876 A EA 200700876A EA 200700876 A EA200700876 A EA 200700876A EA 200700876 A1 EA200700876 A1 EA 200700876A1
Authority
EA
Eurasian Patent Office
Prior art keywords
angiopoetin
specifically binding
agents specifically
antibodies
fragments
Prior art date
Application number
EA200700876A
Other languages
Russian (ru)
Other versions
EA011866B1 (en
Inventor
Джонатон Даниел Олайнер
Кевин Грэхэм
Original Assignee
Амджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/982,440 external-priority patent/US7658924B2/en
Application filed by Амджен Инк. filed Critical Амджен Инк.
Publication of EA200700876A1 publication Critical patent/EA200700876A1/en
Publication of EA011866B1 publication Critical patent/EA011866B1/en

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Раскрыты специфические связывающие агенты, такие как полностью человеческие антитела, которые связывают ангиопоэтин-2. Раскрыты также фрагменты тяжёлых цепей, фрагменты лёгких цепей и участки, определяющие комплементарность (CDR), в составе антител, а также способы получения и применения этих антител.Specific binding agents are disclosed, such as fully human antibodies that bind angiopoietin-2. Also disclosed are fragments of heavy chains, fragments of light chains, and regions that determine complementarity (CDR) in the composition of antibodies, as well as methods for producing and using these antibodies.

EA200700876A 2004-10-19 2005-10-19 Angiopoetin-2 specific binding agents EA011866B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62016104P 2004-10-19 2004-10-19
US10/982,440 US7658924B2 (en) 2001-10-11 2004-11-04 Angiopoietin-2 specific binding agents
PCT/US2005/037911 WO2006045049A1 (en) 2004-10-19 2005-10-19 Angiopoietin-2 specific binding agents

Publications (2)

Publication Number Publication Date
EA200700876A1 true EA200700876A1 (en) 2007-10-26
EA011866B1 EA011866B1 (en) 2009-06-30

Family

ID=39608222

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700876A EA011866B1 (en) 2004-10-19 2005-10-19 Angiopoetin-2 specific binding agents

Country Status (10)

Country Link
JP (2) JP2008520188A (en)
CN (1) CN101495513B (en)
BR (1) BRPI0518209A (en)
EA (1) EA011866B1 (en)
IL (1) IL182279A0 (en)
MA (1) MA29015B1 (en)
MX (1) MX2007004247A (en)
RU (2) RU2404992C2 (en)
SG (1) SG156668A1 (en)
ZA (1) ZA200704020B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014100834A1 (en) * 2012-12-21 2014-06-26 The Regents Of The University Of California Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101495513B (en) * 2004-10-19 2014-08-06 安姆根有限公司 Angiopoietin-2 specific binding agents
JO3182B1 (en) * 2009-07-29 2018-03-08 Regeneron Pharma Human antibiotics with high pH generation - 2
AU2010285740C1 (en) 2009-08-19 2016-03-17 Eisai R&D Management Co., Ltd. Quinoline derivative-containing pharmaceutical composition
EA022546B1 (en) * 2011-09-28 2016-01-29 Федеральное Государственное Бюджетное Учреждение Науки Институт Биоорганической Химии Им. Академиков М.М. Шемякина И Ю.А. Овчинникова Российской Академии Наук Method for inhibiting growth of ehrlich carcinoma in laboratory animal
CA2850542A1 (en) * 2011-09-30 2013-04-04 Dana-Farber Cancer Institute, Inc. Therapeutic peptides
KR102063028B1 (en) * 2012-01-23 2020-01-07 리제너론 파아마슈티컬스, 인크. Stabilized formulations containing anti-ang2 antibodies
US10517861B2 (en) * 2013-05-14 2019-12-31 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
AR100270A1 (en) * 2014-05-19 2016-09-21 Lilly Co Eli ANTIBODIES ANG2
JP6659554B2 (en) 2014-08-28 2020-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 High purity quinoline derivative and method for producing the same
LT3263106T (en) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. METHOD OF REDUCING BITTERNESS OF QUINOLINE DERIVATIVES
AU2015384801B2 (en) 2015-03-04 2022-01-06 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
AU2016279474B2 (en) 2015-06-16 2021-09-09 Eisai R&D Management Co., Ltd. Anticancer agent
SG11201801083UA (en) 2015-08-20 2018-03-28 Eisai R&D Man Co Ltd Tumor therapeutic agent
CN106512006A (en) * 2016-07-25 2017-03-22 广州道瑞医药科技有限公司 Application of ANGPT2 secretion inhibitor to preparation of medicine for treating hemangiomas
CN106075448A (en) * 2016-07-25 2016-11-09 广州道瑞医药科技有限公司 ANGPT2 inhibitor is used for treating the application in angiomatous medicine in preparation
CN110072528B (en) 2017-02-08 2022-04-26 卫材R&D管理有限公司 Pharmaceutical composition for treating tumor
KR20200013644A (en) 2017-05-16 2020-02-07 에자이 알앤드디 매니지먼트 가부시키가이샤 Treatment of Hepatocellular Carcinoma
CN109096368B (en) * 2018-09-30 2021-07-20 华南理工大学 A polypeptide having both anti-oxidative and liver-protecting activities, a gene encoding the polypeptide, and a preparation method and application thereof
JP7177284B2 (en) * 2019-02-25 2022-11-22 ファームアブシン・インコーポレイテッド Anti-ANG2 antibody and use thereof
CN112126671B (en) * 2020-08-18 2021-08-31 中山大学附属第五医院 Application of Streptococcus agalactiae in the treatment of endometriosis
CN116265487B (en) * 2021-12-16 2025-01-10 三优生物医药(上海)有限公司 Anti-ANG 2-VEGF bispecific antibodies and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1165115E (en) * 1999-03-26 2003-10-31 Univ California MODULATION OF VASCULAR PERMEABILITY BY TIE2 RECEPTOR ACTIVATORS
HK1045700B (en) * 1999-04-28 2007-07-27 德克萨斯大学董事会 Compositions an methods for cancer treatment by selectively inhibiting vegf
DE60128685T2 (en) * 2000-06-23 2009-03-05 Bayer Schering Pharma Aktiengesellschaft COMPOSITIONS INTERFERING TO VEGF / VEGF AND ANGIOPOIETIN / TIE RECEPTOR FUNCTIONS
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
AU2002362772B2 (en) * 2001-10-12 2007-09-06 Aquestive Therapeutics, Inc. Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
CN101495513B (en) * 2004-10-19 2014-08-06 安姆根有限公司 Angiopoietin-2 specific binding agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014100834A1 (en) * 2012-12-21 2014-06-26 The Regents Of The University Of California Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity
US9534007B2 (en) 2012-12-21 2017-01-03 The Regents Of The University Of California Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity

Also Published As

Publication number Publication date
SG156668A1 (en) 2009-11-26
RU2007118670A (en) 2008-12-27
CN101495513A (en) 2009-07-29
EA011866B1 (en) 2009-06-30
JP2008520188A (en) 2008-06-19
JP2011207882A (en) 2011-10-20
RU2404992C2 (en) 2010-11-27
RU2010132956A (en) 2012-02-10
MA29015B1 (en) 2007-11-01
CN101495513B (en) 2014-08-06
MX2007004247A (en) 2007-06-12
ZA200704020B (en) 2008-06-25
BRPI0518209A (en) 2008-11-04
IL182279A0 (en) 2007-07-24

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU