EA200601226A1 - Производные 2-(1н-индолилсульфанил)бензиламина в качестве ssri - Google Patents
Производные 2-(1н-индолилсульфанил)бензиламина в качестве ssriInfo
- Publication number
- EA200601226A1 EA200601226A1 EA200601226A EA200601226A EA200601226A1 EA 200601226 A1 EA200601226 A1 EA 200601226A1 EA 200601226 A EA200601226 A EA 200601226A EA 200601226 A EA200601226 A EA 200601226A EA 200601226 A1 EA200601226 A1 EA 200601226A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- indolylsulphanil
- ssri
- benzylamine
- disorders
- Prior art date
Links
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 title 2
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 title 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000027520 Somatoform disease Diseases 0.000 abstract 1
- 206010066218 Stress Urinary Incontinence Diseases 0.000 abstract 1
- 125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 abstract 1
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 abstract 1
- 208000027753 pain disease Diseases 0.000 abstract 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Данное изобретение относится к производным анилина общей формулы I и их применению в качестве ингибиторов обратного захвата серотонина и предпочтительно также ингибиторов обратного захвата норадреналина для лечения депрессии, тревожных расстройств, аффективных расстройств, болевых расстройств, синдрома дефицита внимания и гиперактивности и стрессового недержания мочи:
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301923 | 2003-12-23 | ||
| PCT/DK2004/000894 WO2005061455A1 (en) | 2003-12-23 | 2004-12-21 | 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200601226A1 true EA200601226A1 (ru) | 2006-10-27 |
| EA010666B1 EA010666B1 (ru) | 2008-10-30 |
Family
ID=36603121
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200601226A EA010666B1 (ru) | 2003-12-23 | 2004-12-21 | Производные 2-(1h-индолилсульфанил)бензиламина в качестве ssri |
| EA200702258A EA012752B1 (ru) | 2003-12-23 | 2004-12-21 | Производные 2-(1н-индолилсульфанил)бензиламина в качестве ssri |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200702258A EA012752B1 (ru) | 2003-12-23 | 2004-12-21 | Производные 2-(1н-индолилсульфанил)бензиламина в качестве ssri |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1860100B1 (ru) |
| KR (2) | KR100872022B1 (ru) |
| CN (2) | CN100591666C (ru) |
| AR (1) | AR046978A1 (ru) |
| AT (1) | ATE500220T1 (ru) |
| CA (1) | CA2551168C (ru) |
| DE (1) | DE602004031680D1 (ru) |
| DK (1) | DK1860100T3 (ru) |
| EA (2) | EA010666B1 (ru) |
| ES (1) | ES2362237T3 (ru) |
| IS (2) | IS2551B (ru) |
| ME (1) | ME01040B (ru) |
| MY (1) | MY143038A (ru) |
| NO (1) | NO336676B1 (ru) |
| NZ (1) | NZ547046A (ru) |
| PL (1) | PL1860100T4 (ru) |
| PT (1) | PT1860100E (ru) |
| RS (1) | RS51899B (ru) |
| SG (1) | SG141463A1 (ru) |
| SI (1) | SI1860100T1 (ru) |
| TW (1) | TWI347183B (ru) |
| UA (1) | UA82920C2 (ru) |
| ZA (1) | ZA200705870B (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224201B (zh) * | 2007-01-18 | 2011-10-05 | 和泓生物技术（上海）有限公司 | 多巴胺转运蛋白和去甲肾上腺素转运蛋白双重抑制剂的应用 |
| WO2012024620A2 (en) * | 2010-08-20 | 2012-02-23 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3803143A (en) | 1969-09-08 | 1974-04-09 | Eisai Co Ltd | 6-amino alkylene 6,7-dihydro-5h-dibenzo (b,g),(1,5)thiazocines |
| US4018830A (en) | 1969-09-22 | 1977-04-19 | Merck & Co., Inc. | Phenylthioaralkylamines |
| US4055665A (en) | 1974-11-25 | 1977-10-25 | Merck & Co., Inc. | Treating arrythmia with phenylthioaralkylamines |
| US4056632A (en) | 1975-07-21 | 1977-11-01 | Burroughs Wellcome Co. | 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use |
| EP0396827A1 (en) | 1989-05-09 | 1990-11-14 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | 2-Phenylthiobenzylamine dervivatives and acid addition salts thereof |
| GB8912971D0 (en) | 1989-06-06 | 1989-07-26 | Wellcome Found | Halogen substituted diphenylsulfides |
| GB9126311D0 (en) | 1991-12-11 | 1992-02-12 | Wellcome Found | Substituted diphenylsulfides |
| CZ293595A3 (cs) | 1995-11-09 | 1999-12-15 | Farmak A. S. | Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích |
| US5912256A (en) * | 1996-06-20 | 1999-06-15 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| EP0923548B1 (en) * | 1996-08-27 | 2003-03-12 | Wyeth | 4-aminoethoxy indoles as dopamin d2 agonists and as 5ht 1a ligands |
| ES2264259T3 (es) | 1999-04-30 | 2006-12-16 | Trustees Of The University Of Pennsylvania | Agentes de obtencion de imagenes por spect (tomografia por emision de foton unico) para transportador de serotonina. |
| US6410736B1 (en) | 1999-11-29 | 2002-06-25 | Pfizer Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
| US6436938B1 (en) | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
-
2004
- 2004-12-16 TW TW093139107A patent/TWI347183B/zh not_active IP Right Cessation
- 2004-12-21 ME MEP-2008-66A patent/ME01040B/me unknown
- 2004-12-21 UA UAA200607149A patent/UA82920C2/uk unknown
- 2004-12-21 SI SI200431671T patent/SI1860100T1/sl unknown
- 2004-12-21 MY MYPI20045285A patent/MY143038A/en unknown
- 2004-12-21 RS RS20110213A patent/RS51899B/sr unknown
- 2004-12-21 SG SG200802454-9A patent/SG141463A1/en unknown
- 2004-12-21 PT PT07017638T patent/PT1860100E/pt unknown
- 2004-12-21 PL PL07017638T patent/PL1860100T4/pl unknown
- 2004-12-21 KR KR1020067011175A patent/KR100872022B1/ko not_active Expired - Fee Related
- 2004-12-21 EP EP07017638A patent/EP1860100B1/en not_active Expired - Lifetime
- 2004-12-21 CA CA2551168A patent/CA2551168C/en not_active Expired - Fee Related
- 2004-12-21 KR KR1020087021534A patent/KR20080092471A/ko not_active Withdrawn
- 2004-12-21 CN CN200480038470A patent/CN100591666C/zh not_active Expired - Fee Related
- 2004-12-21 AR ARP040104830A patent/AR046978A1/es not_active Application Discontinuation
- 2004-12-21 DE DE602004031680T patent/DE602004031680D1/de not_active Expired - Lifetime
- 2004-12-21 DK DK07017638.3T patent/DK1860100T3/da active
- 2004-12-21 EA EA200601226A patent/EA010666B1/ru not_active IP Right Cessation
- 2004-12-21 CN CNA2008101447939A patent/CN101372474A/zh active Pending
- 2004-12-21 ES ES07017638T patent/ES2362237T3/es not_active Expired - Lifetime
- 2004-12-21 ZA ZA200705870A patent/ZA200705870B/xx unknown
- 2004-12-21 NZ NZ547046A patent/NZ547046A/en not_active IP Right Cessation
- 2004-12-21 EA EA200702258A patent/EA012752B1/ru not_active IP Right Cessation
- 2004-12-21 AT AT07017638T patent/ATE500220T1/de active
-
2006
- 2006-05-15 IS IS8467A patent/IS2551B/is unknown
- 2006-07-24 NO NO20063405A patent/NO336676B1/no not_active IP Right Cessation
-
2009
- 2009-06-05 IS IS8827A patent/IS2815B/is unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY RU |