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EA200400301A1 - КОМПОЗИЦИИ ДЛЯ ИНГАЛЯЦИИ, СОДЕРЖАЩИЕ ТРИЦИКЛИЧЕСКИЕ 5,6-ДИГИДРО-9H-ПИРАЗОЛО (3,4-c)-1,2,4-ТРИАЗОЛО (4,3-α) ПИРИДИНЫ - Google Patents

КОМПОЗИЦИИ ДЛЯ ИНГАЛЯЦИИ, СОДЕРЖАЩИЕ ТРИЦИКЛИЧЕСКИЕ 5,6-ДИГИДРО-9H-ПИРАЗОЛО (3,4-c)-1,2,4-ТРИАЗОЛО (4,3-α) ПИРИДИНЫ

Info

Publication number
EA200400301A1
EA200400301A1 EA200400301A EA200400301A EA200400301A1 EA 200400301 A1 EA200400301 A1 EA 200400301A1 EA 200400301 A EA200400301 A EA 200400301A EA 200400301 A EA200400301 A EA 200400301A EA 200400301 A1 EA200400301 A1 EA 200400301A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formulation
triazolo
pyrazolo
dihydro
pyridine
Prior art date
Application number
EA200400301A
Other languages
English (en)
Other versions
EA006742B1 (ru
Inventor
Майкл Джон Хамфри
Пол Роберт Миллер
Майкл Тревор Шеферд
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200400301A1 publication Critical patent/EA200400301A1/ru
Publication of EA006742B1 publication Critical patent/EA006742B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Данное изобретение относится к препаративной форме для ингаляции, содержащей соединение, выбранное из конкретного класса 5,6-дигидро-9H-пиразоло[3,4-c]-1,2,4-триазоло[4,3-α]пиридинов, которая способна доставлять соединение в виде тонкоизмельченных твердых частиц в легкие, и применение указанной препаративной формы при лечении некоторых заболеваний, таких как респираторные заболевания. Применением указанной препаративной формы можно устранить нежелательную реакцию, вызывающую кашель, связанную с применением указанных соединений в ингаляторе, с дозировочной шкалой; так как эта реакция может препятствовать введению терапевтически эффективной дозы и в определенном смысле длительно препятствовать соблюдению больным режима и схемы лечения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400301A 2001-09-12 2002-09-02 КОМПОЗИЦИИ ДЛЯ ИНГАЛЯЦИИ, СОДЕРЖАЩИЕ ТРИЦИКЛИЧЕСКИЕ 5,6-ДИГИДРО-9H-ПИРАЗОЛО(3,4-c)-1,2,4-ТРИАЗОЛО (4,3-α) ПИРИДИНЫ EA006742B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0122031.8A GB0122031D0 (en) 2001-09-12 2001-09-12 Use of pde4 inhibitors in a dry powder inhaler
PCT/IB2002/003599 WO2003022275A1 (en) 2001-09-12 2002-09-02 Inhalation compositions comprising tricyclic 5,6-dihydro-9h-pyrazolo (3,4-c)-1,2,4-triazolo (4,3-alpha) pyridines

Publications (2)

Publication Number Publication Date
EA200400301A1 true EA200400301A1 (ru) 2004-06-24
EA006742B1 EA006742B1 (ru) 2006-04-28

Family

ID=9921954

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400301A EA006742B1 (ru) 2001-09-12 2002-09-02 КОМПОЗИЦИИ ДЛЯ ИНГАЛЯЦИИ, СОДЕРЖАЩИЕ ТРИЦИКЛИЧЕСКИЕ 5,6-ДИГИДРО-9H-ПИРАЗОЛО(3,4-c)-1,2,4-ТРИАЗОЛО (4,3-α) ПИРИДИНЫ

Country Status (34)

Country Link
US (3) US20030064034A1 (ru)
EP (1) EP1427414A1 (ru)
JP (1) JP2005505560A (ru)
KR (1) KR20040036940A (ru)
CN (1) CN1553801A (ru)
AP (2) AP2002002624A0 (ru)
AR (2) AR036474A1 (ru)
BG (1) BG108569A (ru)
BR (1) BR0212449A (ru)
CA (1) CA2457717A1 (ru)
CZ (1) CZ2004310A3 (ru)
EA (1) EA006742B1 (ru)
EC (1) ECSP045018A (ru)
EE (1) EE200400078A (ru)
GB (1) GB0122031D0 (ru)
HN (2) HN2002000253A (ru)
HR (1) HRP20040162A2 (ru)
HU (1) HUP0401890A3 (ru)
IL (1) IL160380A0 (ru)
IS (1) IS7151A (ru)
MA (1) MA27062A1 (ru)
MX (1) MXPA04002354A (ru)
NO (1) NO20041011L (ru)
NZ (1) NZ530929A (ru)
OA (1) OA12660A (ru)
PA (2) PA8554701A1 (ru)
PE (2) PE20030509A1 (ru)
PL (1) PL368736A1 (ru)
SK (1) SK1272004A3 (ru)
SV (2) SV2004001226A (ru)
TN (1) TNSN04040A1 (ru)
TW (1) TW200602054A (ru)
WO (2) WO2003022275A1 (ru)
ZA (1) ZA200401002B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7931022B2 (en) 2001-10-19 2011-04-26 Respirks, Inc. Method and apparatus for dispensing inhalator medicament
TW200503781A (en) * 2002-12-31 2005-02-01 Nektar Therapeutics Aerosolizable pharmaceutical formulation for fungal infection therapy
GB0315889D0 (en) 2003-07-08 2003-08-13 Aventis Pharma Ltd Stable pharmaceutical products
US20060009435A1 (en) * 2004-06-23 2006-01-12 Joseph Kaspi Synthesis and powder preparation of fluticasone propionate
WO2007036029A1 (en) * 2005-09-28 2007-04-05 Merck Frosst Canada Ltd. Aerosol powder formulation comprising sieved lactose
GB0801876D0 (en) * 2008-02-01 2008-03-12 Vectura Group Plc Suspension formulations
TR200909788A2 (tr) * 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Tiotropyum içeren inhalasyona uygun kuru toz formülasyonu
US8834931B2 (en) 2009-12-25 2014-09-16 Mahmut Bilgic Dry powder formulation containing tiotropium for inhalation
SG11201505878UA (en) 2013-02-19 2015-09-29 Pfizer Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders
KR20150076005A (ko) 2013-12-26 2015-07-06 삼성디스플레이 주식회사 액정 표시 장치
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
ES2733502T3 (es) 2014-08-06 2019-11-29 Pfizer Compuestos de imidazopiridazina
SMT201900340T1 (it) * 2014-09-15 2019-07-11 Verona Pharma Plc Formulazione liquida per l’inalazione comprendente rpl554

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2223624C (en) * 1995-06-06 2001-02-20 Pfizer Inc. Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
DE19835346A1 (de) * 1998-08-05 2000-02-10 Boehringer Ingelheim Pharma Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren

Also Published As

Publication number Publication date
US20030064031A1 (en) 2003-04-03
TNSN04040A1 (fr) 2006-06-01
HN2002000254A (es) 2003-04-07
IL160380A0 (en) 2004-07-25
JP2005505560A (ja) 2005-02-24
WO2003022279A1 (en) 2003-03-20
PE20030443A1 (es) 2003-05-17
SK1272004A3 (sk) 2005-03-04
AR036473A1 (es) 2004-09-08
SV2004001227A (es) 2004-02-24
PE20030509A1 (es) 2003-06-23
US20030064034A1 (en) 2003-04-03
EA006742B1 (ru) 2006-04-28
AP2002002624A0 (en) 2002-09-30
KR20040036940A (ko) 2004-05-03
HRP20040162A2 (en) 2004-08-31
MA27062A1 (fr) 2004-12-20
HN2002000253A (es) 2003-04-07
CZ2004310A3 (cs) 2005-02-16
CA2457717A1 (en) 2003-03-20
PA8554701A1 (es) 2003-09-17
HUP0401890A3 (en) 2008-03-28
HUP0401890A2 (hu) 2004-12-28
TW200602054A (en) 2006-01-16
SV2004001226A (es) 2004-02-24
NO20041011L (no) 2004-03-10
PA8554601A1 (es) 2003-09-17
IS7151A (is) 2004-02-13
AP2002002623A0 (en) 2002-09-30
WO2003022275A1 (en) 2003-03-20
NZ530929A (en) 2006-08-31
AR036474A1 (es) 2004-09-08
US20050232871A1 (en) 2005-10-20
CN1553801A (zh) 2004-12-08
MXPA04002354A (es) 2004-06-29
EE200400078A (et) 2004-06-15
EP1427414A1 (en) 2004-06-16
OA12660A (en) 2006-06-19
GB0122031D0 (en) 2001-10-31
BR0212449A (pt) 2004-08-17
PL368736A1 (en) 2005-04-04
ZA200401002B (en) 2005-02-07
BG108569A (bg) 2005-02-28
ECSP045018A (es) 2004-04-28

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM