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EA200201055A1 - Новый стабильный кристалл производного тиазолидиндиона и способ его получения - Google Patents

Новый стабильный кристалл производного тиазолидиндиона и способ его получения

Info

Publication number
EA200201055A1
EA200201055A1 EA200201055A EA200201055A EA200201055A1 EA 200201055 A1 EA200201055 A1 EA 200201055A1 EA 200201055 A EA200201055 A EA 200201055A EA 200201055 A EA200201055 A EA 200201055A EA 200201055 A1 EA200201055 A1 EA 200201055A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tiazolidindion
derivative
preparation
stable crystal
new stable
Prior art date
Application number
EA200201055A
Other languages
English (en)
Other versions
EA004244B1 (ru
Inventor
Михиро Охнота
Казуо Орита
Original Assignee
Киорин Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Киорин Фармасьютикал Ко., Лтд. filed Critical Киорин Фармасьютикал Ко., Лтд.
Publication of EA200201055A1 publication Critical patent/EA200201055A1/ru
Publication of EA004244B1 publication Critical patent/EA004244B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В заявке описаны гомогенные кристаллы, обладающие превосходной стабильностью, которые пригодны для промышленного получения 5-[(2,4-диоксотиазолидин-5-ил)метил]-2-метокси-N-{[4-(трифторметил)фенил]метил}бензамида (KRP-297). Эти новые кристаллы KRP-297 получают перекристаллизацией из спиртового растворителя. При порошковой дифракции рентгеновских лучей они характеризуются проявлением дифракционных углов (2Θ) при, по меньшей мере, 9,7, 15,0 и 22,5°.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200201055A 2000-04-25 2001-04-23 Новый стабильный кристалл производного тиазолидиндиона и способ его получения EA004244B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000124006 2000-04-25
PCT/JP2001/003450 WO2001081327A1 (en) 2000-04-25 2001-04-23 Novel stable crystal of thiazolidinedione derivative and process for producing the same

Publications (2)

Publication Number Publication Date
EA200201055A1 true EA200201055A1 (ru) 2003-06-26
EA004244B1 EA004244B1 (ru) 2004-02-26

Family

ID=18634205

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200201055A EA004244B1 (ru) 2000-04-25 2001-04-23 Новый стабильный кристалл производного тиазолидиндиона и способ его получения

Country Status (23)

Country Link
US (1) US6770133B2 (ru)
EP (1) EP1277745A4 (ru)
KR (1) KR20030007548A (ru)
CN (1) CN1426402A (ru)
AU (1) AU4882801A (ru)
BG (1) BG107200A (ru)
BR (1) BR0110258A (ru)
CA (1) CA2407349A1 (ru)
CZ (1) CZ20023502A3 (ru)
EA (1) EA004244B1 (ru)
EE (1) EE200200601A (ru)
HK (1) HK1053835A1 (ru)
HU (1) HUP0300475A3 (ru)
IL (1) IL152224A0 (ru)
IS (1) IS6586A (ru)
MA (1) MA25664A1 (ru)
MX (1) MXPA02010545A (ru)
NO (1) NO20025069L (ru)
PL (1) PL365533A1 (ru)
SK (1) SK15142002A3 (ru)
WO (1) WO2001081327A1 (ru)
YU (1) YU80302A (ru)
ZA (1) ZA200208293B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE340168T1 (de) 2000-02-01 2006-10-15 Kyorin Seiyaku Kk Alkalimetallsalz von thiazolidin-2,4-dion- derivaten
WO2003062214A1 (en) * 2002-01-23 2003-07-31 Kyorin Pharmaceutical Co., Ltd. Novel stable crystal of benzylthiazolidinedione derivative and method for preparation thereof
DE10308351A1 (de) 2003-02-27 2004-11-25 Aventis Pharma Deutschland Gmbh 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308353A1 (de) 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7148246B2 (en) 2003-02-27 2006-12-12 Sanofi-Aventis Deutschland Gmbh Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
DE10308352A1 (de) 2003-02-27 2004-09-09 Aventis Pharma Deutschland Gmbh Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE10308355A1 (de) 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
CA2546601A1 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
EP1586573B1 (en) 2004-04-01 2007-02-07 Sanofi-Aventis Deutschland GmbH Oxadiazolones, processes for their preparation and their use as pharmaceuticals
DE102005026762A1 (de) 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
TWI383008B (zh) * 2005-08-17 2013-01-21 Nippon Catalytic Chem Ind 吸水性樹脂之製造方法及吸水性樹脂以及其利用
TW201336497A (zh) 2007-02-08 2013-09-16 Daiichi Sankyo Co Ltd 噻唑啶二酮化合物之結晶型及其製法
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864028A (en) * 1983-09-14 1989-09-05 Alcon Laboratories, Inc. Spiro-tricyclicaromatic succinimide derivatives
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
JP3053490B2 (ja) 1991-02-25 2000-06-19 杏林製薬株式会社 チアゾリジン−２，４−ジオン誘導体とその塩及び製造法
JPH04270273A (ja) 1991-02-25 1992-09-25 Kyorin Pharmaceut Co Ltd チアゾリジン−２，４−ジオン誘導体とその塩及びその製造法
JP3644998B2 (ja) * 1995-02-09 2005-05-11 塩野義製薬株式会社 ベンジリデン誘導体の結晶の選択的取得方法
JP3144624B2 (ja) 1995-06-02 2001-03-12 杏林製薬株式会社 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
US6001862A (en) * 1995-06-02 1999-12-14 Kyorin Pharameuticals Co., Ltd. N-benzyldioxothiazolidylbenzamide derivatives and processes for preparing the same
US6147101A (en) * 1995-06-02 2000-11-14 Kyorin Pharmaceutical Co., Ltd. N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same
ZA971637B (en) * 1996-02-28 1997-09-25 Nissan Chemical Ind Ltd Thifluzamide with improved efficacy.
JPH101476A (ja) * 1996-02-28 1998-01-06 Nissan Chem Ind Ltd 効力が向上したチフルザミド
GB9726566D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical

Also Published As

Publication number Publication date
HUP0300475A3 (en) 2004-10-28
IL152224A0 (en) 2003-05-29
KR20030007548A (ko) 2003-01-23
ZA200208293B (en) 2003-10-06
MXPA02010545A (es) 2004-05-14
MA25664A1 (fr) 2002-12-31
SK15142002A3 (sk) 2003-04-01
EP1277745A4 (en) 2004-09-15
CN1426402A (zh) 2003-06-25
US6770133B2 (en) 2004-08-03
AU4882801A (en) 2001-11-07
PL365533A1 (en) 2005-01-10
HK1053835A1 (en) 2003-11-07
CA2407349A1 (en) 2002-10-24
EP1277745A1 (en) 2003-01-22
US20030101925A1 (en) 2003-06-05
BR0110258A (pt) 2003-01-07
HUP0300475A2 (hu) 2003-06-28
CZ20023502A3 (cs) 2003-06-18
BG107200A (bg) 2003-11-28
YU80302A (sh) 2005-11-28
EA004244B1 (ru) 2004-02-26
EE200200601A (et) 2004-04-15
WO2001081327A1 (en) 2001-11-01
NO20025069D0 (no) 2002-10-22
NO20025069L (no) 2002-10-22
IS6586A (is) 2002-10-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU