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EA200000700A2 - НОВЫЕ β- КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИХ - Google Patents

НОВЫЕ β- КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИХ

Info

Publication number
EA200000700A2
EA200000700A2 EA200000700A EA200000700A EA200000700A2 EA 200000700 A2 EA200000700 A2 EA 200000700A2 EA 200000700 A EA200000700 A EA 200000700A EA 200000700 A EA200000700 A EA 200000700A EA 200000700 A2 EA200000700 A2 EA 200000700A2
Authority
EA
Eurasian Patent Office
Prior art keywords
group
cor
beta
preparation
pharmaceutical compositions
Prior art date
Application number
EA200000700A
Other languages
English (en)
Other versions
EA200000700A3 (ru
EA004140B1 (ru
Inventor
Соло Гольдстейн
Гийом Пуассонне
Жан-Жилль Парментье
Жан-Даниель Брион
Марк Миллан
Анн Декейн
Жан Бутэн
Original Assignee
Адир Э Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адир Э Компани filed Critical Адир Э Компани
Publication of EA200000700A2 publication Critical patent/EA200000700A2/ru
Publication of EA200000700A3 publication Critical patent/EA200000700A3/ru
Publication of EA004140B1 publication Critical patent/EA004140B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Соединения формулы (I)в которойпредставляет простую или двойную связь,Rпредставляет атом водорода, алкильную группу, -R-арильную группу, -R-циклоалкильную группу, -R-гетероцикл, -COR, -CORили -CONHR, где R, Rи Rопределены в описании изобретения;Rпредставляет цианогруппу, моно- или диалкиламино-алкиламинокарбонильную группу, или -COR, -CONHR, -NRR, -NHCORили -COR, где R, Rи Rопределены в описании изобретения,Rи R, взятые вместе, образуют (C-C)циклоалкильную группу,Rпредставляет атом водорода, или алкильную группу, или арилалкильную группу,каждый из Ra, Rb, Rc и Rd, которые могут быть одинаковыми или различными, независимо представляет группу, определенную в описании изобретения,их изомеры, а также их аддитивные соли с фармацевтически приемлемой кислотой или фармацевтически приемлемым основанием. Лекарственные препараты.
EA200000700A 1999-07-23 2000-07-21 β-КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ИХ СОДЕРЖАЩАЯ EA004140B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9909576A FR2796644B1 (fr) 1999-07-23 1999-07-23 Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
EA200000700A2 true EA200000700A2 (ru) 2001-02-26
EA200000700A3 EA200000700A3 (ru) 2001-04-23
EA004140B1 EA004140B1 (ru) 2004-02-26

Family

ID=9548447

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000700A EA004140B1 (ru) 1999-07-23 2000-07-21 β-КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ИХ СОДЕРЖАЩАЯ

Country Status (16)

Country Link
US (1) US6350757B1 (ru)
EP (1) EP1070716A1 (ru)
JP (1) JP2001072679A (ru)
KR (1) KR20010049859A (ru)
CN (1) CN1282743A (ru)
AU (1) AU762958B2 (ru)
BR (1) BR0003105A (ru)
CA (1) CA2314473A1 (ru)
EA (1) EA004140B1 (ru)
FR (1) FR2796644B1 (ru)
HU (1) HUP0002843A3 (ru)
MX (1) MXPA00007058A (ru)
NO (1) NO20003764L (ru)
NZ (1) NZ505903A (ru)
PL (1) PL341549A1 (ru)
ZA (1) ZA200003702B (ru)

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* Cited by examiner, † Cited by third party
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UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
US20040253891A1 (en) * 2000-09-12 2004-12-16 Schierenbeck Alan W. Composite structure for protective garment
TWI329111B (en) 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
DE602004017714D1 (de) * 2003-04-29 2008-12-24 Oscient Pharmaceuticals ANTIBIOTISCHE TETRAHYDRO-b-CARBOLINDERIVATIVE
EP1637521B1 (en) 2003-06-23 2013-06-19 Ono Pharmaceutical Co., Ltd. Novel tricyclic heterocycle compound
US20050143371A1 (en) * 2003-07-23 2005-06-30 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
US7855295B2 (en) 2004-01-23 2010-12-21 Novartis Vaccines And Diagnostics, Inc. Tetrahydrocarboline compounds as anticancer agents
EP1737461B1 (en) 2004-03-15 2012-12-12 PTC Therapeutics, Inc. Carboline derivatives useful in the inhibition of angiogenesis
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
PT1829874E (pt) 2004-12-22 2014-04-10 Ono Pharmaceutical Co Composto tricíclico e sua utilização
FR2901795A1 (fr) * 2006-05-30 2007-12-07 Fourtillan Snc Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique
FR2908768A1 (fr) * 2006-06-19 2008-05-23 Fourtillan Snc DERIVES DE 3H,11H-OXAZOLO (3',4':1,2)PYRIDO(3,4-b)INDOLE ET LEUR UTILISATION EN THERAPEUTIQUE
FR2912405A1 (fr) * 2007-02-08 2008-08-15 Fourtillan Snc Derives des imidazo[1',5':1,6]pyrido[3,4-b]indoles et leur utilisation en therapeutique
US20090221627A1 (en) * 2007-09-20 2009-09-03 Alexey Aksinenko Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
EP2225250A2 (en) * 2007-11-30 2010-09-08 Biota Scientific Management Pty Ltd Bicyclic ppat inhibitors as antibacterial agents
ES2530090T3 (es) * 2008-03-12 2015-02-26 Intra-Cellular Therapies, Inc. Sólido de gamma-carbolinas fusionadas con heterociclo sustituido
AU2009228398B2 (en) * 2008-03-24 2014-07-03 Medivation Technologies, Inc. Pyrido [3, 4-b] indoles and methods of use
DE102008025893B4 (de) * 2008-05-26 2014-09-18 Technische Universität Dresden Verfahren zur Herstellung von Fettsäureamiden mit gesättigten, ungesättigten oder Hydroxy-Fettsäuren
CA2775133A1 (en) * 2009-09-23 2011-03-31 Medivation Technologies, Inc. Pyrido[3,4-b]indoles and methods of use
CA2775129A1 (en) * 2009-09-23 2011-03-31 Medivation Technologies, Inc. Pyrido[3,4-b]indoles and methods of use
AU2012219251B2 (en) 2011-02-18 2016-05-12 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
US9353113B2 (en) 2011-03-18 2016-05-31 Ono Pharmaceutical Co., Ltd. Tetrahydrocarboline derivative
KR101534523B1 (ko) * 2013-04-30 2015-07-09 경희대학교 산학협력단 1,2,3,4-테트라히드로-6-메톡시-1-옥소-베타-카르볼린을 포함하는 피부 미백용 화장료 조성물
CN105229004B (zh) * 2013-05-28 2017-05-03 阿斯利康(瑞典)有限公司 化合物
WO2020037155A1 (en) * 2018-08-16 2020-02-20 Recreo Pharmaceuticals Llc 1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indole derivative compounds and uses thereof
WO2020072675A1 (en) * 2018-10-02 2020-04-09 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c)
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof

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AR205452A1 (es) * 1973-12-06 1976-05-07 Endo Lab Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles
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Also Published As

Publication number Publication date
NZ505903A (en) 2001-08-31
FR2796644B1 (fr) 2001-09-07
CN1282743A (zh) 2001-02-07
EA200000700A3 (ru) 2001-04-23
PL341549A1 (en) 2001-01-29
NO20003764L (no) 2001-01-24
US6350757B1 (en) 2002-02-26
JP2001072679A (ja) 2001-03-21
EA004140B1 (ru) 2004-02-26
AU762958B2 (en) 2003-07-10
MXPA00007058A (es) 2002-04-24
ZA200003702B (en) 2001-05-21
BR0003105A (pt) 2001-03-13
EP1070716A1 (fr) 2001-01-24
HUP0002843A2 (hu) 2001-04-28
HU0002843D0 (en) 2000-09-28
HUP0002843A3 (en) 2001-07-30
FR2796644A1 (fr) 2001-01-26
KR20010049859A (ko) 2001-06-15
AU4876900A (en) 2001-01-25
CA2314473A1 (fr) 2001-01-23
NO20003764D0 (no) 2000-07-21

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