EA199900836A1 - Противосудорожные производные изохинолилбензамида - Google Patents
Противосудорожные производные изохинолилбензамидаInfo
- Publication number
- EA199900836A1 EA199900836A1 EA199900836A EA199900836A EA199900836A1 EA 199900836 A1 EA199900836 A1 EA 199900836A1 EA 199900836 A EA199900836 A EA 199900836A EA 199900836 A EA199900836 A EA 199900836A EA 199900836 A1 EA199900836 A1 EA 199900836A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- groups
- hydrogen
- 6alko
- cfco
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- -1 C-alkylCO-- Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Соединения формулы (I) и их фармацевтически приемлемые солигде Rпредставляет водород, Cалкил (необязательно замещенный группой гидрокси или Cалкокси), Cалкенил, Cалкинил, C-алкилCO-, формил, CFCO- или CалкилSO-; Rпредставляет водород или до трех заместителей, выбранных из групп галоген, NO, CN, N, CFO-, CFS-, CFCO-, трифторметилдиазиринил, Cалкил, Cалкенил, Cалкинил, Cперфторалкил, Cциклоалкил, C-циалоалкил-Cалкил-, CалкилO-, CалкилCO-, Cцикло-алкилO-, CциклоалкилCO-, Cциклоалкил-CалкилO-, Cциклоалкил-CалкилCO-, фенил, фенокси, бензилокси, бензоил, фенил-Cалкил-, CалкилS-, CалкилSO-, (Cалкил)NSO-, (C-алкил)NHSO-, (Cалкил)HCO-, (Cалкил)NHCO- или CONH; или группу -NRR, где R- водород или Cалкил, а R- водород, Cалкил, формил, -COCалкил или -COCалкил; или две группы Rвместе образуют карбоциклическое кольцо, насыщенное или ненасыщенное и незамещенное или замещенное группой -OH или =O; и две группы Rи две группы R, каждая независимо, представляют собой водород или Cалкил, либо две группы Rи/или две группы Rвместе образуют Cспироалкильную группу при условии, что, по меньшей мере, одна из групп Rи Rне представляет собой водород, могут быть использованы для лечения и профилактики эпилепсии и других расстройств.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9705620.4A GB9705620D0 (en) | 1997-03-18 | 1997-03-18 | Novel compounds |
| GBGB9726660.5A GB9726660D0 (en) | 1997-12-17 | 1997-12-17 | Novel compounds |
| PCT/GB1998/000781 WO1998041507A1 (en) | 1997-03-18 | 1998-03-16 | Anti-convulsant isoquinolyl-benzamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA199900836A1 true EA199900836A1 (ru) | 2000-04-24 |
Family
ID=26311216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199900836A EA199900836A1 (ru) | 1997-03-18 | 1998-03-16 | Противосудорожные производные изохинолилбензамида |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6277861B1 (ru) |
| EP (1) | EP0971897A1 (ru) |
| JP (1) | JP2001516357A (ru) |
| KR (1) | KR20000076343A (ru) |
| CN (1) | CN1255917A (ru) |
| AP (1) | AP9901635A0 (ru) |
| AR (1) | AR012078A1 (ru) |
| AU (1) | AU732162B2 (ru) |
| BG (1) | BG103807A (ru) |
| BR (1) | BR9809048A (ru) |
| CA (1) | CA2283682A1 (ru) |
| CO (1) | CO4950554A1 (ru) |
| DZ (1) | DZ2446A1 (ru) |
| EA (1) | EA199900836A1 (ru) |
| ID (1) | ID22730A (ru) |
| IL (1) | IL131958A0 (ru) |
| MA (1) | MA24499A1 (ru) |
| NO (1) | NO313753B1 (ru) |
| NZ (1) | NZ337579A (ru) |
| OA (1) | OA11390A (ru) |
| PE (1) | PE62199A1 (ru) |
| PL (1) | PL335675A1 (ru) |
| SK (1) | SK126799A3 (ru) |
| TR (1) | TR199902282T2 (ru) |
| TW (1) | TW509679B (ru) |
| WO (1) | WO1998041507A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999016752A1 (en) * | 1997-09-30 | 1999-04-08 | Molecular Designs International, Inc. | β3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USING |
| GB9817424D0 (en) * | 1998-08-11 | 1998-10-07 | Smithkline Beecham Plc | Novel compounds |
| GB9915589D0 (en) | 1999-07-02 | 1999-09-01 | Smithkline Beecham Plc | Novel compounds |
| US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
| CN109608325A (zh) * | 2018-12-27 | 2019-04-12 | 先尼科化工（上海）有限公司 | 一种卤代苯甲酸衍生物的工业化合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022900A (en) * | 1970-09-09 | 1977-05-10 | Marion Laboratories, Inc. | Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents |
| ES2036213T3 (es) * | 1986-10-28 | 1993-05-16 | Smith Kline & French Laboratories Limited | Procedimiento para preparar derivados tetrahidroisoquinolin-1-ilicos de acidos carboxilicos. |
| GB8807922D0 (en) * | 1988-04-05 | 1988-05-05 | Fujisawa Pharmaceutical Co | Isoquinoline compound & process for preparation thereof |
| US4883593A (en) * | 1988-10-27 | 1989-11-28 | Bend Research, Inc. | Ultrathin-skinned asymmetric membranes by immiscible solvents treatment |
| GB9112721D0 (en) * | 1991-06-13 | 1991-07-31 | Smithkline Beecham Plc | Novel treatment |
| TR199802745T2 (xx) * | 1996-06-17 | 1999-04-21 | Smithkline Beecham Plc | �kameli benzamid t�revleri ve bunlar�n ihtiya�lar� durdurucu veya engelleyici maddeler olarak kullan�lmas�. |
-
1998
- 1998-03-07 DZ DZ980056A patent/DZ2446A1/xx active
- 1998-03-16 CO CO98014463A patent/CO4950554A1/es unknown
- 1998-03-16 IL IL13195898A patent/IL131958A0/xx unknown
- 1998-03-16 MA MA25000A patent/MA24499A1/fr unknown
- 1998-03-16 TR TR1999/02282T patent/TR199902282T2/xx unknown
- 1998-03-16 KR KR1019997008444A patent/KR20000076343A/ko not_active Ceased
- 1998-03-16 BR BR9809048-8A patent/BR9809048A/pt not_active IP Right Cessation
- 1998-03-16 JP JP54024798A patent/JP2001516357A/ja not_active Withdrawn
- 1998-03-16 CN CN98805128A patent/CN1255917A/zh active Pending
- 1998-03-16 SK SK1267-99A patent/SK126799A3/sk unknown
- 1998-03-16 PL PL98335675A patent/PL335675A1/xx unknown
- 1998-03-16 US US09/381,369 patent/US6277861B1/en not_active Expired - Fee Related
- 1998-03-16 AR ARP980101173A patent/AR012078A1/es not_active Application Discontinuation
- 1998-03-16 EA EA199900836A patent/EA199900836A1/ru unknown
- 1998-03-16 AP APAP/P/1999/001635A patent/AP9901635A0/en unknown
- 1998-03-16 EP EP98909646A patent/EP0971897A1/en not_active Withdrawn
- 1998-03-16 ID IDW991041D patent/ID22730A/id unknown
- 1998-03-16 WO PCT/GB1998/000781 patent/WO1998041507A1/en not_active Ceased
- 1998-03-16 CA CA002283682A patent/CA2283682A1/en not_active Abandoned
- 1998-03-16 NZ NZ337579A patent/NZ337579A/en unknown
- 1998-03-16 AU AU64127/98A patent/AU732162B2/en not_active Ceased
- 1998-03-17 PE PE1998000190A patent/PE62199A1/es not_active Application Discontinuation
- 1998-03-20 TW TW087104134A patent/TW509679B/zh not_active IP Right Cessation
-
1999
- 1999-09-17 OA OA9900210A patent/OA11390A/en unknown
- 1999-09-17 NO NO19994504A patent/NO313753B1/no not_active IP Right Cessation
- 1999-10-13 BG BG103807A patent/BG103807A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO4950554A1 (es) | 2000-09-01 |
| IL131958A0 (en) | 2001-03-19 |
| SK126799A3 (en) | 2000-05-16 |
| TR199902282T2 (en) | 2000-07-21 |
| ID22730A (id) | 1999-12-09 |
| AR012078A1 (es) | 2000-09-27 |
| DZ2446A1 (fr) | 2003-01-11 |
| TW509679B (en) | 2002-11-11 |
| AU732162B2 (en) | 2001-04-12 |
| NO994504D0 (no) | 1999-09-17 |
| PE62199A1 (es) | 1999-09-10 |
| NZ337579A (en) | 2001-04-27 |
| BR9809048A (pt) | 2000-08-01 |
| WO1998041507A1 (en) | 1998-09-24 |
| US6277861B1 (en) | 2001-08-21 |
| NO994504L (no) | 1999-09-17 |
| KR20000076343A (ko) | 2000-12-26 |
| NO313753B1 (no) | 2002-11-25 |
| CA2283682A1 (en) | 1998-09-24 |
| OA11390A (en) | 2004-04-14 |
| CN1255917A (zh) | 2000-06-07 |
| BG103807A (bg) | 2001-05-31 |
| AP9901635A0 (en) | 1999-09-30 |
| AU6412798A (en) | 1998-10-12 |
| EP0971897A1 (en) | 2000-01-19 |
| PL335675A1 (en) | 2000-05-08 |
| JP2001516357A (ja) | 2001-09-25 |
| MA24499A1 (fr) | 1998-10-01 |
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