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EA024842B9 - Соединения в качестве модуляторов протеинкиназы pi3k - Google Patents

Соединения в качестве модуляторов протеинкиназы pi3k

Info

Publication number
EA024842B9
EA024842B9 EA201391416A EA201391416A EA024842B9 EA 024842 B9 EA024842 B9 EA 024842B9 EA 201391416 A EA201391416 A EA 201391416A EA 201391416 A EA201391416 A EA 201391416A EA 024842 B9 EA024842 B9 EA 024842B9
Authority
EA
Eurasian Patent Office
Prior art keywords
modulators
protein kinase
compounds
pi3k protein
methods
Prior art date
Application number
EA201391416A
Other languages
English (en)
Russian (ru)
Other versions
EA201391416A1 (ru
EA024842B1 (ru
Inventor
Дханапалан Нагаратхнам
Сваруп Кумар В.С. Ваккаланка
Мейяппан Мутуппаланиаппан
Срикант Висванадха
Говиндараджулу Бабу
Прашант Кашинат Бхавар
Original Assignee
Ризен Фармасьютикалз Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46147717&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA024842(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ризен Фармасьютикалз Са filed Critical Ризен Фармасьютикалз Са
Publication of EA201391416A1 publication Critical patent/EA201391416A1/ru
Publication of EA024842B1 publication Critical patent/EA024842B1/ru
Publication of EA024842B9 publication Critical patent/EA024842B9/ru

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    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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EA201391416A 2011-05-04 2012-05-04 Соединения в качестве модуляторов протеинкиназы pi3k EA024842B9 (ru)

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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE035059T2 (hu) 2009-11-05 2018-05-02 Rhizen Pharmaceuticals S A Új benzopirán-kinát modulátorok
ES2710874T3 (es) 2011-05-04 2019-04-29 Rhizen Pharmaceuticals S A Compuestos novedosos como moduladores de proteína cinasas
KR102109992B1 (ko) * 2012-03-23 2020-05-13 피티씨 테라퓨틱스, 인크. 척수성 근위축증을 치료하기 위한 화합물
US10130635B2 (en) 2012-05-04 2018-11-20 Rhizen Pharmaceuticals Sa Process for preparation of optically pure and optionally substituted 2-(1-hydroxy-alkyl)-chromen-4-one derivatives and their use in preparing pharmaceuticals
KR102073181B1 (ko) * 2012-05-04 2020-02-04 리젠 파마슈티컬스 소시에떼 아노님 광학적으로 순수하고 임의로 치환된 2-(1-히드록시-알킬)-크로멘-4-온 유도체의 제조방법 및 약제 제조에 있어서의 그의 용도
SMT201900334T1 (it) * 2012-07-04 2019-07-11 Rhizen Pharmaceuticals S A Inibitori selettivi di pi3k delta
JP6434416B2 (ja) 2012-11-08 2018-12-05 ライゼン・ファーマシューティカルズ・エスアー ＰＤＥ４阻害剤とＰＩ３δ阻害剤または二重ＰＩ３δ−γキナーゼ阻害剤とを含有する薬学的組成物
MX366449B (es) * 2013-06-07 2019-07-09 Rhizen Pharmaceuticals Sa Inhibidores de pi3 cinasa delta y gama selectivos duales.
EA029614B1 (ru) 2013-07-02 2018-04-30 Ризен Фармасьютикалз Са Ингибиторы протеинкиназы pi3k, в частности ингибиторы pi3k дельта и/или гамма
AR098776A1 (es) 2013-12-18 2016-06-15 Chiesi Farm Spa Derivados del isocromeno como inhibidores de las fosfoinositido-3 quinasas
EA031135B1 (ru) * 2014-06-27 2018-11-30 Ризен Фармасьютикалз Са Замещенные производные хромена как селективные двойные ингибиторы протеинкиназ pi3 дельта и гамма
WO2016011394A1 (en) * 2014-07-18 2016-01-21 The General Hospital Corporation Imaging agents for neural flux
RS60450B1 (sr) * 2014-09-03 2020-07-31 Rhizen Pharmaceuticals Sa Postupak za tretiranje i kompozicije koje sadrže dvojni inhibitor pi3k delta-gama kinaze i kortikosteroid
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
CN104610331A (zh) * 2015-02-26 2015-05-13 成都安斯利生物医药有限公司 4-(1,3-恶嗪-2-基)苯硼酸的制备方法
CN105936635B (zh) * 2015-03-06 2019-06-21 南京圣和药业股份有限公司 作为磷脂酰肌醇3-激酶δ抑制剂的化合物及其应用
CN106008479B (zh) * 2015-03-06 2020-01-10 南京圣和药业股份有限公司 作为磷脂酰肌醇3-激酶δ抑制剂的取代嘧啶类化合物及其应用
US9968604B2 (en) * 2015-04-16 2018-05-15 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors
JP2018525371A (ja) * 2015-07-30 2018-09-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アリール置換された二環式ヘテロアリール化合物
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AR108812A1 (es) 2016-06-20 2018-09-26 Shionogi & Co Proceso para preparar un derivado de piridona policíclica sustituida y cristal del mismo
CN106831636A (zh) * 2016-12-12 2017-06-13 湖南华腾制药有限公司 一种恶二唑化合物的制备方法
DK3606926T3 (da) * 2017-04-05 2021-07-05 Curovir Ab Heteroaromatiske forbindelser anvendelige i terapi
CN107652261B (zh) * 2017-09-30 2020-08-07 桂林医学院 一种毛蕊异黄酮衍生物及其合成方法
US10751339B2 (en) 2018-01-20 2020-08-25 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
GB2578417B (en) * 2018-06-11 2022-09-28 Hunt Dev Uk Ltd Airway sampling device and associated methods
TW202128699A (zh) * 2019-11-27 2021-08-01 美商建南德克公司 治療性化合物
KR20210099402A (ko) * 2020-02-04 2021-08-12 고려대학교 산학협력단 펜벤다졸, 옥시벤다졸 또는 이들의 혼합물을 포함하는 자궁내막 세포 또는 영양막 세포의 비정상적 증식 관련 질환의 예방 또는 치료용 약학적 조성물
WO2021227417A1 (zh) * 2020-05-11 2021-11-18 泰伦基国际有限公司 一种治疗脊髓性肌萎缩症的方法和药物
WO2021229452A1 (en) 2020-05-14 2021-11-18 Rhizen Pharmaceuticals Ag Purine derivatives as sik-3 inhibitors
US20240360154A1 (en) * 2020-09-23 2024-10-31 Genfleet Therapeutics (Shanghai) Inc. Aroyl substituted tricyclic compound, preparation method therefor and use thereof
CN116410195B (zh) * 2021-12-31 2025-07-18 同润生物医药(上海)有限公司 一种己二酸盐结晶及其制备方法
CN116410194B (zh) * 2021-12-31 2025-07-18 同润生物医药(上海)有限公司 一种苯磺酸盐结晶及其制备方法
WO2023123742A1 (zh) * 2021-12-31 2023-07-06 同润生物医药(上海)有限公司 PI3Kδ/γ双重抑制剂化合物的半富马酸盐结晶及其制备方法
CN116410193A (zh) * 2021-12-31 2023-07-11 同润生物医药(上海)有限公司 PI3Kδ/γ双重抑制剂化合物的半富马酸盐结晶及其制备方法
CN114891005B (zh) * 2022-03-30 2024-01-19 武汉九州钰民医药科技有限公司 一种乌帕利斯对甲苯磺酸盐的制备工艺
KR102616744B1 (ko) * 2023-04-10 2023-12-27 한국교통대학교산학협력단 발효 자몽추출물을 포함하는 장 건강 개선용 조성물
WO2025072438A1 (en) * 2023-09-27 2025-04-03 Bristol-Myers Squibb Company Piperidine substituted pyrazolopyrimidine derivatives as inhibitors of sgk1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0245518A1 (en) * 1985-11-18 1987-11-19 Yamanouchi Pharmaceutical Co. Ltd. Isoflavone derivatives, salts thereof, and oncostatic and immunosuppressive agents

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3691016A (en) 1970-04-17 1972-09-12 Monsanto Co Process for the preparation of insoluble enzymes
CA1023287A (en) 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Process for the preparation of carrier-bound proteins
FR2224144B1 (es) * 1973-04-06 1976-04-09 Rech Pharmaceutiq Scientif
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4195128A (en) 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
US4330440A (en) 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
CA1093991A (en) 1977-02-17 1981-01-20 Hideo Hirohara Enzyme immobilization with pullulan gel
US4229537A (en) 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
WO1988001213A1 (en) 1986-08-18 1988-02-25 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
EP0636156B1 (en) 1992-04-14 1997-07-30 Cornell Research Foundation, Inc. Dendritic based macromolecules and method of production
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
JPH08175990A (ja) 1994-12-19 1996-07-09 Mitsubishi Chem Corp Ｐｉ３キナーゼ阻害剤とその製造法
JPH08176070A (ja) 1994-12-19 1996-07-09 Mitsubishi Chem Corp ジデプシド誘導体及びｐｉ３キナーゼ阻害剤
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
US5861510A (en) 1995-04-20 1999-01-19 Pfizer Inc Arylsulfonyl hydroxamic acid derivatives as MMP and TNF inhibitors
GB9521987D0 (en) 1995-10-26 1996-01-03 Ludwig Inst Cancer Res Phosphoinositide 3-kinase modulators
DE69624081T2 (de) 1995-12-20 2003-06-12 Agouron Pharmaceuticals, Inc. Matrix-metalloprotease Inhibitoren
EA199900036A1 (ru) 1996-07-18 1999-06-24 Пфайзер Инк Ингибиторы металлопротеаз матрикса на основе фосфинатов, фармацевтическая композиция, способ лечения
PL331895A1 (en) 1996-08-23 1999-08-16 Pfizer Arylosulphonylamino derivatives of hydroxamic acid
DK0950059T3 (da) 1997-01-06 2004-11-01 Pfizer Cycliske sulfonderivater
ATE248812T1 (de) 1997-02-03 2003-09-15 Pfizer Prod Inc Arylsulfonylhydroxamsäurederivate
JP2000507975A (ja) 1997-02-07 2000-06-27 ファイザー・インク Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
PL334997A1 (en) 1997-02-11 2000-03-27 Pfizer Derivatives or arylosulphonyl-hydroxamic acid
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
GB9725782D0 (en) 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
GB9801690D0 (en) 1998-01-27 1998-03-25 Pfizer Ltd Therapeutic agents
PA8469501A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
PA8469401A1 (es) 1998-04-10 2000-05-24 Pfizer Prod Inc Derivados biciclicos del acido hidroxamico
KR100685336B1 (ko) 1999-02-22 2007-02-23 게젤샤프트 퓌어 비오테크놀로기쉐 포르슝 엠베하(게베에프) Ｃ-21 변형 에포틸론
JP2001247477A (ja) 2000-03-03 2001-09-11 Teikoku Hormone Mfg Co Ltd 抗腫瘍剤
NZ522076A (en) 2000-04-25 2005-08-26 Icos Corp Inhibitors of human phosphatidyl-inositol 3-kinase delta
US6403588B1 (en) 2000-04-27 2002-06-11 Yamanouchi Pharmaceutical Co., Ltd. Imidazopyridine derivatives
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
JP4458746B2 (ja) 2001-01-16 2010-04-28 グラクソ グループ リミテッド 癌の治療方法
EP1417976A4 (en) 2001-07-26 2004-09-15 Santen Pharmaceutical Co Ltd AGENT FOR TREATING GLAUKOM WITH A COMPOUND WITH PI3-KINASE INHIBITING EFFECT
US6703414B2 (en) 2001-09-14 2004-03-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Device and method for treating restenosis
US6894055B2 (en) 2001-10-24 2005-05-17 Iconix Pharmaceuticals Inc. Thieno-2′,3′ -5,6pyrimido[3,4-A]-1,2,4-triazole derivatives as modulators of phoshoinositide 3-kinase
WO2003035618A2 (en) 2001-10-24 2003-05-01 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
BR0213734A (pt) 2001-10-30 2004-10-19 Pharmacia Corp Derivados de carboxamida heteroaromático para o tratamento de inflamação
CN100381437C (zh) * 2002-04-17 2008-04-16 赛特凯恩蒂克公司 化合物、组合物和方法
US20040092561A1 (en) 2002-11-07 2004-05-13 Thomas Ruckle Azolidinone-vinyl fused -benzene derivatives
CA2493843C (en) 2002-07-10 2012-04-17 Applied Research Systems Ars Holding N.V. Azolidinone-vinyl fused-benzene derivatives
CA2489779A1 (en) 2002-07-10 2004-01-22 Applied Research Systems Ars Holding N.V. Use of compounds for increasing spermatozoa motility
WO2004017950A2 (en) 2002-08-22 2004-03-04 Piramed Limited Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents
US7601724B2 (en) 2002-09-04 2009-10-13 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
US7605155B2 (en) 2002-09-04 2009-10-20 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
DE10256174A1 (de) * 2002-12-02 2004-06-09 Merck Patent Gmbh 2-Benzoylchromonderivate
WO2004072029A2 (en) 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
GB0305152D0 (en) * 2003-03-06 2003-04-09 Novartis Ag Organic compounds
ATE446752T1 (de) 2003-04-24 2009-11-15 Merck & Co Inc Hemmer der akt aktivität
DE602004025258D1 (de) 2003-08-06 2010-03-11 Vertex Pharma Aminotriazol-verbindungen als proteinkinase-hemmer
US20050043239A1 (en) 2003-08-14 2005-02-24 Jason Douangpanya Methods of inhibiting immune responses stimulated by an endogenous factor
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
CA2546920A1 (en) * 2003-12-09 2005-06-23 Joel Moss Methods for suppressing an immune response or treating a proliferative disorder
RS55551B1 (sr) * 2004-05-13 2017-05-31 Icos Corp Hinazolinoni kao inhibitori humane fosfatidilinozitol 3-kinaze delta
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
AU2005289644A1 (en) 2004-09-24 2006-04-06 Janssen Pharmaceutica, N.V. Imidazo{4,5-b}pyrazinone inhibitors of protein kinases
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds
WO2008007113A2 (en) 2006-07-14 2008-01-17 Astex Therapeutics Limited Pharmaceutical combinations
FR2882751B1 (fr) 2005-03-04 2007-09-14 Aventis Pharma Sa Hydrazinocarbonyl-thieno[2,3-c]pyrazoles, procede de preparation, compositions les contenant et utilisation
EP1904449A4 (en) 2005-07-08 2010-07-28 Merck Sharp & Dohme CHECKPOINT KINASE INHIBITORS
JP5016601B2 (ja) 2005-08-16 2012-09-05 アイアールエム・リミテッド・ライアビリティ・カンパニー タンパク質キナーゼ阻害剤としての化合物および組成物
CA2621879A1 (en) 2005-09-06 2007-03-15 Smithkline Beecham Corporation Benzimidazole thiophene compounds as plk inhibitors
BRPI0617159B8 (pt) 2005-10-07 2021-05-25 Exelixis Inc compostos de piridopirimidinone inibidores de pi3ka, composições que os contem e processo para preparo
GB0520657D0 (en) 2005-10-11 2005-11-16 Ludwig Inst Cancer Res Pharmaceutical compounds
JP2009512706A (ja) 2005-10-21 2009-03-26 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼインヒビター
AU2007207743B2 (en) 2006-01-18 2010-07-08 Amgen Inc. Thiazole compounds as protein kinase B (PKB) inhibitors
EP1994023A1 (en) 2006-03-02 2008-11-26 AstraZeneca AB Quinazoline derivatives
EP2007373A4 (en) 2006-03-29 2012-12-19 Foldrx Pharmaceuticals Inc INHIBITION OF ALPHA SYNUCLEINE TOXICITY
EP1999135A2 (en) 2006-03-30 2008-12-10 Takeda San Diego, Inc. Kinase inhibitors
CA2909277A1 (en) * 2006-04-04 2007-10-11 Kevan M. Shokat Kinase antagonists
TW200801012A (en) 2006-04-26 2008-01-01 Piramed Ltd Phosphoinositide 3-kinase inhibitor compounds and methods of use
AU2007246793B2 (en) 2006-04-26 2013-02-07 F. Hoffmann-La Roche Ag Thieno [3, 2-D] pyrimidine derivative useful as PI3K inhibitor
CA2652328A1 (en) 2006-05-15 2007-11-22 Takeda Pharmaceutical Company Limited Prophylactic and therapeutic agent for cancer
GB0610243D0 (en) 2006-05-23 2006-07-05 Novartis Ag Organic compounds
ES2393410T3 (es) 2006-08-09 2012-12-21 Bristol-Myers Squibb Company Pirrolotriazinas inhibidoras de quinasas
JP2010503650A (ja) 2006-09-14 2010-02-04 アストラゼネカ アクチボラグ 増殖性疾患の治療のための、ｐｉ３ｋおよびｍｔｏｒ阻害剤としての２−ベンズイミダゾリル−６−モルホリノ−４−ピペリジン−４−イルピリミジン誘導体
CN101605797A (zh) 2006-11-13 2009-12-16 伊莱利利公司 治疗炎症疾病和癌症的噻吩并嘧啶酮
AU2007329352B2 (en) 2006-12-07 2013-01-17 F. Hoffmann-La Roche Ag Phosphoinositide 3-kinase inhibitor compounds and methods of use
BRPI0717907A2 (pt) 2006-12-07 2013-11-05 Genentech Inc "composto, composição farmacêutica, métodos para tratar um câncer, para inbir ou modular a atividade da lipídeo quinase, processo para a produçãoo de uma composição farmacêutica, uso de um composto e kit"
AU2008231384B2 (en) 2007-03-23 2011-09-15 Amgen Inc. Heterocyclic compounds and their use
TW200902008A (en) 2007-05-10 2009-01-16 Smithkline Beecham Corp Quinoxaline derivatives as PI3 kinase inhibitors
US20090263397A1 (en) 2007-07-06 2009-10-22 Buck Elizabeth A Combination anti-cancer therapy
EP2240451B1 (en) * 2008-01-04 2017-08-09 Intellikine, LLC Isoquinolinone derivatives substituted with a purine useful as PI3K inhibitors
CN102083828B (zh) 2008-02-22 2013-11-13 Irm责任有限公司 作为c-kit和pdgfr激酶抑制剂的杂环化合物和组合物
CA2716755A1 (en) 2008-02-29 2009-09-03 Peter C. Chua Protein kinase modulators
CN102015681B (zh) 2008-03-04 2013-08-28 纳科法尔马有限公司 苯氨基嘧啶衍生物的晶形
WO2009111547A1 (en) 2008-03-04 2009-09-11 Wyeth 7h-pyrrolo[2,3-h]quinazoline compounds, their use as mtor kinase and pi3 kinase inhibitors, and their synthesis
JP2011513419A (ja) 2008-03-06 2011-04-28 ブリストル−マイヤーズ スクイブ カンパニー ピロロトリアジンキナーゼ阻害剤
UY31700A (es) 2008-03-13 2009-11-10 Boehringer Ingelheim Int Tiazolil-dihidro-indazoles
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
WO2009114870A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Kinase inhibitors and methods of use
BRPI0910232A2 (pt) 2008-03-19 2015-09-29 Osi Pharm Inc formas de sais inibidores do mtor
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
AU2009226153B2 (en) 2008-03-19 2014-02-20 Chembridge Corporation Novel tyrosine kinase inhibitors
WO2009120094A2 (en) 2008-03-27 2009-10-01 Auckland Uniservices Limited Substituted pyrimidines and triazines and their use in cancer therapy
TWI443102B (zh) 2008-03-31 2014-07-01 Genentech Inc 苯并哌喃及苯并氧呯ｐｉ３ｋ抑制劑化合物及其使用方法
WO2009126635A1 (en) 2008-04-09 2009-10-15 Abbott Laboratories 2-amino-benzothiazole derivates useful as inhibitors of rock kinases
EP2297145A2 (en) 2008-04-16 2011-03-23 Takeda Pharmaceutical Company Limited Polymorphs of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-n- (1-methylpiperidin-4-yl)-9h-pyrido[2, 3-b]indole-7-carboxamide and methods of use therefor
CN102083826A (zh) 2008-04-16 2011-06-01 沃泰克斯药物股份有限公司 磷脂酰肌醇3-激酶的抑制剂
CA2738429C (en) 2008-09-26 2016-10-25 Intellikine, Inc. Heterocyclic kinase inhibitors
DK2358720T3 (en) 2008-10-16 2016-06-06 Univ California Heteroarylkinaseinhibitorer fused-ring
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
US20110269779A1 (en) 2008-11-18 2011-11-03 Intellikine, Inc. Methods and compositions for treatment of ophthalmic conditions
SG176986A1 (en) 2009-06-25 2012-02-28 Amgen Inc Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases
HUE035059T2 (hu) * 2009-11-05 2018-05-02 Rhizen Pharmaceuticals S A Új benzopirán-kinát modulátorok
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
ES2710874T3 (es) 2011-05-04 2019-04-29 Rhizen Pharmaceuticals S A Compuestos novedosos como moduladores de proteína cinasas
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
SMT201900334T1 (it) * 2012-07-04 2019-07-11 Rhizen Pharmaceuticals S A Inibitori selettivi di pi3k delta
WO2014060431A1 (en) 2012-10-16 2014-04-24 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
RU2702908C2 (ru) 2012-11-01 2019-10-14 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
US20140120060A1 (en) 2012-11-01 2014-05-01 Infinity Pharmaceuticals, Inc. Treatment of rheumatoid arthritis and asthma using pi3 kinase inhibitors
JP6434416B2 (ja) * 2012-11-08 2018-12-05 ライゼン・ファーマシューティカルズ・エスアー ＰＤＥ４阻害剤とＰＩ３δ阻害剤または二重ＰＩ３δ−γキナーゼ阻害剤とを含有する薬学的組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0245518A1 (en) * 1985-11-18 1987-11-19 Yamanouchi Pharmaceutical Co. Ltd. Isoflavone derivatives, salts thereof, and oncostatic and immunosuppressive agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SABRINA OKOMBI, ET AL.: "A one-step synthesis of 2-alkyl-5-hydroxychromones and 3-alkoyl-2-alkyl-5-hydroxychromones", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 53, no. 11, 26 June 2012 (2012-06-26), JP, pages 1460 - 1462, XP002678583, ISSN: 0009-2363 *
SHAW, A.Y. ; CHANG, C.Y. ; LIAU, H.H. ; LU, P.J. ; CHEN, H.L. ; YANG, C.N. ; LI, H.Y.: "Synthesis of 2-styrylchromones as a novel class of antiproliferative agents targeting carcinoma cells", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS., FR, vol. 44, no. 6, 1 June 2009 (2009-06-01), FR, pages 2552 - 2562, XP026049353, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2009.01.034 *

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