[go: up one dir, main page]

DK688488D0 - ARALIPHATYLAMINOALKANDIPHOSPHONIC ACIDS - Google Patents

ARALIPHATYLAMINOALKANDIPHOSPHONIC ACIDS

Info

Publication number
DK688488D0
DK688488D0 DK688488A DK688488A DK688488D0 DK 688488 D0 DK688488 D0 DK 688488D0 DK 688488 A DK688488 A DK 688488A DK 688488 A DK688488 A DK 688488A DK 688488 D0 DK688488 D0 DK 688488D0
Authority
DK
Denmark
Prior art keywords
denotes
aliphatic radical
acids
formula
image
Prior art date
Application number
DK688488A
Other languages
Danish (da)
Other versions
DK688488A (en
Inventor
Knut A Jaeggi
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK688488D0 publication Critical patent/DK688488D0/en
Publication of DK688488A publication Critical patent/DK688488A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Araliphatylaminoalkanediphosphonic acids of the formula <IMAGE> in which R1 represents an aromatically substituted aliphatic radical, R2 represents hydrogen or a monovalent aliphatic radical and alk denotes a divalent aliphatic radical, and their salts have a marked regulating action on calcium metabolism and can be used as medicaments for the treatment of diseases which can be traced back to disorders thereof. They are prepared, for example, by reacting a compound of the formula <IMAGE> in which X3 denotes carboxyl and R0 denotes a radical R2, with phosphorous acid and phosphorus trichloride and hydrolysing the primary product.
DK688488A 1987-12-11 1988-12-09 ARALIPHATYLAMINOALKANDIPHOSPHONIC ACIDS DK688488A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH484787 1987-12-11

Publications (2)

Publication Number Publication Date
DK688488D0 true DK688488D0 (en) 1988-12-09
DK688488A DK688488A (en) 1989-06-12

Family

ID=4283590

Family Applications (1)

Application Number Title Priority Date Filing Date
DK688488A DK688488A (en) 1987-12-11 1988-12-09 ARALIPHATYLAMINOALKANDIPHOSPHONIC ACIDS

Country Status (21)

Country Link
EP (1) EP0320455B1 (en)
JP (1) JPH01197495A (en)
KR (1) KR890009956A (en)
AT (1) ATE90353T1 (en)
AU (1) AU609549B2 (en)
CA (1) CA1329609C (en)
DD (1) DD283631A5 (en)
DE (1) DE3881659D1 (en)
DK (1) DK688488A (en)
ES (1) ES2054868T3 (en)
FI (1) FI92704C (en)
HU (1) HU202880B (en)
IE (1) IE62738B1 (en)
IL (1) IL88620A (en)
MX (1) MX14109A (en)
NO (1) NO176663C (en)
NZ (1) NZ227273A (en)
PH (1) PH26416A (en)
PT (1) PT89193B (en)
YU (1) YU221388A (en)
ZA (1) ZA889157B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW198039B (en) * 1988-11-28 1993-01-11 Ciba Geigy Ag
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
SK144494A3 (en) * 1992-05-29 1995-05-10 Procter & Gamble Pharma Sulfur-containing phosphate compounds and their using in pharmaceutical compound for treating abnormal calcium and phosphate metabolism
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
WO1993024500A1 (en) * 1992-05-29 1993-12-09 The Procter & Gamble Pharmaceuticals, Inc. Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism
JPH07506569A (en) * 1992-05-29 1995-07-20 プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド Quaternary nitrogen-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism and tartar and plaque
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
CA2138366C (en) * 1992-06-30 1998-09-22 Kristine Hovancik Methods for the treatment of arthritis using phosphonates and nsaids
CN105829921B (en) * 2013-12-19 2018-11-09 3M创新有限公司 Article comprising a self-assembled layer comprising nanoparticles with a phosphorous surface treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
DE3623397A1 (en) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh NEW DIPHOSPHONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Also Published As

Publication number Publication date
NO885489L (en) 1989-06-12
DE3881659D1 (en) 1993-07-15
AU2673888A (en) 1989-06-15
ES2054868T3 (en) 1994-08-16
ATE90353T1 (en) 1993-06-15
NZ227273A (en) 1991-06-25
EP0320455A1 (en) 1989-06-14
KR890009956A (en) 1989-08-05
ZA889157B (en) 1989-07-26
CA1329609C (en) 1994-05-17
YU221388A (en) 1990-06-30
PT89193A (en) 1989-12-29
AU609549B2 (en) 1991-05-02
FI885710A7 (en) 1989-06-12
IE883680L (en) 1989-06-11
PT89193B (en) 1993-06-30
PH26416A (en) 1992-07-15
NO176663B (en) 1995-01-30
DD283631A5 (en) 1990-10-17
EP0320455B1 (en) 1993-06-09
FI92704B (en) 1994-09-15
IE62738B1 (en) 1995-02-22
IL88620A (en) 1994-11-28
IL88620A0 (en) 1989-07-31
DK688488A (en) 1989-06-12
FI885710A0 (en) 1988-12-09
MX14109A (en) 1994-02-28
HUT48899A (en) 1989-07-28
NO885489D0 (en) 1988-12-09
JPH01197495A (en) 1989-08-09
NO176663C (en) 1995-05-10
FI92704C (en) 1994-12-27
HU202880B (en) 1991-04-29

Similar Documents

Publication Publication Date Title
DE3770787D1 (en) Aromatisch substituierte azacyclo-alkylalkandiphosphonsaeuren.
ATE90353T1 (en) ARALIPHATYLAMINOALKANEDIPHONIC ACIDS.
ATE106889T1 (en) PHENYLALIPHATYLAMINOALKANDIPHOSPHONE ACIDS.
JPS54163558A (en) Substituted amino acid containing medicine* its application and manufacture

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment